Untersuchungen zur evidenzbasierten Auswertung therapeutischer ...

geb.uni.giessen.de

Untersuchungen zur evidenzbasierten Auswertung therapeutischer ...

9 Summary

Under the present study, an analysis of national and international publications of the

last 59 years that deal with the treatment of ovarian cysts, the hypocalcaemia post

partum and retained fetal membranes of cattle, was run taking into account the

assessment criteria of evidence-based medicine. The aim was to detect studies

showing high degree of evidence in order to present the optimal treatment method for

the above mentioned diseases. Furthermore, based on the systematic evaluation of

the publications, weaknesses in the study design as well as influences on the results

were expected to be revealed. Following relevant results were found:

- Most of the publications found were about the treatment of bovine ovarian

cysts (n = 260), followed by publications on the treatment of post-partum

hypocalcaemia (n = 87) and publications on the subject of bovine retained

fetal membranes (n = 92).

- It turned out that the publication dates of the various topics vary. Most studies

were published (n = 17) on the issue of treatment of ovarian cysts of cattle in

1977. On the issue of treatment of post-partum hypocalcaemia most of the

studies (n = 7) were published in 1975. About the treatment of bovine retained

fetal membranes most of the studies were published in 1985 (n = 5). Overall,

studies on the treatment of retained fetal membranes were more recently

published than the studies on other disease complexes.

- In the classification of publications by three independent assessors large

discrepancies stand out. Wrong classifications are particularly frequent and

obvious for fallseries and cohort studies.

- The distribution of study types on the treatment of ovarian cysts of cattle show

a significant excess of so-called "other controlled trials" (36 %). The second

frequent study type is said to be expert opinions / editorials / consensus

reports (19 %). On the issue of treatment of post-partum hypocalcaemia

publications of the study type of expert opinions / editorials / consensus

reports (33 %) outweigh clearly. Finally "other controlled trials” (25 %) and

case series (20 %) follow. For the issue of treatment of bovine retained fetal

membranes an excess of case series (28 %) was documented. Hereafter

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