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Domänen für die

Domänen für die Polarität fates of the different regions of the egg/early embryo indicate (in white) the parts that fail to develop if the anterior, posterior, or terminal system is defective middle row shows schematically the appearance of a normal larva and of mutant larvae that are defective in a gene of the anterior system (for example, bicoid), of the posterior system (for example, nanos), or of the terminal system (for example, torso) bottom row shows the appearances of larvae in which none or only one of the three gene systems is functional lettering beneath each larva specifies which systems are intact (A P T for a normal larva). inactivation of a particular gene system causes loss of the corresponding set of body structures; body parts that correspond to the gene systems that remain functional do form (slightly modified from D. St. Johnston and C. Nüsslein-Volhard, Cell 68:201–219, 1992.) A anterior P posterior T terminal Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Biologie für Physikerinnen und Physiker Kapitel VI Entwicklung 36

Inaktivierung bestimmter Gene/mRNA Teile der Larve entwickeln sich nicht Namen von Genen werden "kursiv" geschrieben; dazugehörige Proteine "Standard" Beispiele von Genen und Transkriptionsfaktoren (Proteine) Gen Protein posterior/anterior, Segmentierung bicoid bicoid Segmentidentität antennapedia antennapedia gap Gen krüppel krüppel pair rule Gen even-skipped even-skipped segment-polarity Gen gooseberry gooseberry dorsal-ventral Polarität spätzle spätzle Gastrulation nudel nudel Biologie für Physikerinnen und Physiker Kapitel VI Entwicklung 37