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Universelle Maschinerie

Universelle Maschinerie in der Entwicklung Organismen entwickeln sich phylenübergreifend gleich (A) A fly protein used in a mouse. The DNA sequence from Drosophila coding for the Engrailed protein (a gene regulatory protein) can be substituted for the corresponding sequence coding for the Engrailed-1 protein of the mouse. Loss of Engrailed-1 in the mouse causes a defect in its brain (the cerebellum fails to develop); the Drosophila protein acts as an efficient substitute, rescuing the transgenic mouse from this deformity. (B) A mollusc protein used in a fly. Eyes develop on legs. Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002 Biologie für Physikerinnen und Physiker Kapitel VI Entwicklung 8

Modellorganismen mit denen in der Entwicklungsbiologie gearbeitet wird Seeigel Drosophila Xenopus Ceanorhabditis Arabidopsis Zebrafisch Gallu gallus Female Drosophila melanogaster flies start laying eggs shortly after mating. (c) IMP-IMBA Graphics Department http://wmpeople.wm.edu/ site/page/dcshak/ researchoverview Echinoidea - Seeigel. (Original von Prof. Dr. Paul Pfurtscheller) Biologie für Physikerinnen und Physiker Kapitel VI Entwicklung 9