18.07.2022 Aufrufe

Kompendium 2021 Forschung & Klinik

Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien; Leitung: o. Univ.-Prof. Dr. Reinhard Windhager www.meduniwien.ac.at/ortho-unfall www.unlimitedmedia.at/orthopaedie2021

Universitätsklinik für Orthopädie und Unfallchirurgie MedUni Wien und AKH Wien; Leitung: o. Univ.-Prof. Dr. Reinhard Windhager

www.meduniwien.ac.at/ortho-unfall
www.unlimitedmedia.at/orthopaedie2021

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Kompendium 2021

Forschung & Klinik

Universitätsklinik für

Orthopädie und Unfallchirurgie

MedUni Wien und AKH Wien

ISBN 978-3-200-08547-3

www.meduniwien.ac.at/ortho-unfall


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Inhalt/Impressum

3

Die Klinik

4 Editorial

6 Klinische Leistungen und Operationen

9 Spezialambulanzen zunehmend gefragt

10 Interview mit o. Univ.-Prof. Dr. Reinhard Windhager:

„Unsere Forschung orientiert sich an den täglichen

klinischen Problemen“

14 Die Expertinnen und Experten auf einen Blick

18 Ambulanzverzeichnis der Universitätsklinik

für Orthopädie und Unfallchirurgie

Impressum:

Herausgeber:

Universitätsklinik für

Orthopädie und Unfallchirurgie

MedUni Wien und AKH Wien

o. Univ.-Prof. Dr. Reinhard

Windhager

Währinger Gürtel 18–20

1090 Wien

Redaktion & Gestaltung:

Unlimited Media

www.unlimitedmedia.at

Lektorat: Sophie Hermann,

BSc, Alexandra Lechner

Fotos: iStock-458810669/

SomkiatFakmee,

Unlimited Media, MedUni

Wien/Christian Houdek,

Mark Glassner, Alexander

Bumberger

Druckerei: Copydruck KG

Sandleitengasse 9–13

1160 Wien

Wien, Juli 2022

ISBN 978-3-200-08547-3

TOP-Studien

22 Clinical Comparison of Four Different Graft Types in

Matrix-Associated Autologous Chondrocyte transplantation

26 Patient-Specific Implants for Pelvic Tumor Resections

30 Size Matters as Critical Parameter for the Reliability

of Spheroids in Drug Screening Applications

34 Pseudotumors in Metal-on-Metal Total Hip Arthroplasty

37 Safe Bone Block Harvesting for Quadriceps Tendon Autografts

40 Semi-Quantitative and Quantitative MRI for the

Assessment of Cartilage Repair and Intervertebral Discs

43 Bone Mineral Density of the Thoracic Spine

46 Asso ci a tion of Varus Deformity and Coronal

Tibiofemoral Subluxation

49 Outcome after Arthroscopically Assisted TFCC Refixation

52 Osseointegration Can Be Improved by Conventionally Used

Anti-Osteoporotic Drugs Proven in a Clinically Relevant

Murine Implant Model

56 Mimicking the Zonal Organization of Articular

Cartilage in Vitro

58 Relevance of Follow-up CCT in Patients on Intracranial

Pressure Monitoring

Publikationen

62 Originalarbeiten 2021

E-Book

www.meduniwien.ac.at/ortho-unfall

www.unlimitedmedia.at/orthopaedie2021


Editorial

4

Liebe Leserinnen und Leser!

o. Univ.-Prof. Dr. Reinhard Windhager

Ein Bild sagt mehr als tausend Worte. Wie Sie den Histogrammen

entnehmen können, erzielte die Universitätsklinik für Orthopädie

und Unfallchirurgie seit ihrer Zusammenlegung nicht nur eine

Steigerung des gesamten wissenschaftlichen Outputs, sondern

auch der Leistungen pro MitarbeiterIn. Besonders erfreulich ist,

dass das Ranking der Klinik kontinuierlich verbessert werden

konnte und dies vor dem Hintergrund, dass die Publikationsleistung

universitätsweit unentwegt ansteigt. Da hier nicht der Platz

ist, Ihnen alle Studien überblicksmäßig darzustellen, haben wir

wie immer eine Auswahl von zehn wichtigen, in Top-Journalen publizierten

Veröffentlichungen ausgewählt, die sowohl in der Klinik

als auch im Labor wesentliche Ergebnisse generieren konnten und

international Beachtung gefunden haben. Nehmen Sie die Zusammenstellung

nicht nur als Leistungsschau, sondern auch als Anregung,

um in Zukunft weitere Kooperationen etablieren zu können.

Ich wünsche Ihnen viel Vergnügen beim Studium dieser Lektüre.

Ihr Reinhard Windhager

Gesamtoutput

245

286

199 193

50

83

82

104

Output pro MitarbeiterIn

1,84

2,33

1,72 1,67

2,11

2,43

1,065

0,65


Ihr Rehabilitationszentrum für Orthopädie und Neurologie

Wir richten Sie auf !

ambulantes rehazentrum

WIEN BAUMGARTEN

Schwerpunkte:

• aktivierte und chronische Abnützungserscheinungen

der Gelenke (Arthrosen)

• Erkrankungen der Wirbelsäule und Zustand

nach operativen Eingriffen an der Wirbelsäule

• Zustand nach arthroskopischen Eingriffen

an Gelenken

• Zustand nach Gelenksersatz

• Zustand nach offenen Operationen am

Bewegungsapparat

• orthopädisch-rehabilitative Schmerztherapie

• Cerebrale Gefäßerkrankungen

• Polyneuropathien

• Bewegungsstörungen (z.B.Morbus Parkinson)

• Neuromuskuläre Erkrankungen

• Multiple Sklerose und ähnliche entzündliche

Erkrankungen

Ambulante Rehabilitation

mit den Schwerpunkten:

• Kardiologie (Phase 2 und 3)

• Neurologie (Phase 3)

• Onkologie (Phase 2)

• Orthopädie (Phase 2 und 3)

• Psychiatrie (Phase 2 und 3)

• Stoffwechselerkrankungen (Phase 2 und 3)

Vorteile der ambulanten Rehabilitation:

• Wohnortnah und im gewohnten Umfeld

• Vereinbarkeit von Behandlung - Familie - Beruf

• Fortschritte können im Alltag geübt und

überprüft werden

• Anpassung der Therapien an persönliche

Bedürfnisse

• Verschiedene Rehaphasen unter einem Dach

• Kostenübernahme durch die Sozialversicherung

www.rehawienbaumgarten.at

Rehaklinik Wien Baumgarten Betriebs-GmbH, 1140 Wien, Reizenpfenninggasse 1, Tel: +43 1 41500-0


Zahlen und Fakten

6

Klinische Leistungen

und Operationen

Trotz der Einschränkungen durch die Corona-Pandemie im Jahr

2021 wurden an der Universitätsklinik für Orthopädie und

Unfallchirurgie insgesamt 5.863 Operationen durchgeführt.

Die Universitätsklinik für Orthopädie und Unfallchirurgie ist eine Groß klinik mit

einem breitgefächerten Leistungsspektrum. Im Bereich der Orthopädie

wurden insgesamt 2.413 Operationen durchgeführt. Dabei handelte es sich

vielfach um hochspezifische Eingriffe, die oft an anderen Spitälern in Österreich

nicht durchgeführt werden konnten: 293 Hüftendoprothesen, 265 Knieendoprothesen

und 168 Fusionen der Wirbelsäule. Hinzu kamen 417 Arthroskopien,

102 Fußoperationen, 298 Tumorresektionen und 83 Osteosynthesen.

An der Klinischen Abteilung für Unfallchirurgie wurden im Jahr 2021

insgesamt 3.450 Operationen vorgenommen.

Klinische Leistung Orthopädie 2020 2021

Operationen gesamt 2.449 2.413

unter anderem:

Fusionen der Wirbelsäule 149 168

Endoprothetische Versorgungen (gesamt) 653 621

davon Hüftendoprothesen 315 293

davon Knieendoprothesen 277 295

Arthroskopien (alle Gelenke) 341 417

Fußoperationen 78 102

Tumorresektionen 286 298

Osteosynthesen 83 83

Klinische Leistung Unfallchirurgie

Anzahl Operationen 3.265 3.450

unter anderem:

Endoprothetische Versorgungen (gesamt) 192 218

Schädel-Hirn-Trauma 57 30

Wirbelsäulen-OP 70 39

Becken-/Acetabulum-Frakturen 32 33

Knie-Binnenverletzungen 334 379

Rekonstruktive Operationen an der Schulter 83 93

Handverletzungen 329 427

Thorax-/Abdomenverletzungen 24 32

Periprothetische Frakturen 46 37

Osteosynthesen 606 603

Stationäre Aufnahmen 6.054 6.342


Spherox

ist das einzig

EMA-zugelassene

ATMP zur

Behandlung von

Knorpelschäden.

Spherox

erzeugt

hyalin-ähnlichen

Knorpel.

Spherox

repariert

Knorpeldefekte

im Knie bis

10 cm².

Spherox

ist 100% autolog

und frei von

Zusatzstoffen.

ERSCHAFFE

DIE BÜHNE FÜR

PERSONALISIERTE HEILUNG

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Zahlen und Fakten

9

Spezialambulanzen

zunehmend gefragt

Die Diagnose, Therapie und Prävention von angeborenen und

erworbenen Erkrankungen des Bewegungsapparates sind die

zentrale Ausrichtung der Universitätsklinik für Orthopädie und

Unfallchirur gie im AKH Wien. Die hochgradige Spezialisierung

auf bestimmte Fachgebiete hat dazu geführt, dass die mittlerweile

22 Spezial ambulanzen im vergangenen Jahr eine

steigende Frequenz aufweisen konnten.

Im Vergleich zum Jahr 2020 wurden in allen Ambulanzen im Jahr 2021

höhere Frequenzen verzeichnet. So kam es im Jahr 2021 zu 24.993

Ambulanzbesuchen (im Vergleich zu 23.306 im Jahre 2020). Die höchsten

Frequenzen wiesen folgende Ambulanzen auf: Schmerztherapie (2.047),

Tumororthopädie (3.192), Rheumaorthopädie (2.364), Kinderorthopädie

(2.138), Wirbelsäule (1.578), Sportorthopädie (1.486), Endoprothetik (1.046),

Sarkome (666) und die Fußambulanz (581).

Die ambulanten Frequenzen der Klinischen Abteilung für Unfallchirurgie

lagen ebenfalls über den Vorjahreszahlen. So wurden 2021 insgesamt

51.293 ambulante Besuche in der Erstversorgung verzeichnet

(2020: 49.342) und auch die ambulanten Kontrollen bei den Nachbehandlungen

lagen mit 36.476 höher als im Jahr davor (2020: 34.704).

2020 2021

Ambulante Frequenzen Orthopädie (gesamt) 23.306 24.993

Schmerztherapie 2.343 2.047

Tumororthopädie 2.872 3.192

Rheumaorthopädie 2.468 2.364

Kinderorthopädie 1.805 2.138

Wirbelsäule 1.550 1.578

Sportorthopädie 1.512 1.486

Endoprothetik 1.133 1.046

Sarkome 852 666

Fußambulanz 403 581

Ambulante Frequenzen Unfallchirurgie

Ambulante Frequenzen (ABF) Erstversorgung 49.342 51.293

Ambulante Kontrollen (ABK) Nachbehandlung 34.704 36.476

SchockraumpatientInnen 507 566

Eingriffe in der Wundversorgung 3.616 3.872

Versorgungen im Gipszimmer 19.579 21.017


Klinik

10

Unsere Forschung orientiert

sich an den täglichen

klinischen Problemen

Die Universitätsklinik für Orthopädie und Unfallchirurgie ist

eine der größten im AKH Wien und der MedUni Wien und genießt

vor allem im Bereich der hochspezialisierten Operationen

interna tionalen Ruhm. Die Corona-Pandemie hat aber bei der

Behandlung der Patientinnen und Patienten massive Probleme

bereitet und zu Rückgängen der über die letzten Jahre steigenden

Operations fallzahlen geführt. Die Auswirkungen im Bereich der

Forschung und Lehre waren unterschiedlich.

o. Univ.-Prof. Dr. Reinhard Windhager

Für welche hochspezialisierten Operationen, die sonst kaum in Österreich

gemacht werden, ist die Universitätsklinik für Orthopädie und Unfallchirurgie

bekannt?

Hierzu zählt in erster Linie die Tumororthopädie mit allen ihren Facetten und

Detailbereichen. So wurden an der Universitätsklinik für Orthopädie und

Unfallchirurgie En-Block-Resektionen bei hochmalignen Knochentumoren

der Wirbelsäule bereits vor 30 Jahren als weltweit führende Klinik begonnen

und in weiterer Folge perfektioniert, sodass diese heutzutage Routineoperationen

darstellen, die aber kaum anderswo durchgeführt werden.

Weiters zu erwähnen sind komplexe Eingriffe bei Infektionen des Knochens

in verschiedenen Lokalisationen und vor allem der Wirbelsäule, die ein interdisziplinäres

Management voraussetzen, ebenso wie eine hohe Expertise in

Bezug auf Planung der Operationsabfolgen und Umsetzung derselben.

Ein weiterer herausragender Schwerpunkt ist die Deformitätenkorrektur nicht

nur im Bereich der Extremitäten, die häufig interdisziplinär mit der plastischen

Chirurgie durchgeführt wird, sondern auch im Bereich der Wirbelsäule. Ein

weiterer Spezialbereich ist die moderne Amputationschirurgie mit direkter

Verbindung der Exoprothesen an den Knochen, wodurch vor allem im Oberschenkelbereich

enorme Funktionsvorteile zu registrieren sind.

Schließlich ist noch das hochspezialisierte Polytraumamanagement zu

erwähnen, welches aufgrund der hohen Frequenz und der Schwere der

Fälle nicht nur im nationalen, sondern im internationalen Vergleich hervorragend

repräsentiert ist.

Die Zuweisungen für diese Spezialeingriffe erfolgen nicht nur aus den umgebenden

Bundesländern und Gesamtösterreich, sondern sehr häufig auch

aus dem benachbarten, aber auch fernen Ausland.


Klinik

11

Über 20 Spezialambulanzen werden von der Universitätsklinik für

Orthopädie und Unfallchirurgie angeboten. Wie wichtig sind diese für

die Versorgung der Patientinnen und Patienten?

Die hohe Zahl an Spezialambulanzen repräsentiert die Differenziertheit in

der Behandlung und die zunehmende Spezialisierung dieses umfangreichen

Faches. Diese Spezialambulanzen werden von hochengagierten Kolleginnen

und Kollegen betrieben, die aufgrund ihrer Expertise und Hingebung an diese

spezielle Tätigkeit eine enorme Attraktion für die PatientInnen darstellen.

Wie überlastet sind diese Ambulanzen?

Alle Spezialambulanzen werden als Terminambulanzen geführt, sodass eine

Überlastung regulierbar ist. Allerdings entstehen in einzelnen Bereichen sehr

lange Vormerkzeiten, sodass zu Alternativen, wie telemedizinische Beratung,

gegriffen werden musste.

Wie funktioniert die Zusammenarbeit mit den niedergelassenen

ÄrztInnen – bei der Zuweisung und auch Nachsorge?

Die Kooperation mit dem niedergelassenen Bereich ist hervorragend und

hat sich in der Vergangenheit in erster Linie auf die Nachsorge beschränkt.

Neuerdings werden auch telemedizinische Beratungen angeboten, wodurch

einerseits die Wartezeiten verkürzt werden können, andererseits eine bessere

Vorbereitung der Patienten auf die Erstvorstellung gewährleistet wird.

„Die Zuweisungen für die hochspezialisierten

Operationen erfolgen nicht nur

aus den umgebenden Bundesländern

und Gesamtösterreich, sondern sehr

häufig auch aus dem benachbarten, aber

auch fernen Ausland.“

Reinhard Windhager

Welche Leistungen bietet die neue Patellofemoral-Spezialambulanz an?

Der Fokus dieser Ambulanz liegt auf dem Patellofemoralgelenk, welches

einen Teilbereich des Kniegelenkes darstellt. Probleme mit dem Patellofemoralgelenk

sind extrem häufig und betreffen funktionelle Dysbalancen, die angeboren

sein oder nach Unfällen auftreten und zu dauerhaften Belastungen

der Patientinnen und Patienten führen können. Das Wissen in diesem Spezialbereich

hat sich in den letzten 30 Jahren enorm ausgeweitet und bedingt,

dass eine multimodale Abklärung zur Analyse der Probleme erforderlich ist,

um eine patientenspezifische Behandlung und Korrektur dieser Problematik

gewährleisten zu können.

Welche Neuentwicklungen gibt es bei den einzelnen Operationen und

Behandlungen – Knie, Hüfte, Wirbelsäule, Endoprothetik …?

Bei dem heutigen Wissensstand ist es schwer, von reinen Neuentwicklungen

zu sprechen, da viele diagnostische und therapeutische Ansätze bereits

versucht worden sind, allerdings heutzutage mit neuen Methoden andere

Zugänge ermöglichen und auch bessere Ergebnisse erwarten lassen.

Im Kniegelenksbereich ist sicherlich die kinematische Ausrichtung der

Gelenkachsen bei Implantationen der totalen Endoprothese ein Ansatz,

der neuerdings weitere Verbreitung findet. Dabei wird versucht, die individuellen

Achsverhältnisse mehr zu berücksichtigen und nicht alle Kniegelenke

einheitlich auf die gleichen Maße einzustellen.

Im Bereich der Hüftendo prothetik ist es vor allem die verbesserte Ausrichtung

der Gelenke unter Einbeziehung der Stellung zwischen Becken und

Wirbelsäule, bei welchen große individuelle Unterschiede bestehen. Verbesserungen

und Innovationen sind auch im Bereich Navigation und vor allem

Robotik zu verzeichnen, sowohl was die Endoprothetik betrifft als auch die

Wirbelsäulenchirurgie. Inwieweit diese Neuentwicklungen zu dauerhaften

Verbesserungen führen, bleibt momentan Gegenstand intensiver Forschung.


Klinik

12

Welche Forschungsthemen sind in naher Zukunft zu erwarten?

Da sich aus einer interessanten Studie immer neue Fragen ergeben, ist

eine Auflistung interessanter Forschungsthemen in der Zukunft hier nicht

abzuhandeln. Die Forschung bleibt weiterhin ausgerichtet auf die Individualisierung

therapeutischer Konzepte, Charakterisierung von Patientenansprüchen

auf Basis von PROMS (patient related outcome measures), wofür große

Datenmengen herangezogen werden müssen, Analyse von Dispositionen einzelner

Patienten für unerwünschte Krankheitsverläufe und Verhinderung von

Infektionen als schwerwiegendste Komplikation bei Operationen, vor allem

bei multimorbiden Patienten. Bei Durchsicht der ausgewählten Top-Publikationen

lassen sich unschwer wichtige Themen für die Zukunft erkennen.

Welches Standing hat die Wiener Universitätsklinik international?

Das Universitätsklinikum AKH Wien ist Teil der sogenannten European

University Hospital Alliance, in der sieben renommierte Kliniken Europas im

ständigen Austausch und Vergleich stehen. Somit ist ein direktes Benchmarking

gewährleistet und auch durch direkte Kooperationen die Möglichkeit

gegeben, Optimierungen in einzelnen Bereichen rasch herbeizuführen.

„Unsere Forschungsansätze sind translational,

das heißt, dass Forschungsthemen

aus der Klinik und von klinischen

Problemen generiert werden und

durch Entwicklungen im Labor mit den

entsprechenden Ergebnissen wieder

Eingang in die Klinik finden und damit

den Patientinnen und Patienten zugutekommen.“

Reinhard Windhager

Wie wichtig sind für Sie Kooperationen mit Firmen bzw. anderen Kliniken?

Was erwarten Sie sich davon?

Die Kooperation mit anderen Kliniken ist im Forschungsbereich zur Generierung

größerer Fallzahlen unabdingbar, um international mit größten Institutionen,

vor allem im asiatischen Bereich, mithalten zu können. Kooperationen

mit Firmen sind in Bezug auf Produktentwicklungen interessant, um durch

komplementäre Vermengung verschiedener Expertisen rascher zu Ergebnissen

und Produktentwicklungen zu kommen. Die Abteilung Technologie Transfer

der Medizinischen Universität Wien bietet hierfür eine ausgezeichnete

Plattform und unterstützt unsere Forscherinnen und Forscher bei Patentanmeldungen

und weiteren Entwicklungen.

Wie wirkt sich die laufende Forschungstätigkeit auf die tägliche Arbeit

für die Patientinnen und Patienten aus?

Unsere Forschungsansätze sind in erster Linie translational, das heißt, dass

Forschungsthemen aus der Klinik und von klinischen Problemen generiert

werden und durch Entwicklungen im Labor mit den entsprechenden Ergebnissen

wieder Eingang in die Klinik finden und damit den Patientinnen und

Patienten zugutekommen.

Wie wirkt sich die Coronakrise derzeit noch auf die Klinik aus?

Die früher noch aufwendigen organisatorischen Änderungen haben sich

gut eingespielt und in den Alltag integrieren lassen, allerdings sind wegen

Corona-bedingter Personalausfälle noch Engpässe zu verzeichnen gewesen.

Auch wenn die Situation derzeit als stabil gewertet werden kann, ist nicht

abzu sehen, was an weiteren Änderungen auf uns zukommen wird. Wichtig ist

hierbei, die Motivation der Mitarbeiterinnen und Mitarbeiter hochzuhalten

und zu bündeln, da sich dauerhafte Restriktionen negativ auf das Gesamtergebnis

der Leistung sowohl im klinischen als auch im wissenschaftlichen

Bereich auswirken können. Überraschend ist immer noch die gelegentlich

hohe Kumulation von Ereignissen, wie die positive Covid-19-Testung von

Mitarbeiterinnen und Mitarbeitern oder aber Patientinnen und Patienten,

die vereinzelt zu plötzlichen Ausfällen führen können, die nicht aufgefüllt

werden können, und somit kostbare Behandlungsressourcen verloren gehen.


Comparative 3 Year

ACTIS Stem data

Survival analysis for all-cause

revision following primary total hip

arthroplasty with a medial collared,

triple-tapered primary hip stem versus

other implants in real-world settings.

Chitnis A, Mantel J, Ruppenkamp J, Bourcet A, Holy C

Current Medical Research Opinion. 2020 Sep 22:1-7.

• A retrospective cohort study identified 1,213 patients who received the

ACTIS Total Hip. This group was compared to 6,916 patients who

received other THA implants.

• Data was drawn from the Mercy Healthcare Systems Orthopedics

Database, a large US based multi-state database.

• Kaplan-Meier survival curves were generated, and a multivariable

Cox proportional hazard model was used to compare the relative risk

of revision.

57% lower risk of revisions

Adjusted Hazard Ratio 0.43 ((0.19-0.97) p=0.042)

3

ACTIS Stem revision rate estimated

at 1.08% at years 2 and 3

2.63%

(2.19%-3.16%)

2

1.9%

(1.57%-2.29%)

2.29%

(1.91%-2.74%)

2.63%

(2.19%-3.16%)

1.08%

(0.43%-2.72%)

ALL-CAUSE REVISION RATE AT 3 YEARS

1

0

0.64%

(0.28%-1.43%)

1.08%

(0.43%-2.72%)

1.08%

(0.43%-2.72%)

YR 1 YR 2 YR 3

ACTIS STEM

OTHER THA IMPLANTS

57% Reduced Risk of Revision when

Compared to Other THA Implants

Please refer to the instructions for use for a complete list of indications, contraindications, warnings and precautions.

Johnson & Johnson Medical Limited. Baird House, 4 Lower Gilmore Bank, Edinburgh, EH3 9QP, United Kingdom.

Incorporated and registered in Scotland under company number SC132162.

www.jnjmedicaldevices.com

© DePuy Synthes 2020. All Rights Reserved.

155950-201015 DSUS/EMEA


Das ÄrztInnenteam

14

Die Expertinnen und

Experten auf einen Blick

Neben dem Fortschritt in der Medizintechnik und innovativen

Medikamenten sind vor allem die Mitarbeiterinnen und Mitarbeiter

ein essenzieller Garant für den optimalen medizinischen

Erfolg. Die rund 100 ÄrztInnen der Universitätsklinik für

Orthopädie und Unfallchirurgie von MedUni Wien und AKH

Wien profitieren dabei auch vom exzellenten Netzwerk, dem

wertschätzenden Umgang miteinander und der zielorientierten,

individuellen Fort- und Weiterbildung.


Das ÄrztInnenteam

15

Universitätsklinik für Orthopädie und Unfallchirurgie

Leiter: o. Univ.-Prof. Dr. Reinhard WINDHAGER

Klinische Abteilung für Orthopädie

o. Univ.-Prof. Dr. Reinhard WINDHAGER

ao. Univ.-Prof. in Dr. in Catharina CHIARI, MSc

Univ.-Prof. Dr. Alexander GIUREA

Klinische Abteilung für Unfallchirurgie

Assoz. Prof. Priv.-Doz. Dr. Stefan HAJDU, MBA

Assoz. Prof. in Priv.-Doz. in Dr. in Silke ALDRIAN

Mitarbeiterinnen und Mitarbeiter

(in alphabetischer Reihenfolge):

Dr. Jürgen ALPHONSUS

Dr. in Anna ANTONI

Dr. Sebastian APPRICH

Univ.-Prof. in Dr. in Michaela AUER-GRUMBACH

Mag. a Dr. in Rita BABELUK

Dr. Oskar BAMER

Dr. in Elena BATRINA

Dr. Harald BINDER, MSc

Priv.-Doz. DDr. Christoph BÖHLER

Dr. Robert BREUER (karenziert)

Dr. Alexander BUMBERGER

Dr. in Alexandra CHRIST

Dr. in Britta CHOCHOLKA

Dr. in Theresia DANGL

Dr. Michél DEDEYAN

Dr. in Danielle DIARRA

Dr. Kevin DÖRING

Dr. in Nevenka DRMIC

Dr. in Larissa EGKHER

Dr. Alexander EGKHER

Dr. Lukas EICHELBERGER

Dr. in Emilia EREDANSKY

Dr. Jozsef-Tibor ERDÖS

Mag. a Seyma ERGÜN

Assoz. Prof. Priv.-Doz. Dr. Philipp FUNOVICS, MSc

Mag. Dr. Georg FRABERGER

Dr. Stephan FRENZEL

Dr. in Nina JANJIC

Ass.-Prof. Dr. Martin FROSSARD

Dr. Bernhard GASSER

Mag. a Andrea GAVENDOVA

Dr. Markus GREGORI

Dr. Fabian GREINER

Ass.-Prof. Dr. Manfred GREITBAUER

ao. Univ.-Prof. Dr. Josef GROHS

Dr. in Luiza GRÜNBERG

Priv.-Doz. Thomas HAIDER, MBA (karenziert)

DDr. Gabriel HALAT

ao. Univ.-Prof. Dr. Thomas HEINZ

Dr. Stephan HEISINGER

Priv.-Doz. Dr. Gerhard HOBUSCH, MSc

Assoz. Prof. Priv.-Doz. Dr. Marcus HOFBAUER

Dr. Christoph HOFER

Dr. Florian HOFMANN

Dr. in Anna HOHENSTEINER

Dr. in Katharina HOHENSTEIN-SCHEIBENECKER

Dr. in Sabrina HOLZER (karenziert)

Dr. in Laura HRUBY, PhD

Dr. Florian HRUSKA

Dr. Zhaohui HU

Dr. Michael HUMENBERGER

Dr. in Manuela JAINDL

Dr. Nikolaus JANTSCH

Dr. Fatmir KABASHI

Dr. Georg KAISER

ao. Univ.-Prof. Dr. Richard KDOLSKY

Dr. Maximilian KEINTZEL

Dr. in Ahkin KEIZER

Dr. in Anne KLEINER

Priv.-Doz. Dr. Alexander KOLB

Dr. Paul KOLBITSCH (karenziert)

Priv.-Doz. Dr. Ulrich KOLLER, MSc

Dr. in Irena KRUSCHE-MANDL

Assoz. Prof. Priv.-Doz. Dr. Bernd KUBISTA, MSc

Priv.-Doz. Dr. Nikolaus LANG, MSc

Dr. in Roberta LAGGNER

Assoz. Prof. Priv.-Doz. Dr. Richard LASS, MSc

Assoz. Prof. Priv.-Doz. Dr. Johannes LEITGEB, PhD

Dr. in Marie-Christine LUTSCHOUNIG

Dr. in Monika LUXL

Ass.-Prof. Dr. Wolfgang MACHOLD

Dr. Bernhard MAIER


Das ÄrztInnenteam

16

Dr. in Ulrike MARQUART

Dr. Michael MATZNER

Dr. Timon MOFTAKHAR

Dr. in Raffaela MORGENBESSER

Dr. Arastoo NIA (karenziert)

Ap. Prof. Priv.-Doz. Dr. Lukas NEGRIN, PhD, MMSc

Ass.-Prof. Dr. Gholam PAJENDA

Dr. in Karin PAGANO-BRAUN

Assoz. Prof. Priv.-Doz. Dr. Joannis PANOTOPOULOS

DDr. Stephan PAYR, PhD

Dr. Lorenz PICHLER

Dr. Stefan PLESSER (karenziert)

Dr. in Sigrid POLZER

Dr. Domenik POPP (karenziert)

Priv.-Doz. Dr. Stephan PUCHNER, MSc

Dr. in Colleen RENTENBERGER

Dr. Gregor RETTL

DI in Dr. in Anna RIENMÜLLER

Dr. Stephan SALZMANN

Dr. Paul SCHADLER

Ass.-Prof. Dr. Klaus-Dieter SCHATZ

Dr. Philipp SCHEIDER

Dr. in Eleonora SCHNEIDER

Dr. Markus SCHREINER

Dr. Rupert SCHUSTER

Dr. Gilbert SCHWARZ (karenziert)

Ass.-Prof. in Dr. in Elisabeth SCHWENDENWEIN

Priv.-Doz. in DDr. in Irene SIGMUND

Ass.-Prof. Dr. Gobert SKRBENSKY

Dr. Bernhard SPRINGER

Dr. Kevin STAATS

Priv.-Doz. in Dr. in Julia STARLINGER, LL.M, FEBOT,

PhD (karenziert)

Dr. in Beate STELZENEDER (karenziert)

Dr. in Sandra STENICKA (karenziert)

Priv.-Doz. Dr. Christoph STIHSEN

Dr. in Geraldine STURZ

Dr. in Gerhild THALHAMMER

Priv.-Doz. Dr. Thomas TIEFENBÖCK, MSc

Dr. Klemens VERTESICH

Dr. Rainer WAGNER

Dr. in Rebecca WAGNER

Ap. Prof. Priv.-Doz. Dr. Wenzel WALDSTEIN-

WARTENBERG

Dr. in Valerie WEIHS

Ap. Prof. Priv.-Doz. Dr. Harald WIDHALM, MBA

Priv.-Doz. in Dr. in Madeleine WILLEGGER, FEBOT

Dr. Gregor WOLLNER

ao. Univ.-Prof. Dr. Gerald E. WOZASEK

Priv.-Doz. Dr. Lukas ZAK

Dr. in Cornelia ZEITLER (karenziert)

Mitarbeiterinnen und Mitarbeiter in Forschungslabors

(in alphabetischer Reihenfolge):

Melanie ACOSTA, BSc

Ana BREIL

Isabel CASADO LOSADA, MU

Marian FÜRSATZ, MSc MMSc

Dr. in scient. med. Verena KOPATZ, MSc

Priv.-Doz. in Dr. in rer. nat Sylvia NÜRNBERGER

Dr. Emir BENCA

Dr. Mario ROTHBAUER

Dr. in Anita FISCHER

Dr. in Katharina PICHLER (Karenz)

Melanie CEZANNE, BMA

Ruth GRÜBL-BARABAS, BMA

Alexander STÖGNER, BMA

Bettina RODRIGUEZ-MOLINA, BMA (Karenz)

Dr. Jürgen ALPHONSUS

Ingeborg Eva REIHS, MSc

Tamara COLOVIC

Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan TÖGEL

Mitarbeiterinnen des Studiensekretariats

(in alphabetischer Reihenfolge):

Sandra HACKER, MSc

Anna-Theresia KOURIMSKY, BSc

Anja LANGER

Carmen TROST, BA MA


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Das ÄrztInnenteam

18

Wiener Gesundheitsverbund

Teilunternehmung AKH Wien

Universitätsklinik für

Klinische Abteilung für Orthopädie

PatientInnenversorgung

Forschung

Spezialambulanzen

Schulter und Ellbogen

Sportchirurgie Knie

Hand

Fuß

Orthopädische

Schmerzambulanz

Hüfte

Knie

Knorpelschäden

Neuromuskuläre

Fußamb.

Patellofemoral

Knochen- und

Weichteilsarkome

Klumpfuß

Extremitätendeformität

Spezialteams

Sportorthopädie

Rheumaorthopädie

Rehabilitation

und Prothetik

Komplexe Revision und

Extremitätenrekonstruktionen

Endoprothetik

Kinderorthopädie

Tumororthopädie

Forschungscluster

Arthrose und

Geweberegeneration

Deformitäten und

Frakturheilung

Endoprothetik

Hand

Infektionen

Kinder

Neuropathien

Poly- und Schädelhirntrauma

Sport und Gelenkserhaltung

Tumor

Spezielle

biomedizinischtechnische

Verfahren

3D OP

Ganganalyse

MRT und biochemische

Bilddiagnostik

PROMS/RDA

Rapid Prototyping

RSA

Skoliose und WS-

Deformitäten

Wirbelsäule

Wirbelsäule


Das ÄrztInnenteam

19

Medizinische Universität Wien

Orthopädie und Unfallchirurgie

Klinische Abteilung für Unfallchirurgie

Lehre

PatientInnenversorgung

Orthopädie

Diplom- und

Doktoratsstudium

Unfallchirurgie

Diplom- und

Doktoratsstudium

Erstbehandlungsambulanz

+

Nachbehandlungsambulanz

Spezialambulanzen

Postgraduelle Aus-/

Weiterbildung

inkl. PhD

Facharztausbildung

Postgraduelle Aus-/

Weiterbildung

inkl. PhD

Facharztausbildung

Wirbelsäulenverletzungen

Traumatische Knorpelschäden

Posttraumat. Deformitäten

und Gliedmaßenrekonstruktion

Kindertraumatologie

Sportambulanz

Handambulanz

Schulterambulanz

Hüftambulanz


Ambulanzen

20

Ambulanzverzeichnis der

Universitätsklinik für

Orthopädie und Unfallchirurgie

Die Spezialambulanzen der Klinischen Abteilung für Ortho pädie

befinden sich im AKH Wien auf Ebene 7D unter dem grünen

Betten haus. Für diese Bestellambulanzen sind telefonische Terminvereinbarungen

unter der Telefonnummer +43/1/404 00-40800

erforderlich. Zuweisungen erfolgen jeweils durch die niedergelassenen

Fachärztinnen und -ärzte für Orthopädie.

Die Spezialambulanzen der Klinischen Abteilung für Unfallchirurgie

und die Nachbehandlung in der Unfallambulanz

befinden sich auf Ebene 6B und sind unter der Telefonnummer

+43/1/404 00-59380 zu kontaktieren.


Ambulanzen

21

Spezialambulanzen Klinische Abteilung für Orthopädie

Spezialambulanz für orthopädische Schmerztherapie

Endoprothesenzentrum der Maximalversorgung

• Spezialambulanz für Endoprothetik

• Spezialambulanz für Knie

• Spezialambulanz für Hüfte

• Spezialambulanz für komplexe Revisionen und Extremitätenrekonstruktionen

• Patellofemoral-Spezialambulanz

Tumororthopädie

• Spezialambulanz für Tumororthopädie

• Spezialambulanz für Knochen- und Weichteilsarkome

• Spezialambulanz für Rehabilitation und Prothetik

Wirbelsäulenorthopädie

• Spezialambulanz für Wirbelsäule

• Spezialambulanz für Skoliose und Wirbelsäulendeformitäten

Kinderorthopädie

• Spezialambulanz für Kinderorthopädie

• Spezialambulanz für Knorpelschäden

• Spezialambulanz für Klumpfuß

• Spezialambulanz für Extremitätendeformitäten

• Neuromuskuläre Fußambulanz

Rheumaorthopädie

• Spezialambulanz für Rheumaorthopädie

• Spezialambulanz für Fuß

• Spezialambulanz für Hand

Sportorthopädie

• Spezialambulanz für Sportorthopädie

• Spezialambulanz für Sportchirurgie Knie

• Spezialambulanz für Schulter und Ellbogen

Spezialambulanzen Klinische Abteilung für Unfallchirurgie

• Allgemeine Unfallambulanz – Erstversorgung

• Allgemeine Unfallambulanz – Nachbehandlung

• Ambulanz für Kindertraumatologie

• Ambulanz für Handchirurgie

• Ambulanz für Hüftverletzungen und posttraumatische Hüftbeschwerden

• Schulterambulanz

• Ambulanz für traumatische Knorpelschäden

• Ambulanz für posttraumatische Deformitäten und Gliedmaßenrekonstruktion

• Ambulanz für Sportverletzungen

• Ambulanz für posttraumatische Wirbelsäulenbeschwerden


TOP-Studien

22

Clinical Comparison of Four

Different Graft Types in

Matrix-Associated Autologous

Chondrocyte transplantation

Articular cartilage lesions are one of the most frequent types of

injuries encountered in orthopaedic practice: They show no

spontaneous healing response and often lead to unicompartmental

osteoarthritis (OA), which is a common problem among

young and active people. Focal defects to the cartilage lead to

progredient cartilage self-destruction and joint pain, ultimately

resulting in secondary OA.

Because of improvements and developments in cartilage repair, autologous

chon-drocyte transplantation (ACT) has become an increasingly popular

treatment method. The most common techniques are third-generation

matrix-associated autologous chondrocyte transplantation (MACT) procedures,

which follow a two-step surgical approach: First, a three-dimensional

biocompatible scaffold serving as cell growth carrier is seeded with

chondrocytes from an initial arthroscopy, to be then implanted in the patient

during a subsequent mini-arthrotomy.

Study:

Binder H, Hoffman L, Zak L,

Tiefenboeck T, Aldrian S,

Albrecht C.

Clinical evaluation after

matrix-associated autologous

chondrocyte transplantation:

A comparison of four different

graft types.

Bone Joint Res. 2021

Jul;10(7):370-379. doi:

10.1302/2046-3758.107.

BJR-2020-0370.R1.

This scaffold is composed of cartilage extracellular matrix molecules or biopolymers,

forming a biological matrix leading to more hyaline-like repair tissue

in articular cartilage defects. The matrix traps the cells in the chondral defect

and provides cell-matrix interactions, stimulating differentiation into articular

chondrocytes and the production of a hyaline-like extracellular matrix.

Compared to bone marrow-stimulating techniques such as MFX, MACT

provides the possibility of differentiation of the cartilage repair tissue, leading

to the reformation of hyaline or hyaline-like cartilage. It has also been

shown that MACT consistently improves patient-reported functional outcomes

compared with microfracture.

However, comparisons between different types of MACT grafts are lacking

in the literature. The four most common ones are Hyalograft ® C autografts

(Fidia Advanced Biomaterials, Italy), MACI ® (Genzyme, USA, former Verigen,

Germany), CaReS ® (Arthro Kinetics Biotechnology GmbH; Krems, Austria),

and Novocart ® 3D (TeTeC, Reutlingen, Germany).


TOP-Studien

23

A B C

Figure 1: Preoperative (A) and follow-up MRI after one year (B) and two years (C) of a 25-year-old female patient after matrix-associated autologous

chondrocyte transplantation procedure with the Hyalograft®C Transplantation system.

„Our data demonstrated that MACT

resulted in good clinical improvement

for tibio-femoral defects two years

after transplantation, regardless of

the graft type used.“

Harald Binder

Hyalograft ® C consists of a hyaluronan web seeded with previously obtained

cells that are cultivated in 2D for at least two weeks. MACI ® is a collagen

type I/III membrane seeded with Chondrocytes that are cultivated in 3D for

one week. CaReS ® is composed of a collagen type I gel, the obtained cells are

mixed with the gel directly without monolayer cultivation, instead, a three

weeklong 3D-cultivation is performed. Novocart ® 3D is a bilayered collagen

type I sponge, containing chondroitin-sulphate. The cells are isolated from

full depth cartilage cylinders, multiplied in monolayers, and seeded onto the

scaffold. Cultivation lasts for two days and is performed in 3D.

Aim and Methods

This retrospective study aims to determine the possible differences in shortterm

clinical outcome among these four different types of MACT, since up to

now, no comparison of these four commonly used transplant types has been

documented.

This case control study includes 88 patients (mean age: 34 years, mean

BMI: 25) with full-thickness chondral lesions of the tibiofemoral joint who

underwent MACT. Clinical examinations were performed preoperatively, and

24 months after transplantation. Clinical outcomes were evaluated using the

International Knee Documentation Committee (IKDC), the Brittberg score,

the Tegner Activity Scale, and the visual analog scale (VAS) for pain. The

Kruskal-Wallis test by ranks was used to compare the clinical scores of the

different transplant types.

Results and Conclusion

The average defect size of the tibiofemoral joint compartment was 4.28 cm 2 .

Eleven patients (12.6 %) underwent transplantation with Chondro-Gide

(MACI), 40 patients (46.0 %) with Hyalograft (HYAFF) (Figure 1), 21 patients

(24.1 %) with CaReS and 15 patients (17.2 %) with Novocart 3D. The mean

IKDC score improved from 35.71 (± 6,44) preoperatively to 75.26 (± 18.36)


TOP-Studien

24

after 24 months postoperatively in the Hyalograft group, from 35.94 (± 10.29)

to 71.57 (± 16.31) in the Chondro-Gide (MACI) group, from 37.06 (± 5.42) to

71.49 (± 6.76) in the Novocart 3D group and from 45.05 (± 15.83) to 70.33

(± 19.65) in the CaReS group. Similar improvements were observed in the VAS

and Brittberg scores.

Our data demonstrated that MACT resulted in good clinical improvement for

tibiofemoral defects two years after transplantation, regardless of the graft

type used. Different transplant composition and architecture did not significantly

influence clinical outcomes in our study population.

Resume

The novelty of the herein presented study is the comparison of four different

graft types among their clinical results in human. Published studies

have varied in terms of their quality and which techniques have been compared

with one another. To our knowledge, there are no studies comparing

more than two different matrices in a clinical trial. Therefore, this is the

first study comparing 2-year clinical outcomes of patients treated with different

graft types for symptomatic, traumatic chondral defects restricted

to the tibiofemoral joint area. The major finding of this study was that our

data showed no significant differences in the clinical outcomes regarding

the graft types used.

References:

[1] Curl, W.W., et al., Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy, 1997.

13(4): p. 456-60.

Dr. Harald Binder, MSc

Author:

As a member of the outpatient’s

clinic for traumatic cartilage

defects and shoulder surgery

of the AKH Vienna, Harald

Binder specialises in trauma

surgery and orthopaedics. His

clinical and scientific

focus includes shoulder surgery,

cartilage trauma, traumatic

brain injuries, clinical

paediatric traumatology, and

sports medicine.

[2] Hunziker, E.B., Articular cartilage repair: basic science and clinical progress. A review of the

current status and prospects. Osteoarthritis Cartilage, 2002. 10(6): p. 432-63.

[3] Schinhan, M., et al., Critical-size defect induces unicompartmental osteoar-thritis in a stable

ovine knee. J Orthop Res, 2012. 30(2): p. 214-20.

[4] Schulze-Tanzil, G., Activation and dedifferentiation of chondrocytes: implica-tions in

[5] Brittberg, M., Autologous chondrocyte transplantation. Clin Orthop Relat Res, 1999(367 Suppl):

p. S147-55.

[6] Marlovits, S., et al., Cartilage repair: generations of autologous chondrocyte transplantation. Eur

J Radiol, 2006. 57(1): p. 24-31.

[7] Bartlett, W., et al., Autologous chondrocyte implantation versus matrix-induced autologous

chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised

study. J Bone Joint Surg Br, 2005. 87(5): p. 640-5.

[8] Knutsen, G., et al., Autologous chondrocyte implantation compared with mi-crofracture in the

knee. A randomized trial. J Bone Joint Surg Am, 2004. 86(3): p. 455-64.

[9] Wondrasch, B., et al., Effect of accelerated weightbearing after matrix-associated autologous

chondrocyte implantation on the femoral condyle on radiographic and clinical outcome after

2 years: a prospective, randomized controlled pilot study. Am J Sports Med, 2009. 37 Suppl 1: p.

88s-96s.

[10] Albrecht, C., et al., Gene expression and cell differentiation in matrix-associated chondrocyte

transplantation grafts: a comparative study. Osteoar-thritis Cartilage, 2011. 19(10): p. 1

219-27.


Integriertes Patientenversorgungskonzept zur MACT-

Gelenksknorpelrekonstruktion

Exakte Indikationsstellung

Indikations- und Durchführungs empfehlungen

der Arbeits gemeinschaft „Geweberegeneration

und Gewebe ersatz“ zur Autologen

Chondrozyten-Transplanta tion (ACT). Behrens

P, Bosch U, Bruns J, Erggelet C, Esenwein SA, Gaissmaier

C, Krackhardt T, Löhnert J, Marlovits S, Meenen NM,

Mollenhauer J, Nehrer S, Niethard FU, Nöth U, Perka C,

Richter W, Schäfer D, Schneider U, Steinwachs M, Weise K

(2004). Z Orthop 142: 529-539

Hohe Zelldichte und hohe Zellvitalität

des Implantats

Effect of cell seeding concentration on the quality

of tissue engineered constructs loaded with adult

human articular chondrocytes. Concaro S, Nick lasson E,

Ellowsson L, Lindahl A, Brittberg M, Gatenholm P (2008).

J Tissue Eng Regen Med

Flexible Anpassung des Implantats bei

der Trans plantation und Wahrung einer

homogenen Zellmatrix

Stabilization of fibrin-chondrocyte constructs for

cartilage reconstruction. Meinhart J, Fussenegger M, Höbling W

(1999), Ann Plast Surg 42(6): 673-678

Knorpelbiobsat­Entnahme

Zellkultur züchten

MACT­Transplantation

Seit 2001 züchtet das Institut

für Gewebe- und Organrekonstruk

tion, kurz igo®,

autologe Zell kul turen für die

Knorpel zell rekon struk tion für mehr als 1.500 Patienten

erfolgreich an.

igo® ist ein privates biopharmazeutisches Unternehmen

und Pionier auf dem Gebiet der Zellkulturtechnik

und des Tissue Engineerings und aktiv

beteiligt an Entwicklung neuer Heilmethoden. Als

österreichisches Unternehmen glänzen wir mit

der besonderen räumlichen Nähe und dem direkten

Kontakt zu unseren Kunden.

Informieren Sie sich unter www.igor.at

Hohe Compliance des Patienten: Die für

die Nachtherapie verwendeten Geräte,

CPM Schiene sowie HPM Gerät verfügen

über eine Compliance­Überwachung. Wenn

der Patient hier compliant ist, kann man

davon ausgehen, dass er auch bei der

Physio therapie konsequent mitarbeitet, was

für den Erfolg der Therapie wesentlich ist.

Low frequency EMF regulates chondrocyte

differentiation and expression of matrix proteins.

Ciombor DM, Lester G, Aaron RK, Neame P, Caterson B (2002).

J Orthop Res, Vol. 20(1): 40-50

Postoperative Therapie

Die Kontrollierte Nachtherapie: wird

durch das Netz werk von geschulten Physiotherapeuten

unterstützt

MACT­Langzeittherapie

Autologous chondrocyte implantation postoperative

care and rehabilitation. Hambly K, Bobic V, Wondrasch B,

VanAssche D, Marlovits S (2006). Science and Practice.

Am J Sports Med 34(6): 1020-1038

A prospective, randomized comparison of traditional

and accelerated approaches to postoperative

rehabilitation following autologous chondrocyte

implantation: 2-year clinical outcomes. Jay R. Ebert,

William B. Robertson, David G. Lloyd, M.H. Zheng, David J. Wood,

Timothy Ackland (2010). Catilage 1(3)180-187

Wissenschaftliche Publikationen

mit igor Chondro­Systems

Clinical experience with matrix associated

autologous chondrocyte transplantation

(MACT). Ramadani F, Orthner E, Kitzler B,

Wallner B, Burghuber C, Fußenegger M, Meinhart J

(2005). Revista de ortopedie si traumatologie 1(6):

106-110

Transplantation of chondrocytes – longtime

experiments. Prof. Dr. Lars Peterson (2006)

Ergebnis nach ca. 18 Monaten

Quelle:

Klinik Diakonissen

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TOP-Studien

26

Patient-Specific Implants

for Pelvic Tumor Resections

„Internal hemipelvectomy and

reconstruction using custom-made

implants comes with a high risk for

postoperative complications. However,

good functional outcomes can be

regularly achieved.“

Kevin Döring

Limb-sparing surgery of primary malignant pelvic tumors has

become the treatment of choice over the last decade, mainly due

to improvement in surgical technique, imaging, and perioperative

management. However, limb-sparing surgery remains challenging

with respect to defect reconstruction and management of complications.

Several methods have been applied for reconstruction

after periacetabular tumor resections, such as iliofemoral arthrodesis,

allograft reconstruction, irradiated, autoclaved or frozen

autografts, and allograft-prosthetic composites.

Endo prosthetic replacement bears the advantage of immediate stability and

allows early weight bearing, which is of utmost importance in this mainly

young patient group. Among the endoprosthetic replacements, custom-made

endoprostheses have been used in the last three decades and still represent

the technique of choice due to high variability in pelvic anatomy (Figure 1).

However, as pelvic reconstruction using custom-made implants is only rarely

necessary, follow up data on this type of reconstruction are rare. Thus, we

conducted this study to analyse the outcome of custom-made prostheses in

a single centre setting over a follow-up period of three decades.

Patients and Methods

Between 1990 and 2000, 26 patients underwent resection of pelvic malign

bone tumors at the orthopaedic department of the Medical University of

Vienna and received reconstruction using custom made pelvic prostheses

(Howmedica, Kiel, Germany). Except of oncological survival analyses, 6 of

these 26 patients were excluded due to a follow up below one year and, thus,

no possibility of an adequate prosthesis assessment regarding function and

complications. The median (range) age at surgery was 25 (13–63) years, the

median follow-up after surgery was 5 (1–17) years.

Study:

Döring K, Staats K, Puchner S,

Windhager R.

Patient-Specific Implants for

Pelvic Tumor Resections.

J Pers Med. 2021 Jul

21;11(8):683.

Results

At the time of last follow up, four patients had no surgical revision after prosthesis

implantation, while 16 patients had at least one revision. The median

number of revision surgeries per patient was 1.5 (0–7). The first surgical

revision was performed with a median of 27 (0 days – 6 years) days after surgery.

Regarding type I complications according to the ISOLS classification by

Henderson et al., we found a revision free survival of 90 % after one year and

84 % after two and five years. Type I complications occurred in three patients

suffering from dislocation of their pelvic prosthesis, which required surgical

revision after a median of five months (14 days – 20 months) after surgery.

Type II complications or aseptic loosening showed a revision free survival of


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27

Figure 1: Real-size planning model for preoperative prosthesis and osteotomy planning.

95 % after one year, 89 % after two years and 78 % after five years. Aseptic

loosening occurred in four patients after a median of 38.5 (10–80) months.

Type IV complications or deep infections were the most prevalent surgical

complications, with 9 out of 20 patients suffering from infections which

needed surgical revision after a median of 86 days (13 days – 5 years) after

primary prosthesis implantation. Although most of these infections could

be treated with debridement and antibiotic therapy, three patients required

implant removal due to otherwise uncontrollable infections after a median of

15 months (95 days – 16 years) after surgery. There were no revisions due to

type III complications or periprosthetic fractures, as well as type V complications

or tumor progression in this study.

Four patients suffered from sciatic nerve lesions, of whom 2 patients received

singular surgical neurolysis with a median of 26 (24–28) months after

surgery. Thromboembolic events were frequently observed after surgery,

with 5 out of 20 patients suffering from thromboses. Three of these patients

required immediate revision surgery at the day of prosthesis implantation,

while two patients were successfully treated conservatively.

15 patients with a minimum follow up of one year could be functionally

assessed, while a complete Harris Hip Score (HHS) could be retrieved in

eleven patients, showing good results with a median score of 81 (37–92)

points at time of last follow up visit at the outpatient clinic. Six patients were

able to walk without walking aid and six patients needed one walking stick,

while three patients were mobilized with two crutches. No information regarding

walking limitations could be assessed in five patients.


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28

Figure 2: Left: Twenty-four-year-old patient with pelvic osteosarcoma. Middle: Same patient after receiving a modern 3D-printed custom-made prosthesis

(Materialise, Gilching, GER), with a cemented Durasul inlay (Zimmer Biomet, Warsaw, IN, USA) articulating with an Actis femoral stem (DePuy

Synthes, Raynham, MA, USA). Right: Two years after the surgery, the patient is pain free and has a moderately limb walk with no walking aid required.

Discussion

Although the use of custom-made prostheses led to primary stable reconstructions,

complications were common at medium- to long-term follow ups.

Especially in reflection of a high postoperative prosthesis morbidity with

potentially devastating complications, patients need to be carefully selected,

thoroughly educated, and integrated into the decision-making process.

At our institution, these high complication numbers led to a diminished use

of custom-made endoprostheses at the expense of saddle endoprostheses

or ice-cone shaped endoprostheses in the last decade.

However, not all types of periacetabular tumors may be addressed with

saddle- or ice-cone shaped endoprostheses, as enough iliac bone is required

for implant fixation. We believe that emerging 3D-printed custom-made

prostheses show great promise in reconstruction of extensive periacetabular

tumors, due to a potential reduction of duration of surgery and thus

postoperative complications, a higher prosthesis survival and stability, and

better availability due to a fast 3D-printing process (Figure 2).

Dr. Kevin Döring

Author:

Kevin Döring has been a

resident at the Department

of Orthopedics and Trauma

Surgery at the Medical University

of Vienna since 2018.

His research focuses on the

promotion of patient-centered

implant solutions in foot surgery,

tumor orthopaedics and

arthroplasty.

In frontiers of limb salvage surgery, functional outcomes are of particular importance

to justify invasive and complication-ridden procedures. This study

showed good functional results, with a median HHS of 81 (37–92) points at

time of last follow up. More than half of all patients showed a high weight

bearing capability, as six patients walked without walking aid and six other

patients only needed one walking stick.

Conclusion

Internal hemipelvectomy and reconstruction using custom-made implants

comes with a high risk for postoperative complications. However, good

functional outcomes can be regularly achieved. This information may help

treating surgeons to find adequate indications, as eligible patients need

to be critically selected. Future studies evaluating new generations of

3D-printed custom-made pelvic implants are needed to determine their

clinical value.


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TOP-Studien

30

Size Matters as Critical

Parameter for the Reliability

of Spheroids in Drug Screening

Applications

Study:

Eilenberger C, Rothbauer M,

Selinger F, Gerhartl A, Neuhaus

W, Jordan C, Harasek M,

Schädl B, Grillari J, Küpcü S,

Weghuber J, Ertl P, A microfluidic

multi-size spheroid array

for multi-parametric screening

of anti-cancer drugs and

blood-brain barrier transport

properties, Advanced Science,

2021, 2004856, 4. (16,806)

In 2021, a cooperative project of researchers of the ‚Karl Chiari

Lab for Orthopaedic Biology‘ in collaboration with partners at

the Vienna University of Technology, the University of Natural

Resources and Life Sciences Vienna (BOKU), the Austrian Institute

of Technology GmbH, the Ludwig-Boltzmann-Institute for

Experimen tal and Clinical Traumatology, and the University of Applied

Sciences Upper Austria developed a microfluidic multi-size

spheroid array platform to standardize and validate spheroid

tissue models for drug screening. The study resulted in the article

entitled ‘A Microfluidic Multisize Spheroid Array for Multiparametric

Screening of Anticancer Drugs and Blood–Brain Barrier

Transport Properties’ in Wiley Advanced Science (IF 16.8). The

work is a result of years of interdisciplinary research at the interface

of basic biological research, engineering, and bioengineering.


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31

„This study overall proves that size is

a vital parameter that needs to be

considered in the future to allow

validation and standardization of

organotypic spheroid-based models for

pharmaceutical research, because

it severely affects study outcome.“

Mario Rothbauer

The disadvantages associated with the development of novel drugs include

the high costs for development, regulatory approval, and market introduction.

Even though remaining the golden standard for clinical trials to this day, animal

testing does not reflect what happens in the human body. Consequently, most

drug candidates fail during development, with approx. 1 out of 20 successful

drug candidates entering the market. Over the last two decades, in vitro assays

based on artificial human tissues as three-dimensional cultures have gained

momentum in pharmaceutical development, toxicology, and biomedicine.

These complex three-dimensional tissue-like structures are not only

intended to circumvent expensive animal experiments, but also to replace

the currently existing and inadequate in vitro models, because both approaches

that fail to resemble human tissue architecture and function. Thus,

various culture techniques have been established over the years (e.g., pellet

cultures, micro masses, Trans-wells, etc.) that aim to resemble function of

human tissues on architectural down to molecular levels. The undisputed

most promising technology for drug screening, allowing for the high scalability

requirements of pharmaceutical industry, are multi-cellular organotypic

spheroids, which create complex tissue structures based on the proficiency

of primary cells to form tissue-like structures when being joined together as

heterogenous aggregates.

Even though the research community has promised that such next-generation

models are of physiological relevance and ideal for improving the efficiency

of drug screening during clinical studies, so far artificial human tissue

technologies still severely lack the proper validation necessary for integration

into development and production pipelines and certification procedures.

Furthermore, not a single well-plate derived solution can maintain cells under

the dynamic and perfused conditions needed to create a tissue-like microenvironment.

Aside from variations in donor tissue and consequently cell

function, the most significant drawback to use organ-like spheroids is simple:

Every laboratory – be it academic or industrial – has its own protocol and

recipe how to fabricate organotypic spheroids including variations in initial

cell density, cell mixture ratios, spheroid size, culture duration as well as the

utilization of medium composition and supplements. These simple facts lead

to the nearly impossible task of comparing different study outcomes.

Since 2019, tissue modelling with microfluidic biochips has been a new additional

research focus of bioengineer Dr. Mario Rothbauer at the ‚Karl Chiari

Lab for Orthopaedic Biology‘ (KCLOB) of the Department of Orthopaedics and

Trauma Surgery. His microsystems team wants to use organotypic tissue-like

microsystems as three-dimensional disease models for basic science and

drug screening applications.

As vice president of the European Society for Alternatives to Animal Experiments

(EUSAAT), Dr. Rothbauer aims at a patient-derived approach, focusing

on animal-free methods and approaches as complimentary tools to animal

experiments.

Aim and Methods

Due to the current shortcomings of spheroid model validation and comparability,

in the current study the team developed a scalable microfluidic biochip

tool that can create multiple differently sized spheroids within a micro-


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32

fluidic biochip-plate using a single step injection. The tool is compatible with

multi-pipetting and pipetting robots and allows to reproducibly produce 360

spheroids of five sizes on a single well plate by minimal user interaction of

six cell suspension injections per plate. To demonstrate the broad applicability

and effectiveness of our multi-spheroid array, we investigated the most

common microwell shapes against our new hemispherical microwells that

are replicated from optical micro lens-like shapes, hoping to prove that size

control as well as placement accuracy of our approach outperforms standard

elliptical as well as spherical and cylindrical approaches.

To create a scalable model that facilitates perfused culture of multiple sizes

of organoids under controllable flow profiles, liquids in our multi-tissue

spheroid arrays are driven by hydrostatic pressure on a simple tilting plate

that can hold multi-spheroid arrays. As initial screening demonstration we

identified the best initial seeding densities for a pool of human cancer and

primary cells frequently used in drug screening (e.g., liver cancer, intestinal

cancer, lung cancer, dermal fibroblasts, and brain endothelial cells). As more

practical demonstration, the team decided to investigate the anti-cancer effect

of combinatorial drug screening on lung cancer spheroids, as well as the

pharmaceutical function and barrier properties of a complex triple-co-culture

model of the human blood brain barrier.

Results and Conclusion

The first demonstration on combinatorial drug treatment demonstrated

that the most effective concentration against A549 lung cancer spheroids

is 50 µM Doxorubicin with 5µM CIS-Platin independently of cancer spheroid

size. In the latter demonstration, for the first time we investigated transport

properties of a human blood-brain barrier (BBB) triple-coculture spheroids

of brain endothelial with astrocytes and pericytes in a microfluidic environment,

optimized seeding densities as well as cell ratios to identify the

healthiest barriers, and tested the effect of mannitol as well as verapamil on

paracellular transport of molecules through the BBB. This study overall proves

that size is a vital parameter that needs to be considered in the future to

allow validation and standardization of organotypic spheroid-based models

for pharmaceutical research, because it severely affects study outcome.

Dr. Mario Rothbauer, MSc

Author:

Mario Rothbauer is currently

working on the bioengineering

of human disease models

using organ- and lab-on-a-chip

technologies as University

Assistant and group leader at

the „Karl Chiari Lab for Orthopaedic

Biology“. In 2015, he

received his doctorate in biotechnology

from the University

of Natural Resources and Life

Sciences Vienna (BOKU).

This technology, which was awarded with the 2022 state award for alternative

methods to animal tests of the Austrian Ministry of Science (BMBWF)

to collaborator Prof. Ertl, will be used in the future to demonstrate that the

size of the tissue models also affects the performance and reproducibility of

musculoskeletal tissue models in the orthopaedic drug screening sector.

References:

[1] A Decade of Organs-on-a-Chip Emulating Human Physiology at the Microscale: A Critical Status

Report on Progress in Toxicology and Pharmacology“ Micromachines 2021, 12 (5), 470, M Rothbauer,

BEM Bachmann, C Eilenberger, SRA Kratz, S Spitz, G Höll, and P Ertl.

[2] Recent Advances in Additive Manufacturing and 3D Bioprinting for Organs-On-A-Chip and Microphysiological

Systems. Frontiers in Bioengineering and Biotechnology 2022, 10. M Rothbauer, C

Eilenberger, S Spitz, BEM Bachmann, SRA Kratz, EI Reihs, R Windhager, S Toegel and P Ertl.

[3] A microfluidic multi-size spheroid array for multi-parametric screening of anti-cancer drugs

and blood-brain barrier transport properties, Advanced Science, 2021, 2004856, 4. C Eilenberger,

M Rothbauer, F Selinger, A Gerhartl, W Neuhaus, C Jordan, M Harasek, B Schädl, J Grillari, S

Küpcü, J Weghuber and P Ertl.

[4] https://www.bmbwf.gv.at/Ministerium/Presse/20220413.html


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34

Figure 1: Transversal T1-TSE MRI with arrows showing a type 3 pseudotumor, regarding to Hauptfleisch et al. 3

Pseudotumors in Metal-on-Metal

Total Hip Arthroplasty

Study:

Kolbitsch P, Noebauer-

Huhmann IM, Giurea A,

Kubista B, Windhager R,

Lass R. Pseudotumors in

Small-Head Metal-on-Metal

Total Hip Arthroplasties at

a Minimum Follow-Up of 20

Years. J Arthroplasty. 2021

Aug;36(8):2871-2877. doi:

10.1016/j.arth.2021.03.022.

Epub 2021 Mar 10. (4,757)

Total hip arthroplasty (THA) is one of the most successful

surgeries nowadays and the method of choice for end stage

osteo arthritis (OA) of the hip joint with good clinical results and

long survivorship of implants. Metal-on-metal (MOM) surfaces

have been used for a long time and are still used nowadays in

some young and active patients, because of their hardness and

their reduced risk of wear. These bearings have shown high

survival rates and very satisfying clinical results, but there is the

risk of metal ion release and systemic accumulation. Consequently,

carcinogenicity, neurological, cardiovascular, and endocrine

deficits can result. Adverse reactions to metal debris (ARMD) and

pseudotumors are possible complications in MOM THAs. Literature

shows rates of up to 69 % of pseudotumors in symptomatic

patients, and up to 61 % in asymptomatic patients.


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35

Figure 2: Transversal T1-TIRM MRI with arrow showing a type 3 pseudotumor, regarding to Hauptfleisch et al. 3

Serum Cobalt and Chromium levels are recommended as monitoring tool for

the detection of elevated metal ion levels. For evaluating pseudotumors in

symptomatic or asymptomatic patients, either magnetic resonance imaging

or ultrasound is preferred. The data of this cohort have already been published

at the follow-up period of 10, 17 and 18 years.

„The most important finding of our

study is the presence of pseudotumors

also in asymptomatic patients, along

with the conclusion that serum metal

ion levels alone were not enough for

following-up metal-on-metal THAs […].“

Paul Kolbitsch

These prior publications resulted in our recent publication with the title

„Pseudotumors in Small-Head Metal-on-Metal Total Hip Arthroplasties at a

Minimum Follow-Up of 20 Years.“ in the Journal of Arthroplasty (IF 4.757).

The purpose of this study was to detect pseudotumors in patients with

28mm-head MOM-THA using MRI at a minimum follow-up of 20 years. In

addition, we analysed the correlation between serum metal levels, clinical

outcome scores, activity scores and pseudotumors. For conducting our study

we were supported by the „Medizinisch-Wissenschaftliche Fonds des Bürgermeisters

der Bundeshauptstadt Wien“ in 2017.

Methods

We were able to recruit 26 patients with 29 THAs for the follow-up investigation

at a minimum of 20 years after initial surgery with a mean age of 72.2

years (range, 51–87 years) and a mean body-mass-index (BMI) of 28.5 (range,

15.9–38.3). In all cases cementless tapered stems (Alloclassic ® Zweymüller ® ,

Zimmer GmbH, Winterthur, Switzerland) with 28mm high-carbide-concentration

metal-on-metal surfaces (Metasul ® , Zimmer GmbH) and a titanium made

conical screw cup (CSF ® , Zimmer GmbH) were used. For the clinical investigation

several scores were evaluated, including Harris Hip Score, University of

California Los Angeles (UCLA) activity score, Western Ontario and McMaster

Universities Osteoarthritis Index (WOMAC) and visual analogue scale (VAS).


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36

For radiologic follow-up standard X-rays as well as metal artifact reduction

sequence (MARS) magnetic resonance imaging (MRI) were used (Figure 1).

The detected pseudotumors were classified using a grading system described

by Hauptfleisch et al. in 2012. It describes four different subtypes of

pseudotumors regarding its walls, shape, and fluid or solid behaviour.

The systemic blood metal ion levels of Cobalt and Chromium were evaluated

using atomic absorption spectrometer.

Of the initially included 98 patients and 105 hips included between November

1992 and May 1994, 43 patients have died, 14 patients remained lost

to follow-up, 6 patients could only be contacted via phone and 9 patients

underwent revision surgery.

Blood metal ion levels showed a mean serum cobalt level of 1.87μg/L (± 3.44)

and mean chromium level of 2.23μg/L (± 2.96). For further analysis patients

were divided in in a „single-metal“, and „multi-metal“ group, showing significantly

higher levels in the second group (p = 0.018 for cobalt levels and

p = 0.020 for chromium levels).

The clinical scores showed good results in both groups. Mean HHS was 88.6

(range, 62.0–100), UCLA 6.4 (range 3–10 points), VAS 0.76 (range, 0–5) and WO-

MAC was at 1.66 (range 0–5.75 points). No significant differences were found

between patients with pseudotumors in MRI and those with no alterations.

MRI showed pseudotumors in 21 of 29 investigated hips (72 %). Comparing

the serum metal ion levels showed mean cobalt and chromium of 2.2μg/L

(± 3.98) and 2.39μg/L (± 3.41) in the pseudotumor group and 0.88μg/L (± 0.64)

and 1.80μg/L (± 1.23) in the other group. Though levels were clearly higher

in pseudotumor group, no statistically significant difference was found

(p = 0.139 for cobalt and p = 0.504 for chromium). We found a cumulative rate

of survival counting revision with aseptic loosening as the end point of 91.4 %

at 22.8 years (95 % confidence interval).

Dr. Paul Kolbitsch

Author:

Paul Kolbitsch is currently a

resident at the Department

of Orthopaedics and Trauma

Surgery at the Medical University

of Vienna. Since his time

as student, he has actively

participated in several studies

of the adult reconstruction

team of the Division of Orthopaedics.

He has finished his

medical school in 2017.

Results

The most important finding of our study is the presence of pseudotumors

also in asymptomatic patients, along with the conclusion that serum metal

ion levels alone were not enough for following-up metal-on-metal THAs,

as most of our patients with pseudotumor were below the recommended

threshold of 7μg/L. In addition, we could show that 28mm metal-on-metal

bearings have a high incidence of pseudotumors in long term follow-up. The

consequences that should be taken in cases of asymptomatic pseudotumor

patients have not yet been clearly stated and will need further investigations.

References:

[1] Kolb A, Schneckener CD, Chiari C, et al. Cementless total hip arthroplasty with the rectangular

titanium Zweymüller stem: a concise follow-up, at a minimum of twenty years, of previous

reports. J Bone Joint Surg Am. 2012;94(18):1681-1684. doi:10.2106/JBJS.K.01574

[2] Kolbitsch P, Noebauer-Huhmann IM, Giurea A, Kubista B, Windhager R, Lass R. Pseudotumors

in Small-Head Metal-on-Metal Total Hip Arthroplasties at a Minimum Follow-Up of 20 Years. J

Arthroplasty. 2021;36(8):2871-2877. doi:10.1016/J.ARTH.2021.03.022

[3] Hauptfleisch J, Pandit H, Grammatopoulos G, Gill HS, Murray DW, Ostlere S. A MRI classification

of periprosthetic soft tissue masses (pseudotumours) associated with metal-on-metal resurfacing

hip arthroplasty. Skeletal Radiol. 2012;41(2):149-155. doi:10.1007/S00256-011-1329-6


TOP-Studien

Safe Bone Block Harvesting for

Quadriceps Tendon Autografts

37

Quadriceps tendon (QT) autografts with and without a bone

block have gained popularity in recent years for both primary

and revision anterior cruciate ligament reconstruction due to

the shortcomings of other graft choices. A bone block facilitates

length and can also be used for tibial bone defects in revision

surgery if necessary. However, the main advantage of an

autograft with a bone block lies in quicker bone-to-bone healing.

Unfortunately, it is associated with a potential risk for intra- and

postoperative patellar fractures.

Study:

Negrin LL, Zeitler C, Hofbauer

M. Patellar Size Variation at

the Quadriceps Tendon-Bone

Block Harvest Site: A Magnetic

Resonance Imaging Study

to Evaluate the Safe Zone for

Harvesting a Sufficient Bone

Block. Am J Sports Med. 2021

Dec;49(14):3850-3858. doi:

10.1177/03635465211049226.

Epub 2021 Oct 21. (6,202)

Aim and Methods

The objective of this study was to assess the maximum individual-related

patellar bone block depth and length and to identify the location and the

dimensions of the bone block (in mm), which can be safely excised in most

individuals with high success probability, by performing measurements on

patellar geometry. Since guidelines for patellar bone block harvesting have

been based solely on personal experience, we intended to derive recommendations

from physical regularities and objective criteria. Our study population

of 50 males and 50 females, all Caucasians and aged ≥ 18 years, underwent

3.0-T magnetic resonance imaging of their knees at our institution.

Figure 1A presents the patella in coronal view. The length of the centerline

corresponds to the superoinferior height of the patella, the medial (lateral)

Figure 1: Patella in coronal (A) and axial (B) views. C: Harvest site of BBmedial (open box in white) and subjacent bone bridge (closed box in dotted lines).

D: Safe harvesting of a QT bone block (open box in white). The central area of the patella is shaded. The medial endpoint represents the suggested starting

point for initial saw placement.


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38

Figure 2: Frequency distributions of

patients providing/not providing

bone blocks with a depth

of 8mm and a length of 15mm.

„The objective of this study was to assess

the maximum individual-related patellar

bone block depth and length and to

identify the location and the dimensions

of the bone block (in mm), which can be

safely excised in most individuals with

high success probability, by performing

measurements on patellar geometry.“

Lukas Negrin

patellar height is defined by the length of the medial (lateral) line. The medial

and lateral lines border the central area (shaded). The medial, central, and

lateral thickness of the patella was measured at the height of each of the

three midpoints in the axial view (Figure 1B).

Our patients (mean age, 29.4 ± 7.9 years; mean height 174.4 ± 10.3cm) provided

a mean QT width and thickness of 49.0 ± 7.6mm and 7.3 ± 1.0mm, respectively.

The mean patellar thickness in reference to the medial endpoint, the center,

and the lateral endpoint was 18.3 ± 2.4mm, 17.9 ± 2.3mm, and 15.1 ± 2.3mm,

respectively, whereas the mean patellar height was 35.1 ± 4.1mm,

36.7 ± 4.2mm, and 35.1 ± 3.9mm. As expected, the tendon and patellar

dimensions were significantly larger in males than in females (p ≤ 0.016).

We focused on physical modeling to provide limits for the bone block dimensions.

In general, the 3-point bending force in knee flexion or a direct blow to

the knee is believed to cause patellar fractures.


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39

After bone block harvesting, these forces act directly on the bone bridge,

which is defined as the remaining bone posterior to the harvest site, and

may lead to its fracture. The maximum bending stress turned out to be

inversely proportional to the squared depth of the bone bridge, indicating

that the risk for a patellar fracture increases with increasing bone block

depth. On one hand, the bone block should be deep enough to enable standard

interference screw fixation techniques, on the other hand, the bone

bridge depth should be sufficient to minimize fracture risk. To satisfy both

prerequisites, we restricted the bone block depth to 50 % of the patellar

thickness at the harvest site. Because the patella is asymmetrically thickest

in its proximal half, we limited the bone block length to 50 % of the patellar

height measured at its harvest site.

Ap. Prof. Priv.-Doz. Dr. Lukas Negrin, PhD, MMSc

Author:

Lukas Negrin has devoted

most of his research work to

severely injured and multipletraumatized

patients from

the beginning of his scientific

career. Currently, he leads

the interdisciplinary working

group „Biomarkers in polytrauma“,

and the research cluster

„Polytrauma and traumatic

brain injury“. Moreover, he is

the head of the working group

„Polytrauma“ and the task

force „Special trauma surgery“

of the Austrian Society for

Trauma Surgery (ÖGU). Additionally,

he has already drawn

his interest to knee injuries

early during his career. During

his work as team doctor of the

Austrian alpine skiing world

cup team and the Austrian

Olympic Committee, he

rediscovered his passion for

research in sports injuries.

After setting the maximal dimensions of the bone block, its exact location

had to be analyzed. Inherently, it has to be attached to the graft, which is

commonly excised from the middle third of the QT, as it primarily consists of

fibers from the rectus femoris and vastus intermedius, resulting in a natural

plane. Following these fibers roughly indicates the bone block harvest

site on the superior pole of the patella. To highlight the effect of the patellar

geometry on osseous graft volume, we created three virtual bone blocks –

BBlateral , BBcentral, and BBmedial – following our specifications within the

central area in all patient knees, each with a given width of 10mm. BBmedial

represented the outermost region of safe graft harvesting medially. Its length

was 50 % of the medial patellar height, and its depth was 50 % of the patellar

thickness at the medial midpoint (Figure 1C). BBlateral was characterized

analogously. BBcentral was symmetrical to the centerline with a length of

50 % of the patellar length and a depth of 50 % of the patellar thickness at

the central midpoint.

Results and Conclusion

Pair-by-pair comparisons of the three bone block depths revealed significant

differences in all cases (BBmedial, 9.2 ± 1.1mm, BBcentral, 8.9 ± 1.1mm;

BBlateral, 7.6 ± 1.1mm; p < 0001). Whereas the mean length of BBcentral

was significantly larger than the lengths of both BBmedial and BBlateral

(18.4 ± 2.1mm versus 17.6 ± 2.0mm and 17.6 ± 1.9; p < 0.0001), there was no

significant difference between the mean lengths of BBmedial and BBlateral

(p = 0.887).

As the patella is more shallow at the lateral side than at the center or the

medial side, harvesting BBlateral should be avoided. Unfortunately, both

maximal graft length and depth can neither be provided by BBcentral nor

by BBmedial. Since the squared depth of the bone bridge is included in the

formula of the maximum bending stress, the bone block depth has to be

considered the determining factor of patellar fracture risk. Consequently, we

gave particular emphasis to the patellar thickness.

Bone block harvesting, with its depth not exceeding 50 % of the patellar

thickness and its length accounting for < 50 % of the patellar height, poses

the least risk for a patellar fracture when the bone block is excised from

the medial half of the central area, with the outer edge of the saw positioned

at the medial border of the central area (Figure 1 D). In almost all of our

patients, a bone block of 15mm length, 10mm width, and 8mm depth could

be safely harvested (Figure 2). Only in five females the depth and length of

BBmedial did not reach 8mm and 15mm, respectively.


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Semi-Quantitative and

Quantitative MRI for the

Assessment of Cartilage Repair

and Intervertebral Discs

Studies:

Schreiner MM, Raudner M,

Marlovits S et al (2021) The

MOCART (Magnetic Resonance

Observation of Cartilage

Repair Tissue) 2.0 Knee Score

and Atlas.

Schreiner MM, Raudner M, Rohrich

S et al (2021) Reliability of

the MOCART (Magnetic Resonance

Observation of Cartilage

Repair Tissue) 2.0 knee score

for different cartilage repair

techniques-a retrospective observational

study. Eur Radiol.

Schreiner MM, Raudner M,

Szomolanyi P et al (2020)

Chondral and Osteochondral

Femoral Cartilage Lesions,

Treated with GelrinC: Significant

Improvement of Radiological

Outcome Over Time and

Zonal Variation of the Repair

Tissue Based on T2 Mapping

at 24 Months.

Raudner M, Toth DF, Schreiner

MM et al (2021) Synthetic

T2-weighted images of the

lumbar spine derived from

an accelerated T2 mapping

sequence: Comparison to

conventional T2w turbo spin

echo. Magn Reson Imaging

84:92-100

Morphological MRI has become the method of choice for

the assessment of cartilage lesions and repair as well as intervertebral

discs. However, radiographic reports from morphological

MRI are inherently subjective and not standardised.

The ability to measure and accurately define the extent of

pathology and outcome after surgical treatment is a prerequisite

for high-quality studies that use a radiological endpoint.

One solution could be the introduction of semi-quantitative

scoring systems. Another possibility is the use of quantitative

MRI techniques that promise correlation with the composition

and ultrastructure of the tissues studied. With respect to articular

cartilage and intervertebral discs, T2 mapping is the most widely

used and extensively studied technique. However, multi-echo

spin-echo T2 mapping is time-consuming and therefore rarely

feasible in the clinical setting.

It is challenges like these on which the biomedical MR-imaging Cluster of

orthopaedic disorders focuses. This fruitful collaboration between the High

field MR Centre (Prof. Siegfried Trattnig) and the Department of Orthopaedics

and Trauma Surgery involves physicists, radiologists as well as orthopaedic

surgeons with a special interest in MRI of the musculoskeletal system.

The increasing number of different surgical repair techniques of articular

cartilage lesions required a non-invasive and reproducible tool to evaluate

the outcome. In this endeavour, the MOCART (Magnetic Resonance Observation

of Cartilage Repair Tissue) score was developed in collaboration between

radiologists and orthopaedic surgeons and was widely accepted.

However, with advances in surgical techniques, MRI hardware, and software,

the original MOCART score was overdue for an update. Therefore, the

MOCART 2.0 Knee Score and Atlas was introduced. In addition to revising the

scoring system, a comprehensive atlas was introduced to increase reproducibility

by providing an example for each possible score on the MOCART 2.0

Knee Score. The new MOCART 2.0 knee score was then used by two experi-


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Figure 1:

T2w turbo spin echo image witch CPMG overlay

(left), on the right synthetic T2w image with

GRAPPATINI overlay (right) – with courtesy of

Marcus Raudner MD, PhD.

„These developments of novel

semi-quantitative and quantitative

imaging techniques greatly increase

the possibilities for reproducible

non-invasive diagnosis, characterisation,

and monitoring of both

disease and surgical repair.“

Markus Schreiner

enced radiologists and two junior radiologists with little or no experience in

musculoskeletal radiology to evaluate the MRI examination of 24 patients

after MACI. To assess whether access to the atlas would improve reproducibility,

the inexperienced readers performed a second examination after

a four-week interval and were allowed to use the atlas. The expert readers

demonstrated almost perfect overall intrarater (ICC = 0.88, p < 0.001) as well

as the interrater (ICC = 0.84, p < 0.001) reliability. The overall interrater reliability

of the inexperienced readers increased from poor (ICC = 0.34, p < 0.019)

to moderate (ICC = 0.59, p = 0.001), with additional access to the atlas during

assessment.

A limitation of the study, in which the MOCART 2.0 knee score was introduced,

was that only patients after MACI were included, leaving its application

to other cartilage repair techniques or lesion types, i.e., chondral vs.

osteochondral lesion, unclear. Therefore, another study was performed,

showing similar reproducibility of the MOCART 2.0 knee score in patients

after MACI, MFX as well as osteochondral repair techniques. Interestingly,

we observed higher reproducibility in patients with osteochondral lesions


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42

compared to chondral lesions.However, semi-quantitative and quantitative

imaging techniques can also be used complementing each other as in the

following study: „Chondral and Osteochondral Femoral Cartilage Lesions

Treated with GelrinC: Significant Improvement of Radiological Outcome

Over Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at

24 Months“. In this prospective multicenter study, the MOCART score and

multi-echo spin-echo (MESE) T2 mapping were used to assess the outcome

of cartilage repair of femoral cartilage lesions using GelrinC at different time

points with a maximum follow-up of 24 months. In this study, the MOCART

score increased significantly during the follow-up period. In addition, based

on T2 mapping, significant zonal variation was observed between the deep

and superficial zones of cartilage repair, which is considered a hallmark of

hyaline cartilage.

Dr. Markus Schreiner

Author:

Since 2016, Markus Schreiner

has been a resident at the

Department of Orthopaedics

and Trauma Surgery at the

Medical University of Vienna

and a member of the biomedical

MR-imaging Cluster of orthopaedic

disorders. Together

with Sebastian Apprich M.D.,

he coordinates the scientific

collaborations between the

Orthopaedic department and

the High Field MR Centre (Prof.

Siegfried Trattnig) at the Medical

University of Vienna.

Within the biomedical

MR-imaging cluster, his research

focuses on the development

and implementation of

MR-imaging techniques used

for qualitative and quantitative

assessment of cartilage,

tendons, and intervertebral discs,

as well as clinical projects

on cartilage repair surgery.

More possibilities for reproducible non-invasive diagnosis

However, as mentioned above, T2 mapping with a classical multi-echo spinecho

technique is time-consuming and therefore not commonly used in

daily clinical routine. To overcome this limitation, GRAPPATINI was recently

developed. GRAPPATINI is a novel MR sequence that combines „model-based

accelerated relaxometry by iterative nonlinear inversion“ (MARTINI) and

„generalized autocalibrated partial parallel acquisition“ (GRAPPA). It allows

accelerated T2 mapping and additionally provides synthetic morphological

images, which in theory significantly reduce scan time, as one acquisition

should provide both the T2 map and the morphological images. While the

quality of the T2 maps of the intervertebral discs generated with GRAPPATINI

has already been evaluated and compared with MESE T2 mapping, the quality

of the synthetic T2-weighted images has not been evaluated and compared

with conventional T2w turbo spin echo (TSE) images. Therefore, we studied

58 patients with both sequences. All images were assessed by two blinded

readers who determined disc degeneration and the presence of herniation or

annular tear. Interrater and intrarater agreement correlated significantly in

both sequences, and the agreement was substantial to near perfect.

Overall, these developments of novel semi-quantitative and quantitative

imaging techniques greatly increase the possibilities for reproducible

non-invasive diagnosis, characterisation, and monitoring of both disease

and surgical repair. This, in turn, could accelerate the understanding of

underlying pathological processes and drive the development of new

therapeutics.

References:

[1] Schreiner MM, Raudner M, Marlovits S et al (2021) The MOCART (Magnetic Resonance Observation

of Cartilage Repair Tissue) 2.0 Knee Score and Atlas. Cartilage 13:571S-587S

[2] Schreiner MM, Raudner M, Rohrich S et al (2021) Reliability of the MOCART (Magnetic Resonance

Observation of Cartilage Repair Tissue) 2.0 knee score for different cartilage repair

techniques-a retrospective observational study. Eur Radiol. 10.1007/s00330-021-07688-1

[3] Schreiner MM, Raudner M, Szomolanyi P et al (2020) Chondral and Osteochondral Femoral

Cartilage Lesions Treated with GelrinC: Significant Improvement of Radiological Outcome Over

Time and Zonal Variation of the Repair Tissue Based on T2 Mapping at 24 Months. Cartilage. 10.

1177/1947603520926702:1947603520926702

[4] Raudner M, Toth DF, Schreiner MM et al (2021) Synthetic T2-weighted images of the lumbar spine

derived from an accelerated T2 mapping sequence: Comparison to conventional T2w turbo

spin echo. Magn Reson Imaging 84:92-100


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43

Bone Mineral Density

of the Thoracic Spine

„From a purely BMD standpoint,

choosing UIVs in the upper thoracic

spine for long fusion constructs might

enhance instrumentation performance,

especially in patients with osteoporosis.“

Stephan Salzmann

The thoracic spine is commonly affected by osteoporotic vertebral

fractures, which occur in a bimodal distribution. The peak

frequencies are at the thoracolumbar junction and the midthoracic

spine. Besides osteoporotic vertebral fractures, the thoracic

spine is a typical location for instrumentation failure after long

spinal fusion procedures. Patients undergoing surgery for adult

spinal deformity with low local bone mineral density (BMD) at

the upper instrumented vertebra (UIV) have a higher risk for

complications including proximal junctional kyphosis.

Regional BMD variation has already been described for the cervical, lumbar,

and sacral regions of the spine and the association between BMD and postoperative

complications is well established. Despite the clinical importance of

osteoporotic vertebral fractures, as well as instrumentation failure after long

spinal fusions, no prior studies have comprehensively assessed level-specific

BMD of the entire thoracic spine in patient undergoing spine surgery.

The current gold standard to assess BMD in the spine is thought to be dual

energy x-ray absorptiometry (DXA). However, due to the projectional nature

of DXA measurements, the overlying sternum and ribs interfere with thoracic

DXA measurements in the clinical setting. Quantitative computed tomography

(QCT) is one of the alternatives to assess spinal BMD, circumventing

several limitations of DXA measurements allowing for level-specific BMD

measurements of the entire thoracic spine.

Study:

Salzmann SN, Okano I, Jones

C, Basile E, Iuso A, Zhu J,

Reisener MJ, Chiapparelli E,

Shue J, Carrino JA, Girardi FP,

Cammisa FP, Sama AA, Hughes

AP. Thoracic bone mineral

density measured by quantitative

computed tomography

in patients undergoing

spine surgery. Spine J. 2021

Nov;21(11):1866-1872. (4,166)

Aim

This study was created not only to assess the reliability of newly described

thoracic QCT measurement protocol, but also to quantify the level-specific

BMD of the thoracic spine in patients undergoing spinal surgery and to examine

the correlation between the BMDs of the thoracic levels T1–T12.

Material and Methods

The study was approved by the hospital institutional review board. Spine surgery

patients from 2016–2020 at a single, academic institution with available

preoperative thoracic spine CT imaging were included in this study. Exclusion

criteria included previous instrumentation at any thoracic level, concurrent

vertebral fractures, a Cobb angle of more than 20 degrees, or incomplete

thoracic spine CT imaging. Quantitative computed tomography measurements

of the thoracic vertebra T1 to T12 were performed using the previously

described asynchronous QCT. The method for thoracic QCT bone mineral


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Figure 2: T1aT12 mean quantitative computed tomography (QCT) bone mineral density (BMD)

in mg/cm 3 with standard deviation (SD).

Figure 1: Representative thoracic QCT

measurement. Axial (top) and sagittal (bottom)

view of the region of interest (ROI).

density measurements was similar to the clinically established approach to

lumbar spine QCT measurements using a commercially available software

program (QCT Pro, Mindways Software, Inc., Austin, TX, USA). Since the thoracic

vertebra are smaller compared to the lumbar vertebrae, the predefined

height of the volume of interested was adjusted to 7mm (predefined to 9mm

for lumbar QCT measurements). An elliptical region of interest was placed in

the trabecular bone at mid-vertebral height and displaced from the vertebral

cortex (Figure 1). Bone islands or sclerotic regions were avoided. However, if

this was not possible due to the extent of the lesion, the vertebra had to be

excluded from the analysis.

To assess intra- and inter-observer reliability of the experimental thoracic

QCT measurements, a validation study was performed. A subsample of 120

vertebrae in ten randomly selected patients were remeasured by another

independent rater. In addition, the same rater remeasured the selected

subsample six weeks after the first measurements. To assess inter- and

intra-observer reliability the interclass correlation coefficient (ICC) was

calculated. The ICC cut-offs were defined as follows: Values below 0.70

indicated poor, 0.70 – 0.80 acceptable, 0.80 – 0.90 good, and ≥ 0.90 excellent

agreement. A pairwise comparison of BMD was performed using the paired

t-test, and correlations between each spinal level were evaluated using the

Pearson’s correlation coefficient. The statistical significance level was set at

p < 0.05 and all analyses were performed in R software (R for 3.5.3 GUI 1.64).

Results

In all, 60 patients (men, 51.7 %) undergoing spine surgery met the inclusion

criteria. The study population was 90 % Caucasian with a mean age of 62.2

years and a mean BMI of 30.2 kg/m². The inter-observer (ICC of 0.97, 95 %

confidence interval 0.86–0.99) and intra-observer (ICC of 0.97, 95 % confidence

interval 0.88–0.99) reliability of the thoracic QCT measurements was excellent.

The highest trabecular BMD was found in the upper thoracic spine and

decreased in the caudal direction (T1 = 182.3 mg/cm³, T2 = 168.1 mg/cm³,

T3 = 163.5 mg/cm³, T4 = 164.7 mg/cm³, T5 = 161.4 mg/cm³, T6 = 152.5 mg/cm³,

T7 = 143.5 mg/cm³, T8 = 141.3 mg/cm³, T9 = 143.5 mg/cm³, T10 = 145.1 mg/cm³,


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T11 = 145.3 mg/cm³, T12 = 133.6 mg/cm³) (Figure 2). The BMD of all thoracic

levels caudal to T6 was statistically lower than the BMD of all levels cranial

to T6 (p < 0.001). Nonetheless, there were significant correlations in BMDs

among all measured thoracic levels. The Pearson’s correlation coefficient

ranged from 0.74 to 0.97.

Discussion

The results of this study indicate significant regional BMD differences in the

thoracic spine depending on spinal level. The variation in thoracic BMD might

contribute to several clinically observed phenomena:

Firstly, vertebral fractures have a bimodal distribution and occur most

commonly at the thoracolumbar junction (T12-L1), followed by the midthoracic

region (T7-T8) as the second most common site. Besides mechanical

reasons, this could be partially attributed to the thoracic BMD, which has

been shown to be lowest at the T12 level (133.6 mg/cm³), followed by the T8

level (141.3 mg/cm³).

Secondly, choosing the optimal upper instrumented vertebra for stopping

long fusions to the sacrum and pelvis is controversial. In this study, surgically

relevant upper thoracic stopping points (T2-T4) showed significantly higher

BMDs than lower thoracic stopping points (T10-T12). In addition to stress

concentration at the relatively mobile lower thoracic segments, the low BMD

at these levels might contribute to previously suggested higher rates of junctional

failures of fusion constructs with UIVs in the lower thoracic spine.

Conclusion

In conclusion, the BMD is not uniform across the entire thoracic spine. It

significantly varies by spinal level with a higher BMD in the upper thoracic

levels compared to the lower thoracic levels. The data of this study might be

used as a reference for future investigations and aid surgical planning. From

a purely BMD standpoint, choosing UIVs in the upper thoracic spine for long

fusion constructs might enhance instrumentation performance, especially in

patients with osteoporosis.

References:

Dr. Stephan Salzmann

Author:

Stephan Salzmann is an orthopaedic

surgery resident. His

research interests include

novel clinical tools to assess

bone quality. He completed

a re search fellowship at the

Hospital for Special Surgery

(NY) and received the Austrian

Ministry of Science Honorary

Prize and the Lumbar Spine

Research Society Best Paper

Award.

[1] Wasnich RD. Vertebral fracture epidemiology. Bone 1996;18:S179–83. https://doi.

org/10.1016/8756-3282(95)00499-8.

[2] Smith MW, Annis P, Lawrence BD, Daubs MD, Brodke DS. Acute proximal junctional failure in patients

with preoperative sagittal imbalance. Spine J 2015;15:2142–8. https://doi.org/10.1016/j.

spinee.2015.05.028.

[3] Duan P-G, Mummaneni P V, Rivera J, Guinn JM V, Wang M, XiZ, et al. The association between

lower Hounsfield units of the upper instrumented vertebra and proximal junctional kyphosis in

adult spinal deformity surgery with a minimum 2-year follow-up. Neurosurg Focus 2020;49:E7.

https://doi.org/10.3171/2020.5.FOCUS20192.

[4] Salzmann SN, Okano I, Ortiz Miller C, Chiapparelli E, Reisener M-J, Winter F, et al. Regional

bone mineral density differences measured by quantitative computed tomography in patients

undergoing anterior cervical spine surgery. Spine J 2020;20:1056–64. https://doi.org/10.1016/j.

spinee.2020.02.011.

[5] Salzmann SN, Shirahata T, Yang J, Miller CO, Carlson BB, Rentenberger C, et al. Regional

bone mineral density differences measured by quantitative computed tomography: does the

standard clinically used L1-L2 average correlate with the entire lumbosacral spine? Spine J

2019;19:695–702. https://doi.org/10.1016/j.spinee.2018.10.007.

[6] Salzmann SN, Ortiz Miller C, Carrino JA, Yang J, Shue J, Sama AA, et al. BMI and gender increase

risk of sacral fractures after multilevel instrumented spinal fusion compared with bone mineral

density and pelvic parameters. Spine J 2018:1–8. https://doi.org/10.1016/j.spinee.2018.05.021.


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46

Association of Varus

Deformity and Coronal

Tibiofemoral Subluxation

Osteoarthritis (OA) of the knee is one of the most common orthopaedic

disorders, a burden to health care systems, and a major

reason for knee pain, with Varus OA of the knee occurring more

frequently than valgus OA. Total knee arthroplasty (TKA) and

unicompartmental knee arthroplasty (UKA) are two reliable and

successful treatment options for patients with end- stage OA with

benefits on patient’s quality of life. Before scheduling patients

for TKA or UKA, a critical preoperative evaluation is crucial. For

UKA, an unstable knee joint is problematic. A functionally insufficient

anterior cruciate ligament (ACL) often induces meniscus

lesions and ultimately medial compartment OA and varus

deformity of the knee. The current literature only provides a few

studies investigating combined UKA and ACL reconstruction.

An additional radiographic finding that gained recognition over the last few

years is coronal tibiofemoral subluxation (CTFS). It has been shown that CTFS

already develops in early stages of joint degeneration and continuously contributes

to varus OA of the knee. It was also associated with impingement of the

medial aspect of the lateral femoral condyle on the tibial spine. Furthermore,

CTFS was considered as a potential reason for unexplained knee pain following

UKA. Even if CTFS is a well- recognized radiographic finding, its impact

on biomechanics and clinical symptoms are still not clear. The current study

evaluates the association of a functional status of the ACL and the overall varus

deformity of the knee or CTFS.

Study:

Springer B*, Waldstein W*,

Bechler U, Jungwirth-

Weinberger A, Windhager R,

Boettner F.

J Arthroplasty. 2021

Feb;36(2):501-506. doi:

10.1016/j.arth.2020.08.049.

*Both authors contributed equally

Materials and Methods

The current study prospectively enrolled 100 consecutive knees in 84 patients

who underwent primary TKA for varus OA between July 2010 and January

2012. A standardised radiological work-up was performed pre operatively

including a hip-to- ankle AP standing radiograph, an AP standing knee

radiograph, a lateral radiograph, a valgus stress radiograph, and a magnetic

resonance imaging (MRI) of the affected knee. After exclusion, 79 knees in 63

patients were available for evaluation. The study-cohort consisted of 29 men

(46 %) and 34 women (54 %) with a mean age of 69 years (range 50 – 89 years)

and a mean body mass index of 26.1 kg/m 2 (range 17 – 47). Hip-to-ankle AP

standing radiographs were used to assess the alignment of the lower limb.

Alignment (mechanical tibiofemoral angle, mFTA) was measured as the angle


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47

11,0

10,0

∆ ACL –

• ACL +

Figure 1: Illustration of the distribution of

CTFS and mTFA in the entire cohort.

Most knees (98 %, 40/41) with


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48

„A functionally intact anterior cruciate

ligament (ACL) is essential for medial

unicompartmental knee arthroplasty.

The current study showed that varus

alignment and coronal tibiofemoral

subluxation are associated with ACLinsufficiency.

It remains unknown if the

functional insufficiency of the ACL is a

result of end-stage arthritic changes, or

if an insufficient ACL leads to accelerated

degenerative changes in the medial

compartment with higher degrees of

varus deformity.“

Bernhard Springer

used to evaluate the degree of correctability of mTFA. Finally, an MRI was

used to evaluate the structural integrity of the ACL. The categorisation used

differed between three cases: intact, with degenerative changes, or completely

torn. The grading was based on the report of a blinded board-certified

radiologist.

In addition, the amount of intact posterior tibial cartilage (TCPOST) in the

medial compartment was evaluated on sagittal T1-weighted images. A previously

published study showed that a functionally insufficient ACL is likely

if the intact TCPOST is < 14 %. Two groups were formed based on ACL grading

and proportion of intact TCPOST. The first group included patients that had

an intact ACL or a degenerative altered ACL with < 14 % intact TCPOST. These

patients were considered to have a functionally intact ACL (ACL+).

On the other hand, patients with a torn ACL or a degenerative altered ACL

with < 14 % intact TCPOST were considered to have a functionally insufficient

ACL (ACL-).

Results

68 knees (86 %) of the included 79 knees were considered as ACL+. Regarding

KL classification in the lateral compartment, there was no difference between

knees with a functionally intact ACL and ACL- deficient knees (p = 0.116).

ACL- deficient knees showed significantly more femoral and tibial osteophytes

in the medial compartment compared to knees with a functionally

intact ACL (p < .001). ACL-deficient knees also showed a significantly higher

mTFA on hip- to-ankle AP standing radiographs (p < 0.001) and on valgus

stress radiographs (p = 0.017) than knees with a functionally intact ACL.

The performed measurements are summarised in Table 1.

Dr. Bernhard Springer

Author:

Bernhard Springer has been a

resident at the Department of

Orthopaedics and Trauma Surgery

at the Medical University

of Vienna since 2020. His research

is focused on the knee,

specialising in injuries of the

anterior cruciate ligament and

consequences of ACL-injuries.

Seventy-three per cent of the ACL- deficient knees and 24 % of the knees

with a functionally intact ACL had a mechanical varus alignment of ≥ 10°

(p = 0.001). The mTFA correlated significantly with the functional status of

the ACL (rs = 0.362; p = 0.001). In 64 % of the knees with a functionally insufficient

ACL and in 22 % of the knees with a functionally intact ACL, a CTFS

≥ 6mm was observed (p = 0.004). The CTFS also correlated significantly with

the functional status of the ACL (rs = 0.227; p = 0.044). Eight patients (10 %)

had ≥ 10° of varus and ≥ 6mm CTFS on AP radiographs (Figure 1). 98 % of the

knees with < 10° varus and < 6mm CTFS had a functionally intact ACL. There

was only one single patient with a functionally insufficient ACL when a mechanical

varus of


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Outcome after Arthroscopically

Assisted TFCC Refixation

49

In 2011, Dr. Thalhammer was given the opportunity to complete

a one-year hand surgery training programme in the private

practice of Dr. Heinrich-Geert Tünnerhoff and Dr. Martin Lauffer,

the former being a European pioneer of wrist arthroscopy and

arthroscopic TFCC repair. Among other things, Dr. Thalhammer

was able to expand her knowledge in this field and has since

promoted the use of arthroscopic techniques at the Clinical

Department of Trauma Surgery. The idea for this study also

arose during this stay.

Study:

Thalhammer G, Haider T, Lauffer

M, Tünnerhoff HG. Mid- and

Long-Term Outcome After

Arthros copically Assisted

Trans osseous Triangular Fibrocartilage

Complex Refixation-Good

to Excellent Results

in Spite of Some Loss of

Stability of the Distal Radioulnar

Joint. Arthroscopy. 2021

May;37(5):1458-1466. doi:

10.1016/j.arthro.2021.01.056.

Epub 2021 Feb 6. (4,772)

Ulnar-sided wrist pain is frequently caused by either degenerative or

traumatic lesions of the triangular fibrocartilage complex (TFCC). Espe -

cially a rupture of the deep part of the radioulnar ligaments (RUL), which

are considered to be the primary stabilizers of the distal radioulnar joint

(DRUJ) during forearm rotation, may cause pain and recognizable instability.

Because clinical diagnosis of TFCC lesions remains difficult, and also

magnetic resonance imaging does not provide clear answers in all cases,

arthroscopy of the wrist is crucial to detect and localize tears of the superficial

or deep parts of the RUL.

Arthroscopy proves to be not only a diagnostic, but also a therapeutic procedure,

with the advantage of small skin incisions, less destruction of the surrounding

structures, and the possibility of precise reattachment of the deep fibers

of the RUL at the ulnar fovea with transosseous sutures or suture anchors.

Short- and mid-term outcome reports of these methods indicate favourable

results, but data regarding long-term outcome remain scarce.

a

b

Figure 1: (a) Schematic illustration of a rupture of the RUL (purple; superficial layer of TFCC in orange) with dorsal subluxation of the ulnar head,

(b) and after transosseous reattachment running dorsally and palmarly of the PSU (ulnar styloid process) and through an transosseous channel created

with a K-wire in the centre of the ulnar fovea (©Tünnerhoff).


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100

***

*** **

60

***

***

Mayo Wrist Score

80

60

40

DASH

40

20

0

Preoperative

1 st Follow-up

2 nd Follow-up

n=28 – 29 n=24 – 30

Preoperative

1 st Follow-up

2 nd Follow-up

Figure 2: Time course of the Modified Mayo Wrist Score (MMWS) and the Disabilities of the Arm, Shoulder and Hand (DASH) score. Squares

and whiskers represent mean and SEM; **…p < 0.01, ***…p < 0.001.

Aim and Method

The surgical technique used in this study was developed by Heinrich-Geert

Tünnerhoff: He adapted the principles of open reattachment and developed

an arthroscopically assisted procedure. The aim of this study was to evaluate

mid- and long-term outcome of this technique and to analyse the association

of DRUJ stability with the clinical outcome.

„[…] arthroscopically assisted

reattachment of the RUL provides

reliable and satisfying long-term

results. All study participants achieved

good to excellent clinical outcome, as

indicated by the MMWS at a median

follow-up of 106 months.“

Gerhild Thalhammer

Patients with ulnar-sided wrist pain who underwent diagnostic wrist arthroscopy

and arthroscopically assisted transosseous reattachment of the

TFCC to the fovea between 2000 and 2009 were retrospectively evaluated.

Inclusion criteria were arthroscopically confirmed avulsion of the deep RUL

classified as Palmer type 1B and a minimum of 12 months for mid-term and

4-years for long-term follow-up. The indication for surgery was persistent

pain after unsuccessful conservative treatment of acute or chronic traumatic

TFCC lesions. All surgeries were performed by either one of the senior

authors (ML and HGT).

Patient surveys were obtained at three separate time points, including

preoperative assessment and two follow-up examinations. To reduce possible

bias, the two postoperative evaluations of all patients were performed by

two experienced hand surgeons not involved in the primary treatment. These

included measurements of functional and clinical outcome using the Mayo

Modified Wrist Score (MMWS) and the Disabilities of the Arm, Shoulder and

Hand (DASH) Score. At the third follow–up examination, the Patient Rated

Wrist Evaluation (PRWE) score was surveyed additionally.

Pain was assessed using a visual analogue scale (VAS). Physical examination

included quantification of active range of motion (ROM), including flexion/

extension, radial/ulnar abduction, forearm rotation, and grip strength of


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both wrist joints. The ballottement test was used to assess DRUJ instability

pre- and postoperatively. The severity of the instability was graded as either

dynamically unstable, statically unstable, or stable.

Patients and Results

A total of 30 patients were included in this study. Preoperatively, the median

MMWS was 60 (50 – 75), the DASH score was at a median of 48.3 (25.0 – 56.7),

and VAS scores ranged from 3 to 10 with a median of 7 (6.0 – 8.0). The first

evaluation took place at a median of 30 months postoperatively (2.5 years,

range 12 – 83 months). Stability assessment showed a stable DRUJ in 23

(76.7 %) patients and a dynamic instability in 5 (16.7 %) patients. All collected

scores demonstrated statistically significant improvements following

TFCC-repair (preoperative vs. 1st follow-up; MMWS: 60 vs. 100, p < 0.001;

DASH score: 48.3 vs. 2.5, p < 0.001; VAS: 7 vs. 1, p < 0.001).

At a median of 106 months (8.83 years, range 52 – 215 months), the second

clinical assessment was performed. Stability assessment showed a stable

DRUJ in 19 patients (63.3 %), while nine patients (30 %) had a dynamically

unstable DRUJ, and two patients (6.7 %) had a statically unstable DRUJ. At

the final follow-up, the PRWE was additionally performed with a median

score of 5 (0 – 18).

When compared to preoperative measures, evaluated scores demonstrated

persisting and significant improvement (preoperative vs. 2nd follow-up;

MMWS: 60 vs. 90, p < 0.001; DASH score: 48.3 vs. 2.5, p < 0.001; VAS: 7 vs. 1.8,

p < 0.001). Comparing patients with DRUJ instability to patients with stable

DRUJ at final follow-up, no significant differences in evaluated scores between

these two groups were found.

Dr. in Gerhild Thalhammer

Author:

Gerhild Thalhammer is a certified

hand surgeon and head

of the outpatient hand clinic

at the Department of Trauma

Surgery. She has been a

senior physician at the Clinical

Department of Traumatology

since 2013 and is specialist in

Trauma Surgery and Orthopaedics

and Traumatology.

Her research focuses on new

techniques in wrist arthroscopy

and the treatment of distal

radius fractures and scaphoid

fractures.

These results demonstrate that arthroscopically assisted reattachment

of the RUL provides reliable and satisfying long-term results. All study

partici pants achieved good to excellent clinical outcome, as indicated by

the MMWS at a median follow-up of 106 months. DASH-score and VAS also

showed a statistically significant improvement in all patients compared to

preoperative findings. Moderate deterioration of MMWS and VAS was observed

at the final examination compared to the mid-term results, whereas

the DASH score remained unchanged and the more wrist-specific PRWE

score showed an average of 5 points.

Regarding the stability of the DRUJ, we found no difference in clinical outcome

between patients with static or dynamic DRUJ instability preoperatively,

neither in mid-term follow-up examinations, nor in the long-term

follow-up. Comparing the mid-term and long-term results of our study population,

we found loss of DRUJ stability in some cases. This loss of stability of

the DRUJ did not correlate with any of the evaluated scores in our statistical

analysis. Despite this increase of instability, overall satisfying results in clinical

outcome and high rates of patient satisfaction were observed.

Conclusion

Arthroscopically assisted transosseous reattachment of the deep fibres

of RUL leads to excellent and good clinical results in mid- and long-term

follow-up. Loss of DRUJ stability during follow-up was not associated with

deterioration of clinical parameters or diminution of patient satisfaction.


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Osseointegration Can Be

Improved by Conventionally Used

Anti-Osteoporotic Drugs Proven

in a Clinically Relevant Murine

Implant Model

„This study reveals that post-operative,

short-term bisphosphonate treatment

enhances osseointegration by increasing

bone quantity. Furthermore, the

decrease in osteoclast number and

activity caused by bisphosphonates

does not adversely affect osteogenesis

and angiogenesis. Taken these together,

bisphosphonates are potential therapeutic

candidates for patients with a

high risk of aseptic loosening caused by

the failure of initial osseointegration.“

Klemens Vertesich

Study:

Vertesich K, Sosa BR, Niu Y, Ji G,

Suhardi V, Turajane K, Mun S,

Xu R, Windhager R, Park-Min

KH, Greenblatt MB, Bostrom

MP, Yang X. Alendronate enhances

osseointegration

in a murine implant model.

J Orthop Res 2021

Apr;39(4):719-726. doi:

10.1002/jor.24853 (3.494)

Reliable and stable fixation of implants in total joint arthroplasty

represents a crucial factor for long-term survival after

adult joint reconstruction. In this study, the Department of

Orthopaedics in collaboration with the Arthroplasty Research

Laboratory at the Hospital for Special Surgery investigated

the impact of bisphosphonates on osseointegration of

cementless titanium implants.

The success and longevity of cementless total joint arthroplasties depends

on sufficient osseointegration and the process of structural and functional

attachment of implants to the surrounding bone. Early and excessive implant

micromotion impairs bone formation and induces the formation of fibrotic

tissue, which leads to aseptic loosening and further to expensive and complex

revision surgery. Bisphosphonates represent the most frequently used

agents to treat osteoporosis. Arthroplasty registry studies have demonstrated

that bisphosphonate treatment before, during, or after total joint arthroplasty

is beneficial for long term survival.

However, these studies do not allow the assessment of the cellular mechanism

of osseointegration and mechanical properties of the bone-implant

interface. Therefore, a reliable murine implant model has been developed,

that encompasses all critical factors of cementless arthroplasty: implant

positioning in metaphyseal cancellous bone, intraarticular positioning of the

implant, and the ability of postoperative physiological weight-bearing.

This study aimed to assess the ability of bisphosphonates to promote peri-implant

bone formation, the inhibition of osteoclastogenesis at the bone-implant

interface, and the enhancement of osseointegration. The hypothesis was that

postoperative, short-term bisphosphonate treatment improves mechanical

stability of the implant by increasing peri‐ implant bone volume, decreasing

peri‐implant osteoclasts without impairing osteoblasts or angiogenesis.


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Figure 1: (A) Lateral radiograph 28 days after proximal tibial implantation surgery. (B) Schematic overview on regions of interest for µCT measurements. (C)

Biomechanical testing revealed a significant increase in maximum pull-out load in the alendronate group compared with the vehicle group. (D) Significant

increase of bone volume over trabecular volume (BV/TV) in the peri-implant and distal to implant region in the alendronate group compared to vehicle.

Methods

In this study 44 female C57BL/6 mice at the age of 17-weeks underwent

arthroplasty surgery of the right knee joint. Under isoflurane anaesthesia

and sterile conditions, a 8mm midline incision was made over the right knee.

A medial parapatellar approach was used to dislocate the patella. Menisci

and anterior cruciate ligaments were resected. The articular cartilage of

the tibia was removed and a 0.9mm diameter hole was drilled into the tibial

medullary canal. A 3D-printed titanium implant, with a smooth oval formed

articular surface (2.0mm x 1.5mm x 0.2mm) and with an intramedullary stem

with rough surface (1.0mm in diameter and 2.0mm in length), was press-fitted

into the hole (Figure 1A). Joint capsule and skin were closed in layers. The

mice started to ambulate with full weight‐bearing on both knees immediately

after recovery from anaesthesia.

Postoperatively, the mice were randomly divided into two groups and injected

with the bisphosphonate, alendronate (BioVision Inc.; n = 22, 73 μg/kg, i.p.), or

vehicle (n = 22, 200 μl phosphate‐buffered saline, i.p.) 5 days a week starting

from the day of surgery until the day of euthanasia. The animals were

euthanized by CO2 for histological assessment on postoperative days 1, 3, 7,


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Figure 2: (A) TRAP staining revealed a significant reduction of osteoclasts per bone perimeter (N.Oc/B.Pm) and a significant increase in bone area percent

(BV/TV) with 14 days of alendronate treatment. (B) Immunofluorescence staining showed a reduction of peri-implant cathepsin K at 7-days post-implantation

with alendronate treatment. (C) Immunofluorescent imaging of the proximal tibia and peri-implant region highlights a robust presence of endothelial

cells and osteoblasts through endomucin (EMCN) and osteocalcin (OCN) staining, respectively.

14, and 28, or microcomputed tomography (µCT) analysis and pull-out testing

at day 28 after surgery. µCT was performed to assess bone volume fraction,

trabecular number, trabecular thickness, and trabecular separation in two

regions of interest: Peri-implant region (cancellous bone around the distal

500µm of the stem) and distal to implant (cancellous bone 500µm distal

from the tip of the stem) (Figure 1B). Pull-out tests were performed to assess

the mechanical stability. Immunofluorescence staining was performed to

assess the impact of bisphosphonates on osteogenesis, angiogenesis, and

osteoclastogenesis. Antibodies for anti-Osteocalcin (OCN), anti-Endomucin

(EMCN), and anti-cathepsin K (CTSK) were used. Further, frozen sections

were stained for tartrate‐resistant acid phosphatase (TRAP), and histomorphometry

according to recommendations of the Nomenclature Committee of

the American Society for Bone and Mineral Research was performed.

Results

Short-term, postoperative bisphosphonate treatment ultimately increased

implant stability. The maximum load of pull-out was significantly increased

by 45 % (p < 0.001) (Figure 1C). µCT showed that alendronate increased both

peri‐implant and distal‐to‐implant bone mass compared with the control

group (Figure 1D). In the distal‐to‐implant region, the alendronate treatment

increased bone volume fraction by 139 % (p < 0.001), trabecular number by

31 % (p < 0.001), and trabecular thickness by 18 % (p < 0.01). In the peri‐implant

region, alendronate treatment increased bone volume fraction by 60 %

(p < 0.05), trabecular thickness by 7 % (p < 0 .05), and trabecular spacing by

22 % (p < 0.001).

Although peri‐implant bone formation increased over time in both the

alendronate‐treated and control mice, alendronate accelerated the rate of

peri‐implant ossification with increased peri‐implant bone mass at 7‐ and

14‐day postoperative. Histology demonstrated that alendronate increased


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the percent of the bone area in the total area from 12.7 ± 1.6 in the control

group to 20.7 ± 0.9 in the alendronate group at 14 days after surgery (p < 0.05)

(Figure 2A). Immunofluorescence imaging showed that short‐term, post-operative

alendronate treatment did decrease the presence of osteoclasts

marked by cathepsin K (CTSK) (Figure 2B) but did not attenuate peri‐implant

EMCN‐positive endothelial cells or OCN‐positive osteoblasts after 7 and 14

days of treatment (Figure 2C).

Conclusion

This study reveals that post-operative, short-term bisphosphonate

treatment enhances osseointegration by increasing bone quantity.

Furthermore, the decrease in osteoclast number and activity caused by

bisphosphonates does not adversely affect osteogenesis and angiogenesis.

Taken these together, bisphosphonates are potential therapeutic candidates

for patients with a high risk of aseptic loosening caused by the failure of

initial osseointegration.

References:

[1] Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated Titanium Implants:

Requirements for Ensuring a Long-Lasting, Direct Bone-to-Implant Anchorage in Man. Acta

Orthopaedica Scandinavica 52(2): 155, 2009

[2] Bishop NE, Hohn JC, Rothstock S, Damm NB, Morlock MM. The influence of bone damage on

press-fit mechanics. J Biomech 47(6): 1472, 2014

Dr. Klemens Vertesich

Author:

Klemens Vertesich started his

residency at the Department of

Orthopaedics and Trauma Surgery

at the Medical University

of Vienna in 2018. His research

interests are total joint arthroplasty

and revision arthroplasty,

osseointegration of implants

as well as hip-preservation

surgery. He was awarded the

Ines Mandl Research Fellowship

in 2018 and got the opportunity

to conduct research on

the impact of bone formation

on implant osseointegration

ant the Arthroplasty Research

Laboratory at the Hospital for

Special Surgery/Weill Cornell

University, New York City.

[3] Ollivere B, Wimhurst JA, Clark IM, Donell ST. Current concepts in osteolysis. J Bone Joint Surg Br

94(1): 10, 2012

[4] Mann KA, Miller MA, Costa PA, Race A, Izant TH. Interface micromotion of uncemented femoral

components from postmortem retrieved total hip replacements. J Arthroplasty 27(2): 238, 2012

[5] Fehring TK, Murphy JA, Hayes TD, Roberts DW, Pomeroy DL, Griffin WL. The Coventry Award

Paper: Factors Influencing Wear and Osteolysis in Press-Fit Condylar Modular Total Knee Replacements.

Clinical Orthopaedics and Related Research 428: 40, 2004

[6] Favus MJ. Bisphosphonates for osteoporosis. The New England journal of medicine 363(21):

2027, 2010

[7] Russell RG. Bisphosphonates: the first 40 years. Bone 49(1): 2, 2011

[8] Rogers MJ, Crockett JC, Coxon FP, Monkkonen J. Biochemical and molecular mechanisms of

action of bisphosphonates. Bone 49(1): 34, 2011

[9] Khatod M, Inacio MC, Dell RM, Bini SA, Paxton EW, Namba RS. Association of Bisphosphonate

Use and Risk of Revision After THA: Outcomes From a US Total Joint Replacement Registry. Clin

Orthop Relat Res 473(11): 3412, 2015

[10] Prieto-Alhambra D, Javaid MK, Judge A, Murray D, Carr A, Cooper C, Arden NK. Association

between bisphosphonate use and implant survival after primary total arthroplasty of the knee

or hip: population based retrospective cohort study. BMJ 343: d7222, 2011

[11] Prieto-Alhambra D, Lalmohamed A, Abrahamsen B, Arden NK, de Boer A, Vestergaard P, de

Vries F. Oral bisphosphonate use and total knee/hip implant survival: validation of results in an

external population-based cohort. Arthritis Rheumatol 66(11): 3233, 2014

[12] Thillemann TM, Pedersen AB, Mehnert F, Johnsen SP, Soballe K. Postoperative use of bisphosphonates

and risk of revision after primary total hip arthroplasty: a nationwide population-based

study. Bone 46(4): 946, 2010

[13] Yang X, Ricciardi BF, Dvorzhinskiy A, Brial C, Lane Z, Bhimani S, Burket JC, Hu B, Sarkisian

AM, Ross FP, van der Meulen MC, Bostrom MP. Intermittent Parathyroid Hormone Enhances

Cancellous Osseointegration of a Novel Murine Tibial Implant. J Bone Joint Surg Am 97(13):

1074, 2015


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Figure 1: Fiber orientation in

the collagen matrix of chondroprogenitor

pellets. Birefringent

collagen fibers show developing

zonation in the newly formed

hyaline matrix. (A) Horizontally

arranged birefringent fibers

parallel to the pellet surface (PS).

(B) Randomly organized collagen

fibers were found in the central

area. (C) Perpendicularly oriented

birefringent fibers were located

in proximity to the pellet center

(PC). Scale bar equals 30 µm,

400× magnification.

Mimicking the Zonal Organization

of Articular Cartilage in Vitro

In 2021, the Karl Chiari Lab for Orthopaedic Biology described an in

vitro based cell model comprising human chondroprogenitor cells

that form zonally organized engineered hyaline tissue comparable

to the three zones of native cartilage. The collaboration of the Department

of Orthopedics and Trauma Surgery (MedUni Vienna and

AKH Wien) with the Hospital Speising, the Medical University of

Graz, and the Danube University Krems resulted in the publica tion

of an article entitled „A 3-Dimensional In Vitro Model of Zonally

Organized Extracellular Matrix“ in the scientific journal „Cartilage“.

Study:

Walzer SM, Toegel S, Chiari C,

Farr S, Rinner B, Weinberg

AM, Weinmann D, Fischer MB,

Windhager R. A 3-Dimensional

In Vitro Model of Zonally

Organized Extracellular

Matrix. Cartilage 2021;13(2_

suppl):336S-345S. (4,634)

In articular joints, cartilage integrity is key for patients’ mobility and activity.

The sophisticated architecture of the extracellular matrix (ECM), in particular

regarding the zonal distribution of collagen fibers across the cross-section of

cartilage, contributes to the unique properties of the tissue. Injuries or degenerative

changes often result in cartilage lesions that cause tremendous burden

for patients and healthcare systems worldwide. Numerous tissue engineering

approaches aim to restore the functionality of damaged cartilage, but so far fail

to reconstruct zonally organized hyaline tissue that might fulfil the expectations

of long-term functionality. To study hyaline cartilage repair in vitro, endogenous

stem cells of the mesenchymal lineage resident in growth plate tissue could

represent a promising cell source. Previously, we showed that these human

chondroprogenitors (CPs) can be isolated from polydactyl digits 2 . The hyaline

cartilage formation of human CPs in vitro, however, as well as their ability to

differentiate into the three mesenchymal linages remained largely unknown.


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„To study hyaline cartilage repair

in vitro, endogenous stem cells of

the mesenchymal lineage resident in

growth plate tissue could represent

a promising cell source.“

Stefan Toegel

Methods

Clinical specimens of the human growth plate were obtained from the supernumerary

digits of eight different donors (age < 36 months) with polydactylism

at the time of surgical excision. Isolated CPs were characterized by

FACS analysis using specific antibodies (CD45−, CD34−, CD73+, CD90+, and

CD105+). Three-dimensional cell constructs were prepared by centrifugation

and cultured for up to five weeks. Constructs were processed for histology

and stained with Alcian blue or Picrosirius red (PSR) and analysed using light

microscopy and polarised light microscopy (PLM). In addition, deparaffinised

sectiones were stained with antibodies against collagen I or collagen II and

DAPI, prior to analysis with an LSM 700 confocal laser scanning microscope.

In vitro osteogenic and adipogenic differentiation of CPs was confirmed

using RT-qPCR of respective target genes as well as alkaline phosphatase

(ALP) activity assay, Alizarin Red S (ARS) staining and oil red O staining.

Results

In presence of osteogenic medium, ALP staining as well as ARS quantification

significantly increased over time for up to 21 days, as compared to

undifferentiated controls. In agreement, mRNA levels of ALP, a marker for

early osteogenesis, and BGLAP, a marker of late osteogenesis, were increased

20.9 ± 25.2-fold and 6.7 ± 4.69-fold, respectively, while those for transcription

factor RUNX2 were significantly upregulated 2.88 ± 1.04-fold, supporting the

osteoinduction of CPs. Adipogenic differentiation of cultures stimulated with

adipogenic medium was demonstrated by oil red O staining of lipid droplets,

with simultaneous upregulation of mRNA levels of early (PPARG: 2.0 ± 0.6-

fold) and late (LPL: 1054 ± 906-fold)) adipogenic markers. The chondrogenic

phenotype of CPs was promoted in self-assembling pellet cultures.

Assoz. Prof. Priv.-Doz. Mag. Dr. Stefan Toegel

After 21 days, histological analyses showed an augmented amount of glycosaminoglycans

(Alcian blue) as well as column-like formations of cells.

Collagen type II positivity was detected in the newly formed ECM around the

centre of the pellet, whereas collagen type I immunostaining was mainly

found in the superficial zone, with weak positivity in the central area of the

CP pellet. PSR staining and PLM after five weeks of cultivation revealed

horizontally arranged birefringent fibers, parallel to the pellet surface, as

well as randomly organized collagen fibers, and perpendicularly oriented

birefringent fibers in the central and deep areas of the cartilaginous matrix,

respectively (Figure 1). Equally processed native articular cartilage indicated

similar collagen fibril assembly.

Author:

Stefan Toegel is head of the Karl

Chiari Lab for Orthopaedic

Biology. In 2015, he became

an Associate Professor at the

Medical University of Vienna,

and he obtained his habilitation

in Cell Biology in 2018.

The main focus of his research

is on the pathomechanisms of

osteoarthritis.

Concluding remarks

Confirming the trilineage potential of CPs, osteogenic and adipogenic differentiation

was induced in monolayer cultures using differentiation media. Under

conditions promoting the chondrogenic signature in 3D constructs, CPs formed

an aligned extracellular matrix positive for glycosaminoglycans and collagen

type II, showing developing zonation of birefringent collagen fibers along the

cross section of pellets, which reflect the distribution of collagen fibers in hyaline

cartilage.

References:

[1] Walzer S.M. et al. A 3-Dimensional In Vitro Model of Zonally Organized Extracellular Matrix.

Cartilage 2021;13:336S-345S.

[2] Walzer S.M. et al. Vascularization of primary and secondary ossification centres in the human

growth plate. BMC Dev Biol. 2014;14(1):36.


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Relevance of Follow-up CCT

in Patients on Intracranial

Pressure Monitoring

„The standard of care in patients suffering from a severe

traumatic brain injury (TBI) includes an invasive monitoring of

the intra cranial pressure (ICP) via a probe that is surgically placed

in the brain parenchyma. Based on the clinical observation that

cranial computed-tomography (CCT) follow-ups are frequently

performed even in patients on continuous ICP monitoring

within physiological limits, the authors of our study questioned

the clinical relevance and necessity of these scans.“

Study:

Bumberger A, Braunsteiner T,

Leitgeb J, Haider T. Intracranial

pressure monitoring following

traumatic brain injury:

evaluation of indications,

complications, and significance

of follow-up imaging-an

exploratory, retrospective

study of consecutive patients

at a level I trauma center.

Eur J Trauma Emerg Surg.

2022 Apr;48(2):863-870.

doi: 10.1007/s00068-020-

01570-3. Epub 2020 Dec 22.

PMID: 33351163; PMCID:

PMC7754179.

According to a recent meta-analysis the overall incidence of traumatic brain

injury (TBI) in Europe is around 262/100.000 with considerable heterogeneity

between the included studies. Cranial computed tomography (CCT) is

the gold standard of imaging in these patients and can guide further treatment

strategies. Furthermore, the Brain Trauma Foundation recommends

ICP-monitoring for patients with severe TBI (Glasgow Coma Scale 3 – 8 after

resuscitation). While ICP-monitoring can be associated with catheterrelated

complications, such as focal haemorrhage and local infection in

about 6 percent of the interventions, it is considered an essential monitoring

tool in sedated patients following severe TBI. Neurological examination of intubated

patients is limited, prompting frequent follow-up CCT examinations

which require patient transportation and positioning, both potentially increasing

ICP. Moreover, suspected compartmentalization and flawed ICP-monitoring

due to technical issues can prompt physicians to perform follow-up CCT

scans, even in patients under ICP monitoring.

The aim of the present study was threefold: To evaluate indications for follow-up

CCT imaging with respect to ICP-monitoring and clinical findings, to

analyse frequency and findings of follow-up CCTs and their impact on clinical

decision making, and to report on complications associated with invasive

ICP-monitoring.

Methods

We performed a systematic database search for patients on ICP-monitoring

between January 2007 and September 2017 at an urban level I trauma centre.

Initial CCT scans as well as the first two follow-up CCT scans were reviewed

regarding relevant features indicating TBI (intracranial haemorrhage, fracture,

edema, and midline-shift) and their spatiotemporal characteristics. As


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„The aim of the present study was

threefold: To evaluate indications for

follow-up CCT imaging with respect to

ICP-monitoring and clinical findings,

to analyse frequency and findings of

follow-up CCTs and their impact on

clinical decision making, and to report

on complications associated with

invasive ICP-monitoring.“

Alexander Bumberger

follow-up scans were routinely performed after implantation of the ICP-probe,

the third follow-up CT scan was considered the first „true“ follow-up scan.

Indications for these scans were extracted from clinical records and stratified

as „routine follow-up“ (without clinical deterioration or elevated ICP), „follow-up

due to clinical deterioration“ (new onset of anisocoria, cardiovascular

decompensation etc.), and „follow-up due to elevated ICP“ (> 20 mmHg).

The physical and neurological status of patients was extracted from letters of

discharge and then quantified according to the Glasgow Outcome Scale (GOS).

In case of patient decease, time and cause of death were recorded. All statistical

analyses were performed using SPSS Statistics 25.0 (IBM, Armonk, NY, USA).

Results

A total of 214 patients at a mean age of 44 (range 1–92) years were on ICP-monitoring

at our department between January 2007 and September 2017. The

overall in-hospital mortality was 21.6 %. There were 12 (5.6 %) complications

associated with the ICP-probe leading to 5 cases of surgical revision. Altogether,

there were no severe adverse events (major bleeding, death) directly related to

the probe or its implantation, and no catheter-associated infections.

There were 192 cases where at least one follow-up CCT was performed, with

an average of 7 CCT scans per patient. Most scans were routine follow-up

scans (n = 137, 64.3 %). One out of four follow-up scans (n = 55, 25.8 %) was

performed due to either clinical deterioration or elevated ICP. The prevalence

of bleeding progression on routinely performed follow-up CCTs was 16.1 %

(22/137). In case of clinical deterioration or elevated ICP, deterioration of findings

(i.e. bleeding progression, additional intracranial haemorrhage, and/or

increase of cerebral edema) was observed in 50.0 % (6/12) and 55.8 % (24/43)

of the cases, respectively. Follow-up scans performed due to clinical deteriora-


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Figure 1: Side-by-side comparison

of progression and non-progression

of cranial computed tomography (CCT)

findings grouped by indication of

follow-up CCT.

( intracranial pressure)

tion or elevated ICP were both more frequently associated with a deterioration

of CCT findings, as compared to routine follow-up scans (clinical deterioration:

x2(1) = 8.94, p < 0.01, OR = 5.52, 95 % CI 1.63 – 18.77; elevated ICP: x2(1) = 28.61,

p < 0.001, OR = 6.98, 95 % CI 3.26 – 14.93). Figure 1 demonstrates the prevalence

of bleeding progression according to the indication of CCT.

Dr. Alexander Bumberger

Routine follow-up CCT did not prompt any intervention in 94.9 % (130/137)

of the cases. In case of aggravation of findings, the percentage was 68.2 %

(15/22). The most common clinical consequence was a delay of antithrombotic

therapy in 18 % (4/22) of the cases. There was one case of surgical

intervention with removal of a newly detected epidural hematoma on routine

follow-up. When CCT was performed due to either clinical deterioration or

elevated ICP, a deterioration of findings was detected in 54.5 % (30/55) of the

cases. In most of these patients (76.7 %, 23/30), haemorrhage progression on

CCT did not result in any clinical consequence regarding the further treatment.

The most common consequence was a craniectomy in 10 % (3/30) of

the cases. Overall, a total of six patients (3.1 %) underwent surgical intervention

prompted by follow-up imaging.

Author:

Alexander Bumberger started

his residency at the Department

of Orthopaedics and

Traumatology at the Medical

University of Vienna in 2018

and is currently working at the

OCM Orthopaedic Surgery Munich.

While his primary research

interest and PhD project

focus on reconstructive knee

surgery and joint preservation,

he has been working on various

topics in the field of trauma

surgery and orthopaedics.

Conclusion

The present data show a high number of CCT scans performed in patients on

invasive ICP monitoring following severe TBI. The number of cases in which

a deterioration of findings on follow-up scans prompted any clinical intervention

was very low. Therefore, the necessity of CCT scans should be more

critically evaluated in each individual case, with respect to potential clinical

consequences.

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·


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Originalarbeiten 2021

Der Impact Factor ist eine errechnete Zahl, deren Höhe den Einfluss einer wissenschaftlichen

Fachzeitschrift wiedergibt. Er gibt an, wie häufig im Durchschnitt ein in

dieser Zeitschrift veröffentlichter Artikel von anderen wissenschaftlichen Artikeln

pro Jahr zitiert wird. Die ersten 20 Prozent der Zeitschriften des Fachgebietes im

Journal Citation Reports (geordnet nach Höhe des Impact Factors) sind Top-Journale.

Die zwischen 20 und 60 Prozent liegenden Zeitschriften gelten als Standard-Journale.

Folgend sind hier die Top- und Standard-Publikationen des Jahres 2021 angeführt.

Universitätsklinik für

Orthopädie und Unfallchirurgie

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an ANGPTL3 mimetic, in the knee of patients with

a focal cartilage defect“, Abstracts / Osteoarthritis

and Cartilage 29 (2021) S10eS432

Lass R, Kolbitsch P, Nöbauer I, Giurea A, Kubista B,

Windhager R, Pseudotumoren bei Metall-Hüftendoprothesen

– Follow-up von mindestens 20 Jahren,

Deutscher Kongress für Orthopädie und Unfallchirurgie

(DKOU 2021), 26. – 29.10.2021, Berlin

Schreiner MM, Apprich S, Staats K, Aletaha D,

Windhager R, Böhler C, The influence of biologicals

on aseptic arthroplasty loosening, Deutscher Kongress

für Orthopädie und Unfallchirurgie (DKOU

2021), 26. – 29.10.2021, Berlin

Sigmund IK, McNally M, Luger M, Böhler C, Windhager

R, Sulzbacher I, Der optimale Grenzwert

der neutrophilen Granulozyten in histologisch

aufarbeiteten Gewebeproben zur Diagnostik von

periprothetischen Gelenksinfektionen, Deutscher

Kongress für Orthopädie und Unfallchirurgie (DKOU

2021), 26. – 29.10.2021, Berlin

Springer B, Stihsen C, Rienmüller A, Funovics P,

Krepler P, Grohs J, Windhager R. Surgical Treatment

of Spinal Metastases-Results of a Large

Single Centre Study. 22nd EFORT Annual Congress

30.6. – 2.7.2021

Springer B, Stihsen C, Rienmüller A, Funovics P,

Krepler P, Grohs J, Windhager R. Surgical Treatment

of Spinal Metastases – Results of a Large Single

Centre Study. Eurospine 2021


Der Weg der Shark Screw®

Vom Spenderknochen zu

Patientenknochen

Die Spenderauswahl

Bevor der für die Produktion der Shark Screw® verwendete kortikale

Spenderknochen für den weiteren Herstellungsprozess in Österreich

und Deutschland freigegeben wird, werden zahlreiche Tests

durchgeführt, Proben entnommen und der serologische Status

erhoben. Dadurch kann maximale Sicherheit für Arzt und Patient

gewährleistet werden. Die Wahrscheinlichkeit einer

Krankheitsübertragung mit einem solchen Allograft liegt dabei bei

1

1:10.000.000.000.000.000.

Der Herstellungsprozess

Die Formgebung von Shark Screw® erfolgt in Linz, Oberösterreich.

Damit aus kortikalem Knochen schlussendlich eine einwandfreie

Shark Screw® wird, durchläuft jede Schraube eine aufwendige

Qualitätskontrolle, bevor diese einen seit Jahrzehnten erprobten

Sterilisationsprozess durchlaufen. Schrauben, welche die

Qualitätskontrolle nicht bestanden haben, werden für die klinische

Anwendung ausgeschlossen. Diese Schrauben stehen jedoch den

ChirurgInnen bei Shark Screw® Wet-Labs zur Verfügung.

Mission 2030

surgebright ist die österreichische

Gewebebank für Spitäler und Ihre

Ansprechperson für Knochen- und

Gewebeersatz sowie biointelligente

Osteosynthesen. Gemeinsam mit Shark

Screw® Chirurgen möchten wir durch den

Einsatz von Shark Screw® bis 2030,

500.000 Patienten das Risiko einer zweiten

Operation zur Metallentfernung ersparen.

In Shark Screw® Workshops sollen 5.000

ChirurgInnen die Verwendung von Shark

Screw trainieren können. Werden Sie jetzt

Teil der Shark Screw® Peer Group auf:

www.surgebright.com

Der erste klinische Einsatz der

Shark Screw®

Nach dem erfolgreich absolvierten Shark Screw® Workshop

können die ersten Operationen mit der allogenen

Knochenschraube durchgeführt werden und die Shark

Screw® in die klinische Routine implementiert werden.

OP-Videos und Betreuung vor Ort werden hierbei als

Unterstützung angeboten.

Remodeling & Integration in

Knochenstoffwechsel

Nach und nach wird Shark Screw® von

Stammzellen, Osteoblasten, Osteoklasten,

und Osteozyten besiedelt und in

Patientenknochen remodelt. Dabei löst

sich Shark Screw® nicht auf, sondern wird

narbenlos ein und umgebaut. Bereits

nach wenigen Monaten ist die humane

Knochenschraube gänzlich remodelt.²

1 J. Brune, Update: Allogene Gewebetransplantation in Deutschland, AFRO Expertengremium Pontresina 2019 | Association for Orthopaedic Research

2 I. Brcic, K. Pastl, H. Plank, J. Igrec, J. E. Schanda, E. Pastl, M. Werner. Incorporation of an Allogenic Cortical Bone Graft Following Arthrodesis of the First

Metatarsophalangeal Joint in a Patient with Hallux Rigidus Life (2021)

Mehr Infos unter:

www.surgebright.com


Publikationen

74

Trost C, Heisinger S, Funovics PT, Windhager R,

Hobusch GM, Stamm T, Patients’ Perceptions of

Changes and Consequences after Tumor Resection.

A Qualitative Study in Austrian Patients with

musculoskeletal Malignancies. EMSOS, 33. Annual

Meeting, 1. - 3.12.2021, Austria.

Vetchy V, Trost C, Funovics PT, Panotopoulos J,

Windhager R, Hobusch GM, Secondary Amputation –

A qualitative Study of Quality of Live in Patients

after Primary Limb Salvage Surgery and after later

Ablative Sarcoma Treatment”. EMSOS, 33. Annual

Meeting, 1. – 3.12.2021, Austria.

Sonstige Publikationen und Substandard 2021

Alfertshofer M, Frank K, Melnikov DV, Möllhoff N,

Gotkin RH, Freytag DL, Heisinger S, Giunta RE,

Schenck TL, Cotofana S. Performing Distance Measurements

in Curved Facial Regions: A Comparison

between Three-Dimensional Surface Scanning

and Ultrasound Imaging. Facial Plast Surg. 2021

Jun;37(3):395-399. doi: 10.1055/s-0041-1725166.

Epub 11.3.2021. (1.446)

Apprich S, Nia A, Schreiner MM, Friedrich K, Windhager

R, Trattnig S. The Vienna morphological Achilles

tendon score-VIMATS : Description, reproducibility

and initial clinical results. Wien Klin Wochenschr.

2021 Jun;133(11-12):560-7. Epub 6.4.2021. (1.704)

Apprich SR, Nia A, Schreiner MM, Jesch M, Böhler

C, Windhager R. Modular megaprostheses in the

treatment of periprosthetic fractures of the femur.

Wien Klin Wochenschr. 2021 Jun;133(11-12):550-

9. Epub 14.4.2021. (1.704)

Bumberger A, Borst K, Hobusch GM, Willegger M,

Stelzeneder D, Windhager R, Domayer S, Waldstein

W. Higher patient knowledge and resilience

improve the functional outcome of primary total

knee arthroplasty. Wien Klin Wochenschr. 2021

Jun;133(11-12):543-549. (1.704)

Casari FA, Navab N, Hruby LA, Kriechling P, Nakamura

R, Tori R, de Lourdes Dos Santos Nunes F,

Queiroz MC, Fürnstahl P, Farshad M. Augmented

Reality in Orthopedic Surgery Is Emerging from

Proof of Concept Towards Clinical Studies: a Literature

Review Explaining the Technology and Current

State of the Art. Curr Rev Musculoskelet Med.

2021 Apr;14(2):192-203. doi: 10.1007/s12178-

021-09699-3. Epub 5.2.2021

Carlin GL, Baumgartner JS, Moftakhar T, König D,

Negrin LL. Impact of COVID-19 lockdown on suicide

attempts: A retrospective analysis of the springtime

admissions to the trauma resuscitation room at

the Medical University of Vienna from 2015-2020.

Wien Klin Wochenschr. 2021 Sep;133(17-18):915-

922. doi: 10.1007/s00508-021-01839-6. Epub

31.3.2021. (1.704)

Chiari C, Willegger M, Kolb A, Windhager R, Epiphysiolysis

capitis femoris: Notfallversorgung Jatros

Orthopädie und Traumatologie 1/21: S 12-15.

Chiari C, Editorial Fokusthema Kinderorthopädie

und Kindertraumatologie, Jatros Orhopädie und

Traumatologie 4/21: S3.

Dekhne MS, Thomas HM, Haider T, Mortensen S,

Rodriguez EK, Weaver MJ, von Keudell A. Treatment

and outcomes of basicervical femoral neck

fractures: A systematic review. J Orthop Surg (Hong

Kong). 2021 Jan – Apr;29(1):23094990211003344.

doi: 10.1177/23094990211003344.

Farr S, Scheider P. The Molding Hands of Time:

Remodeling of Sagittal Plane Malunion After Pediatric

Supracondylar Humerus Fractures. J Pediatr

Orthop. 2021 Sep 1;41(8):e700.

Haider T, Hanna P, Mohamadi A, Merchan N, McNichol

M, Wixted JJ, Appleton PT, Nazarian A ,von Keudell AG,

Rodriguez EK. Revision Arthroplasty Versus Open Reduction

and Internal Fixation of Vancouver Type-B2

and B3 Periprosthetic Femoral Fractures. JBJS Rev.

20.8.2021, 9(8). doi: 10.2106/JBJS.RVW.21.00008.

Haider T, Notter L. Das funktionelle Querschnittsyndrom

– ein Fallbericht. Functional Para plegia –

A Case Report. Neurologie Open Access Published:

14.4.2021 psychopraxis. neuropraxis volume 24,

pages 178–181 (2021)


Publikationen

75

Lang NW, Kasparek MF, Synak L, Waldstein W,

Funovics PT, Windhager R, Hobusch GM. What

sports activity levels are achieved in long-term

survivors with modular endoprosthetic humerus

reconstruction following primary bone sarcoma

resection? Wien Klin Wochenschr. 2021 Jan;133(1-

2):14-20. (1.704)

Negrin LL. Knieverletzungen im alpinen Skibreiten-

und Skileistungssport – eine selektive Aufarbeitung

der aktuellen Literatur. Sports Orthop

Traumatol. 2021 37: 313 -321. doi: org/10.1016/j.

orthtr.2021.11.007.

Negrin LL und Puchwein P. REBOA in der Polytraumaversorgung:

State of the Art und Case Report.

Jatros Orthopädie & Traumatologie Rheumatologie

1/2021

Nia A, Popp D, Diendorfer C, Apprich S, Munteanu

A, Hajdu S, Widhalm HK. Impact of lockdown during

the COVID-19 pandemic on number of patients

and patterns of injuries at a level I trauma center.

Wien Klin Wochenschr. 2021 Apr;133(7-8):336-343.

(1.704)

Nürnberger S. Gewebekleber nach dem Vorbild der

Natur. Jatros Orthopädie & Traumatologie Rheumatologie

2/2021

Rentenberger C, Salzmann SN, Shue J, Hughes AP.

Heel Lift for Skiing to Compensate for Corrected

Sagittal Vertical Axis After Spinal Surgery: A Case

Report. Int J Spine Surg. 2021 Feb;14(s4): S33-S36.

doi: 10.14444/7162.

Salom M, Chiari C, Alessandri JMG, Willegger M,

Windhager R, Sanpera I. Diagnosis and staging

of malignant bone tumours in children: what is

due and what is new? J Child Orthop. 2021 Aug

20;15(4):312-321. (1.548)

Salzmann SN, Knochenqualität in der spinalen MRT

sagt Fragilitätsfrakturen voraus. Die Wirbelsäule

2021; 5: Seiten: 15 – 17, DOI: 10.1055/a-1222-6211

Schitz F, Rilk, S, Schabus R. Arthroskopische Versorgung

einer suprakondylären Femurfraktur bei

einliegender Knietotalendoprothese mittels retrogradem

Femurnagel. Arthroskopie 34, 74–79 (2021).

https://doi.org/10.1007/s00142-020-00422-x

Seilern Und Aspang J, Böckmann D, Erhart J,

Haider T. Ossification of the pseudarthrosis following

the Sauvé-Kapandji procedure: a case

report and review of the literature. Case Reports

Plast Surg Hand Surg. 2021 Apr 16;8(1):66-71. doi:

10.1080/23320885.2021.1910040.

Sigmund IK, Puchner SE, Windhager R. Serum

Inflammatory Biomarkers in the Diagnosis of Periprosthetic

Joint Infections. Review. Biomedicines

2021, 9(9), 1128. (6.081)

Sigmund IK, Windhager R, State of the Art: Behandlung

von periprothetischen Gelenksinfektionen

nach Implantation einer Hüft- bzw. Knietotalendoprothese.

JATROS, Orthopädie & Traumatologie

Rheumatologie 6/2021.

Soffin EM, Reisener MJ, Padgett DE, Kelly BT, Sama

AA, Zhu J, Salzmann SN, Chiapparelli E, Okano I,

Oezel L, Miller AO, Cammisa FP, Girardi FP, Hughes

AP. Coronavirus Disease 2019 Exposure in Surgeons

and Anesthesiologists at a New York City Specialty

Hospital: A Cross-Sectional Study of Symptoms

and SARS-CoV-2 Antibody Status. J Occup Environ

Med. 2021 Jun 1;63(6):521-527. doi: 10.1097/

JOM.0000000000002182. PMID: 34048384; PM-

CID: PMC8168673.

Ternovoy S, Ustyuzhanin D, Shariya M, Shabanova

M, Gaman S, Serova N, Mironov V, Merkulova I,

Rienmueller A, Meyer EL, Rienmueler T. Reliability

of coronary computed tomography angiography in

acute coronary syndrome in an emergency setting.

Heliyon. 1.2.2021;7(2):e06075

Trost C, Hofer C, Stamm T, Windhager R, Hobusch

GM, Cross-cultural adaption, translation and validation

of the Toronto extremity salvage score (TESS)

for patients in German-speaking countries; Wien

Klin Wochenschr. 2021 Jun;133(11-12):536-542.

Weihs V, Pogran E, Kunschitz E, Weihs W, Prinz E,

Eichenberg C, Fiegl J, Friedrich O, Huber K.

Psychocardiological assessment in the acute

phase of the takotsubo syndrome: Somatic and de


Publikationen

76

pressive disorders, resilience and illness perception.

Wien Klin Wochenschr. 2021 Oct 20. doi:

10.1007/s00508-021-01957-1. Online ahead of

print. (1,704)

Willegger M, Schreiner M, Kolb A, Windhager R,

Chiari C. Epiphysiodesis for the treatment of tall

stature and leg length discrepancy. Wien Med Wochenschr.

2021 Apr;171(5-6):133-41.

Willegger M, Hirtler L, Schwarz GM, Windhager

RH, Chiari C. Peronealsehnenpathologien: Von der

Diagnose bis zur Behandlung [Peroneal tendon pathologies:

From the diagnosis to treatment]. Orthopade.

2021 Jul;50(7):589-604.

Willegger M., Kolb A., Chiari C. Timing von Epi- und

Hemiepiphysiodese an der unteren Extremität. Jatros

Orthopädie & Traumatologie, Rheumatologie

2021, 4:25-27

Windhager R. Tumorendoprothetik [Tumour arthroplasty].

Orthopade. 2021Oct;50(10):839-842.

Buchbeiträge 2021

Bostrom MP, Sosa B, Staats K; „Trochanteric Osteotomy“,

Advances in Specialist Hip Surgery, Seite:

225-235; Verlag: Springer Medizin, ISBN: 978-

3030618292

Chiari C, Kainberger F. Gliederschmerzen, Arthralgie,

Muskel- und Knochenschmerz, In Klinisches

und Kritisches Denken. Manual klinischer Symptome,

Syndrome und Risikofaktoren inklusive

e-Learning-Plattform Taschenbuch Facultas,

ISBN: 978-3-7089-2073-0; 2. Auflage 2021, Kainberger

F, Karanikas G, Schernthaner G, Szekeres T

(Herausgeber)

Grohs J, Kainberger F. Rückenbeschwerden. In Klinisches

und Kritisches Denken. Manual klinischer Symptome,

Syndrome und anderer Anlassfälle inklusive

e-Learning-Plattform. Franz Kainberger, Georgios

Karanikas, Gerit Schernthaner, Thomas Szekeres.

ISBN: 978-3-7089-2073-0; 2. Auflage 2021; 415-8

Hager B, Raudner M, Juras V, Zaric O, Szomolanyi

P, Schreiner M, Trattnig S. MRI of Early OA in: Early

Osteoarthritis - State-of-the-Art Approaches to

Diagnosis, Treatment and Controversies, Springer

2021, pp. 17-26

Hobusch GM, Windhager R, Chondrosarcoma of

the Pelvis, Book chapter in Surgery of Pelvis Bone

Tumors, Springer ISBN: 978-3-030-77007-5, Book

chapter, Pages 55-62

Hobusch GM et al, Implant Reconstruction of the

Distal Femur: Expandable Prosthesis.in Orthopedic

Surgical Oncology For Bone Tumors, A case Study

Atlas, DOI 10.1007/978-3-030-73327-8_24 book

Chapter

Hruby LA, Mayer JA, Aszmann OC. Inner Amputations

of the Upper Extremity. In: Bionic Limb Reconstruction,

Oskar C. Aszmann and Dario Farina.

2021, Springer

Hruby LA. Deafferentation Pain Following Brachial

Plexus Avulsion Injuries. In: Bionic Limb Reconstruction,

Oskar C. Aszmann and Dario Farina. 2021, Springer

Hruby LA, Sturma A.Treatment Algorithm for Bionic

Hand Reconstruction in Patients with Global Brachial

Plexopathies. In: Bionic Limb Reconstruction,

Oskar C. Aszmann and Dario Farina. 2021, Springer

Hruby LA, Sturma A, Pittermann A. Functional and

Psychosocial Outcomes of Bionic Reconstruction

and Impact on Quality of Life, Body Image Perception

and Deafferentation Pain In: Bionic Limb Reconstruction,

Oskar C. Aszmann and Dario Farina.

2021, Springer

Negrin LL: Epidemiology and Classification of Distal

Femur Fractures. In: Knee Fractures. Marc Hanschen,

Peter Biberthaler, James P. Waddell, Springer,

ISBN 978-3-030-8175-6. 297 Seiten

Pittermann A, Hruby LA, Sturma A, Aszmann OC.

Psychosocial Importance of the Hand and Consequences

of Severe Hand Trauma, Amputation and

Complete Brachial Plexus Injury. In: Bionic Limb Reconstruction,

Oskar C. Aszmann and Dario Farina.

2021, Springer


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Pittermann A, Hruby LA, Sturma A, Aszmann OC.

Ethical Considerations and Psychosocial Evaluation

in Elective Amputation for Brachial Plexus

Injuries. In: Bionic Limb Reconstruction, Oskar C.

Aszmann and Dario Farina. 2021, Springer

Staats K, Mokrusa, Sauer, Kainberger; Medizininformatik,

Kritisches und Klinisches Denken, Seite:

43 - 53; Verlag: Facultas ISBN: 978-3708920719

Sturma A, Hruby LA, Diers M. Epidemiology and

Mechanisms of Phantom Limb Pain. In: Bionic Limb

Reconstruction, Oskar C. Aszmann and Dario Farina.

2021, Springer

Sturma A, Hruby LA, Vujakilija I, Østlie K, Farina

D. Treatment Strategies for Phantom Limb Pain.

In: Bionic Limb Reconstruction, Oskar C. Aszmann

and Dario Farina. 2021, Springer

Diplomarbeiten/Dissertationen 2021

Apprich S: Moritz Priol. Einfluss der medialen

Menis kusextrusion auf den Knorpel der Belastungszone

des femoromedialen Kompartiments im

Kniegelenkretrospektive Evaluierung anhand von

quantitativem T2 Mapping auf 3 Tesla

Benca E: Beatrice Ferrante (Politecnico di Milano).

Analysis of thermal effects in the bone cortex caused

by the implantation of transfemoral osseointegrated

prosthesis.

Giurea A: Franz Xaver Feichtinger: Vergleich: Navigationsdaten

und Röntgenanalyse

Giurea A: Richard Koza. Outcome von Knierevisionsprothesen

7 Jahresergebnisse

Gregori M, Aldrian S: Anna Hohensteiner. Mittelfristige

und Langzeitergebnisse nach operativer

Refixation von chondralen und osteochondralen

Abscherfrakturen im Kniegelenk (18.11.2020)

Haider T, Negrin L: Philipp Pauli. The role of thrombocytes

after severe thoracic trauma – a retrospective

study (17.12.2020)

Haider T, Hajdu S: Melanie Winter. Kalkaneus

Frakturen - Vergleich operativer und konservertiver

Therapie - eine retrospektive Studie (21.12.2020)

Hasenöhrl T, Widhalm H: Sebastian Rilk. Isokinetic

and Isometric Biodex quadriceps strength

testing following anterior cruciate ligament reconstruction:

A systematic review and meta-analysis.

(28.6.2021)

Hofbauer M, Binder H: Maximilian Gruber. Management

und Outcome der seltenen unteren Schulterluxation

(Luxation Erecta): eine single-center Studie

(8.10.2020)

Hofbauer M, Ostermann R: Claus Derek Bukowsky.

Ist der Discus acromioclavicularis durch eigene

Schmerzfasern eine mögliche Ursache für Schulterschmerzen?

(16.12.2020)

Humenberger M, Hajdu S: Cornelia Naß. Inzidenz

und Ursache der Peroneusläsion nach Verriegelungsnagelung

bei Unterschenkelfrakturen - Eine

retrospektive Studie (31.3.2021)

Kdolsky R: Jakob Ulreich. Effektivität der radialen

extrakorporalen Stoßwellentherapie im Vergleich

zu anderen konservativen Therapien und Placebo

für die laterale Epikondylitis des Ellenbogens.

Eine systematische Literaturarbeit und Metaanalyse

von randomisiert kontrollierten Studien

(8.10.2020)

Kdolsky R: Benjamin Nikolaus Janda. Die Rolle des

operativen Eingriffs in der Behandlung des lateralen

Bandapparates im oberen Sprunggelenk nach

Supinationstrauma (24.2.2021)

Lass R, Rentenberger C: Daniel Birgsteiner. Navigierte

Hüftendoprothetik – Verlaufsbeobachtung

einer prospektiv randomisierten Kontrollstudie.

Lass R: Co-Betreuer: Lukas Rabitsch. 10-Jahres

Untersuchung nach zementfreier Knietotalendoprothese.

Maier B, Aldrian S: Julia Strasser. Funktioneller

Outcome nach Therapie von Luxationen und Luxationsfrakturen

der Mittelhand (21.4.2021)


Publikationen

78

Negrin L: Greta Carlin. Serum level alterations of

matrix metalloproteinases (MMPs) and tissue

inhibitors of metalloproteinases (TIMPs) in polytraumatised

patients (24.2.2021)

Payr S, Hofbauer M: Karin Valentina Leitner.

Eine retrospektive und epidemiologische Datenanalyse

von Übergangsfrakturen – Inzidenz,

Ursachen, Diagnostik, Therapie und Outcome

einer Verletzung im Kindes- und Jugendalter

an einem Level I Trauma zentrum

(27.5.2021)

Payr S, Hofbauer M: Andrea Schuller. Spine injuries

in children and adolescents - frequency, causes,

diagnostics, therapy and outcome at a Level I

trauma center a retrospective, epidemiological

data analysis (29.9.2021)

Sarahrudi K, Tiefenböck T: Christian Schützner.

Die Inzidenz und Therapie von Frakturen nach

Lungentransplantationen - Eine explorative Single

Center Studie (4.12.2020)

Schreiner M: Ina Bischofs, Beinlängenausgleich

durch Epiphysiodese im Kindesalter – eine retrospektive

Vergleichsstudie zwischen RigidTack und

PETS (29.9.2021).

Staats K: Alexander Banyai. Der Einfluss des

Kragens auf das Prothesenüberleben bei zementfreien

Hüfttotalendoprothesen, eine retrospektive

Datenanalyse (21.4.2021).

Tiefenböck T, Hofbauer M: Manuel Wildtgrube.

The All-inside Anterior Cruciate Ligament Reconstruction

Technique? A Gender-Based Difference

in Results and Outcome After 2 Years of Experience

(21.4.2021)

Tiefenböck T: Thomas Sator. Surveillance von

postoperativen Wundinfektionen nach operativer

Versorgung pertrochantärer und subtrochantärer

Frakturen? Eine retrospektive Datenauswertung

(3.5.2021)

Tiefenböck T, Sarahrudi K: Olga Bajenov. Die Anwendung

von BMP-2 in der Therapie von Knochendefekten

am Mausmodell (10.6.2021)

Tiefenböck T: Thomas Böhm. Die Behandlung von

diaphysären Femurfrakturen mittels Fixateur externe

Versorgung bei PatientInnen im Alter von zwei

bis 16 Jahren (10.6.2021)

Tiefenböck T: Vinzenz Bussek. Sekundäre Nagelung

nach primärer Versorgung mittels Externen

Fixateur eine Single Center Studie (10.6.2021)

Tiefenböck T: Silvina Elena Ohnesorg. Thoraxverletzungen

bei polytraumatisierten Kindern und

Jugendlichen Epidemiologie, Behandlung und Ergebnisse

Eine retrospektive Studie (1.9.2021)

Toegel S: Patrick Mannsberger. Biocompatibility of

3D printed materials: Cytotoxicity tests with L929

cells, primary chondrocytes and synovial fibroblasts.

(4.5.2021)

Waldstein W: Eugen Lacic. Präoperative Beurteilung

der Meniskusrampe im MRT bei Patienten mit

Ruptur des vorderen Kreuzbands.

Walzer S, Toegel S: Christopher Bauer. Effects of

BMP-6 and inflammatory cytokines in human fibroblast-like

synoviocytes under mechanical stimulation.

(27.7.2021)

Widhalm H: Julia Elisabeth Zieger. Epidemiologische

Aspekte von Frakturen im Kindes- und Jugendalter

- Einfluss der Zunahme der Verwendung

elektronischer Geräte. Eine retrospektive Studie an

circa 5.000 Patienten. (7.7.2021)

Preise 2021

Casado Losada I: Best Poster Presentation 2. Prize,

Young Scientist Association (YSA)

Casado Losada I: Science Art contest,

Young Scientist Association (YSA)

Fürsatz M: Best Poster Chair Award, TERMIS 2021

Hobusch GM: Austrian Musculo-Skeletal-Oncologic

Society (AMSOS) Research Promotion Prize


Publikationen

79

2020/2021: Electronically Patient Reported Outcomes

(EPROS) Analysis in Patients with Musculoskeletal

Sarcomas.

Morgenbesser R: AUB Wissenschafts-Posterpreis.

Jahrestagung der Österreichischen Arbeitsgemeinschaft

für Urogynäkologie und rekonstruktive

Beckenbodenchirurgie (AUB)

Nürnberger S: Battle for the topic „Scaffolds“ on

EORS 15. – 17.9.2021, Rome/Italy

Willegger M, Karin Hebenstreit, Martin Zalaudek, Alexander

Kolb, Reinhard Windhager, Catharina Chiari,

1. Poster Preis, Use of the bimalleolar method shows

the highest reliability in measuring tibial torsion on

paediatric rotational MRI, Vereinigung für Kinderorthopädie

(VKO), Graz, Austria, Oktober 2021

Zak L: 2. Platz des ÖGU Förderpreises für Open

Access Publikationen “Third generation Autologous

Chondrocyte Implantation at the knee joint using

the Igo ® scaffold – a case series”

Drittmittelfinanzierte Projekte 2021

Projektleitung: Benca E

Fixation of the ACL using an allograft osteosynthesis

system. Surgebright GmbH (Industrie),

Projektlaufzeit: 22.2.2021 – 22.2.2022

Laufzeit: 12 Monate

Gesamtfördersumme: 6.000 €

Projektleitung: Halát G

Vorstellung einer innovativen, Anker-basierten

Rekonstruktionstechnik in der chirurgischen

Therapie der A2-Ringband Ruptur. Eine experimentelle

Studie am humanen Kadavermodell.

Medizinisch-Wissenschaftlichen Fonds des

Bürgermeisters der Bundeshauptstadt Wien

Projektnummer: 20029

Zuteilungsdatum: Juni 2020

Laufzeit: 18 Monate

Fertigstellung des Projektes: November 2021

Gesamtfördersumme 1.000 €

Projektleitung: Maier B

Beurteilung des Heilungsprozesses bei

konservativ behandelten distalen Radiusfrakturen

sowie Identifizierung osteoporotischer

Frakturen bei postmenopausalen Frauen mittels

HrPQCT (hochauflösende periphere quantitative

Computertomographie)

Medizinisch-Wissenschaftlicher Fonds des

Bürgermeisters der Bundeshauptstadt Wien

Projektnummer: 20043

Zuteilungsdatum: 4.6.2020

Laufzeit: 18 Monate bis Juni 2022

Gesamtfördersumme 2.000 €

Projektleitung: Negrin L

Welche Schlussfolgerungen lässt der

zeitliche Verlauf von Biomarkerspiegeln, die

im Blut von Polytrauma-Patienten erhoben

werden, zu? – Eine Pilotstudie

Förderung der Österreichischen Gesellschaft

für Unfallchirurgie

Start: Jänner 2019

Laufzeit: 48 Monate

Projektlaufzeit: 01.2019 – 12.2022

Gesamtfördersumme 10.000 €

Projektleitung: Nürnberger S

Cartilage for Cartilage regeneration: Laser engraved

decellularized cartilage as biomaterial for

defect treatment

FFG Bridge 1 Projekt

Projektnummer: 874759

Bewilligung: Juni 2019

Laufzeit: 36 Monate + 12 Monate

Projektlaufzeit: 1.10.2019 – 30.9.2023

Gesamtfördersumme 317.936 € (UCO 40.748 €)

Projektleitung: Nürnberger S

Laserbasierte Methode zur Wiederbesiedelung

von dezellularisierter Knorpelmatrix

(LaserScaffold) für die Knorpelregeneration

Lorenz Böhler Fonds

Projektnummer: 5/19

Bewilligung: Mai 2019

Laufzeit: 18 Monate + 10 Monate

Projektlaufzeit: 1.9.2019 – 31.12.2021

Gesamtfördersumme 33.464 €


Publikationen

80

Projektleitung: Schwarz G

Titel: Femorale Stabilität nach Marknagel-

Entfernung – Anatomische und biomechanische

Auswertung.

Geldgeber: Medizinisch-wissenschaftlicher Fonds

des Bürgermeisters der Bundeshauptstadt Wien

Nummer des Projektes: 21072

Zuteilungsdatum: 1.7.2021

Laufzeit: 12 Monate

Voraussichtliche Fertigstellung: Juli 2022

Gesamtfördersumme 13.500 €

Projektleitung: Staats K

Titel: Functionalization of Nanopatterned Titanium

(Ti) for Biomedical Application (FTiBA)

Geldgeber: CEST

Zuteilungsdatum: 15.9.2020

Laufzeit: 15,5 Monate

Voraussichtliche Fertigstellung: 31.12.2021

Gesamtfördersumme 33.696 €

Projektleitung: Toegel S.

Titel: Identifizierung von Galektinrezeptoren in

arthrotischen Knorpelzellen

Geldgeber: Johnson&Johnson

Zuteilungsdatum: 1.8.2019

Laufzeit: 18 Monate

Voraussichtliche Fertigstellung des Projekts:

Ende 2021

Gesamtfördersumme 75.000 €

Projektleitung: Toegel S.

Titel: AFOR Wissenschaftspreis 2020

Geldgeber: Association for Orthopaedic Research

Zuteilungsdatum: 1.11.2020

Laufzeit: 23 Monate

Voraussichtliche Fertigstellung des Projekts:

Ende 2022

Gesamtfördersumme 6.250 €

Projektleitung: Widhalm HK

The Clinical Relevance of micro RNAs in Mild

Traumatic Brain Injury - A Pilot Study

(Micro RNA Diagnostik bei Schädelhirntrauma)

Medizinisch-Wissenschaftlichen Fonds des

Bürgermeisters der Bundeshauptstadt Wien

Zuteilungsnummer des Projekts: 15113

Zuteilungsdatum: 1.12.2015

Laufzeit: 60 Monate

Fertigstellung des Projekts: Ende 2021

Gesamtfördersumme 13.000 €

Vorsitz bei Tagungen 2021

Aldrian S

Minimalinvasive Osteosynthesen II, 57. ÖGU &

2. ÖGOuT Jahrestagung (Online) „Minimalinvasive

Unfallchirurgie und Orthopädie“, 7. – 9.10.2021,

Österreich

Casado Losada I

Mechanisms of action in skeletal biology and repair,

6. World Congress of the Tissue Engineering and Regenerative

Medicine International Society (TERMIS),

Maastricht, 15. – 19.11.2021 (online), Niederlande;

Engineering extracellular matrices: fabrication methods,6.

World Congress of the Tissue Engineering

and Regenerative Medicine International Society

(TERMIS), Maastricht, 15. – 19.11.2021 (online)

Chiari C

Surgical Treatment: What is best for spine and pelvis?

39. EPOS Annual Meeting, European Paediatric

Orthopaedic Society, 14.4.2021 (online)

Deformitäten II, Trauma, Varia. 1.10.2021, 34. Jahrestag

und der Vereinigung der Kinderorthopädie e.V.,

30.9. – 2.10.2021, Graz

Kursorganisation. Ausbildungskurs der Medizinischen

Universität Wien - Sonografie der Säuglingshüfte

nach Graf – 15. – 16.10.2021

Vortragsblock 4: Wirbelsäule operative, ÖGO/BVDO

Tagung, 20.11.2021 Wien

Frenzel S

Workshop des Jungen Forums der ÖGU – „Minimalinvasive

Chirurgie“. 57. Jahrestagung der Österreichischen

Gesellschaft für Unfallchirurgie,

(7. – 9.10.2021): 7.10.2021

Fürsatz M

Postersession: Use of bioelectronic, biomagnetic

and biophysical approaches in Regenerative Medicine

6. World Congress of the Tissue Engineering and

Regenerative Medicine International Society (TER-

MIS 2021), Maastricht, 15. – 19.11.2021 Niederlande


Publikationen

81

Grohs J

22. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.

virtuelle Live Diskussion Wirbelsäule mit

Abstand 20.2.2021. Wien, 30.1.2021

Halát G

Aktuelle Herausforderungen in der Schwerstverletztenversorgung

4. Interdisziplinären Polytraumasymposium

Österreich

Humenberger M

Sitzung des Jungen Forums der ÖGU & Assistent*innenversammlung

57. ÖGU & 2. ÖGOuT Jahrestagung

(Online) ‚Minimalinvasive Unfallchirurgie

und Orthopädie‘, 7. – 9.10.2021 Österreich

Kdolsky R

ESTES webinar: „Management of periarticular injuries

of the knee“, 22.3.2021,ESTES virtual week:

„Recommendations on thoraco-lumbar fractures“,

25.4.2021

Nürnberger S

Knorpel-Session, „Annual Meeting Austrian Cluster

for Tissue Regeneration“, 30. – 31.8.2021, Wien

Pajenda G

Postervorträge 57. ÖGU & 2. ÖGOuT Jahrestagung

(Online) „Minimalinvasive Unfallchirurgie und

Ortho pädie“, 7. – 9.10.2021 Österreich

Sigmund IK

Best Paper Session. 39. Annual Meeting of the European

Bone and Joint Infection Society. 7. – 9.10.2021

Ljubljana, Slovenia

Springer B

Workshop des Jungen Forums der ÖGU – „Minimalinvasive

Chirurgie“, 57. ÖGU & 2. ÖGOuT Jahrestagung

(Online) ‚Minimalinvasive Unfallchirurgie und

Orthopädie‘, 7. – 9.10.2021, Österreich

Thalhammer G

Spezielle Fragestellungen 57. ÖGU & 2. ÖGOuT

Jahrestagung (Online) ‚Minimalinvasive Unfallchirurgie

und Orthopädie‘ vom 7. – 9.10.2021, Wien

Widhalm H

Interdisziplinäres Management 5. Österreichisches

Symposium für Perioperative Medizin – Hybridveranstaltung,

MUW, 01. Oktober 2021 Österreich

Weill Cornell Seminar Weill Cornell Seminar: Trauma

& Emergency Surgery: Austrian American Foundation

(AAF), 12. – 18.12.2021, Salzburg Österreich

Willegger M

Ausbildungskurs der Medizinischen Universität

Wien – Sonografie der Säuglingshüfte nach Graf, ao.

Univ.-Prof. Dr. Catharina Chiari, MSc; OA Priv. Doz. Dr.

Alexander Kolb, Priv. Doz. Dr. Madeleine Willegger

FEBOT, Dr. Markus Schreiner

Windhager R

Block I: OP Technik und die schwierige primäre TKA

AE-Masterkurs „Knie“, Arbeitsgemeinschaft Endoprothetik

GmbH Linz, 1.10.2021

ASG-Fellows: Hüftgelenk – von der Säuglingshüfte

bis zum Hüft-TEP-Wechsel, DKOU 2021, Berlin,

28.10.2021

Wissenschaftliche Leitung 2021

Negrin L

Wissenschaftliche Leitung: 23. GOTS Wintertreffen

– Stabil und Mobil – Vom Rumpf bis zur Extremität,

Online, 26. – 27.3.2021 Österreich

Leiter des Organisationskomitees: 4. Interdisziplinäres

Polytraumasymposium – Aktuelle Herausforderungen

in der Schwerstverletztenversorgung,

Online, 7.5.2021 Österreich

Wissenschaftliche Leitung: Beckenkurs – Osteosynthese

bei Beckenfrakturen am Humanpräparat,

Salzburg, 6. 10.2021 Österreich

Windhager R

Wissenschaftliche Leitung: Online Ausbildungskurs

„Tumororthopädie“ ÖGO, 12.3.2021

Wissenschaftliche Leitung: Medacta Surgical Days,

15. – 18. 6.2021, Graz

Wissenschaftliche Leitung: AE-Masterkurs „Knie“,

Arbeitsgemeinschaft Endoprothetik GmbH Linz,

1. – 2.10.2021


Publikationen

82

Präsidentschaften und

Funktionen bei Journalen 2021

Antoni A

Vorstandsmitglied der ADNANI (Interdisziplinäre

Arbeitsgemeinschaft Neuromedizin)

Döring K

Reviewer

World Journal of Surgical Oncology

Frenzel S

Reviewer

PLOS ONE

Giurea A

Guest Editor. Acta Chirurgica Austriaca

Wissenschaftlicher Beirat bei IATROS

Kolumne in: Sport in Wien, Echo Verlag Wien

Kolumne in: Running, Echo Verlag Wien

Grohs J

Corresponding Member, North American Spine

Society (NASS)

Reviewer Wiener Medizinische Wochenschrift

Beirat der Österreichischen Gesellschaft für

Wirbelsäulenchirurgie

Preiskommittee Otto Kraupp Preis

26.10.2021

Haider T

Reviewer

British Medical Journal (BMJ) Open

Injury – International Journal of the Care

of the Injured

European Journal of Trauma and Emergency

Surgery

Scientific Reports

BMC Musculoskeletal Disorders

Hajdu S

Preiskommission für den Günther-Schlag

Abstractpreis für junge Forscher*innen

Holzer S

Präsidiumsmitglied der Österreichische Gesellschaft

für Musik und Medizin (ÖGfMM) Leitung der

AG Musikermedizin 2020 – 2022

Kdolsky R

Section Chair

ESTES: skeletal trauma and sports medicine

Reviewer

International Journal of Environmental Research

and Public Health

Medicina

World Journal of Orthopedics

Medicines

Lass R

Editorial Boards

Austin Journal of Orthopedics & Rheumatology

World Journal of Orthopedics

Reviewer

Journal of Orthopedic Research

Bone & Joint Research

BMC Muskuloskeletal Disorders

Diagnostic Microbiology

European Journal of Clinical Microbiology & Infectious

Diseases

Expert Reviews

Journal of Functional Biomaterials

Negrin L

Editorial Board Member

Journal of Clinical Trials

Journal of Trauma & Treatment

Nürnberger S

Reviewer

Acta Biomaterialia

EBiomed

Ticks and Tick born deseases

Payr S

Reviewer

Journal of Orthopaedic Surgery and Research

Journal of Clinical Medicine

International Journal of Environmental Research

and Public Health

Children

Rothbauer M

Reviewer

RSC Lab on a chip, Acta Biomat, Small, Anal Chem,

Adv Science, Adv Materials, Adv functional mat,

Nature sci rep, Nature comms, World J Surg Onc,


Publikationen

83

Molecules, Micromachines, E&I Elektrotechnik,

Biophys rev, Biology, Adv mat techn, ACS biomat

sci eng, ACS appl bio mat, Biosensors, Methods

Biomech Bioeng, Life, Cell Biol Int, Pharmaceutics,

Vet Med, Appl Sci, Expert Opin Drug Deliv, Nanomaterials,

Eng rep, IJMS, J TERM, Electronics,

BioTechniques

Scientific Evaluator

The Dutch Cancer Society (KWF)/The Netherlands

Fundação para a Ciência e a Tecnologia, I. P. (FCT) –

the Portuguese public funding agency for R&D/

Portugal

The Dutch Research Council/The Netherlands

The Swiss National Science Foundation

Switzerland

Editorial and Board Positions

Reviewing Editor, Frontiers in Biotechnology

and Bioengineering

Reviewing Editor, MDPI Sensors

Editorial Board Member, Organs-on-a-Chip

(Elsevier)

Financial auditor for the EUSAAT

Salzmann S

Reviewer

Spine (Phila Pa 1976), World Neurosurgery

Current Sports Medicine Reports

Osteoporosis International

Sigmund IK

Ordinary Member of the Executive Committee

of the European Bone & Joint Infection Society

(EBJIS)

Associate Editor Journal of Bone and Joint Infection

(JBJI)

Reviewer

Bone & Joint Research (BJR)

Journal of Bone and Joint Infection (JBJI)

Archives of Orthopaedic and Trauma Surgery (AOTS)

Stelzeneder B

Reviewer

European Radiology

Thalhammer G

Reviewer

Journal of Plastic Surgery and Hand Surgery

Arthroscopy - the Journal of Arthroscopic and

Related Surgery

Tiefenböck T

Guest-Editor

Children – Special Issue ‚Frontier Research of

Orthopedic Trauma Surgery‘

Reviewer

Journal of Orthopaedic Surgery and Research

Journal of Clinical Medicine

International Journal of Environmental Research

and Public Health

Biomechanics

Plos ONE

Children

Toegel S

Reviewer

Arthritis Research & Therapy

Biochemical and Molecular Toxicology

Journal of Orthopecis Research

Osteoarthritis and Cartilage

Proteomics Clinical Application

Wiener Klinische Wochenschrift

Experimental and Molecular Pathology

Member of the Editorial Academy. ‚International Journal

of Molecular Medicine‘, Spandidos Publications.

Waldstein W

Reviewer

Archives of Orthopaedic and Trauma Surgery (AOTS)

Widhalm H

Reviewer

Orthopaedic Journal of Sports Medicine

Wiener Klinische Wochenschrift

Obesity Surgery

Neurosurgical Review

Knee Surgery Sports Traumatology Arthroscopy

American Journal of Sports Medicine

Journal of Clinical Medicine

Willegger M

Generalsekretärin – Österreichische Gesellschaft

für Fußchirurgie

Genderbeauftrage – Österreichische Gesellschaft

für Orthopädie

Vollmitglied – AGA Fuss- und Sprunggelenk Komitee

Reviewer

Arthroscopy

Clinical Orthopaedics and Related Research –

Journal of Orthopaedic Research


Publikationen

84

International Orthopaedics

Journal of Pediatric infectious diseases

BMC Musculoskeletal Disorders

Journal of Oncology

Windhager R

Section-Editor, Wiener Klinische Wochenschrift

(seit Juli 2021)

Mitherausgeber von Journal of Ortopaedic

and Traumatology (SIOT)

Mitglied des Redaktionsrates des JOT, Journal

of Othopaedic Translation (seit Sept. 2018)

Mitherausgeber der Z ORTHOP (2003 bis dato)

Jubiläumsfonds der Österreichischen Nationalbank

(OeNB)

Medizinisch wissenschaftlicher Fonds des

Bürgermeisters der Bundeshauptstadt Wien,

Mitglied des wissenschaftlichen Beirates der

Zeitschrift „Der Orthopäde“

Mitglied des wissenschaftlichen Beirates der

Zeitschrift „Arzt + Patient“

Reviewer

EFORT Open Reviews

Clinical Orthopaedics and Related Research

Journal of Clinical Medicine

Journal of Orthopaedics and Traumatolog

Zak L

Guest Editor

Journal of Clinical Medicine - Special Issue: Deformity

Correction, Bone Lengthening and Correction

Osteotomies of the Lower Limb

Reviewer

Medicina

World Journal Orthopaedics

Besuchte Kurse und Kongresse

Antoni A

14. Endoprothetikkongress, 25. – 27.2.2021 (online)

Arbeitsgemeinschaft Endoprothetik „Master kurs

Hüfte“ 25. – 26.3.2021 (online)

21. European Congress of Trauma & Emergency

Surgery, 25. – 30.4.2021 (online)

Virtual Instructional Pelvic (VIP) Course,

2.9.2021 (online)

57. ÖGU & 2. ÖGOuT Jahrestagung „Minimalinvasive

Unfallchirugie & Orthopädie”, 7. – 9.10.2021

(online)

34. Wissenschaftliche Sitzung der ADNANI

„Neuro-Radiologie eine Erfolgsgeschichte“

15. – 16.10.2021 Hannover/Deutschland

AE-Online-Kompaktkurs Spezial: Periprothetische

Frakturen, 10. – 11.11.2021 (online)

Trauma Oggi, 25.11.2021, Rom/Italien (online)

Aldrian S

ÖGU: Öffentliche Sitzung des Arbeitskreises Knie –

15.1.2021 (online)

70. ÖGU Fortbildung/„Alterstraumatologie – Frakturversorgung

bei Osteoporose und perioperatives

Management“ – 19.3.2021 und 20.3.2021

(online)

57. Jahrestagung der ÖGU und 2. Jahrestagung

der ÖGOuT – Minimalinvasive Unfallchirurgie &

Orthopädie, 7. – 9.10.2021

ÖGU öffentliche Sitzung des Arbeitskreises

Knorpel, 26.11.2021, (online)

2. Tiroler Osteotomie Kurs, Rum, Austria,

18.6.2021

Benca E

Thermal effects during bone preparation for- and

during insertion of osseointegrated transfemoral

implants 26. Congress of the European Society of

Biomechanics (online). 14.7.2021

Bumberger A

7. Master Class Symposium: Funktionelle Anatomie

und periphere Ligamentrekonstruktion des

Kniegelenks. Münster November 2021

Chiari C

34. Jahrestag und der Vereinigung der Kinderorthopädie

e.V., 30.9. – 2.10.2021, Graz.

AGA Akademie Kurs, Arthroskopie des Hüftgelenks

Würzburg, 5. – 6.11.2021

ÖGO Ausbildungsseminar Kinderorthopädie

18.11.2021, OSS Wien

ÖGO/BVDO Tagung, 20.11.2021 Wien

„Advanced Orthopedics and Traumatology – Aktuelle

Konzepte der Orthopädie und Traumatologie

(MSc)“ Modul 11 „Extremitätenkorrektur, Kinderorthopädie-

und traumatologie, Osteotomien“,

25. – 27.11.2021


Publikationen

85

Döring K

Wiener Handkurs – Basiskurs, 17. – 21.5.2021, Wien

Sharkscrew – Operationskurs Fuß, 30.9. – 1.10.2021,

Oberösterreich

Frenzel S

70. ÖGU Fortbildung „Alterstraumatologie –

Fraktur versorgung bei Osteoporose und perioperatives

Management“ (19.3.2021, online)

71. ÖGU Fortbildung „Der Fuß das unbekannte Wesen

– Diagnostik und Therapie der akuten Verletzung

und Möglichkeiten der späteren Korrektur“

(28. – 29.5.2021, online)

41. SICOT Orthopaedic World Congress, Budapest,

Ungarn; 15. – 18.9.2021

57. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie, 7. – 9.10.2021

72. ÖGU Fortbildung „Das Hüftgelenk – Von der Rekonstruktion

bis zum Gelenksersatz“, 12.11.2021,

(online)

IRCAD- Wrist Surgery Course, 10. – 11.12.2021;

Strasbourg, Frankreich

4. interdisziplinäre Polytraumasymposium, „Aktuelle

Herausforderungen in der Schwerstverletztenversorgung“,

7.5.2021

Grohs J

22. Symposium der Österr. Ges. für Wirbelsäulenchirurgie.

Wirbelsäule mit Abstand, Wien 30.1.2021

Nextar Kurs Luzern 22. – 23.6.2021

Haider T

Deutscher Kongress für Orthopädie und Unfallchirurgie

(DKOU 2021), 26. – 29.10.2021, Berlin

Halát G

4. Interdisziplinäres Polytraumasymposium „Aktuelle

Herausforderungen in der Schwerstverletztenversorgung“,

7.5.2021, Wien

Symposium der Deutschsprachigen Arbeitsgemeinschaft

für Handchirurgie (DAH)

Rhizarthrose, Radius, PIP Gelenk und 3-D Planung,

7. – 8.5.2021(online)

Ehrensymposium für Prof. Dr. Leixnering, Der

Aufstieg der Handchirurgie in Österreich,

1.10.2021, Wien

Rheumahandkurs (Wiener Handkurse),

10. – 12.11.2021, Wien

IRCAD – Wrist Surgery Course „All around the Scaphoid“,

10. – 11.12.2021, Strasbourg, Frankreich

Hruby L

81. Jahreskongress swiss orthopaedics 2021 online

AGA Kongress September 2021 Innsbruck

Kolb A

34. Jahrestag und der Vereinigung der Kinderorthopädie

e.V., 30.9. – 2.10.2021, Graz

Negrin L

Minimal invasive Hüfttotalendoprothetik, Salzburg,

4. – 5.11.2021

ITS-Beckenkurs, Salzburg, 6.10.2021

Master Knee Course 2021, Hochrum, 23. – 24. 9.2021

IOC World Conference on Prevention of Injury & Illness

in Sport, Monaco, 25. – 27.11.2021

12 th IOC Advanced Team Physician Course, Istanbul,

1. – 3.11.2021

Deutscher Kongress für Orthopädie und Unfallchirurgie,

Berlin, 27. – 28.10.2021

57. Jahrestagung der ÖGU und 2. Jahrestagung der

ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,

(online), 7. – 9.10.2021

36. Jahreskongress der der Gesellschaft für

Orthopädisch-Traumatologische Sportmedizin,

1. – 2.7.2021 (online),

Virtual EFFORT Congress – VEChybrid, Online,

30.6.2021

SPORTMED GRAZ 21 – Spitzensport braucht

Spitzenbehandlung, Graz, 11.6.2021

Payr S

57. ÖGU & 2. ÖGOuT Jahrestagung (online)

„Minimal invasive Unfallchirurgie und Orthopädie“,

7. – 9.10.2021, Wien

Hüftsonographie bei Säuglingen (Stolzalpe)

Rentenberger C

Wiener Handkurs – Basiskurs, 7. – 11.6.2021, Wien

57. Jahrestagung der Österreichischen Gesellschaft

für Unfallchirurgie (07. – 09.10.2021, online)

Deutscher Kongress für Orthopädie und Unfallchirurgie

(Berlin 26. – 29.10.2021, online)


Publikationen

86

Salzmann S

ORS (Orthopaedic Research Society) 2021 Annual

Meeting, 12. – 15.2.2021

International Society for the Study of the Lumbar

Spine (ISSLS) Virtual Annual meeting

31.5. – 4.6.2021

AO Spine Basis Kurs–Notfälle und Degeneration in

der Wirbelsäulenchirurgie

10. – 11.9.2021, Anatomischen Institut der Paracelsus

Medizinische Universität Salzburg

North American Spine Society 36. Annual Meeting

29.9. – 2.10.2021, Boston, MA

Global Spine Congress, 3. – 6.11.2021

Scheider P

Wiener Handkurs (Basis) Nr. 167/2 (12. – 16.04.2021)

Virtual EFORT Congress 2021 (30.6. – 2.7.2021)

34. Jahrestagung der VKO in Graz mit Operationskurs

(30.9. – 2.10.2021)

Sigmund IK

EBJIS (Webinar) 18.5.2021 Infection after

arthroscopy & sport-orthopaedic procedures

AE Masterkurs Knie, Linz 1. – 2.10.2021

39. EBJIS annual meeting Ljubljana, Slovenia,

7. – 9.10.2021

DKOU Berlin, 26. – 29.10.2021

Springer B

57. Jahrestagung der ÖGU und 2. Jahrestagung der

ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,

7. – 9.10.2021 (online)

Stelzeneder B

ÖGU: Öffentliche Sitzung des Arbeitskreises Knie -

15.1.2021 (online)

70. ÖGU Fortbildung / „Alterstraumatologie - Frakturversorgung

bei Osteoporose und perioperatives

Management“, 19.03.2021 und 20.03.2021 (online)

4. Interdisziplinäres Polytraumasymposium „Aktuelle

Herausforderungen in der Schwerstverletztenversorgung“,

7.5.2021 (online)

71. ÖGU Fortbildung „Der Fuß – das unbekannte

Wesen – Diagnostik und Therapie der akuten Verletzung

und Möglichkeiten der späteren Korrektur-

28. – 29.5.2021 (online)

57. Jahrestagung der ÖGU und 2. Jahrestagung der

ÖGOuT – Minimalinvasive Unfallchirurgie & Orthopädie,

7. – 9.10.2021 (online)

72. Fortbildung „Das Hüftgelenk - Von der Rekonstruktion

bis zum Gelenksersatz“, 12. – 13.11.2021

(online)

Sportmedizin Leistungsphysiologisch-Internistisch-Pädiatrischer

Grundkurs IV + Traumatologisch-Pädiatrischer

Grundkurs III + Praxisseminar

+ Ärztesport, 18. – 21.11.2021, St. Pölten

ÖGU öffentliche Sitzung des Arbeitskreises Knorpel,

26.11.2021, (online)

Thalhammer G

Surgery of the Spastic Upper Limb, 16.4.2021

4. Interdisziplinäres Polytraumasymposium „Aktuelle

Herausforderungen in der Schwerstverletztenversorgung“,

7.5.2021

Virtuelles DAH Symposium, „Rhizarthrose, Radius,

PIP Gelenk und 3-D Planung“, 7. – 8.5.2021

71. Fortbildung ÖGU: „Der Fuß das unbekannte Wesen

– Diagnostik und Therapie der akuten Verletzung

und Möglichkeiten der späteren Korrektur“,

28. – 29.5.2021

„Operationskurs Hand - Osteosynthese mit humanbiologischem

Gewebe“ 7. – 8.6.2021

ISAKOS Innovative Techniques in Elbow Arthroscopy,

17.6.2021

57. ÖGU & 2. ÖGOuT Jahrestagung (online) „Minimalinvasive

Unfallchirurgie und Orthopädie“,

7. – 9.10.2021, Wien

72. Fortbildung ÖGU: „Das Hüftgelenk – Von der Rekonstruktion

bis zum Gelenksersatz, 12.11.2021

IRCAD - Wrist Surgery Course / Open Wrist Surgery

Workshop, 10. – 11.12.2021, Strasbourg, Frankreich

Tiefenböck T

ÖGU Jahrestagung

AGA Jahrestagung

ÖÄK ärztliche Wundbehandlung

Toegel S

2021 OARSI Virtual World Congress on Osteoarthritis,

29.4. – 1.5.2021

Scientific Advisory board meeting 2021 of the Ludwig

Boltzmann Institute for Arthritis and Rehabilitation.

7.5.2021 ( online).

Waldstein W

DKOU Berlin 26. – 29.10.2021


Publikationen

87

Weihs V

Wiener Handkurse - Rheuma Handkurs

10. – 12.11.2021

ESICM 34 th ESICM LIVES Digital Annual Congress

2021, 3. – 6.10.2021

SICOT 41.SICOT Orthopaedic World Congress,

Budapest 15. – 18.9.2021

Jahrestagung 2021 Österreichische Kardiologische

Gesellschaft 27. – 28.5.2021

DAH Symposium 2021, 8.5.2021 (online)

4. Interdisziplinäres Polytrauma Symposium

„Akutelle Herausforderungen in der Schwerverletztenversorgung“,

7.5.2021

Widhalm HK

Knie Konsensus Meeting – Update Kreuzband –

Transplantatwahl und extraartikuläre Zusatzeingriffe,

15.1.2021, (online)

The Meniscus – Webinar NEWS – ESSKA,

30.1.2021

Modern Trauma Care – Expertenforum zur Zukunft

der Orthopädie und Traumatologie, AUVA

Webinar, 25. – 26.2.2021

Orthopädisch-Traumatologisch-Physikalischer

Grundkurs II – Ärztekammer, 27. – 28.2.2021 (online)

ÖGO-Ausbildungsseminar: Tumor-Orthopädie,

12.3.2021 (online)

70. ÖGU-Fortbildungsveranstaltung: „Alterstraumatologie

– Frakturversorgung bei Osteoporose

und perioperatives Management“ ONLINE,

19. – 20.3.2021

4.Interdisziplinäres Traumasymposium – MUW

Unfall, Wien, Online, 7.5.2021

GOTS-Webinar, 29.6.2021

AGA-Jahrestagung, Innsbruck – Hybrid Online,

9. – 11.09.2021

Fusskurs – Fußchirurgie in der Orthopädie – ÖGO

Ausbildungsseminar – Speising, 10. – 11.9.2021

TNT-Traumaregister-Jahrestreffen-Meeting, Salzburg

(Hybrid & Online), 17.9.2021

Mathys Hüfte – optimys / RM Pressfit, Salzburg –

Paracelsus Privatuniversität Salzburg (PMU), 29.-

30.9.2021

57. ÖGU & 2. ÖGOuT Jahrestagung (Online) „Minimalinvasive

Unfallchirurgie und Orthopädie“ vom

7. – 9.10.2021, Wien

5. Österr. Symposium für Perioperative Medizin –

Hybridveranstaltung, MUW, 29. – 30.10.2021

Behandlung von Wirbelkörperfrakturen - Hands-

On Training, Düsseldorf – Stryker, 2. – 3.11.2021

72.ÖGU Fortbildung - Das Hüftgelenk –Von der Rekonstruktion

bis zum Gelenksersatz, AUVA Online,

12. – 13.11.2021

Öffentliche Sitzung des Arbeitskreises Knorpel der

österreichischen Gesellschaft für Unfallchirurgie –

Update in der Knorpelchirurgie, 26.11.2021 (online)

Willegger M

IPOS – International Paediatric Orthopaedic Symposium

2021 – 7. – 11.12.2021, Orlando, FL, USA

Vorträge

Aldrian S

Eingeladender Vortrag: Update in der Knorpelchirurgie

Sitzung des Arbeitskreis Knorpel der ÖGU

Österreich

Eingeladender Vortrag: State of the Art der Knorpelchirurgie

Fachgruppensitzung der Ärztekammer

Österreich

Eingeladender Vortrag: Kniegelenksarthroskopie –

Grundlagen und Expertentipps 57. ÖGU & 2. ÖGOuT

Jahrestagung (Online) ‚Minimalinvasive Unfallchirurgie

und Orthopädie‘ vom 7. – 9.10.2021 Österreich

Eingeladender Vortrag: Das Polytrauma aus unfallchirurgischer

Sicht (Thorax, Abdomen, Becken)

1. Notarztkurs der Univ. Klinik für Anästhesie, Allg.

Intensivmedizin & Schmerztherapie in Kooperation

mit der Univ. Klinik für Notfallmedizin und dem

WIGEV Österreich

Antoni A

Eingeladender Vortrag: Diagnostik & Management

des leichten Schädel-Hirn Traumas bei antithrombotischer

Therapie 34. Wissenschaftliche Sitzung

der ADNANI, 16.10.2021, Hannover/Deutschland

Deutschland

Complex Pelvic Trauma: A territory disputed by

orthopedics and trauma surgeons Trauma Oggi,

25.11.2021, Rom/Italien (online)

Casado-Losada I

Técnicas de descelularización para regeneración

de cartílago (translation: decellularization


Publikationen

88

techniques for cartilage regeneration III Congreso

Internacional de Tecnología Médica – EAP Tecnología

Médica. Universidad Norbert Wiener, Perú.

(Translation: III International Congress of Medical

Technology) 22. – 24.10.2021 Peru

Pitch talk: in vitro model of decellularized cartilage

scaffolds for articular cartilage regeneration 1st

Annual Retreat of the Ludwig Boltzmann Institut

für Traumatologie, das Forschungszentrum in Kooperation

mit der AUVA. 22. – 24.9.2021 Österreich

It’s the stiffness not the density – decellularized auricular

cartilage scaffold (AuriScaff) as a model for

migration research Annual Meeting of the Austrian

Cluster for Tissue Regeneration, 30. – 31.8.2021.

Veterinary Medicine of Vienna (Vetmed). Österreich

Laser-engraving auricular cartilage scaffolds

enhance scaffold recellularization TERMIS SYIS

Virtual Seminar Series (online) Österreich

Cartilage Regeneration Group presentation from

LBI Traumatology TERMIS-EU Virtual Lab Tour series

Österreich

Stiffness or GAGs, what counts? A story of cell infiltration

Lunch seminars from the Ludwig Boltzmann

Institut Traumatologie, das Forschungszentrum in

Kooperation mit der AUVA Österreich

Chiari C

Grundkonzept „FAI und Dysplasie“. AGA Akademie

Kurs, AGA Hüftkomitee, Arthroskopie des Hüftgelenks

Würzburg, 5. – 6.11.2021

Wichtige Zugangswege zum Hüftgelenk. AGA Akademie

Kurs, AGA Hüftkomitee, Arthroskopie des

Hüftgelenks Würzburg, 5. – 6.11.2021

Grenzen der Hüftarthroskopie. Welche offenen Verfahren

haben sich bewährt? AGA Akademie Kurs,

AGA Hüftkomitee, Arthroskopie des Hüftgelenks

Würzburg, 5. – 6.11.2021

Epiphysiolysis capitis femoris. ÖGO

Ausbildungsseminar Kinderorthopädie

18.11.2021, OSS Wien

Gutartige Knochentumore. ÖGO Ausbildungsseminar

Kinderorthopädie 18.11.2021, OSS Wien

Wachstum. „Advanced Orthopedics and Traumatology

– Aktuelle Konzepte der Orthopädie und Traumatologie

(MSc)“ Modul 11 „Extremitätenkorrektur,

Kinderorthopädie- und traumatologie, Osteotomien“

25. – 27.11.2021

Beinachsenvermessung, Deformitätenanalyse,

Wachstumsprognose. „Advanced Orthopedics and

Traumatology – Aktuelle Konzepte der Orthopädie

und Traumatologie (MSc)“ Modul 11 „Extremitätenkorrektur,

Kinderorthopädie- und traumatologie,

Osteotomien“ 25. – 27.11.2021

Behandlung der SCFE, spezielle Techniken und

Komplikationen: Pinning, Verschraubung, SH Osteotomie,

Trochanter-Flip. „Advanced Orthopedics

and Traumatology – Aktuelle Konzepte der Orthopädie

und Traumatologie (MSc)“ Modul 11 „Extremitätenkorrektur,

Kinderorthopädie- und traumatologie,

Osteotomien“ 25. – 27.11.2021

DDH: Epidemiologie, Screening, wissenschaftliche

Basis. „Advanced Orthopedics and Traumatology –

Aktuelle Konzepte der Orthopädie und Traumatologie

(MSc)“ Modul 11 „Extremitätenkorrektur, Kinderorthopädie-

und traumatologie, Osteotomien“

25. – 27.11.2021

Overview of malignant bone tumors, 39 th EPOS Annual

Meeting, European Paediatric Orthopaedic

Society, 14.4.2021 (online)

Tumor und Hüfte: Reliabilität und Unterschiede verschiedener

Messmethoden der Fermoralen Torsion

im Rotations-MRT. 34. Jahrestag und der Vereinigung

der Kinderorthopädie e.V., 30.9. – 2.10.2021, Graz

3 beste Vorträge, 3 beste Poster: Die Verwendung

der BImalleolar-Methode zeigt die reliabelsten Ergebnisse

zur Vermessung der Tibialen Torsion im

MRT. 34. Jahrestag und der Vereinigung der Kinderorthopädie

e.V., 30.09. – 2.10.2021, Graz

Döring K

Klinikwissen 21.1.2021: Grundlagen in der Diagnostik

und Therapie des Hallux Valgus Results in

the surgical treatment of aneurysmal bone cysts,

EMSOS 2021, 1.12.2021

Frenzel S

Eingeladender Vortrag: Versorgungskonzepte bei

periprothetischen Frakturen 72. ÖGU Fortbildung

„Das Hüftgelenk – Von der Rekonstruktion bis zum

Gelenksersatz“ 12.11.2021 (online) Österreich

Compex pelvic fractures with soft tissue injuries:

What to treat first International Conference of the

„Kazakhstan Association of Traumatologists and

Orthopedists“ 29.9. – 1.10.2021 (online) Kasachstan

ORIF in Tibial Plateau Fractures- Planning and Strategy

International Conference of the „Kazakhstan

Association of Traumatologists and Orthopedists“

29.9. – 1.10.2021 (online) Kasachstan


Publikationen

89

Emergency room requirements- the Vienna experience

International Conference of the “Kazakhstan

Association of Traumatologists and Orthopedists”

29.9. – 1.10.2021 (online) Kasachstan

Compex pelvic fractures with soft tissue injuries:

What to treat first 41. SICOT Orthopaedic World

Congress (Budapest, Ungarn; 15. – 18.9.2021)

Ungarn

Funovics Ph

Eingeladender Vortrag: Tumoren am Fuß – mit welcher

Inzidenz muss ich rechnen? 16.KLAUSURTA-

GUNG ZUR KONSENSUSFINDUNG DER ÖSTERREI-

CHISCHEN GESELLSCHAFT FÜR FUSSCHIRURGIE

Fuss-Tumoren und „PROMINENZEN“. 25.6.2021.

Fürsatz M

TERMIS SYIS Virtual Seminar Series, 29.6.2021

„Induction of spheroid-self assembly via growth

surface compartmentation“

Annual Meeting Austrian Cluster for Tissue Regeneration,

30. – 31.8.2021 „SpheroWell – a platform

technology for (cartilage) spheroids“

6 th World Congress of the Tissue Engineering and

Regenerative Medicine International Society (TER-

MIS 2021), Maastricht, 15. – 19.11.2021 „Self-assembly

of chondrogenic spheroids from cell-monolayers

via growth surface subdivision“

Haider T

Revisionsendoprothetik oder ORIF in Periprothetischen

Proximalen Femurfrakturen vom Typ Vancouver

B2 & B3: Systematischer Review und Meta-Analyse.

Deutscher Kongress für Orthopädie

und Unfallchirurgie (DKOU 2021), 26. – 29.10.2021,

Berlin

Halát G

Eingeladender Vortrag: Das Thoraxtrauma 32. NÖ

Notärztetagung der Ärztekammer Niederösterreich

am 30.5.2021 Österreich

Refixationstechniken bei Beugesehnenverletzungen

Arthrex Future Group Meeting – Distal Extremity

Österreich

Hobusch G

Eingeladender Vortrag: Functional Results after

Bone Sarcoma – Should we allow sports, virtual

EMSOS Graz 2021 (1. – 3.12.2021)

Expert Opinions about Sports Activity after Tumorendoprostheses-do

they differ in different parts of

the world? Virtual EMSOS Graz 2021(1. – 3.12.2021)

Functional Outcome and QOL after Sarcomas of the

Foot and Ankle Region-is early Amputation justified?

Virtual EMSOS Graz 2021 (1. – 3.12.2021)

Training day-Interactive Cases Soft tissue Sarcoma-Vienna

cases, virtual EMSOS Graz 2021

(1. – 3.12.2021), invited talk

Biopsy as the final point of staging, VEC (Virtual

EFORT Congress) Vienna 2021 (30.6.2021), invited

talk

Shall we improve sarcoma outcome and function

towards sporting activities? Functional Outcome in

Musculoskeletal Oncology, ISOLS Orthopedic Oncology

Webinar Series, 19.10.2021

Hruby L

Iatrogenic nerve injuries in primary and revision

reverse total shoulder arthroplasty Morgenfortbildung

Universitätsklinik für Orthopädie und Unfallchirurgie

Österreich

Bionische Rekonstruktion, Wiederherstellung an

der Grenze zwischen Mensch und Maschine Morgenfortbildung

Universitätsklinik für Orthopädie

und Unfallchirurgie Österreich

Iatrogenic nerve injury in primary and revision reverse

total shoulder arthroplasty 38. AGA Kongress,

9 – 11.9.2021, Innsbruck Österreich

Kdolsky R

Complications in pilon fractures. ESTES virtual

week: “Skeletal – Intraarticular fractures of the distal

tibia / Pilon tibiale” – 28.4.2021

Lass R

Senior Mentoring-Programm der MedUniWien im

Studienjahr 2020/21, 2021/22

Wahlpflichtfach Orthopädie-Konservativ-Operativ,

WS 21

Medacta Surgical Days, 15. – 18.6.2021, Graz

AE-Masterkurs Knie, 1. – 2.10.2021 Linz

11. Wiener Schmerztag, 8.10.2021 Rathaus Wien

DKOU 2021, 26. – 29.10.2021, Berlin

Negrin L

Serum Levels Of SRAGE Assessed AT Hospital Admission

may Provide Valuable Insights Regarding

The Appropriate Treatment Regimen in Polytrau-


Publikationen

90

matized Patients Virtual EFFORT Congress – VEC

hybrid, Online, 30.6.2021 Österreich

Morphologische MRT-Auswertungen liefern Größenvorgaben

für die adäquate Entnahme eines

Quadrizepssehnen-Knochenblocks 36. Jahreskongress

der der Gesellschaft für Orthopädisch-Traumatologische

Sportmedizin, Online, 1.7.2021 Österreich

Eingeladender Vortrag: Frakturversorgung 1. Notarztkurs

der Universitätsklinik für Anästhesie, Allgemeine

Intensivmedizin und Schmerztherapie

in Kooperation mit der Universitätsklinik für Notfallmedizin

und dem Wiener Gesundheitsverbund,

Wien, 9.2.2021 Österreich

Eingeladender Vortrag: Wintersport „Ski alpin“ Universitätslehrgang

‚Sportmedizin, MSc‘, Donauuniversität

Krems, 20.6.2021 Österreich

Nürnberger S

Eingeladender Vortrag: Cartilage for Cartilage Regeneration:

Development of a new scaffold generation.

Internationaler Tag der Frauen und Mädchen

in der Wissenschaft 11.2.2021 virtual

Scaffold based biological enhancement of cartilage

regeneration. EORS 15. – 17.9.2021 Rome Italy

Pajenda G

Konservative Behandlung der thorakolumbalen

Wirbelsäulenverletzungen AO Spine Kurs, Salzburg

September 2021 Österreich

Salzmann S

Thoracic Bone Mineral Density measured by Quantitative

Computed Tomography in Patients undergoing

Spine Surgery. International Society for the

Study of the Lumbar Spine (ISSLS) Virtual Annual

meeting May 4. Juni 2021

Preoperative MRI-based Vertebral Bone Quality

(VBQ) Score Assessment in Patients undergoing

Lumbar Spinal Fusion. North American Spine Society

36th Annual Meeting 29.9. – 2.10.2021 Boston, MA

Thoracic Bone Mineral Density measured by Quantitative

Computed Tomography in Patients undergoing

Spine Surgery. Global Spine Congress Paris,

France, (online) 3. – 6.11.2021

Preoperative MRI-based Vertebral Bone Quality

(VBQ) Score Assessment in Patients undergoing

Lumbar Spinal Fusion. Global Spine Congress Paris,

France, (online) 3. – 6.11.2021

Scheider P

Posttraumatischer Wachstumsfugenverschluss

an der kindlichen oberen Extremität Morgenfortbildung

Universitätsklinik für Orthopädie und Unfallchirurgie

Österreich

Schreiner MM

The influence of biologicals on aseptic arthroplasty

loosening, DKOU 2021, Berlin

Sigmund IK

Eingeladener Vortrag: Giftiger Dienstag, Wien –

Protheseninfektionen, 11.5.2021

(Ärztekammer, Wien) Webinar

Eingeladener Vortrag: AE Masterkurs Knie, Linz –

Infektdiagnostik bei PPI – Standardvorgehen ein

Muss! 2.10.2021

Eingeladener Vortrag: 39 th Annual Meeting of the

European Bone and Joint Infection society, Ljubljana

– The use of histology in the diagnosis of bone

and joint infections 7.10.2021

39 th Annual Meeting of the European Bone and Joint

Infection society, Ljubljana: Performance of routinely

available Serum Parameters in diagnosing periprosthetic

joint infections

DKOU Berlin 26. – 29.10.2021: Wilhelm- Roux-Preis-

Session: Der optimale Grenzwert der neutrophilen

Granulozyten in histologisch aufgearbeiteten Gewebeproben

zur Diagnostik von periprothetischen

Gelenksinfektionen

Block 21: Septische Arthritis und Osteomyelitis

Thalhammer G

Eingeladender Vortrag: Das instabile Handgelenk

Symposium Blickpunkt – Die instabile obere Extremität,

16.10.2021, Graz Österreich

Handgelenksarthroskopie – Grundlagen und Expertentipps

57. ÖGU & 2. ÖGOuT Jahrestagung

(Online) ‚Minimalinvasive Unfallchirurgie und Orthopädie‘,

07. – 09.10.2021 Österreich

Toegel S

Glycobiology: An emerging regulator of OA pathobiology.

Oral presentation at the 11 th Scientific Meeting

of the Ludwig Boltzmann Institute for Arthritis

and Rehabilitation. 24.3.2021.

Presentation of the Programme line „Chondrocyte

biology“. Oral presentation at the Online Evaluation

Meeting of the Ludwig Boltzmann Institute for Arthritis

and Rehabilitation. 5. – 6.10.2021


Publikationen

91

Waldstein W

VSOU 2021: Die radiologische Beurteilung der

Funktionalität des vorderen Kreuzbandes bei Patienten

mit Varusgonarthrose.

Weihs V

Comparison of characteristics of polytraumatized

patients with or without severe traumatic brain

injury and patients with isolated traumatic brain

injury 41 st SICOT Orthopaedic World Congress,

15.09. – 18.9.2021, Budapest Ungarn

Widhalm H

Polytrauma Strategies Weill Cornell Seminar:

Trauma & Emergency Surgery: Austrian American

Foundation (AAF), 12. – 18.12.2021, Salzburg Österreich

Traumatic Brain Injuries Weill Cornell Seminar:

Trauma & Emergency Surgery: Austrian American

Foundation (AAF), 12. – 18.12.2021, Salzburg Österreich

Windhager R

Eingeladener Vortrag: BMP signalling in Bone and

Cartilage Biology, 13.1.2021, BMP Virtual Forum

Eingeladender Vortrag: Therapie von Knochentumoren,

Online Ausbildungskurs „Tumororthopädie“

ÖGO, 12.3.2021

Eingeladener Vortrag: Spondylitis, Tumor und

Rheuma der Wirbelsäule, Lehrgang „Advanced Orthopedics

and Traumatology“, 19.3.2021, Zentrum

für Gesundheitswissenschaften und Medizin der

Donau-Universität Krems

Eingeladener Vortrag: Recombinant human BMP6

applied within Autologous Blood Coagulum accelerates

bone healing: Randomized controlled trials“,

14.4.2021, Salzburg

Eingeladener Vortrag: Reconstruction after tumor

resection in the extremities, OMI Hospital for Special

Surgery Seminar in Bone and Joint Surgery,

15.4.2021, Salzburg

Eingeladener Vortrag: Management of bone metastases,

OMI Hospital for Special Surgery Seminar in

Bone and Joint Surgery, 15.4.2021, Salzburg

„Survival of megaprostheses in oncology and revision“,

ISOLS Webinar, 20.4.2021, Houston, Texas

Keynote: Orthopädie 2030: Fokus Endoprothetik, 6.

Praevenire Gesundheitstage, 17. – 21.5.2021, Stift

Seitenstetten

Eingeladener Vortrag: „Kragen bei zementfreiem

Hüftschaft – hilfreich oder hinderlich?“ 26.5.2021,

Österreichischer Kongress für Orthopädie und

Traumatologie, Graz

Honorary Lecture: „Erwin Morscher Award”, EFORT

Annual Congress, 30.6. – 2.7.2021, Wien, Austria

Moderation: Blöcke Knie und Hüfte, Medacta Surgical

Days, 17.6.2021, Graz

„Der Kurzschaft in der Revisionsendoprothetik –

Was ist möglich?“, 1. Wiener Kurzschaftsymposium,

11.9.2021, Wien

Moderation: Functional Outcome in Musculoskeletal

Oncology, ISOLS Orthopedic Oncology Webinar

Series, 19.10.2021

Eingeladener Vortrag: „Hüftgelenknahe Tumoren:

Differentialdiagnostik und Therapie“, DKOU 2021,

Berlin, 28.10.2021

Eingeladener Vortrag: „Battle: Silver coating: Risk or

reason?“ 1.12.2021, 33 rd Annual Meeting of EMSOS

to take place on 1. – 3.12.2021, Graz Austria.

Moderation: „New guidelines and studies in sarcoma“,

2.12.2021, 33 rd Annual Meeting of EMSOS to

take place on 1. – 3.12.2021, Graz Austria.

Willegger M

Rotations-MRT, Accessorische Knochen am Fußskelett

und deren Relevanz. 16. Klausurtagung

zur Konsensfindung der Österreichischen Gesellschaft

für Fußchirurgie 25.6.2021, Mondsee

Österreich

Poster

Casado-Losada I

An in vitro model to unravel the mysteries of the

chondrogenic niche.

Osteoarthritis Research Society International

(OARSI) Virtual World Congress on Osteoarthritis

Connect 21, 29.4. – 1.5.2021.

Laser-engraving auricular cartilage scaffolds enhance

scaffold recellularization.

Young Scientist Association (YSA) MUW Symposium,

Wien, 17. – 18.6.2021.

Laser-engraved auricular cartilage scaffolds: the

next step on recellularization.

6 th World Congress of the Tissue Engineering and


Publikationen

92

Regenerative Medicine International Society (TER-

MIS 2021), Maastricht, 15. – 19.11.2021.

Chiari C

Die Verwendung der Bimalleolar-Methode zeigt die

reliabelsten Ergebnisse zur Vermessung der Tibialen

Torsion im MRT. 34. Jahrestag und der Vereinigung

der Kinderorthopädie e.V., 30.9. – 2.10.2021, Graz

Use of the bimalleolar method for tibial torsion

measurement shows the most reliable results in

MRI of paediatric patients, 39 th EPOS Annual Meeting,

European Paediatric Orthopaedic Society,

14.4.2021 (online)

Hofer C

Using means of transport and walking aids after

treatment for primary malignant bone tumors in the

lower extremity – A minimum follow-up of 20 years.

EMSOS 2021, 1. – 3.12.2021, Graz, Austria

Funovics P

Do extended reconstructions compensate prognostically

unfavourable soft tissue sarcoma? Deutscher

Kongress für Orthopädie und Unfallchirurgie

(DKOU 2021), 26.. – 29.10.2021, Berlin

Kolb A

Entwicklung eines elektronischen Navigationssystems

zur Eliminierung untersucherabhängiger Faktoren

in der Säuglings-Hüftsonographie nach Graf:

Preliminary Results. 34. Jahrestag und der Vereinigung

der Kinderorthopädie e.V., 30.9. – 2.10.2021,

Graz

Morgenbesser R

Verbessert lokales Östrogen Prolaps-assoziierte

Beschwerden bei postmenopausalen Patientinnen

mit symptomatischem Beckenorganprolaps?

Jahrestagung der Österreichischen Arbeitsgemeinschaft

für Urogynäkologie und rekonstruktive

Beckenbodenchirurgie (AUB) 1. – 2.10.2021

Innsbruck

Salzmann S

A Comprehensive MRI Analysis of Paraspinal and

Psoas Muscle Size, Lean Muscle, and Fatty Infiltration

in Patients undergoing Lumbar Spinal Fusion.

ORS (Orthopaedic Research Society) 2021 Annual

Meeting, 12. – 15.2.2021

Preoperative MRI-based Vertebral Bone Quality

(VBQ) Score Assessment in Patients undergoing

Lumbar Spinal Fusion. ORS (Orthopaedic Research

Society) 2021 Annual Meeting, 12. – 15.2.2021

Thoracic Bone Mineral Density measured by Quantitative

Computed Tomography in Patients undergoing

Spine Surgery. ORS (Orthopaedic Research

Society) 2021 Annual Meeting, 12. – 15.2.2021

A Comprehensive MRI Analysis of Paraspinal and

Psoas Muscle Size, Lean Muscle, and Fatty Infiltration

in Patients undergoing Lumbar Spinal

Fusion. International Society for the Study of the

Lumbar Spine (ISSLS) Virtual Annual meeting

31.5. – 4.6.2021

Preoperative MRI-based Vertebral Bone Quality

(VBQ) Score Assessment in Patients undergoing

Lumbar Spinal Fusion. International Society for the

Study of the Lumbar Spine (ISSLS) Virtual Annual

meeting 31.5. – 4.6.2021

A Comprehensive MRI Analysis of Paraspinal and

Psoas Muscle Size, Lean Muscle, and Fatty Infiltration

in Patients undergoing Lumbar Fusion. Global

Spine Congress Paris, France, 3. – 6.11.2021

Scheider P

Temporary epiphysiodesis in adolescent patients

with ulnocarpal impaction syndrome 22 nd EFORT

Congress 2021 in Wien Österreich

Temporary epiphysiodesis in adolescent patients

with ulnocarpal impaction syndrome 34. Jahrestagung

der Vereinigung für Kinderorthopädie, Graz

Staats K

Langzeituntersuchungen des Zweymüller-Alloclassic

Geradschaftes mit einem Minimum-follow-up

von 30 Jahren, Deutscher Kongress für

Orthopädie und Unfallchirurgie (DKOU 2021),

26. –29.10.2021, Berlin

Weihs V

Psychocardiological Assessment in the Acute Phase

of the Takotsubo Syndrome. Somatic and Depressive

Disorders, Resilience and Illness Perception Jahrestagung

2021 Österreichische Kardiologische

Gesellschaft 27. –28.5.2021, Österreich

Treatment of Polytraumatized Patients in a Level 1

Trauma center between 1995 and 2019. 25-Year Experience

– what has changed? 34 th ESICM LIVES Digital

Annual Congress 2021, 3. –6.10.2021 Österreich


Publikationen

93

Willegger M

Die Verwendung der Bimalleolar-Methode zeigt

die reliabelsten Ergebnisse zur Vermessung der

Tibialen Torsion im MRT. Jahrestagung Vereinigung

für Kinderorthopädie (VKO), Graz, Austria,

Oktober 2021

Accessibility of the metatarsal head comparing

distraction and plantarflexion in a 2-portal

technique for first metatarsophalangeal (MTP 1)

joint arthroscopy.

Annual Meeting American Association for Anatomy,

April 2021

Gastärzte/Beobachter

Zaur Mugutdinov, Russland, 6.9. – 29.10.2021


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