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Wellness Foods + Supplements 3/2022

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages. Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.

Wellness Foods & Supplements is the first European magazine devoted exclusively to health ingredients, nutraceutical foods and beverages.

Questions about the trade magazine Wellness Foods & Supplements? Interested in subscribing or advertising? The board of editors at Wellness Foods & Supplements kindly remains at your disposal.


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No. 3, November/Dezember 2022

www.harnisch.com | ISSN 2364-8104

Women's health Gut health

Mental health Antioxidants

Lactoferrin Stress Tinnitus

Heart & Brain health Skin health

Photo © : Adobe Stock/nobeastofierce









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SILKE WATKINS, Editor-in-Chief

Pervasive global shortage of raw materials?

Early November I attended SPS in Nuremberg,

one of the largest international trade

fairs for electrical automation technology. All

the euphoria of the trade fair notwithstanding,

the issues of raw material scarcity and supply

chain disruptions occupied both companies

and trade fair visitors. Manufacturers offered

assurances that they are well prepared

and have many parts for their pro ducts in

stock. However, they also admitted that long

delivery terms or component allocations are

in part forcing them to find different solutions

to produce the pro ducts that are in demand.

Then there is the matter of price increases

that have become entirely unpredictable. At

least outwardly, manufacturers are projecting

optimism. Nobody can predict how long this

dry spell is going to last.

When this topic is viewed through the lens of

food production, we can clearly see during

our shopping how the higher costs are being

passed on to consumers. Food prices have

increased to such an extent in recent months

that many consumers are being forced to

consider exactly what to actually buy. High

energy prices are particularly problematic

for producers that use a lot of energy, such

as bakeries. It is therefore little wonder that

even long-standing businesses are facing

great hardship when, in addition to high raw

material costs, energy costs now keep on

rising more and more as well.

What are politicians doing about this? There seems to be a general

feeling of helplessness in Germany, even as the government attempts

to calm the nation’s people with onomatopoeic announcements of

the oomph in June and the double oomph in the autumn. Facing a

winter with gas shortages, the citizens on the other hand seem to be

asking: What’s next?

Raw material scarcity, rising raw material costs and high energy

prices are interrelated. Not only do manufacturers need assurances

that they will be able to maintain their operations into the future,

consumers also have to be in a position to afford foodstuffs going

forward. What’s more, the quality of these should not suffer from

adverse conditions. I don’t know exactly what the situation is like in

other countries, but surely I am not the only one looking to the future

with concern.

With this edition 3 of Wellness Foods & Supplements, we are also

presenting ourselves at Fi & Hi Europe in Paris.

With kind regards,

Silke Watkins

No. 3 November/Dezember 2022




Convenience Food

Food & Beverages


Cover Photo © : Adobe Stock/nobeastsofierce

The microbiome is the community of microorganisms

(such as fungi, bacteria and viruses) that exists in a

particular environment. In humans, the term is often

used to describe the microorganisms that live in or on a

particular part of the body, such as the skin or gastrointestinal

tract. These groups of microorganisms are

dynamic and change in response to a host of environmental

factors, such as exercise, diet, medication and

other exposures. (Definition by NIH, National Human

Genome Research Institute)

Sports Nutrition

Health Care


Personal Care

Women's health

06 Active at every stage of life: Focus on women

Gut health

11 The benefits of acacia gum in gut health

Mental health

14 Coping with occasional stress to support mental health

Antioxidant capacity of caramel

17 Antioxydant properties


18 Lactoferrin – also a real alternative for urinary tract infections


22 Balm for the soul – Melissa officinalis L. alleviates stress symptoms

28 The hyper-specialization of anti-stress solutions

31 Cultivating a sustainable source of a stress-busting adaptogen

Brain health

34 Highly bioavailable solution for brain health

Heart and brain health

38 With heart and brain: leading a healthy life

Skin health

42 Protection and stimulation


45 Effective relief from tinnitus symptoms

Fi & Hi Europe 2022

48 Let’s meet in Paris!

50 Impressum

4 No. 3 November/Dezember 2022

New study on lactoferrin as non-antibiotic

alternative available! Read now:



free-range and


Vivatis Pharma in partnership with Saputo

International can now provide NatraFerrin

➜ High quality lactoferrin from free-range, grass-fed cows in Australia

➜ Clinically proven to reduce episodes of recurrent cystitis

➜ A non-antibiotic alternative against urinary tract infections

WWW.VIVATIS.DE | NE@VIVATIS.DE | +49 (0)40 236 90 90

Women's health

Photo © : Freepik/gpointstudio

Active at every stage of life: Focus on women

Anita Käser, Brigitte Hicks

Women and men are now equal in many areas [1]. Nevertheless,

women have different strengths, experiences, circumstances and

visions and also experience changes in the different phases of life.

A possible desire to have children, pregnancy, breastfeeding and

menopause demand a different lifestyle and diet and have specific

nutrient requirements [2]. But even in everyday life, when it comes

to organizing work, family and the household, a healthy body and a

positive mindset are essential. As a result, the interest in women’s

health has been growing steadily. In 2021, the dietary supplement

market reported an average growth of + 17% [3]. The following article

looks at the different phases of a woman's life in more detail.

Planning to have children

Women planning to have children should pay attention to a few

things. For example, it may be advisable to provide the body with

ideal conditions for a pregnancy. Healthy eating and exercise as well

as patience and joy of life should of course be part of this phase. Similarly,

negative triggers, such as smoking or drinking alcohol, should

be eliminated when trying to conceive. [4] Additionally, food supplements

can provide specific nutrients during

this time. In particular, folic acid, also known

as vitamin B9, should be taken before pregnancy

to reduce the risk of malformations,

such as the neural tube defect in the growing

fetus. The German Society of Nutrition (DGE)

recommends an additional daily intake of

400 µg folate (folic acid) for any woman who

wishes to have children. In addition, vitamin

D and iodine are usually recommended, as

they are equally essential for the body. Folate

and vitamin D also have a function in cell

division, which is an authorized health claim.



With successful fertilization and implantation

into the endometrium, the need for vitamins

& minerals for the body of the expectant

6 No. 3 November/Dezember 2022

Women's health

mother increases. The extra demand can be

compensated by foods with a high nutrient

density. These include whole grains, fruits,

vegetables, potatoes, and dairy products. [8]

One of the most important vitamins for

women planning to have a baby, for pregnant

and breastfeeding women is folic acid

or folate. It takes on critical functions in

cell division and growth processes in the

body and is involved in numerous metabolic

processes. To support the increased

need for folic acid, foods rich in folate such

as lettuce, spinach, broccoli and whole

grains are beneficial. The D-A-CH societies

(Germany, Austria, Switzerland) for nutrition

recommend that pregnant and breastfeeding

women supplement their daily diet

with 400 µg folic acid. A lack of folate during

pregnancy can have an extremely negative

effect on the development of the fetus and

can lead to a low birth weight or increase the

risk of a miscarriage. Folate supplementation

also reduces the risk of neural tube defects

in the unborn child.

Another important part of the diet during pregnancy

is iodine. Iodine is an essential trace

element maintaining many important body

functions and which must be supplied via

the diet. The thyroid gland needs the mineral

mainly for the build-up of thyroid hormones.

These are crucial for the growth and development

of the nervous system, musculature

and internal organs of the child. They also

regulate crucial processes in metabolism,

even before birth. Intake recommendations

depend, for example, on age, gender, and

state of health. The thyroid gland of the fetus

matures only in the 18 th -20 th week of pregnancy

and is therefore depending on the

supply from the mother. The German Society

of Nutrition (DGE) recommends a total daily

intake of 230-260 µg iodine for pregnant

and breastfeeding women, with 100-150 µg

taken in capsule or tablet form. [6]

In addition to folic acid, iodine and vitamin D,

omega 3 fatty acids also play a crucial role

in pregnancy. Omega 3 fatty acids cannot

be made by the body itself and need to be

supplied through food or supplements. The

intake of mono- and polyunsaturated fatty

acids, such as omega 3 from vegetable oils or the consumption of

cold-water fish, is crucial in the last trimester of pregnancy. During

this phase, long-chain fatty acids, especially arachidonic acid and

docosahexaenoic acid (AA, DHA) are stored in the brain of the fetus.

The DHA status of the mother is significant here, as DHA can affect

the structure and function of the brain and eyes of the fetus. Also,

the duration of pregnancy can be influenced by the formation of

hormone-like substances from the fatty acid eicosapentaenoic acid

(EPA). The recommendation of DHA intake for pregnant women is at

least 200 mg DHA per day. The exact fatty acid status can be determined

at the beginning by the Omega 3 Index as a blood test to

prevent a deficiency. Goerlich Pharma offers a wide range of marine

and vegan Omega 3 capsules in the desired private label packaging.

Additional vitamins that can be taken if needed, including vitamin

C, vitamin B1 (thiamine), vitamin B2 (riboflavin), niacin, vitamin B6,

vitamin B12, vitamin A and vitamin E as well as the minerals calcium,

iron and zinc. [9]

For this purpose, Goerlich Pharma developed a new basic formulation:

A pregnancy capsule containing valuable micronutrients such

as iodine, folic acid, vitamin D, B12, magnesium, zinc, and choline.

The capsule is vegan and can be customized with other vitamins,

minerals or trend ingredients to a Plus product. In combination with

Omega 3 products containing algae or fish oil, customer-specific

product concepts for pregnancy can be offered.


The amount of breast milk depends, among other things, on the

mother’s diet and lifestyle. More attention should be paid to a healthy,

balanced diet with lots of fruits, vegetables and whole grains. The

length of time the baby is breastfed depends on the individual situation

and can range from three months to one year and more. [10] An

additional energy intake of 635 kcal daily is recommended in the first

four months of lactation, as the need for vitamins and minerals can

be higher than during pregnancy. A daily calcium intake of 1000 mg

and iron intake of 20 mg per day is advised during the first four to six

months of breastfeeding. In addition, the need for iodine increases to

approx. 260 µg daily. [9] A blood test is also recommended here in

order to prevent deficiencies and to specifically provide support with


Female cycle

A woman’s cycle is a real miracle of nature and changes steadily from

birth to first menstruation and possible pregnancy to menopause. At

birth, the ovaries already contain the entire supply of eggs for the later

life of a woman. Egg cells are enclosed in small bubbles, so-called

follicles. At puberty, a part of the hormones will maturate the 1st

follicle and release an egg cell into the uterus. In addition, hormones

control the body temperature and the menstrual cycle by triggering

ovulation once a month. [11] If the egg is not fertilized subsequently,

No. 3 November/Dezember 2022


Women's health

gut, it is also important to maintain good bowel health [15]. Pre-, pro-,

and postbiotics can help in this area. Goerlich Pharma offers a probiotic

mixture in the form of capsules and as a direct stick, as well as a

direct stick with beta-glucan from the walls of yeast cells.

it dies and is excreted as menstrual period along with the top layer

of the endometrium. On average, approximately 20 to 60 milliliters

of blood are lost per menstrual period. During this time, iron supplements

can be used to support the body and ensure iron supply. [11,

12] Goerlich Pharma offers, for example, an iron acerola stick in the

flavors of raspberry or blackcurrants delivering 14 mg iron and 80 mg

vitamin C. Vitamin C helps the body to achieve better and higher

iron absorption as well as many other EFSA-approved health claims.

Additionally, health claims have been authorized for iron. It contributes

to normal oxygen transport in the body, as well as to the normal

formation of red blood cells and hemoglobin. Beyond that, magnesium

can help to relax the muscles when suffering from menstrual

cramps. Magnesium contributes to normal muscle function and the

function of the nervous system. Goerlich Pharma offers a magnesium

stick with 375 mg magnesium as a basic formulation, which can be

customized with additional vitamins or minerals. The stick formulations

are also available in capsule or tablet form.

The middle years: Balance in everyday life

Photo © : Adobe Stock/ssstocker

Women still do 80 % of care work, and often juggle between different

roles: They are employed, responsible for taking care of the children

and the household. They are partners, caregivers and managing

the tasks of everyday life [24]. In 2022, around 75 % of mothers are

employed [13]. Organizational talent, resilience and good physical

and mental health are the prerequisites to maintain this balance in

everyday life. Moreover, there often is not enough time left for hobbies

or sports as compensation to the daily tasks.

Children, pets and household chores also need to be taken care of

when you feel sick and the energy level is low. A strong immune system

is required to avoid getting sick. Exercise, a balanced diet and enough

sleep are essential to strengthen the immune system. Various vitamins

and minerals can also contribute to the normal function of our

immune system. For example, the EFSA has approved corresponding

health claims for copper, folic acid, iron, selenium, zinc and vitamin A,

B12, B6, C and D [14]. Because most of our immune system is in the

In addition to physical health, mental health also plays a major

role in meeting all the challenges in the everyday life of a modern

woman. Mental strength is required in particular during phases with

unplanned, unexpected and short-term changes, such as restrictions

on child care, overtime on the job, etc. Here too, the EFSA has

approved health claims for numerous vitamins and minerals [16].

In addition, there are indications that adaptogens can increase the

body's resis tance to stress. [17] The herbal adaptogen Rhodiola can

be found in the Anti-Stress capsule of Goerlich Pharma. Other basic

formulations include the vitamin B complex capsule, the magnesium

direct stick and the duo-magnesium capsule.

The daily routine of a working mother might look like this: Getting up

– Caring for pets – Making lunch/snack(s) – Waking up child(ren)

– Getting everyone ready and out of the house – Working – Picking

up child(ren) – Shopping – Taking care of the household – Cooking

– Eating dinner – Cleaning up – Family time – Going to sleep – the

day is usually filled with a variety of tasks from morning to evening.

In order for the body to have sufficient energy and strength, a normal

energy metabolism is necessary. Biotin, calcium, copper, iodine,

iron, magnesium, manganese, niacin, pantothenic acid, phosphorus,

riboflavin, thiamine, vitamin B12, B6 and C may help, which was

confirmed by the EFSA with the approval of a corresponding health

claim. However, if you feel tired or exhausted, folic acid, iron, magnesium,

niacin, pantothenic acid, riboflavin, vitamin B12, V6 and C can

help to reduce this feeling. [14] Here it is possible to select from

several basic formulations containing B vitamins, magnesium or iron.

Often underestimated, but very important is, of course, finding or

creating enough time to look after yourself. For some this is reading a

good book, spending time with friends, playing sports or going to the

Photo © : Freepik/pressfoto

8 No. 3 November/Dezember 2022

Women's health

hairdresser or a cosmetician. If there is a lack

of time due to a fully packed daily scedule,

“beauty from the inside” is the keyword.

Goerlich Pharma’s skin-hair-nails capsule

contains ingredients that can help maintain

normal skin, hair and nails, or normal skin

and hair pigmentation.

Menopause/climacteric period

Menopause refers to the period of hormonal

changes at the end of the fertile life phase of

a woman. The concentration of female sex

hormones decreases, resulting in the loss

of the period at the end of menopause and

thus no natural pregnancy being possible

any longer. The beginning, duration and

course of this period of life vary in each

woman, but at the age of 52, about half of all

women have had their last menstrual period.

The appearance and severity of menopause

symptoms vary just as much. These include

hot flashes, sweating, sleep disturbances,

dryness of the mucous membranes, e.g. in

the urogenital area, mood swings, weight

gain and memory problems. [18.19] In addition,

the risk of osteoporosis in women after

menopause is approximately twice as high

as in men due to the lowering of estrogen

levels. [20.21]

calcium through the intestines and the incorporation

of the mineral in the bones. This

prevents a decrease in bone density and

osteoporosis. If the vitamin D level is low,

supplementation can be useful. Targeted

strength training can also stimulate bone

formation. [21]

In addition to the above-mentioned menopause

symptoms, the decrease in estrogen

levels can often also be felt in the joints.

Blood circulation to muscles and joints

is reduced, collagen production and the

amount of joint fluid decrease and the joint

cartilage becomes thinner. In addition, with

age and also due to the lack of estrogen,

the skin becomes thinner, dryer, less elastic

and more prone to injury. [18] An adequate

supply of vitamin C can support the function

of the joints and the skin. The vitamin

contributes to normal collagen formation,

which is responsible for the normal functioning

of bones, cartilage and skin. [22].

Goerlich Pharma can offer a collagen stick

for dissolving in water as a basic formulation.

Outlook for probiotics

A future topic, which is becoming increasingly

important in women’s health, are

Bioactive Collagen Peptides (BCP ® )

stimulate the body’s own collagen


Body Toning

Beauty from Within

In order to maintain the usual quality of

life in this phase of life, there are different

approaches to treat the symptoms,

depending on their severity. This can range

from general measures to hormone replacement

therapy. However, the latter is disputed

due to possible serious side effects (e. g.

increased risk of breast or uterine cancer

and increased risk of blood clots) and is only

prescribed by doctors to women with severe


Bone Health

Joint Health

Connective Tissue


However, general measures such as relaxation

exercises, exercising outdoors, targeted

strength training and a healthy diet and

lifestyle can actively combat some of the

unwanted symptoms. Exercise can have a

positive effect on our mood, help with weight

loss, and counteract age-related muscle

loss. If the exercise takes place outside, the

body’s own vitamin D production is stimulated.

Vitamin D promotes the absorption of

GELITA AG · Uferstr. 7 · 69412 Eberbach · Germany · www.gelita.com

Women's health

Photo © : Freepik/mego-studio

probiotics. The interest in finding solutions to women’s health problems

is increasing the demand for natural ingredients such as probiotics.

Benefits include specific applications of bacteria that offer a

natural, over-the-counter and easily ingestible alternative without side

effects to women’s health. From puberty to menopause, there are

charac teristic probiotics for every woman at every stage of life that

can affect the intestinal or vaginal microbiota. The balance of the

microflora is a key factor in supporting health, is increasingly recog-

nized and supported by studies. Above all,

the probiotic genus of Lactobacilli, must

be mentioned here. They have shown in

some studies, that they can help to find the

balance of the microflora and lead to better

well-being. The Health Canada Ministry of

Health approved the additional indication

for the probiotic L. Plantarum Rosella that

has been shown to support the health of the

female intimate area. In order to be able to

colonize the vaginal microflora as accurately

as possible in the future, the choice of the

right bacterial strain is essential. In addition

to vaginal health, the most important growth

areas in women’s health include urinary tract

infections, pregnancy and skin health. [23]

In this area, Goerlich Pharma also offers

basic formulations: the probiotic immune

and probiotic gastrointestinal direct stick,

as well as a probiotic capsule containing a

variety of bacterial strains. Those products

can be customized to a Plus product by

adding other raw materials.


[1] https://www.bundesregierung.de/breg-de/themen/nachhaltigkeitspolitik/rechtliche-gleichstellung-841120

[2] https://www.bundesgesundheitsministerium.de/service/begriffe-von-a-z/f/frauengesundheit.html

[3] https://www.nutritioninsight.com/key-trends/b-life-womens/npd-in-action-womens-health.html

[4] https://www.apotheken-umschau.de/familie/kinderwunsch/schwanger-werden/schwanger-werden-das-sollten-sie-vorher-beachten-790043.html

[5] https://www.femibion.de/produkte/femibion-babyplanung#naehrwerte

[6] https://www.pharmazeutische-zeitung.de/ausgabe-362006/iod-und-folsaeure-supplementieren/

[7] https://www.femibion.de/schwangerschaft/vitamine-mineralstoffe

[8] https://www.ernaehrung.de/tipps/schwangerschaft/schwanger11.php

[9] https://fet-ev.eu/schwangerschaft-stillzeit/

[10] https://www.femibion.de/stillzeit/ernaehrung-stillen

[11] https://www.gesundheitsinformation.de/wie-funktioniert-der-weibliche-zyklus.html

[12] https://www.frauenaerzte-im-netz.de/koerper-sexualitaet/zyklus-hormone/

[13] https://www.destatis.de/DE/Presse/Pressemitteilungen/2022/03/PD22_N012_12.html#:~:text=M%C3%BCtter%20in%20Deutschland%20waren%20damit,noch%20bei%20



[15] https://www.bzfe.de/ernaehrung/ernaehrungswissen/gesundheit/das-immunsystem-staerken/

[16] https://eur-lex.europa.eu/legal-content/DE/TXT/PDF/?uri=CELEX:32012R0432&from=DE

[17] https://www.mdpi.com/2072-6643/13/8/2861

[18] https://www.frauenaerzte-im-netz.de/koerper-sexualitaet/wechseljahre-klimakterium/

[19] https://www.msdmanuals.com/de-de/heim/gesundheitsprobleme-von-frauen/wechseljahre/wechseljahre

[20] https://www.msdmanuals.com/de-de/heim/knochen-,-gelenk-und-muskelerkrankungen/osteoporose/osteoporose

[21] https://www.apotheken-umschau.de/krankheiten-symptome/gelenks-und-knochenerkrankungen/osteoporose-risikofaktoren-diagnose-therapie-734881.html

[22] https://eur-lex.europa.eu/legal-content/DE/TXT/PDF/?uri=CELEX:32012R0432&from=EN

[23] https://www.nutritioninsight.com/news/probiotics-for-womens-health-no-longer-taboo-as-lallemand-projects-market-growth.html

[24] https://www.gender-mediathek.de/de/care-arbeit

For more information, please contact

Goerlich Pharma GmbH

Edling, Germany



10 No. 3 November/Dezember 2022

Gut health

The benefits of acacia gum in gut health

According to a study by Alland & Robert,

80 % of people who consumed acacia gum

every day for 2 months improved their intestinal


Acacia gum, also known as gum arabic, is

a natural, safe and plant-based additive or

ingredient. It comes from an exudation of

Acacia trees after the incision of their stems

and branches. Acacia gum has been used for

centuries and provides many different functional

properties such as emulsifying properties

or fibre enrichment. It is now adays found

in a wide variety of consumer products all

over the world.

Now, in addition to its versatility, digestive health can be added to the

list the benefits of acacia gum. Alland & Robert, a leading manufacturer

of acacia gum and expert of natural gums since 1884, recently

conducted a study that confirms that people who consume acacia

gum every day improve their intestinal health. The objective of the

Alland & Robert study was to provide scientific data that support the

use of acacia gum as a gut health improver. Scientific research has

already highlighted that in addition to being a fibre, acacia gum is a

prebiotic. Alland & Robert decided to go further and conducted a

study to evaluate the impact of acacia gum on consumers who suffer

from intestinal disorders regularly.

In recent years, the gastrointestinal system has been linked to general

health: from weight management to immunity to chronic illnesses,

and even to sleep problems or skin health. About 70 million Ameri-

No. 3 November/Dezember 2022


Gut health

cans are estimated to be affected by digestion discomforts. As scientists

continue to explore the role played by the GI on human health,

there is no doubt that the digestive health market will continue to

boom: the global digestive health products market is expected to

grow to $ 59 billion by 2025 1 . Many consumers today know that a

happy, healthy gut is key for overall wellbeing. There is significant

demand for food, beverage and dietary supplements with digestive

health advantages. Manufacturers must understand the expectations

of consumers and provide safe and natural products that answer their

demands, and acacia gum is a multi-functional and natural option to

formulate gut-friendly food and beverages.

Consuming acacia gum daily improves intestinal

discomfort and pain

Alland & Robert worked with a leading company in consumer insight.

The study consisted in the recruitment of 240 consumers who

declared they suffer regularly from intestinal disorders such as flatulence,

bloating, stomach aches, accelerated or slowed down transit.

Consumers were separated in 3 groups and took various dosages of

acacia gum daily for 2 months. After 60 days, 80 % of the consumers

declared their intestinal discomfort had improved. 78 % of consumers

agreed the intake of acacia gum daily had a beneficial effect on their

digestive health, and 88 % of the participants said they had low intestinal

pain after 2 months of consuming acacia gum. According to Dr

Isabelle Jaouen, R&D Director of Alland & Robert, this study shows

that acacia gum improves global digestive wellness and relieves

the symptoms of intestinal discomfort. She

declared: “Intestinal disorders impact the

daily lives of a large portion of the human

population. At Alland & Robert, we wanted to

explore the possibility that acacia gum would

provide an answer to these needs. Thanks

to this study, we can affirm that acacia gum

contributes to the improvement of the gut

health and therefore the general well-being

of a large majority of those tested. It is very

likely that acacia gum, a natural fibre, favourably

feeds our microbiota, which has already

been described in the scientific literature in

connection with its prebiotic effects“.

As a prebiotic fibre, acacia gum can

be used for the formulation of many


Scientific research has shown that acacia

gum is a prebiotic fibre. Its functional properties

make it a perfect ingredient to enhance

the fibre content of food and beverages. And

the addition of acacia gum doesn’t impact

or compromise the texture, appearance

or texture product. According to Professor

Christian Sanchez who works on basic

12 No. 3 November/Dezember 2022

Gut health

research on acacia gum at the IATE 2 laboratory

at the University of Montpellier, France:

“Because of its classification as a fibre and

its emulsifying properties, acacia gum could,

theoretically, be used in all formulated food

products since it also has the advantage of

being temperature stable. Think yogurts,

dairy products and derivatives, as well as

baked goods and, more broadly, any flourbased


Commenting on the FDA decision, Mr.

Frédéric Alland, CEO at Alland & Robert said:

“We are extremely satisfied that the FDA

agrees with us that acacia gum is a fibre and

can be labelled as such. It’s a great news for

the American consumers, who will be able

to enjoy this natural ingredient in their daily

food. Alland & Robert remains committed to

providing the highest quality of natural and

non-GMO Acacia Fibre”.



2018 to 2025. https://www.fiormarkets.com/report/digestivehealth-products-market-by-ingredients-dairyproducts-385973.html

February 20, 2020.


In English: Agropolymers Engineering and Emerging

Technolo gies/In French : Ingénierie des Agropolymères et

Technologies Emergentes

For more information, please contact

Alland & Robert, France


Violaine Fauvarque, Marketing Manager at

Alland & Robert, added: “Multifunctional

and versatile, acacia gum has many advantages.

It can give texture, sweeten a taste or

mask an aftertaste, and it can increase the

fibre or prebiotic content with a very lowcalorie

intake. Today, our study shows that

acacia gum is a good fit in products formulated

to improve digestive comfort. This also

confirms that acacia gum responds in an

innovative way to the challenges encountered

in many industries!”

Acacia gum, now a dietary fibre

FDA approved

In December 2021, a decision from the

American FDA was made public acacia gum

will be able to count as a dietary fibre on

American Nutrition and Supplement Facts

labels. The FDA agreed it has physiological

effects beneficial to human health, such as

the reduction of blood glucose and insulin

levels after it is eaten with a meal containing a

carbohydrate that raises blood glucose levels.

Alland & Robert, along with a work group of

other acacia gum stakeholders, submitted

two science-backed citizen petitions in 2019

and 2020, in order to provide the FDA with

data showing proof that acacia gum has

indeed “physiological benefits to human

health”. Dr Isabelle Jaouen, R&D Director

at Alland & Robert said: “We have provided

the FDA with numerous data coming from

several clinical trials to support our request

that acacia gum be recognized as a dietary

fibre. Two laboratories that specialize in clinical

nutrition, including one university, have

been mandated for the design and realization

of the clinical tests. Our citizen petitions

included data showing the benefits of acacia

gum on blood glucose levels”.

The flexitarian way of living.

Tasty and nutritious plant-based ingredients.

A mind-boggling 25% of consumers globally are flexitarians. They are drawn to plantbased

options because of their healthful appeal, ecological convictions or the pleasure

of trying something new. BENEO helps you develop plant-inspired options that are

simply delicious. Sharpen up your recipe with natural ingredients that bring out pure

flavours and exciting textures. Create a taste experience consumers will thoroughly

enjoy with new and inspiring dairy-free or meat-free recipes. What will be your

signature ingredient?

Follow us on:


Mental health

Photo © : Adobe Stock/Prostock-studio

Coping with occasional stress to support

mental health

The World Health Organization defines mental health as “a state of

mental well-being that enables people to cope with the stresses of

life, realize their abilities, learn well and work well, and contribute to

their community”. With globally one third of consumers that are not

satisfied with their mental well-being 1 it is indeed quite concerning

and worth talking about.

Mental well-being in healthy individuals

One of the burdens of modern lifestyle is everyday stress – heavily

impacting mental well-being. Stress is common across the globe, but

in the last two years it has been drastically increasing, with half of the

population stating they experience stress most of the time or all the

time 2 . No matter their age, half of global consumers claim that they

are currently undergoing moderate, high, or extreme stress levels 3 .

Just as stress, stress-induced digestive discomfort, and anxietylike

symptoms, can in turns impact sleep quality, hence worsening

mental well-being… establishing an unwelcomed pattern 4 .

When asked about what they think causes their stress and troubles

their sleep, consumers mention being most concerned about the

health and well-being of loved ones, followed by being concerned

about their own health, financial situation,

work obligations, or feeling insecure

about worldwide problems such as global

warming 5 . Recurring bad night sleep can

in turn impact learning capacity, memory,

decision making, and even creativity.

But there are good news! A large majority

of consumers have a proactive approach

towards their mental health and stress

management, and they opt for natural solutions

6 such as increasing physical activit

ies. According to the Physical Activity

Guidelines for Americans, being physically

active on a regular basis, is one of

the most important things people can do to

improve both physical and mental health 7 .

Other solutions include taking actions

to address familial, work, or financial

issues. Consumers also understand that

by improving their mental wellbeing, they

can improve their quality of sleep. Estab-

14 No. 3 November/Dezember 2022

Mental health

lishing a soothing bedtime routine is also

relevant. Warm comforting drinks such as

herbal tea or milk, and taking nutritional

supplements, are cited by consumers to

help lowering stress levels before bedtime 8 .

Specific probiotic supplements also appeal

to consumers to improve sleep, as they help

cope with day-to-day stressors 9 . Beside

dietary supplements, an increased number

of consumers are exploring the power of

botanical extracts, to manage their stress

and enhance their moods.

Carefully selected botanical extracts

to boost mood

Turning to natural health solutions is

rooted in traditional methods to help maintain

holistic health. Over time and years of

research, scientists came to harness microorganisms

and plants benefits leading

more precisely to proven health applications.

Modern science allows to skillfully

isolate specific bioactive compounds and

study how botanical extract have an impact. For example, ashwagandha

traditionally used in Indian, or Ayurvedic, medicine, is well

known for its stress-lowering effects. It helps decrease levels of

cortisol; a hormone produced by the adrenal glands in response

to stress. Saffron was conventionally used to bring joy and happiness.

Thanks to an isolate from saffron, safranal, involved in serotonin

amplification, Safr’Inside, an Active’Inside product, naturally

supports positive mood and emotional health.

The most documented probiotic to support a healthy

response to occasional daily stress

In 2019, a good proportion of consumers bought probiotic pro ducts

to support mental health. This proportion is in constant increase

and in 2020, it has raised to reach 23.7 % globally 10 . When comes

the time to deal with the physical and psychological symptoms of

everyday stress and feelings of anxiety, one natural solution stands

out from the crowd and it’s the probiotic formula Cerebiome ®

(L. helveticus Rosell ® -52 and B. longum Rosell ® -175). Cerebiome ®

has been largely documented on the reduction of psychologi cal stress

in humans by five clinical studies and over ten translational studies.

Clinically proven, it offers natural support to help enhance mood and

acts on the microbiome-gut brain axis to support a healthy response

to everyday stress.

Lipoid GmbH | info@lipoid.com | www.Lipoid.com




PHOSAL ® Curcumin – An Innovative

Formulation for Bioavailable Curcumin

With highly purified phosphatidylcholine

from sunflower lecithin for an increased

bioavailability in a natural way.

We Invest in Quality.

Mental health

Photo © : Adobe Stock/Grispb

Botanical extract and probiotics: The perfect mix

Cerebiome ® can also be formulated with other relevant ingredients

that promote relaxation, sleep, emotional and mood balance, such

as melatonin and ashwagandha. And now, it is possible to combine

the best of both worlds. Cerebiome ® and Safr’Inside is a unique,

documented, and powerful combination for mental wellness and

emotional balance. In a consumer satisfaction trial, 96 % of consumer’s

reported a reduction on daily stress, and more than 80 % were

satisfied by the product effectiveness. 11

A unique formulation’s expertise

Probiotic industrial production requires a precise expertise in the

fermentation of living microorganisms. When adding botanical

extracts in the mix, the level of complexity amplifies. New ingredients

must follow a strict validation process to ensure product compatibility,

stability, and shelf-life longevity. Formulations represent a real

production challenge as microorganisms have complex nutritional

needs and marked sensitivities at certain key stages of bioproduction.

Lallemand Health Solutions cumulates over 85 years of microbial

fermentation production know-how to successfully combine

probiotics and other health ingredients, such as botanical extracts,

prebiotics, bacteria, yeast, vitamins, and minerals.

Along with a well-balanced diet and a healthy

lifestyle, probiotics and carefully chosen

ingredients synergistic effect in support to

mental health is a trend to watch.



FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020


FMCG GURUS: Stress and Sleep Management Survey, 15 000 consumers in 15 countries,

2019 and 2021

³Euromonitor’s Health and Nutrition Survey 2020, 21 countries, 21 000 respondents


FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020


FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020


FMCG Gurus: Mental Wellbeing: Targeting Stressed and Anxious Consumers in 2020 and

beyond October 2020





FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020


FMCG GURUS: Stress and Sleep Management Survey, 15 consumers in 15 countries, 2020


FMCG GURUS: Probiotic Survey, 15 000 consumers in 15 countries 2019 & 2020


Lallemand Health Solutions and Activ’Inside proprietary study

For more information, please visit



16 No. 3 November/Dezember 2022

Photo © : Adobe Stock/Apolikhina Anna

Antioxidant capacity of caramel

Antioxydant properties

Nigay SAS has been carrying out researches

for a better knowledge of caramel for many

years. In order to do so, they worked with

several laboratories to show the antioxidant

properties of caramel.

A scientific article describing the results of

these studies has been published:

Investigation of the antioxidant capacity of

caramels: combination of laboratory assays

and C. elegans model – Journal of Functional

Foods – Volume 78 (2021) 104308.

Caramel is produced by a controlled heating

of sugars (sucrose – glucose syrup,...)

with or without presence of caramelization

promoters to provide a wide range of ingredients

(aromatic caramels, burnt sugars or

specialities) or additives (caramel colours).

Caramelization is close to the Maillard reaction

and begins with a dehydration of the

sugars then a polymerization of the molecules

formed. These multiple reactions

create a complex mixture of compounds

ranging from small molecules responsible

for the typical taste of caramel (maltol – furaneol…)

to large molecules responsible for

the brown colour of caramel.

Several methods have been tested simultaneously:

1. Chemical analysis using a blue molecule

called ABTS in solution which discolours in

the presence of antioxidant

2. Analysis of the effect of caramel on the

lifespan of blood cells when they are

attacked by strong oxidants

3. Analysis of the impact of caramels on the

lifespan of Caenorhabditis elegans worms

in the presence of strong oxidants

=> 40 % increase in worm lifespan after 18

hours of exposition

These three studies, using radically different

methods, have jointly shown that caramel

has antioxidant properties in caramels.

The greater the degree of caramelization,

the greater the antioxidant activity’s will be.

Further studies will be carried out to identify

the molecules or families of molecules

responsible for this activity.

In conclusion, caramel contributes significantly

to the consumption of antioxidants

that can lead to interesting nutritional benefits.

Based on 2012 EFSA exposure data, the

current daily intake of caramel colour would

provide antioxidant equivalent to a glass of

orange juice or a cup of coffee. The aim of

the following studies will be to explore these

potential benefits due to the antioxidant

pro perties in caramels.

Who’s the expert

The family-run business is specialized in

the production of caramels used in many

forms (liquid, paste, powder, pieces) by artisans

and food industries. Producing aromatic

caramels, caramel colours, burnt sugars and

caramel specialities, Nigay is unique in its

dedication to the art and science of caramelization

which has made its name “The expert

in caramels” around the world.

With a turnover of nearly 90 million euros

(72 % in exports), the company ships its

products on the 5 continents. Focused on

human values and driven by their profession,

Henri and Yves Nigay lead a team of

more than 320 people. They aim to perpetuate

their caramel expertise and to pass it

on to the 6 th generation thanks to anchored

company values: Passion, Tradition, Innovation,

High Standards & Ethics.

For more information, please visit


No. 3 November/Dezember 2022



Lactoferrin – also a real alternative for

urinary tract infections

A new preliminary study demonstrates the effect in cystitis

Diana Kalustova

Lactoferrin is a true all-rounder when it comes to treating various

diseases and deficiency symptoms. As the name, composed of the

Latin words milk and iron, suggests, the main function of lactoferrin

is to bind and transport iron in the body. This special glycoprotein,

which is found in mammals, for example in breast milk, and belongs

to the transferrins, has antiviral as well as antimicrobial and antiinflammatory

properties with its multifunctional enzyme activities.

Effective from periodontitis to Alzheimer’s disease

and infections

The broad spectrum of activity of lactoferrin has been demonstrated

in various studies for more than 100 years. As early as the beginning

of the 21st century, lactoferrin was shown to have positive

results in the treatment of chronic periodontitis. Since then, lactoferrin

has demonstrated its efficacy in many areas. For example,

a recent study* by neurologists in Cairo tested the effects of lactoferrin

in Alzheimer’s patients. In this study, Alzheimer’s patients were

treated with lactoferrin for 3 months and compared to both healthy

patients and Alzheimer’s patients. Lactoferrin measurably reduced

the levels of the disease markers amyloid-beta and tau proteins in

Alzheimer’s patients. In addition, thinking performance improved

after treatment. Lactoferrin also showed potential in the treatment of

Covid-19. Preliminary results from a recently published meta study**

in the U.K. show that lactoferrin has a detectable effect in reducing

the risk of respiratory infection and also as a supplement in Covid-19.

Recent study on positive effects in urinary tract infections

A brand-new study*** on bovine lactoferrin (bLf) shows that there is

much more to lactoferrin. It shows that this glycoprotein can be used as

an alternative or adjunct to antibiotic treatments for urinary tract infections.

A disease that affects more than 15 million people each year.

Urinary tract infections (UTI) are most commonly caused by uropathogenic

Escheria coli (UPEC) strains. Cystitis is defined as inflammation

of the urinary bladder and is characterized by dysuria, frequent

urination, and urinary urgency with or without suprapubic pain.

18 No. 3 November/Dezember 2022


Supplementary Fig. S1. Incidence rate of cystitis before and after the date of enrolment by treatment groups. Data are expressed

as events per 100 persons-month, and 95% confidence interval (CI). Given the fact that the number of patients treated with “bovine

lactoferrin (bLf) + probiotics” and that of those treated with “bLf + probiotics + antibiotics” was relatively low (n=3 and n=5,

respectively), these two groups were merged together (n=8) for the scope of this analysis.

An effective antibiotic alternative

The traditional treatment for urinary tract

infections is antibiotic therapy. However, due

to increasing bacterial resistance, effective

non-antibiotic alternatives are being sought.

The use of bLf as an alternative or complementary

treatment to conventional antibiotics

is based on its systemic effects in

balancing, in particular, disturbances in

iron and inflammatory homeostasis. What

the tested bovine lactoferrin can do in this

regard has now been investigated by several Italian scientists in a first

study at the University of Rome.

Lactoferrin in recurrent urinary tract infections:

In vitro and in vivo evidence

The bovine lactoferrin (bLf) study was conducted in patients with

recurrent cystitis and showed a significant decrease in the number

of such episodes over the observation period. Exceptionally positive

results were observed both with bLf alone and as an adjunct to antibiotics,

probiotics or both. The current, scientific findings are preliminary,

promising studies whose results should be verified in further

studies. Already today, the bovine lactoferrin under investigation is

No. 3 November/Dezember 2022



produced in Australia at the same purity level (99%) as NatraFerrin.

NatraFerrin is derived from the milk of free-range and grass-fed

cattle, which is explicitly emphasized by both the partner manufacturer

Saputo, as well as Vivatis Pharma.

Supplementary Fig. S2. Incidence rate reduction (and 95% CI) from pre- to

post-study period. Data are point estimates, 95% confidence interval (CI),

and p-values.


*A pilot study on the effect of lactoferrin on Alzheimer’s disease pathological sequelae: Impact of the p-Akt/PTEN pathway

Mohamed et al., Kairo

Published: Biomed Pharmacother, March 2019

**Lactoferrin reduces the risk of respiratory tract infections: A meta-analysis of randomized controlled trials

Ali et al., University of Huddersfield

Published: Clin Nutr ESPEN, October 2021

***Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences

Conte et al., University or Rome

Published: Biometals, 29. June 2022

For more information, please contact

Diana Kalustova,

Business Development Manager

Vivatis Pharma GmbH

Hamburg, Germany

20 No. 3 November/Dezember 2022

Pioneering psychobiotic.

Game-changing science.

• 5 clinical studies

• 8 elucidated modes of action

on the brain-gut axis

• Exclusive and strong health claims

on mood and stress granted

in Canada and Brazil

Visit the dedicated website



Photo © : Adobe Stock/Prostock-studio (adapted)

Balm for the soul – Melissa officinalis L.

alleviates stress symptoms

Dr Annette Masuch

In today's ever-accelerating world, almost everyone has probably

heard the phrase: take care of yourself, too much stress can make

you sick. But, how much is too much? Certainly, there is no universal

answer and one person might be able to cope with more stress

compared to another. Fortunately, our body is able to signal that we

are reaching our limits. And we should listen and react.


First of all, we should remember, a stress reaction is nothing negative.

Stress enables us to act quickly in a threatening environment to

ensure our survival. However, from the biological point of view, the

aim of the stress reaction is to quickly deal with the acute danger

by fight or flight. Nowadays, however, we mainly experience stress

situations that cannot be solved simply by flight or attack, e. g. overtime

and performance pressure at work, being constantly available

or the continuous flood of information we are exposed to through

the internet. If we classify these circumstances as threatening and

the situation persists, the stress reaction

may become a health risk. Symptoms of

chronic stress may be diverse and affect the

body, the psyche, the mind and behaviour.

The following symptoms may occur among

others [1]:

– Physical: e. g. trembling, accelerated

heartbeat, sweating, tension (mostly in the

neck and shoulders), reduced performance,

exhaustion, headaches and backaches,

sleep disorders, gastrointestinal

complaints (constipation, diarrhoea).

– Psychological and emotional: e. g. nervousness,

inner restlessness, irritability

(“thin nerves”), panic, anxiety, anger.

– Mental (cognitive): e. g. reduced ability to

concentrate, slowed thinking, reduced

ability to react, forgetfulness.

22 No. 3 November/Dezember 2022


Usage of medicinal plants as remedy for all kind of symptoms has long

tradition all over the world. One plant appears to be extra ordinarily

suitable to address stress-related symptoms: Melissa officinalis L.,

commonly known as lemon balm.

Lemon balm – used for centuries not without reason

Indeed, lemon balm has a very long history of medicinal use for about

2000 years and was already described by Dioskurides (40-90 AD) in

his De materia medica [2]. Paracelsus recommended the plant for

“all complaints supposed to proceed from a disordered state of the

nervous system”; it would completely revivify a man [3]. One of the

most famous remedies containing lemon balm is the Carmelite Water,

crafted originally in the 14 th century by Carmelite nuns from the Abbey

of St. Just for King Charles V. of France [4]. Later on, the nun Maria

Clementine Martin, came to Cologne in the 19 th century and founded

her business Maria Clementine Martin Klosterfrau. Her Carmelite Water

is still sold today as Klosterfrau Melissengeist ® [5]. Over the course of

the centuries, the plant found its way into handbooks and pharmacopoeias.

According to the European Union Herbal Monograph its use

in Europe is traditionally indicated for a) the relief of mild symptoms

of mental stress and to aid sleep, and b) for the symptomatic relief

of mild gastrointestinal complaints including bloating and flatulence

[6]. The ESCOP monograph “MELISSAE FOLIUM” gives the following

therapeutic indications for internal use: tenseness, restlessness, and

irritability; symptomatic treatment of digestive disorders such as minor

spasms. Notably, also external use within a cream is described for the

treatment of Herpes simplex labialis (cold sores) [7].

Major constituents and molecular targets

Lemon Balm or Melissa officinalis L. taxonomically belongs to the

family of Lamiaceae. Originating probably from the Eastern Mediterranean

region to Western Asia lemon balm is today naturalised all

over the world. This perennial herbaceous plant has an intense lemon

scent, growing erect to a height of about 30–70 cm. The branched

stem is quadrangular and the soft hairy leaves are heart-shaped to

ovate and arranged in decussate pairs. The leaf edge is scalloped or

toothed and the leaf nervature is strongly protruding underneath [8].

Only the leaves are used as herbal drug itself, for infusions, as

comminuted powder and for the preparation of various herbal drug

preparations ranging from aqueous or alcoholic dry or soft extracts to

tinctures [6]. The quality of the herbal substance is described in the

European Pharmacopoeia in the monograph 1447 “Melissa leaf”.

According to the HMPC assessment report on Melissa officinalis L.

folium [6], the major characteristic components of lemon balm are:

– Essential oil (0.06–0.8 % containing monoterpene aldehydes,

mainly citral, neral and citronellal);

– Sesquiterpene derivates β-caryophyllen and germacren-D (10 %

each in essential oil);

– Monoterpene glycoside;

– Flavonoids with glycoside of lutein, quercetin, apigenin and


– Phenylpropanoids including hydroxycinnamic acids derivatives

such as caffeic and chlorogenic acid and in particular rosmarinic

acid (up to 6 %);

– Tannins

– Triterpene including ursolic and oleanolic acids

Of note, the exact mechanism of action and therapeutically active

constituents are not yet identified and, further complicating the topic,

different preparations appear to have diverging effect.

Very intriguing, lemon balm extracts and essential oil have been

reported to interfere with the signalling mediated by the neurotransmitter

gamma-aminobutyric acid (GABA). In animal studies,

lemon balm extract inhibited or decreased GABA transaminase.

Furthermore, lemon balm essential oil has been reported to bind


receptors. GABA is the major inhibitory neurotransmitter

in the human brain and is involved in sleep regulation and arousal.

Indeed, several hypnotics as well as tranquilizers are targeting GABA

metabol ism and/or GABAergic signal transduction [2,9] (please refer

also to the info box).

From in vitro studies, using brain membranes prepared by homogenizing

grey matter from human occipital cortex, it has been reported

that ethanolic extracts prepared from lemon balm are able to replace

[ 3 H]-nicotine and [ 3 H]-scopolamine from membranes bearing acetylcholine

receptors [10,11] implicating a direct binding to them (see

below and please refer also to the info box). Furthermore, extracts as

well as the essential oil of lemon balm have been reported to inhibit

the acetylcholine (ACh) esterase activity in a dose-dependent manner,

enhancing the ACh-receptor activation [2]. Both findings implicate a

cholinergic effect of lemon balm herbal preparations and/or essential

oil, which has been reported to be associated with an enhancement

of memory and cognitive function. Of note, not every extract preparation

appears to have cholinergic properties and results may be inconsistent

depending on the type of preparation.

Clinical evidence for the relief of stress symptoms

To transfer molecular findings into clinically relevant observations

several human studies have been performed. In 2002, 2003 and

2004 Kennedy and co-workers reported results from three studies

on hydro-alcoholic extracts from lemon balm leaves [11–13]. All

three studies were randomized, placebo-controlled, double-blind,

balanced cross-over studies. In the first one, 20 healthy volunteers

were included and received 300 mg, 600 mg or 900 mg of

an aqueous-methanolic lemon balm extract or matched placebo.

Participants received the dosage and completed all required tests

pre-dose and at 1 h, 2.5 h, 4 h, and 6 h post dosage, following 7

days wash-out period. This test regimen was repeated three further

times. Overall, the data show sustained improvement in accuracy

of attention following 600 mg of lemon balm extract and time- and

No. 3 November/Dezember 2022



dose-dependent reductions in both secondary memory and working

memory factors. Self-rated “calmness” was elevated already by the

lowest dose and at the earliest time point, whilst “alertness” was

significantly reduced at all time points following the highest dose

of 900 mg [12]. In the following study, different aqueous-ethanolic

extract preparations of lemon balm were screened for the ability

to bind to ACh receptor in vitro since the extract used in the first

study did not show considerable ACh receptor binding abilities. The

extract with highest cholinergic binding properties was then used in

a study with 20 healthy volunteers. The dosage was 600 mg, 1,000

mg, 1,600 mg or matched placebo and tests were performed predose

and at 1 h, 3 h, and 6 h post-dose followed by 7 days washout

period and three times repeat of this regimen. The highest dose

(1,600 mg) results in improved memory performance and increased

calmness at all post-dose time-points [11]. In the third study, the

aqueous-methanolic lemon balm extract utilized in the first study

was examined in 18 healthy volunteers for its effects on laboratoryinduced

psychological stress induced by means of the Defined Intensity

Stressor Simulation (DISS) Computerized Battery. Dosage was

300 mg, 600 mg or matched placebo and cognitive performance and

mood were assessed pre-dose and 1 h after administration followed

by 7 days wash-out period. The procedure was repeated further two

times. The results of this study implicate that ingestion of extract of

lemon balm can directly alleviate effects of stress. The higher dose

(600 mg) mitigated the negative mood effects induced by the DISS

in terms of increased self-rating of calmness and reduced self-rated

alertness [13]. Apparently, lemon balm may support memory performance

depending on the type of extract. Whilst an aqueous-methanolic

extract rather reduced secondary and working memory performance,

the aqueous-ethanolic extract preparation with cholinergic

properties improved memory performance.

Cases et al. report results from a prospective, single-centre, open

label study. Twenty stressed volunteers were included who were

affected by mild-to-moderate anxiety disorder and sleep disturbances.

The participants received for 15 days a standardized lemon

balm leaf aqueous-ethanolic extract that contained more than 7 %

rosmarinic acid and more than 15 % hydroxycinnamic acid derivatives.

Significant improvement of anxiety-related symptoms as well

as insomnia and no adverse effects were reported. Anxiety with associated

symptoms, insomnia at baseline and post-treatment were

assessed by means of the Free Rating Scale of Anxiety (FRSA) and

the Hamilton Rating Scale for Depression (HRSD), respectively. The

overall anxiety manifestation, including agitation, hyperactivity and

tension, was significantly reduced by 18 %. Insomnia was clinically

significant improved. Notably, full remission of symptoms within the

15-day treatment was reached in 17 out of 20 participants [14].

The efficacy of an aqueous lemon balm extract in food products

(drinks and yoghurt) was examined in one pilot and two behavioural

studies in healthy adults. The latter ones were designed as

randomised, placebo-controlled, balanced cross-over studies to

examine the effects of lemon balm extract on the mood, stress-level

and also cognitive function. The findings

support the notion that supplementation of

food with lemon balm extract lowers levels

of anxiety and stress. This was also associated

with reduced cortisol levels as a physiological

measure of stress. The cognitive

performance as assessed by a multi-tasking

framework of four simultaneous tasks was

also enhanced [3].

Taken together, these observations strongly

underline the traditional use of lemon balm

to aid sleep and relief symptoms of stress like

anxiety or tension related to stress.

Lemon balm and its calming effect

on the gut

At the first glance, the indications “relief of

mild symptoms of stress and to aid sleep”

and “relief of mild symptoms of gastrointestinal

complaints” appear to have nothing to

do with each other. Yet, surprisingly, dosages

and preparations are basically identical for

both. Considering bodily signs of stress, one

or the other reader might have already said

the phrase “I am getting a stress ulcer over

this”. Of note, the term “functional gastrointestinal

(GI) complaints” means complaints

like abdominal pain, dyspepsia, diarrhoea,

constipation and bloating in the absence

of demonstrable pathologic condition like

inflammation, GI infection or food intolerance

for instance. Historically, they have

been defined as “of no organic basis”, but

today alterations in the gut-brain communication

are strongly implicated in the aetiology

including altered gut-microbiota [15].

Maybe the connection between brain and

gut might be of importance as well for the

efficacy of lemon balm for the treatment of

mild GI complaints. But, so far this remains

only a speculation. Notably, the use of lemon

balm for this indication is based only on longstanding

tradition and clinical studies are not


The spasmolytic effects of lemon balm

extracts have been shown in ex vivo studies,

however. It was reported that an aqueousethanolic

extract from lemon balm leaves

has site- and dose-dependent effects on

the contractile activity of the GI tract. Aubert

24 No. 3 November/Dezember 2022


and colleagues examined the response of

different segments of the mouse GI tract

under basal conditions as well as precontracted

to observe spasmolytic properties.

Whereas no effects were reported for antrum

and colon, lemon balm extract significantly

and dose-dependently reduced the contractile

activity in ileum and jejunum. The authors

describe that treatment with the extract also

reduced the spontaneous phasic contraction

and overall lemon balm might slow the

GI transit [16].

Several other studies reported spasmolytic

effects of lemon balm essential oil on

isolated guinea pig ileum, rat duodenum and

vas deferens, and on the jejunum of rabbits

[7]. In line with these findings, Sadraei et al.

reported inhibitory effects of lemon balm

essential oil and especially citral as one of

the major components of the essential oil

on rat ileum. Contractions were induced

by addition of 80 mM KCl, 320 nM ACh or

1.28 µM 5-HT (5-Hydroxytryptamine) to the

bath solution of the isolated ileum [17]. The later findings implicate

the essential oil to mediate spasmolytic effects, however, the study of

Aubert et al. analysed the investigated extract phytochemically and

did not detect essential oil [16]. Thus, spasmolytic effects may not

only be attributable to the essential oil but also to other not yet specified

components present in an aqueous-ethanolic extract. Though

clinical data are not available, the use of lemon balm against GI

complaints has long tradition and numerous products are present in

the market.

Antiviral effect to treat cold sores

Lemon balm shows antiviral effects. However, the European Union

Herbal monograph does not cover the indication. A highly concentrated

lemon balm extract with a drug to extract ratio of 70:1 is

contained in a cream for the topic treatment of recurrent Herpes

simplex labialis. The extract is standardised with respect to the antiviral

activity using plaque inhibition test [6]. Symptoms of infections

with Herpex simplex virus (HSV)-1 comprise pain and blistering on

the lips and perioral area (cold sores). Usually, the primary infection

occurs in the childhood and the virus is presumably remaining

latent in the trigeminal ganglion. Of note, stress may be one factor

to trigger recurrence [18]. Clinical studies for this special extract

are available from the 1990s. Application of the cream significantly

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No. 3 November/Dezember 2022



reduced the healing time of cutaneous lesions and extended the

interval of recurrences in a multicentre, open, controlled study with

115 patients. These finding were confirmed in a multicentre, doubleblind,

placebo-controlled study including 116 patients [7, 19]. Independent

from the first studies, Koytchev and coworkers performed

a double-blind, placebo-controlled, randomized trial including 66

patients to investigate the efficacy of the cream containing the above

mentioned standardised aqueous extract. They also reported shortened

healing period and, furthermore, the prevention of spreading of

the infection and rapid effects on typical symptoms [20]. Also other

lemon balm extracts and the essential oil appear to have antiviral

properties at least in vitro. As summarised by Shakeri et al., both

aqueous-alcoholic and aqueous extracts of lemon balm exert antiviral

activity against HSV-1 and HSV-2 in cell-based experiments. Also for

the essential oil inhibition of HSV-1 and HSV-2 has been reported

from in vitro plaque reduction tests [2].

Taken together, lemon balm and various preparations from its leaves

have been under investigation already for a long time and its efficacy

has been reported in several clinical studies. In view of today’s

challenging and fast-moving everyday life, the experience of somatic

signs of stress – like difficulty to fall asleep due to running thoughts,

gastrointestinal complaints, or even recurrent cold sore – is widespread

and well-known to many people. Melissa officinalis L. has

been used successfully for centuries as a

remedy, though still not all her secrets are

elucidated by now.

About Anklam Extrakt GmbH

Anklam Extrakt GmbH is a German company

that stands for top expertise in development,

production and research of high-quality plant

extracts. Our extract portfolio includes both

extracts for the pharmaceutical and nutraceutical

industry. As a specialist in innovative

ingredients, Anklam Extrakt ® also develops

brand concepts that are based on scientific

studies for the healthcare sector.

With a rosmarinic acid content of ≥ 2.0 %

our lemon balm extract is suitable for food

supplement and pharmaceutical applications.

The extract is compliant with the

Ph. Eur. and we can support the registration

process of our customers with a CEP (Certificate

of Suitability of Monographs of the European


Info box: Transmitter systems

a) γ-amino butyric acid (GABA)

GABA is the major inhibitory neurotransmitter maintaining the excitatory/inhibitory balance in the human central

nervous system. GABA can bind to two main types of receptors:

– ionotropic GABA A

receptors: fast-acting ligand-gated Cl - channels; increased influx of chloride ions induces an

inhibitory postsynaptic potential (IPSP)

– metabotropic GABA B

receptors: slow-acting dimeric receptors linked to Gα i/o

activating ligand gated Cl - channels in

the postsynaptic cell (slow IPSP) or closing voltage-gated Ca 2+ channels in the presynapse (consequently reducing

transmitter release)

GABA is cleared from the synaptic cleft by GABA-transporters and about 80 % of the transmitter is recycled. Breakdown

of GABA occurs through the GABA transaminase removing a nitrogen group from GABA to create L-glutamate

in the so-called GABA shunt.

b) Acetylcholine (ACh)

ACh is a ubiquitous signalling molecule. It is an excitatory neurotransmitter in the human central nervous system and

also modulates signal transduction of other transmitter systems. ACh is the transmitter at the neuromuscular junction

(transmitting the signal from the nerve to the muscle), is one of the major transmitters in the autonomic nervous

system (internal transmitter in the sympathetic system and final output transmitter in the parasympathetic system),

and is even involved in non-neuronal signalling. ACh can bind to two main types of receptors:

– nicotinergic ACh (nACh) receptors (ionotropic): fast-acting ligand-gated non-selective cation channels: increased

permeability to Na + and K + (and sometimes Ca 2+ , depending on subunit composition) induces an excitatory postsynaptic

potential (EPSP) in neurons; nicotine is a selective agonist

– muscarinergic ACh (mACh) receptor (metabotropic): slow-acting monomeric receptors with 7 transmembrane

domains coupled to G-proteins (Gα q

or Gα i/o

depending on the receptor subtype). There are 5 subtypes of mACh

receptors with different effectors, thus the downstream signalling varies depending on the subtype; muscarine is a

selective agonist, scopolamine is a high-affinity antagonist

ACh action is terminated by acetylcholine esterase breaking down the molecule into choline and acetate.

26 No. 3 November/Dezember 2022



[1] Stress. Univ Zür https://www.usz.ch/krankheit/stress/ (accessed August 26, 2022).

[2] Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol

2016;188:204–28. https://doi.org/10.1016/j.jep.2016.05.010.

[3] Scholey A, Gibbs A, Neale C, Perry N, Ossoukhova A, Bilog V, et al. Anti-stress effects of lemon balm-containing foods. Nutrients 2014;6:4805–21.


[4] Groom N. The Perfume Handbook. Chapman & Hall; 1992.

[5] Ein Unternehmen mit Tradition: Alles über Klosterfrau erfahren. Klosterfrau | Heilkraft der Pflanzen – wo Wirksamkeit wächst https://www.klosterfrau.de/

ueber-klosterfrau.html (accessed August 26, 2022).

[6] Committee on Herbal Medicinal Products (HMPC). Assessment report on Melissa officinalis L., folium (EMA/HMPC/196746/2012). Eur Med Agency


[7] ESCOP. MELISSAE FOLIUM Melissa Leaf. ESCOP Monographs 2009;2nd Edition:324–8.

[8] Wichtl M. Teedrogen und Phytopharmaka. 5 th Edition 2009.

[9] Bruni O, Ferini-Strambi L, Giacomoni E, Pellegrino P. Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep. Nutrients

2021;13:530. https://doi.org/10.3390/nu13020530.

[10] Wake G, Court J, Pickering A, Lewis R, Wilkins R, Perry E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve

failing memory. J Ethnopharmacol 2000;69:105–14. https://doi.org/10.1016/s0378-8741(99)00113-0.

[11] Kennedy DO, Wake G, Savelev S, Tildesley NTJ, Perry EK, Wesnes KA, et al. Modulation of mood and cognitive performance following acute administration

of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties. Neuropsychopharmacol

2003;28:1871–81. https://doi.org/10.1038/sj.npp.1300230.

[12] Kennedy DO, Scholey AB, Tildesley NTJ, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa

officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953–64. https://doi.org/10.1016/s0091-3057(02)00777-3.

[13] Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).

Psychosom Med 2004;66:607–13. https://doi.org/10.1097/01.psy.0000132877.72833.71.

[14] Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-tomoderate

anxiety disorders and sleep disturbances. Mediterr J Nutr Metab 2011;4:211–8. https://doi.org/10.1007/s12349-010-0045-4.

[15] Fikree A, Byrne P. Management of functional gastrointestinal disorders. Clin Med Lond Engl 2021;21:44–52. https://doi.org/10.7861/clinmed.2020-


[16] Aubert P, Guinobert I, Blondeau C, Bardot V, Ripoche I, Chalard P, et al. Basal and Spasmolytic Effects of a Hydroethanolic Leaf Extract of Melissa officinalis

L. on Intestinal Motility: An Ex Vivo Study. J Med Food 2019;22:653–62. https://doi.org/10.1089/jmf.2018.0154.

[17] Sadraei H, Ghannadi A, Malekshahi K. Relaxant effect of essential oil of Melissa officinalis and citral on rat ileum contractions. Fitoterapia 2003;74:445–

52. https://doi.org/10.1016/s0367-326x(03)00109-6.

[18] Worrall G. Herpes labialis. BMJ Clin Evid 2009;2009:1704.

[19] Wölbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine Int J Phytother Phytopharm

1994;1:25–31. https://doi.org/10.1016/S0944-7113(11)80019-X.

[20] Koytchev R, Alken R, Dundarov S. Balm mint extract (Lo-701) for topical treatment of recurring herpes labialis. Phytomedicine Int J Phytother Phytopharm

1999;6. https://doi.org/10.1016/S0944-7113(99)80013-0.

For more information, please contact

Dr Annette Masuch,

Regulatory Affairs Manager

Anklam Extrakt GmbH, Germany


Photo © : Adobe Stock/GCapture

No. 3 November/Dezember 2022



The hyper-specialization of anti-stress solutions

Laure Egoumenides

Stress is a protective reaction of the body when it is in a situation of

perceived danger or when faced with a major challenge. Considered

the defining disease of the 21 st century due to its association with

negative emotions, stress is a major general health problem.

The global prevalence of anxiety and depression has increased by a

massive 25 % since the Covid-19 pandemic. In 2020, 29.6 % of the

world population were reported to be suffering from stress, 31.9 %

with anxiety and 33.7 % depression. 1

Exposure to stress is not without consequences; it results in several

psychological and physical disorders such as burn out, irritability,

physical and emotional exhaustion, eating disorders or even bodily

dysfunction when this exposure is prolonged. Consumers are therefore

looking for effective solutions to relieve their stress-related


The stress management market is well-established and mature.

Sales for anxiety/stress relief dietary supplements in 2020 have

grown by 79 % since 2018. 2 Thus, there is a wide variety of solutions

and becoming more and more specialized. They respond to different

levels of stress e. g., temporary stress, anxiety and depression, as

well as to the consequences of stress, such as sleep disorders, mood

swings and variations in immune function.

The mechanisms of stress and its consequences

The mechanisms of stress

Stress reactions are triggered by a stimulus. This stimulus can be of

a number of different kinds. Modern sources of stress include work,

geopolitical and climatic conditions, family situations and changes in

daily life.

The body reacts to this stimulus in several phases

The alarm phase immediately follows the stimulus. This is an immediate

survival reaction involving, in particular, the release of adrenaline.

This induces an increase in heart rate, body temperature and

blood pressure. Thus, the body’s vigilance is at its peak, entering

“fight or flight” mode in order to get out of the stressful situation as

quickly as possible.

Then comes the resistance phase. This corresponds to a prolonged

period of stress. The body secretes cortisol, which stimulates the

metabolism of glucose. The released glucose supplies the organs

28 No. 3 November/Dezember 2022


with energy, which allows the body to defend itself and adapt. It also

releases dopamine and serotonin which increase concentration and


Finally, if the period of exposure to stress is prolonged, the exhaustion

phase arrives (corresponding to burn out, depression or chronic

stress disorders). The metabolism is disrupted, and the body

becomes physically and psychologically exhausted.

The consequences of exposure to stress

The consequences of stress are multiple, and manifest themselves

in different ways:

– Poor sleep quality and/or excessive fatigue

– Irritability and/or poor emotional management

– Eating disorders (loss of appetite or, on the

contrary, compulsive eating)

– A lack of productivity, concentration, memory problems

– And many others...

Unique bioactive

for Healthy blood sugar levels

In addition to general malaise, exposure to stress can lead to metabolic

dysfunctions. The hormonal cascade leads in particular to the

secretion of molecules of the corticoid family, responsible for disturbances

in the body’s oxidative status. These molecules can be

responsible for mood disorders such as irritability or anxiety.

The resulting oxidative damage has a signifi cant impact on health

and well-being. Indeed, the excess of free radicals in the body (linked

to oxidative stress) degrade cells and certain metabolites, leading to


Composed of 60 % lipids and representing more than 20 % of our

total oxygen consumption, our brain is particularly sensitive to oxidative


Several studies suggest that oxidative stress may have a role to

play in the onset of feelings of stress and anxiety. There is therefore

a link between oxidative metabolism and the management of

anxiety disorders.

Moreover, stress is also associated with abnormal inflammatory

activity, impacting the digestive system and the intestinal microbiota.

Finally, it induces increased risks of cardiovascular and immune


Stress regulation:

hyper-specialized solutions

There are many ways to manage stress naturally. It is important to

adapt one’s diet in order to promote the development of the intestinal

microbiota. Indeed, the microbiota has a great influence on the ability

to manage stress, especially because the intestine produces 95 % of

serotonin (the so-called “happiness hormone”), and this secretion is

induced by the intestinal microbiota.








No. 3 November/Dezember 2022



Stress is a phenomenon that is becoming

increasingly well known: numerous scientific

studies have looked into its mode of action,

as well as its impact on the metabolism,

the brain, and mental states. Thanks to this

in-depth knowledge of stress, the nutraceutical

industry can offer solutions that respond

to extremely specific problems. Thus, we

can observe different categories of solutions:

Robertet Health & Beauty has therefore

developed an ingredient with clinically proven

efficacy to help relieve stress. A unique melon

juice concentrate, Extramel ® is obtained from

a patented process of cantaloupe, grown

exclusively in the South of France.

Naturally rich in SOD (Superoxide Dismutase),

a powerful anti-oxidant, Extramel ® helps overcome

feelings of stress: people who take

Extramel ® experience less irritability and

weariness, and enjoy a better quality of life.

The development of anti-stress solutions is

thus no longer limited to offering products

that only reduce stress. It is now essential to

also target the consequences and even the

causes of stress.

Solutions responding to different degrees

of stress

– Temporary stress

– Intense stress

– Oxidative stress

– Anxiety

Solutions acting on stress and its consequences

– Stress and reduction of fatigue

– Stress and sleep quality

– Positive mood

– Stress and immunity

– Stress and energy

Solutions targeting a specific problem

related to stress

– Nervous balance

– Cardiovascular system and oxidative stress

– Calming emotional stress

– Relaxation

– Physical and mental resistance to stress

There is therefore a real challenge ahead for

players positioning themselves in the stress

market in three key areas:

– Scientific support, which plays a crucial

role: this allows players to demonstrate

modes of action and the effectiveness of

the solutions, thus justifying their positioning

– The combination of effective ingredients to

meet several objectives (treating stress

and fatigue for example), without negative

interactions between the active ingredients

– The use of holistic ingredients to relieve

different ailments

For more information, please contact

Laure Egoumenides, Product Manager

Robertet S.A., France


Fig. 1: Secondly, Extramel ® helps maintain cognitive and physical performance by significantly increasing

mental concentration and decreasing fatigue, sleep disorders and physical pain.

Fig. 2: In fact, by targeting oxidative stress, Extramel ® acts on both the consequences of stress and

its possible causes. It therefore allows for the development of holistic solutions, which will help attain

several objectives.



OMS. Les cas d’anxiété et de dépression sont en hausse de 25 % dans le monde en raison de la pandémie de COVID-19.

Mars 2022


Francis E. COVID-19 Stress Drives Anxiety-Reducing Supplement Sales Up 79 % In US Since 2018. HBW Insight. 30 Apr

2021. Retrieved July 22, 2021

30 No. 3 November/Dezember 2022


Cultivating a sustainable source of

a stress-busting adaptogen

Growing demand for Rhodiola rosea is creating pressure on wild-harvested supplies. Nektium’s Deborah

Thoma explains how a pioneering cultivation strategy is delivering a sustainable solution

Deborah Thoma

Physical and emotional stress are part of

everyday life for people all over the world

– and the impacts can be severe. In fact,

stress-related non-communicable diseases

such as coronary artery disease, diabetes,

and cancer have been described as “the

major health crisis in the 21 st century.” 1 In

this context, it is little surprise that adaptogens

– ancient plants and herbs that can

help the body adapt to stress – are seeing a

significant increase in demand. 2

The term adaptogen was coined by Dr.

Nikolai Lazarev in 1947 and referred to

substances that meet three criteria. First,

they need to help the body contend with an

array of conditions, such as physical, chemical,

or biological stress. Secondly, they must

regulate homeostasis, which means either

offsetting or resisting physical disorders resulting from external stress.

Thirdly, they must not damage the body’s normal function. 3

While there are many adaptogens on the market today, Rhodiola

rosea, primarily growing wild in the remote Altai mountains, is the

one that best matches Dr. Lazarev’s original definition.

Sustainable sourcing

With demand for Rhodiola rosea accelerating, there is now considerable

pressure on wild supplies – leading to concerns around overharvesting.

Botanical extract manufacturer Nektium is therefore

taking steps to secure the long-term sustainability of its standardized

Rhodiola rosea extract by switching a significant proportion of its

sourcing to cultivated plants.

The company is implementing this pioneering cultivation strategy in

close cooperation with its long-standing partner in the Altai mountains.

The material used to grow the cultivated Rhodiola rosea for

No. 3 November/Dezember 2022



presents significant challenges, especially in maintaining the levels

of actives. Nonetheless, the company’s vegetative propagation technique

is not only faster and more reliable but ensures that the molecular

composition of the cultivated Rhodiola rosea is identical to the

wild-grown plant. This achievement was the outcome of many years

of experimentation, testing, and refinement of techniques.

Growing Rhodiola rosea in a controlled setting also limits unknown

factors and results in a more predictable and secure long-term raw

material supply. Cultivation means improved price stability, superior

safety, and more effective quality control. With a Quality Assurance

system put in place with Good Agricultural and Collection Practices

(GACPs) governing rules of production, harvesting, storage, and record

keeping is monitored. This is accompanied by training programs, as

well as traceability and recall plans, all of which has allowed the initiative

to be established as a successful long-term project.

Harnessing the benefits

Rhodiola rosea’s adaptogenic activity is usually attributed to four

principal active compounds – salidroside, rosin, rosavin, and rosarin

– which are found at high concentrations in the roots. Ensuring the

final ingredient delivers the appropriate quantity of the desired bioactive

components is a task that requires skill and care. Apart from the

expertise in manufacturing the botanical extract, an understanding

for how growing conditions affect the plants and, in turn, when to

harvest them, while putting in place a quality management system

together with the local partner, was developed.

Rhodiola rosea is an extremely hardy plant that is well suited to the

harsh weather conditions in the Altai mountains. The coldest months

are January and February, when the average temperature falls as low

as -15°C. The snow usually begins to melt in early May, providing the

plants with a short window in which to grow.

The bioactive compounds in the Rhodiola rosea root reach their

highest levels between three and five years of growth. If harvested

too early, the overall level of actives is likely to be substantially lower.

Through visual inspection and by analyzing climatic conditions, it is

possible to determine the ideal time to harvest the plant.

the ingredient was originally taken from wild-harvested plants from

the area where the cultivation fields are now established. To ensure

the plant will flourish, Nektium has worked with its partner to establish

fields that offer optimal conditions for the controlled growing of

Rhodiola rosea.

Barren land in undeveloped and unpopulated locations was

selected for conversion to ensure minimal impact on local communities.

Subsequent expansion of the initial cultivated area has been

carried out not from seeds but through vegetative propagation of root

rhizomes extracted from the cultivated Rhodiola rosea. Cultivation

Scientific research

Rhodiola rosea is supported by centuries of traditional use for mental

and physical stress. In the modern era, studies have found that it offers

a range of cognitive health benefits, including reduced stress and

fatigue as well as improved mental sharpness. In addition, Rhodiola

rosea has been shown to deliver a boost to athletic performance by

aiding recovery and enhancing immune health after exercise. 4

A pilot study set out to evaluate whether the ingredient can reduce

symptoms of generalized anxiety disorder (GAD). Ten participants

with a DSM-IV diagnosis of GAD received a total daily dose of 340 mg

32 No. 3 November/Dezember 2022




Fricchione, G.L. 'The Challenge of Stress-Related Non-Communicable Diseases' Medical

Science Monitor Basic Research (2018)


NielsenIQ 'What are nootropics and adaptogens?' (2022)


Liao, L.Y. et al. 'A preliminary review of studies on adaptogens: comparison of their bioactivity

in TCM with that of ginseng-like herbs used worldwide' Chinese Medical Journal



Stojcheva. E.I. et al. “The Effectiveness of Rhodiola rosea L. Preparations in Alleviating

Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions—Encouraging

Clinical Evidence.” Molecules (2022)


Bystritsky, A. et al. 'A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder

(GAD)' Journal of Integrative and Complementary Medicine (2008)


Abidov, M. et al. 'Extract of Rhodiola rosea radix reduces the level of C-reactive protein

and creatinine kinase in the blood' Bulletin of Experimental Biology and Medicine (2004)


Ahmed, M. et al. 'Rhodiola rosea Exerts Antiviral Activity in Athletes Following a Competitive

Marathon Race' Frontiers in Nutrition (2015)

of the Rhodiola rosea extract over a period of ten weeks. Significant

improvements in symptoms, with reduced scores on both the

Hamilton Anxiety Rating Scale and the Four-Dimensional Anxiety and

Depression Scale were demonstrated. 5

Rhodiola rosea extract also has a long history of use among professional

athletes to improve endurance and rapid recovery of muscles.

A double-blind placebo-controlled study explored the effects of the

ingredient on blood levels of inflammatory C-reactive protein (CRP)

and creatinine kinase (CK) before and after exhausting exercise.

Among 36 healthy, untrained volunteers, the extract was found to

exhibit an anti-inflammatory effect and protect muscle tissue during

exercise. Blood levels of CRP were less pronounced among those

taking the Rhodiola rosea extract, while the exercise-induced rise in

CK was also blunted. 6

A further study provided evidence that the ingredient can increase

immune protection after sports. Marathon runners are prone to viral

illnesses shortly after competing in a race. A study set out to measure

the antiviral and antibacterial properties of the bioactive metabolites of

Rhodiola rosea in the serum of experienced marathon runners. The

study found that the use of Rhodiola rosea induced antiviral activity at

early times post-infection by delaying an exercise-dependent increase

in virus replication. This suggests it exerts protective effects against

virus replication following intense and prolonged exercise. 7

For more information, please contact

Deborah Thoma

Marketing Manager

Nektium Pharma S.L.








Plant power


As one of the most powerful adaptogens found in nature, Rhodiola

rosea is seeing a surge in popularity. Rhodiolife ® is a sustainably

produced root extract with a phytochemical profile that reflects all the

natural active ingredient content of the wild Siberian Rhodiola rosea

in terms of both composition and relative concentrations. It is ideally

suited to supplements and can also be used across a wide range of

food and beverage applications, including sports and energy drinks,

dairy products, gummies, and cereal bars.




Supported by scientific research, the ingredient offers wide-ranging

benefits for product development objectives across sports and

cognitive health.

No. 3 November/Dezember 2022


Brain health

Photo © : Fotolia/Okea

Phospholife ®

Highly bioavailable solution for brain health

Stephanie Lennon, Gildas Breton

Phospholife ® is an innovative patented vegan solution, made of

sustainable and highly bioavailable resources. It brings high content

of pure and ultra-stable Omega-3 (DHA) from microalgae and phospholipids

very rich in Phosphatidylcholine. This solution gives higher

bioavailability than standard Omega-3 oils (TG & EE) and it has been

specially designed to target brain health through all stages of life:

from the beginning of intrauterine life to the maintenance of cognitive

faculties in the elderly.

DHA, an essential fatty acid for brain development

and cognitive maintenance

DHA (Docosahexaenoic acid) is an essential long-chain polyunsaturated

fatty acids (PUFAs) Omega-3, highly concentrated in the

brain and retina, which is critical for normal nervous development

and function. DHA accounts for up to 97 % of the Omega-3 fatty

acids in the brain and 93 % of the omega-3 fatty acids in the eyes.

The presence of DHA in the membranes helps for the optimal functioning

of membrane receptors and transporters, signal transduction

and neurotransmission. Furthermore, DHA counteracts pro-inflammatory

effect of Omega 6 arachidonic acid (AA), and the metabolites

of DHA (resolvins, protectins, maresins) play critical roles in the resolution

of inflammation.

Most studies indicates that the DHA accumulation is mainly influenced

by dietary intake, specifically of preformed DHA.

Maternal DHA supplementation and brain development

DHA intake is most important during pregnancy and lactation for

both mom and baby alike. During the prenatal time, there is a very

high demand and rapid accumulation of specific fatty acids including

AA and DHA in the infant brain. The human brain relies on DHA

for proper growth and development. The most active accumulation

occurs during gestation until the age of 2 years and continues until

the age of 18 years. DHA can be synthetized from its essential fatty

acid precursor, α-linolenic acid (ALA). However, the capacity of brain

for synthesizing DHA is very limited especially in early life stage, thus

this fatty acid is mainly supplied via the uteroplacental circulation

during pregnancy and the breast milk during nursing. Because the

mother is the sole source of DHA for the developing baby, it is critical

that a pregnant, and nursing-, mother consumes enough Omega-3s

to ensure brain development for her baby. [1-2]

The composition of human breast milk reflects the nutritional status

and dietary intake of the lactating mother. Over the first 6 months of

life, which is the time exclusive breastfeeding is recommended, the

34 No. 3 November/Dezember 2022

Brain health

with age-related cognitive decline and mild cognitive impairment,

particularly for improving memory. [5-6]

Choline, an essential nutrient for brain health

Choline is recognized by the National Academy of Medicine as an

essential nutrient that must be acquired from diet, as de novo biosynthesis

is insufficient to meet human requirements. Choline plays a

key role in lipid transport and cell membrane structural support (as

phosphatidylcholine), neurotransmission (as acetylcholine), and as a

source of methyl group (as a precursor of betaine).

infant brain doubles in weight, and the large

brain/body weight ratio for infants compared

with adults may put the infant at greater risk

to deficits in nutrients and energy. Much

of the increase in brain weight is attributed

to increased grey matter, corresponding to

the formation of neural synapses which are

rich in DHA. Neurite outgrowth, dendritic

complexity and neurotransmitter metabolism

are also highly reliant on DHA.

DHA supplementation

and brain health

Photo © : Fotolia/Monkey Business

Under its ability to control membrane

fluidity, the DHA also modulated neuronal

density, neurotransmitter concentration, and

synaptic activity by regulating the brain’s

neuro-inflammatory state. Neurons are

the core component of the central nervous

system and are exceptionally rich in DHA. A

diet deficient in DHA will deprive the nervous

system of a critical nutritional component

that could impair your body’s ability to learn,

think, and remember. [3-4]

DHA has been shown to accumulate in areas

of the brain associated with learning and

memory, cerebral cortex and hippocampus.

DHA helps maintaining healthy brain at all

stages of life. The current evidence suggests

that DHA may be of benefit for older adults

In addition to the role of choline in general physiology, choline is critically

during pregnancy. Lower serum choline levels are associated

with increased risk of neural tube defects [7], suggesting that choline

intakes should be increased prior to pregnancy. Choline, transferred

across the placenta from the mother to the foetus, plays a significant

role in foetal development, and particularly brain development. It has

been observed that prenatal choline is essential to the neurophysiological

development of the hippocampus, the so-called “Memory

Centre” of the brain. Furthermore, Choline is needed after birth, as

well, as part of the synaptic connections that continue to be formed

in the hippocampus and basal forebrain after birth. [8-9] Moreover, in

a recent clinical study at Cornell University, increased choline intake

during pregnancy was correlated with improved processing speed in

infants. [10]

Choline is also an essential nutrient for cognitive performance.

Choline has been shown to be associated with lower risk of incident

dementia and better cognitive performance in men. [11] A

reduction in acetylcholine, an essential neurotransmitter for memory

and learning synthesised from choline, has been observed among

patients with Alzheimer’s disease. [12]. Furthermore, researches

have shown the neuroprotective effect of choline supplementation.

[13-14] Another study has shown that Choline supplementa-

Photo © : Adobe Stock/Alex Mit

No. 3 November/Dezember 2022


Brain health

tion is associated with improved cognitive function among young

and middle-aged adults. [15] And to complete the picture, a recent

study has shown that Choline intake has a protective effect on cognitive

function, including learning ability, processing speed, sustained

attention, and working memory. [16]

Phospholife ® , a highly available solution for the brain

DHA and advance memory-related behaviour in mice expressing

human Apolipoprotein E4 (APOE4). Indeed, APOE4 human genotype

was related to cognitive decline and risks of age-related neurological

disorders. A decrease of APOE4 could be related to low levels

of DHA, thus suggesting that a long-term treatment rich with DHA

can protect from neurodegenerative disease. [22]

DHA & Choline are both important components in our brain and

increased intake is better for brain development. The form in which

these two specific nutrients are consumed is important for their

uptake and use in the body. Indeed, DHA and Choline need to cross

2 barriers on the way to our brain: the intestinal barrier and the highly

selective blood-brain barrier (BBD).

DHA as part of this solution is under Re-esterified triglyceride form

(rTG), which has been shown to have a higher index of bioavailability

(124 %) compared to natural triglycerides, free fatty acids

and ethyl-esters forms. Besides, bioavailability of DHA is enhanced

by the plant-based phospholipids. Indeed, studies have shown that

the association of DHA with Phospholipids allows a better emulsification,

increasing the speed of gastrointestinal hydrolysis which

is a crucial step for Omega 3 biovailability. The improvement of

intestinal absorption of Omega 3 would result in a modification of

lipid micellization and would favour the Omega 3 absorption within

enterocytes and would promote the accretion of TG into chylomicrons

in lymph. [17-19]

Fig. 2: Mechanisms of DHA uptake to the brain [24]

Choline, is bound in a lipid-soluble form as phosphatidylcholine,

which is the main form present in tissues. Clinical trials show that

Choline as part of the phospholipids is absorbed to 4 times more efficiently

compared to salt form. [23]

Polaris’ solution

Fig. 1: Polaris illustration

Furthermore, Phosphatidylcholine plays a crucial role in the accretion

of the DHA in the brain. In the liver, the association of Phosphatidylcholine

and DHA leads to Lyso-Phosphatidylcholine-DHA (LPC-

DHA) in sn-2 position, which is the major carrier of DHA responsible

for brain enrichment. Blood DHA is transported across the

BBD more efficiently when esterified at the physi ological sn-2 position

of lyso-phosphat idylcholine. [20] The uptake of LPC-DHA across

the BBD is carried by one transporter, constitutively and exclusively

expressed by brain endothelial cells, named ‘Major facilitator superfamily

domain-containing protein 2A’ (Mfsd2a). The Mfsd2a transports

DHA across the BBD only in the LPC form but not as a nonesterified

fatty acid. [21]

Previous studies highlighted the crucial role of LPC-DHA in brain

development and neuronal cell growth. More recently, studies show

the neuroprotection role of LPC-DHA diets to increase the brain

Polaris’ patented Phospholife ® is the sustainable solution for maintaining

healthy brain at all stages of life via the accretion of DHA

directly to the cerebral cortex and hippocampus which are important

in cognitive functions including memory, thoughts… and for targeting

the brain development of foetus and infant during pregnancy and

lactating. This product is declined in oil and in hard-shell capsules to

meet all development projects. Further bioavailability studies will be

carried out later in 2023.


[1] Brenna JT et al. Docosahexaenoic acid and human brain development: evidence that a

dietary supply is needed for optimal development. J Hum Evol 2012, Apr 26

[2] Shcoltz SA et al. Clinical overview of effects of dietary long-chain polyunsaturated fatty

acids during the perinatal period. Nestel Nutr Inst Workshop Ser 2012;77:145-154

[1] Brenna JT et al. Docosahexaenoic acid and human brain development: evidence that a

dietary supply is needed for optimal development. J Hum Evol 2012, Apr 26

[3] Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim HY. Docosahexaenoic acid

promotes hippocampal neuronal development and synaptic function. J Neurochem

2009;111: 510–521.

[4] Moriguchi T, Greiner RS, Salem N Jr. Behavioral deficits associated with dietary induction

of decreased brain docosahexaenoic acid concentration. J Neurochem 2000;75: 2563–2573

36 No. 3 November/Dezember 2022

[5] Yurko-Mauro et al. 2010. Beneficial effects of docosahexaenoic acid on cognition in

age-related cognitive decline. Alzheimer’s & Dementia 6 456–464

[6] Yurko-Mauro et al. 2015.Docosahexaenoic Acid and Adult Memory: A Systematic Review

and Meta-Analysis. PLOS ONE

[7] Shaw G.M et al. Choline and risk of neural tube defects in a folate-fortified population.

Epidemiology 2009, 20, 714-719

[8] Li Q, Guo-Ross S, Lewis DV, Turner D, White AM, Wilson WA et al. Dietary prenatal choline

supplementation alters postnatal hippocampal structure and function. J Neurophysiol


[9] Albright CD, Tsai AY, Friedrich CB, Mar MH, Zeisel SH. Choline availability alters embryonic

development of the hippocampus and septum in the rat. Brain Res 1999;113:13-20.

[10] Caudill MA, et al. FASEB J, 2017

[11] Amija PT Ylilauri et al. Associations of dietary choline intake with risk of incident

dementia and with cognitive performance : the Kuopio Ischaemic Heat Disease Risk Factor

Study. Am J Clin Nutr. 2019; 110:1416-1423

[12] W. M. Mcdonald and C. B. Nemeroff, “Neurotransmitters and neuropeptides in Alzheimer’s

disease,” Psychiatric Clinics of North America, vol. 14, no. 2, pp. 421–442, 1991.

[13] R. A. Bekdash, “Neuroprotective effects of choline and other methyl donors,” Nutrients,

vol. 11, no. 12, 2019.

[14] J. K. Blusztajn, B. E. Slack, and T. J. Mellott, “Neuroprotective actions of dietary

choline,” Nutrients, vol. 9, no. 8, 2017.

[15] C. Poly, J. M. Massaro, S. Seshadri et al., “The relation of dietary choline to cognitive

performance and white-matter hyperintensity in the Framingham Offspring Cohort1234,”

The American Journal of Clinical Nutrition, vol. 94, no. 6, pp. 1584–1591, 2011.

[16] Lu Liu, Song Qiao, Liying Zhuang, Shanhu Xu, Linhui Chen, Qilun Lai , and Wenfeng

Wang (2021). Choline Intake Correlates with Cognitive Performance among Elder Adults in

the United States. Behavioural Neurology Volume 2021, Article ID 2962245.

[17] Cansell M., Nacka F. and Combe N. (2003). Marine Lipid-Based Liposomes Increase in

vivo Fatty Acid Bioavailability. Lipids, Volume 38, N°5, 10p

[18] Garaiova I., Guschina I.A., Plummer S.F., Tang J., Wang D. and Plummer N.T. (2007). A

randomised cross-over trial in healthy adults indicating improved absorption of omega-3

fatty acids by pre-emulsification. Nutrition Journal, Volume 6, Issue 4, 9p.

[19]Pafumi Y., Lairon D., De la Porte P.L., Juhel C., Storch J., Hamosh M. and Armand M.

(2002). Mechanisms of Inhibition of Triacylglycerol Hydrolysis by Human Gastric Lipase. The

Journal of Biological Chemistry, Volume 277, N°31, p28070-28079.

[20] Mayssa Hachem et al. Efficient docosahexaenoic acid uptake by the brain from a

structured phospholipids. Mol Neurobiol. 2016 Jul;53(5):3205-3215

[21] Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL et

al (2014) Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic

acid. Nature 509:503–506

[22] Mayssa Hachem et al. Emerging role of phospholipids and lysophospholipids for

improving brain docosahexaenoic aicd as potential preventive and therapeutic strategies

for neurological diseases. In J Mol Sci. 2022 Apr; 23(7): 3969

[23] Yvonne Mödinger et al. Plasma Kinetics of Choline and Choline Metabolites After A

Single Dose of SuperbaBoostTM Krill Oil or Choline Bitartrate in Healthy Volunteers. Nutrients.

2019 Oct; 11(10): 2548.

[24] DhavamaniSugasini et al. Potential role of hepatic lipase in the accretion of docosahexaenoic

acid (DHA) by the brain. (BBA) - Molecular and Cell Biology of Lipids, Volume

1866, Issue 10, October 2021

For more information, please contact

Stephanie Lennon,

Product development manager

Gildas Breton, R&D Director

Polaris, France

No. 3 November/Dezember 2022

Heart and brain health

Photo © : Stockphoto/unsplash

With heart and brain: leading a healthy life

Astaxanthin, the red diamond amongst free radical scavengers, supports physical and mental fitness

Katharina Müller, Monika Siebel

Natural astaxanthin has a strong inflammatory effect and is highly

efficient fighting against reactive oxygen species (ROS). Astaxanthin’s

power as strongest antioxidant has lately become increasingly known.

Thanks to its special chemical structure, natural astaxanthin can pass

the blood-brain barrier and take full effect – a property that only few

compounds possess.[1] Furthermore, the blood flow within the body

is impacted in a positive way by an oral intake of natural astaxanthin,

which is not only of great significance for cardiovascular health but

also improves oxygen and nutrient transport to/towards the human

brain.[2] A clinical study from 2019 has proven the holistic positive

effect of natural astaxanthin on the psychophysiological heart-brain

axis and enables new applications of the red diamond as co-therapeutic


The positive effect of natural

asta xanthin on the cardiovascular

system and on the brain

Chronic inflammations and increased oxidative

stress significantly add to cardiovascular

diseases and arteriosclerosis. In the case of

arteriosclerosis, fat is deposited at the inner

lining of the arterial walls, oxidates and may

cause inflammations in the body. This can

lead to a dangerous accumulation of plaques

which constrict arteries and restrict perfusion

and oxygen supply.[4],[5]

38 No. 3 November/Dezember 2022

Heart and brain health

Astaxanthin obstructs the oxidation of lowdensity

lipoprotein (LDL) and raises the level

of high-density lipoprotein (HDL) cholesterol

and adiponectin, a fat tissue hormone that

is, together with other hormones, responsible

for the regulation of the energy metabolism.

Adiponectin originates from fat tissue

and influences insulin activity in the glucose

and fat metabolism. Extensive studies have

demonstrated that astaxanthin can act preemptively

against arteriosclerotic cardiovascular

diseases as it may alleviate oxidative

stress and resultant inflammations as well as

lipid and glucose metabolism.[6],[7]

Cardioprotective effects of natural astaxanthin

have, for instance, been ascertained

in a clinical, randomised, placebocontrolled

double-blind study. In the study,

44 probands with type 2 diabetes were daily

supplemented with 8 mg of asta xanthin

over 8 weeks. The intake of astaxanthin led

to a significant increase of the adiponectin

concentration in the serum (p < 0.05) and

to a reduction of the visceral body fat mass. Moreover, a significant

astaxanthin-induced reduction of triglyceride and LDL cholesterol in

the blood and a lowering of the systolic blood pressure were demonstrated.[7]

These results affirmed findings from previous studies and

illustrated the high potential of natural astaxanthin to pre-emptively

counteract arteriosclerotic cardiovascular diseases. Cognitive health

also plays a major role in maintaining all important body functions.

In some ways, our brain is the control centre of the body. Due to

several blood vessels, it has high oxygen consumption and is susceptible

to oxidative stress. Especially with advancing age, natural antioxidative

enzymes in the body become less effective, through which

inflammations and, consequently, neurodegenerative diseases may

occur. Astaxanthin is one of the less known compounds that can overcome

all the blood-brain barrier by which its antioxidative properties

are also enhanced in the human brain.[8],[9]

A randomised placebo-controlled double-blind study with 89 participants

has shown that a 3-months nutritional supplement with a daily

dose of 12 mg of natural astaxanthin influences the cognitive performance

of older probands. In this clinical study, various parameters to

determine the cognitive performance like working memory, delayed

memory to measure accuracy or short-term working memory were

significantly enhanced in participants supplemented with astaxan-

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Heart and brain health

thin. Probands who had been complaining of age-related obliviousness,

showed better results regarding mental performance and multitasking.[10]

Positive influences of natural astaxanthin on the psychophysiological

hearth-brain axis

Heart and brain communicate in various ways with each other. Best

known are the communication regarding the nervous system and

the electrical impulses that are triggered; in this context, particularly

the sympathetic and parasympathetic nervous system can be

mentioned. The sympathetic nerve fibres originate in the cervical

ganglions and are also termed cardiac nerves (Nervi cardiaci); they

are responsible for the acceleration of the heart rate. The parasympathetic

nerve fibres that are responsible for relaxation and the deceleration

of the heart rate stem from the tenth cranial nerve. These nerve

fibres end in a neuroplexus, the so-called Plexus cardiacus, at the

base of the heart. The stimulation of the Nervus vagus as therapeutic

agent for various diseases plays a central role in today’s research (see

Fig. 1).[12],[13]

tion), investigation of the psychological state by a validated survey

regarding the profile of mood state (POMS) as well as the evaluation

of the global mood. The results of the astaxanthin reference group

were astonishing.

The probands with astaxanthin supplementation showed a significant

decrease of the average heart rate at submaximal stress intensity by

10 percent compared to the placebo group. As shown in Table 1,

their heart beats per minute (bpm) could be reduced significantly

after an 8-week supplement at the aerobic (AeT) as well as at the

anaerobic (AT) threshold. This suggests a substantial easing of the

cardiovascular system. After the astaxanthin supplementation, the

probands did manual work at reduced heart rate and, hence, with

higher cardiovascular efficiency, and were altogether more powerful.

Table. 1: The heart rates of the aerobic (AeT) and the anaerobic threshold

(AT) were significantly lower after the supplementation of natural astaxanthin

compared to PL (AeT; astaxanthin 130+17 vs. PL 145+14 and AT;

astaxanthin 139+20 vs. PL 154+11, p < 0.05), suggesting that the astaxanthin

probands were able to do a certain degree of manual work with lower

relative intensity or higher cardiovascular efficiency. Modified illustration

based on the data from the study by S. Talbott et al., Effect of Astaxanthin

supplementation on psychophysiological heart-brain axis dynamics in

healthy subjects.[3]

Fig. 1: Schematic diagram of the efferent (motoric) projections of the parasympathetic

autonomic nervous system (ANS). Postganglionic axons from

ganglionic cells innervate the heart (deceleration of the heart rate, reduction

of the heart contractility) and other organs.[12]

Most recent studies from the year 2020 addressed that heart-brain

axis and analysed the significance of antioxidants like natural astaxanthin

in connection with cardiovascular and cognitive health. In

this randomised, placebo-controlled double-blind study, 28 healthy

probands were supplemented with a daily dose of 12 mg of natural

astaxanthin or with a respective placebo over 8 weeks. The interaction

of the heart-brain axis was determined through cardiovascular

stress tests (measuring of heart rate and oxygen consump-

Furthermore, there were significant improvements in the astaxanthin

group regarding the evaluation of the psychological state. The parameters

for tension, depression, anger, tiredness and confusion were

significantly reduced and suggested an altogether positive state of

mind. Natural astaxanthin, thus, influences the psychophysiologi cal

heart-brain axis verifiably positively and substantially supports the

physical and mental wellbeing.[3]


An intake of micronutrients of highly dosed natural astaxanthin of

12 mg significantly contributes to physical and mental fitness. While

earlier studies have shown how astaxanthin positively influences

heart health and the cognitive performance, the herein presented

results are the first to prove that supplementation with natural asta-

40 No. 3 November/Dezember 2022

Heart and brain health

xanthin supports the psychophysiological

heart-brain axis with simultaneous enhancement

of the physical and mental wellbeing.

In addition to these psychophysiological

benefits for the heart-brain axis, the results

suggest that a supplementation with natural

astaxanthin from the microalga Haematococcus

pluvialis as co-therapeutic agent

can support persons with physical and

psychological needs. Particularly in old age,

the degree of free radicals can be reduced

through taking antioxidants as by doing so,

endogenous antioxidative enzymes increasingly

lose effect. However, also long-distance

and ultra-distance endurance athletes (e. g.,

marathon runner, ironman triathletes and

ultra-runner/-cyclists) benefit from nutritional

supplementation with antioxidants as

the physiological endurance as well as the

psychological balance are strained, and

their support could be a new approach to

enhance the physical/mental performance.

Due to the double effect of natural astaxanthin

on the health of heart and brain, future

studies will be even more important to also

support other groups of persons signifi cantly.

[9] S. Fakhri, I. Y. Aneva, M. H. Farzaei, and E. Sobarzo-Sánchez, “The neuroprotective

effects of astaxanthin: Therapeutic targets and clinical perspective,” Molecules, vol. 24,

no. 14, pp. 1–19, 2019.

[10] M. Katagiri, A. Satoh, S. Tsuji, and T. Shirasawa, “Effects of astaxanthin-rich Haematococcus

pluvialis extract on cognitive function: a randomised, double-blind, placebocontrolled

study,” J. Clin. Biochem. Nutr., pp. 2012–2013.

[11] D. Zanotta, S. Puricelli, and G. Bonoldi, “Cognitive effects of a dietary supplement

made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in

subjects with mild cognitive impairment: A noncomparative, exploratory clinical study,”

Neuropsychiatr. Dis. Treat., vol. 10, pp. 225–230, 2014.

[12] M. J. Capilupi, S. M. Kerath, and L. B. Becker, “Vagus nerve stimulation and the cardiovascular

system,” Cold Spring Harb. Perspect. Med., vol. 10, no. 2, pp. 1–18, 2020.

[13] E. Al et al., “Heart-brain interactions shape somatosensory perception and evoked

potentials,” Proceedings of the National Academy of Sciences of the United States of

America, vol. 117, no. 19. pp. 10575–10584, 2020.

For more information, please contact

Katharina Müller

Monika Siebel

BDI-BioLife Science



[1] C. Galasso et al., “On the neuroprotective role of astaxanthin:

New perspectives?,” Mar. Drugs, vol. 16, no. 8, pp.

1–16, 2018.

[2] H. Miyawaki, J. Takahashi, H. Tsukahara, and I. Takehara,

“Effects of astaxanthin on human blood rheology,” J.

Clin. Biochem. Nutr., vol. 43, no. 2, pp. 69–74, 2008.

[3] S. Talbott, D. Hantla, B. Capelli, L. Ding, Y. Li, and

C. Artaria, “Effect of Astaxanthin supplementation on

psychophysiological heart-brain axis dynamics in healthy

subjects,” Funct. Foods Heal. Dis., vol. 9, no. 8, pp.

521–531, 2019.

[4] F. Visioli and C. Artaria, “Astaxanthin in cardiovascular

health and disease: Mechanisms of action, therapeutic

merits, and knowledge gaps,” Food Funct., vol. 8, no. 1,

pp. 39–63, 2017.

[5] K. Cervantes Gracia, D. Llanas-Cornejo, and H. Husi,

“CVD and Oxidative Stress,” J. Clin. Med., vol. 6, no. 2, p.

22, 2017.

[6] Y. Kishimoto, H. Yoshida, and K. Kondo, “Potential antiatherosclerotic

properties of astaxanthin,” Mar. Drugs, vol.

14, no. 2, pp. 1–13, 2016.

[7] N. S. Mashhadi, M. Zakerkish, J. Mohammadiasl, M.

Zarei, M. Mohammadshahi, and M. H. Haghighizadeh,

“Astaxanthin improves glucose metabolism and reduces

blood pressure in patients with type 2 diabetes mellitus,”

Asia Pac. J. Clin. Nutr., vol. 27, no. 2, pp. 341–346, 2018.

[8] M. Perluigi et al., “Redox proteomics identification of

4-hydroxynonenal-modified brain proteins in Alzheimer’s

disease: Role of lipid peroxidation in Alzheimer’s disease

pathogenesis,” PROTEOMICS – Clin. Appl., vol. 3, no. 6, pp.

682–693, Jun. 2009.



natural remedy for stress relief,

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Ph. Eur. compliant lemon balm

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For further information

send us an e-mail


or visit our website:


No. 3 November/Dezember 2022


Skin health

Photo © : Yuri Arcurs

Protection and stimulation

Natural astaxanthin and bioactive collagen peptides are proven

to improve skin health from the inside out

Behnaz Shakersain, Oliver Wolf

Let’s go on a journey into the past. We are on a beach or at an outdoor

pool; all around us are people sunbathing … just lying in the blazing

heat for hours. Remember that? Today, things are very different. Most

people now take sunshades, hats, beach tents, etc., and factor 50

sun protection is an absolute essential. Our awareness of skin health

has increased, and now, more and more consumers are looking for

ways to keep their skin healthy, young and supple for longer. Nutricosmetics

that work from the inside out can make a significant contribution


Creams and other topical products such as gels or serums are increasingly

popular when it comes to preventing sunburn or providing shortterm

relief from dry skin. However, they only work on the top layer of

skin: the epidermis. The two underlying layers, the dermis and the

hypodermis, remain literally untouched. Yet, they play an essential

role in keeping the skin elastic and supplying it with nutrients.

An excellent way to reach these deeper layers – and exert a targeted

influence – is through nutrition and the use of dietary supplements.

The latter are demonstrably gaining in popularity: according to the

market research company, Grand View

Research, the beauty and health sector is

predicted to grow at an average annual rate

of 4.8 % between 2022 and 2030. In 2021,

their market was already valued at approximately

$55 billion [1].

Power from algae

One thing is certain, though, dietary supplements

are only as good for the skin as their

ingredients. One promising candidate comes

from the freshwater green alga, Haematococcus

pluvialis. This unicellular microalga

produces astaxanthin in extreme temperatures

and other stressful situations, like

high UV exposure, to maintain its vitality and

function. Being consumed in the aquatic

food web, this red carotenoid not only determines

the colour of salmon or crustaceans,

42 No. 3 November/Dezember 2022

Skin health

Other studies show a similar picture:


placebo-controlled double-blind study CMY

showed that natural astaxanthin (with a daily K

intake of 4 mg for 9 weeks) protects against

UV-induced skin changes [4]. The astaxanthin

group showed a higher minimum

erythema dose (a measure of skin tolerance

to solar radiation) and less moisture

loss in the irradiated skin region than the

placebo group. In their subjective perception,

the participants in the astaxanthin group also rated their skin

to be smoother. In another study involving 28 women, an 8-week

daily intake of 6 mg of asta xanthin combined with topical treatment

resulted in a decrease in the depth and width of wrinkles in the eye

region [5]. In a second part of the study, Tominaga et al. also treated

healthy young men with a daily dose of 6 mg of natural astaxanthin

for 6 weeks. The majority experienced improved skin and a balanced

sebum production, compared with a control group receiving a

placebo, opening up an interesting opportunity for acne control with

natural astaxanthin.

Photo © : AstaReal

it also serves as one of the most powerful

antioxidants in nature – with an effect that

is 110 times stronger than vitamin E [2]. In

contrast to other antioxidants, it can penetrate

both the hydrophilic and hydrophobic

layers of the cell membrane, protecting the

cell from free radicals from the outside and

inside at the same time. It is these same free

radicals that plague the skin and lead to its

visible aging.

The positive antioxidant and anti-inflammatory

effects of astaxanthin on the skin

– as well as for other body functions such

as immune health and visual acuity – have

been demonstrated in more than 500 peerreviewed

studies. The most intensively scientifically

researched brand of natural astaxanthin

is produced by AstaReal. A study

with AstaReal ® Astaxanthin showed that it

protects the skin from the seasonal wear and

tear caused by UV radiation and dryness.

From August to December, participants took

a daily dose of 6 or 12 mg astaxanthin, and


during this time, their skin remained resilient.

In contrast, wrinkles and dryness were



more pronounced in the non-supplemented


control group [3].

Collagen peptides: help for self-help

Just like astaxanthin, collagen peptides also act on the skin from

within but have a completely different mechanism of action. Highly

pure collagen peptides can be obtained from native animal-origin

collagen using a partial hydrolysis process. Quickly absorbed and

utilized by the body, studies have shown that specific Bioactive

Collagen Peptides (VERISOL ® from GELITA) stimulate the fibroblasts

in the dermis after ingestion, and to a certain extent, encourage the

skin to regenerate itself. This significantly increases the production of

collagen, elastin and proteoglycans. These compounds are essential

for the elasticity of the skin. Thus, the epidermis is supported from

within and wrinkling is reduced.

EN Anzeige WFS 2022 Q4 DE Frauengesundheit_CS5_Pfade_beschnitt_3mm.pdf 1 18.10.


No. 3 November/Dezember 2022

Skin health

still detectable 4 weeks after discontinuation of use, indicating a longlasting

stimulation. A clinical follow-up study showed that the intake

of collagen peptides can reduce the depth of skin wrinkles in the eye

area and promote the synthesis of important structural skin components

such as collagen type I, elastin and fibrillin [7].

In addition, VERISOL ® is able to causally combat cellulite in normal

and overweight women. In a double-blind placebo-controlled study,

105 women between the ages of 24 and 50 received 2.5 g of

VERISOL ® or a placebo daily [8]. After just 3 months, the extent of

cellulite had decreased significantly. At the end of the 6-month study,

the researchers noted an average 9 % reduction in participants with

a normal BMI compared with the placebo group. In subjects with a

BMI > 25, this positive effect was also visible but less pronounced

(4 % reduction).

As today’s consumers become more aware about the correlation

between skin health and nutrition, they are starting to favour beautyfrom-within

products with the greatest amount of scientific research

to support them. Natural astaxanthin and collagen peptides can

satisfy these demands and effectively target this growing market.

Three placebo-controlled human studies confirm the positive effects

of supplementation with VERISOL ® collagen peptides on the epidermis

and dermis. The first study investigated the effectiveness of collagen

peptides using biophysical parameters related to skin aging [6]. In

this study, 69 women aged between 35 and 55 took either 2.5 or 5 g

of VERISOL ® or a placebo daily during an 8-week study period. After

only 4 weeks, both VERISOL ® groups showed a statistically significant

improvement in skin elasticity. Interestingly, the positive effect was

more pronounced in participants older than 50. The benefits were

For more information, please contact

Behnaz Shakersain, PhD

Scientific Affairs Manager

AstaReal AB



Photo © : Fotolia/ Leonid & Anna Dedukh


[1] Grand View Research: Women’s Health And Beauty Supplements Market Size, Share &

Trends Analysis Report By Product, By Application, By Age Group, By Consumer Group, By

Sales Channel, By Region, And Segment Forecasts, 2022 – 2030. 2021. www.grandviewresearch.com/industry-analysis/women-health-beauty-supplements-market;


[2] Nishida Y et al.: Quenching activities of common hydrophilic and lipophilic antioxidants

against singlet oxygen using chemiluminescence detection system. Carotenoid Science.


[3] Tominaga K et al.: Protective effects of astaxanthin on skin deterioration. J Clin Biochem

Nutr. 2017;61(1):33-39.

[4] Ito N et al.: The Protective Role of Astaxanthin for UV-Induced Skin Deterioration

in Healthy People-A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients.

2018;10(7).pii: E817.

[5] Tominaga K et al.: Cosmetic benefits of astaxanthin on human subjects. Acta Biochim

Pol. 2012;59(1):43-7.

[6] Proksch E et al.: Oral supplementation of specific collagen peptides has beneficial

effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol.

Physiol. 2014;27,47-55.

[7] Proksch E et al.: Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles

and Increases Dermal Matrix Synthesis. Skin Pharmacol. Physiol. 2014;27,113-119.

[8] Schunck M et al.: Dietary Supplementation with Specific Collagen Peptides Has

a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food.


Oliver Wolf

Global Communication

Gelita AG



44 No. 3 November/Dezember 2022


Photo © : Adobe Stock/andriano_cz

Effective relief from tinnitus symptoms

Dr Franziska Weichmann

Subjective tinnitus is the perception of

sound without any external acoustic noise.

This sound is mostly described as ringing,

sometimes as a buzzing, roaring, whistling

or hissing sensation (1). Several people with

tinnitus suffer from an associated hearing

loss, at least on one ear (1). With a prevalence

of 10 to 20 % of the population worldwide,

tinnitus is one of the most common

and distressing ear-related problems in the

world (2). In many cases, tinnitus affects the

quality of life and can be accompanied by

anxiety, depression, insomnia or increased

sensitivity to noises (hyperacusis) (2).

Effectiveness against tinnitus

Two studies could show that supplementation with Pycnogenol ®

ameliorates the symptoms of tinnitus (4, 5).

In the first clinical study with 82 patients, a supplementation for 4

weeks had an impressive influence on the tinnitus scale (4). In this

subjective scale, presence, intensity and duration of tinnitus, as well

as the changes in the quality of life and drug intake to relieve tinnitus

were each rated from 0 (none/low) to 3 (always/severe). The control

group did not show a significant change in the personal tinnitus rating

with only 16 % reduction, whereas 100 mg Pycnogenol ® per day

improved the tinnitus rating by 41 % and 150 mg Pycnogenol ® per

day even led to a reduction of 63 % on the tinnitus scale.

No medication is currently officially approved

to treat tinnitus, but several medications are

in use, such as anesthetics, antidepressants,

antihistamines, anxiolytics, vasodilators or

calcium channel blockers (3). Many of those

medications come with serious risks for side


The natural extract from French maritime

pine bark Pycnogenol ® was shown to be efficacious

in relieving symptoms of tinnitus

(4, 5). By improving microcirculation (4-8),

normalizing hypertension (9-12), enhancing

endothelial health (11-17) and reducing

inflammation (18-20), Pycnogenol ® positively

affects mechanisms that are associated

with the development of tinnitus.

No. 3 November/Dezember 2022



The study further investigated the effects of

the supplementation on microcirculation in

the inner ear. For that, the blood flow velocity

in the cochlea was measured using ultrasonography.

Only one ear of the patients was

affected by tinnitus, the “tinnitus ear”, while

the other ear was referenced as the “healthy

ear”. The effect of a 4-week supplementation

on the microcirculation in the healthy

ear was neglectable, whereas the very low

cochlear blood flow velocity in the tinnitus

ear could be normalized with 4 weeks of

Pycnogenol ® supplementation. Systolic

as well as diastolic blood flow velocity was

increased to almost normal values by 48 %

and 95 %, respectively. There was however

no observable change of the microcirculation

in the control group.

cally improved after the supplementation,

which helps explain the beneficial effects of

Pycnogenol ® on tinnitus symptoms.

Pycnogenol ® improves microcirculation,

normalizes hypertension and

ameliorates endothelial health

The development of tinnitus has been

associated with cochlear microcirculatory

dysfunction (21). As described in the

previously mentioned studies, it has positively

affects microcirculation in the inner

ear (4, 5). This beneficial effect was not only

observed in the ear but could be confirmed

in other small blood vessels in the body, like

the retinal capillaries in the eye or the very

fine micro vessels in the fingertip (6-8). In

Another study found beneficial effects of

the supplementation on tinnitus in patients,

suffering from Ménière’s disease (5). This

condition is a disorder of the inner ear,

presenting with symptoms such as vertigo,

hearing loss and tinnitus. 107 patients took

part in the 6-month study. The tinnitus scale

of the patients taking Pycnogenol ® was

significantly reduced by 53 %, compared

to the control group with a reduction of only

28 %. Interestingly, 87 % of the patients,

supplemented with Pycnogenol ® stated to be

asymptomatic after 6 months and only 35 %

of the patients in the control group were

symptomless. Furthermore, the supplementation

could significantly improve the

working and social life by 72 % and 81 %

respectively, compared to 50 % and 9 % in

the control group. As in the first study, blood

flow velocity in the inner ear was drastia

3-month study on diabetic retinopathy,

the supplementation improved the retinal

blood flow by around 30 % compared to

no change in the control patients (6). In

another study with patients suffering from

coronary heart disease, microcirculation on

the fingertip improved significantly in 54 %

of the patients, taking Pycnogenol ® and in

33 % of the placebo patients after 4 weeks

(7). A third study showed improved microcirculation

in the legs by 34 % after the intake,

in patients with diabetic microangiopathy

(8). Elevated blood pressure (hypertension)

can also be a causal or at least an adjuvant

factor for tinnitus (21). The normalizing effect

of Pycnogenol ® supplementation on hypertension

was investigated in several studies

(9-12). A double-blind, placebo-controlled,

crossover study with borderline hypertension

patients showed that the supplementation

for 8 weeks significantly lowered elevated

systolic blood pressure by 5 % compared to

placebo (10). Diastolic pressure was found to

be lowered by 2 %. Another study with hypertensive

patients, treated with calcium channel

blockers found that after 3 months, 57 % of

the patients supplemented with Pycnogenol ®

were able to cut their individual hypertension

medication dosage to a quarter of the previous

dose to keep their blood pressure in a healthy

range (11). Only 13 % of the placebo patients

were able to do so.

Microcirculatory problems and hypertension

can both be explained by endothelial

dysfunction, an impairment of the inner lining

of blood vessels. Consistently, endothelial

dysfunction has been described in patients

with tinnitus (22). There is strong evidence

that Pycnogenol ® improves endothelial health

(11-17). One study, among others, showed

that in patients with coronary artery disease,

Pycnogenol ® supplementation had a beneficial

effect on endothelial function (13).

Endothelial function was assessed by flowmediated

dilatation of the brachial artery (the

widening of the artery in response to elevations

in blood flow-associated shear stress).

This 8-week randomized, double-blind,

placebo-controlled cross-over study showed

that flow-mediated dilation was improved by

32 % in the Pycnogenol ® group, whereas it

slightly decreased in the placebo group.

Reduction of inflammatory processes

Recent research has shown that inflammation,

specifically neuroinflammation

is involved in the development of several

hearing disorders including tinnitus (23).

In several studies, Pycnogenol ® exhibited

potent anti-inflammatory activities (18-20).

Already after 5 days of daily intake, a study

reported that Pycnogenol ® significantly

prevented the up-regulation of the proinflammatory

enzymes 5-LOX and COX-2

(18). In another study, plasma samples

of volunteers after intake of Pycnogenol ®

showed to significantly inhibit NF-κB activation

by 15.5 % and matrix metalloproteinase

9 (MMP-9) release by 25%, two important

regulators in the inflammation process

(19). In a similar study, significant inhibi-

46 No. 3 November/Dezember 2022


tion of inflammatory molecules COX-1 and

COX-2 was observed after intake of 300 mg

Pycnogenol ® (20).

French maritime pine bark extract is an

effective, safe and evidence-based natural

solution to manage tinnitus by improving

microcirculation, normalizing hypertension,

enhancing endothelial health and reducing



1. Chari DA, Limb CJ. Tinnitus. Med Clin North Am.


2. Han BI, Lee HW, Ryu S, Kim J-S. Tinnitus Update. Journal of

Clinical Neurology. 2021;17(1):1.

3. Kim SH, Kim D, Lee J-M, Lee SK, Kang HJ, Yeo SG. Review

of Pharmacotherapy for Tinnitus. Healthcare. 2021;9(6):779.

4. Grossi MG, Belcaro G., Cesarone, M.R., Duggall, M., Hosoi,

M Cacchio,. Improvement in cochlear flow with Pycnogenol ®

in patients with tinnitus: a pilot evaluation. Panminerva

Med. 2010;52(2):63-7.

5. Luzzi R BG, Hu S, Dugall M, Hosoi M, Cacchio M, Ippolito

E, Corsi M Improvement in symptoms and cochlear flow with

Pycnogenol in patients with Meniere’s disease and tinnitus.

Minerva Med 2014;105:245-54.

6. Steigerwalt R, Belcaro G, Cesarone MR, Di Renzo A, Grossi

MG, Ricci A, et al. Pycnogenol ® improves microcirculation,

retinal edema, and visual acuity in early diabetic retinopathy.

J Ocul Pharmacol Ther. 2009;25(6):537-40.

7. Wang S, Tan D, Zhao Y, Gao G, Gao X, Hu L. The effect

of Pycnogenol ® on the microcirculation, platelet function

and ischaemic myocardium in patients with coronary

artery diseases. European Bulletin of Drug Research.


8. Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda

A, Vinciguerra G, et al. Improvement of diabetic microangiopathy

with pycnogenol: A prospective, controlled study.

Angiology. 2006;57(4):431-6.

9. Stuard SBG, Cesarone, M.R., Ricci, A., Dugall, M., Cornelli,

U., Gizzi, G. Pellegrini L, Rohdewald, P.J. Kidney function

in metabolic syndrome may be improved with Pycnogenol.

Panminerva Med. 2010;52(2):27-32.

10. Hosseini S LJ, Sepulveda RT, Rohdewald P, Watson RR. A

randomized, double-blind, placebo-controlled, prospective,

16 week crossover study to determine the role of Pycnogenol

in modifying blood pressure in mildly hypertensive patients.

Nutr Res. 2001;21(9):1251-60.

11. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P.

Pycnogenol, French maritime pine bark extract, improves

endothelial function of hypertensive patients. Life Sci.


12. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction

of cardiovascular risk factors in subjects with type

2 diabetes by Pycnogenol supplementation. Nutr Res.


13. Enseleit F, Sudano I, Periat D, Winnik S, Wolfrum M,

Flammer AJ, et al. Effects of Pycnogenol on endothelial

function in patients with stable coronary artery disease: a

double-blind, randomized, placebo-controlled, cross-over

study. Eur Heart J. 2012;33(13):1589-97.

14. Fitzpatrick DF, Bing B, Rohdewald P. Endotheliumdependent

vascular effects of Pycnogenol. J Cardiovasc

Pharmacol. 1998;32(4):509-15.

15. Hu S BG, Cornelli U, et al Effects of Pycnogenol ® on

endothelial dysfunction in borderline hypertensive, hyperlipidemic,

and hyperglycemic individuals: the borderline study.

Int Angiol 2015;34(1):43-52.

16. Nishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D,

Soga J, et al. Pycnogenol, French maritime pine bark extract,

augments endothelium-dependent vasodilation in humans.

Hypertens Res. 2007;30(9):775-80.

17. Uhlenhut K, Högger P. Facilitated cellular uptake and

suppression of inducible nitric oxide synthase by a metabolite

of maritime pine bark extract (Pycnogenol). Free Radic

Biol Med. 2012;53(2):305-13.

18. Canali R, Comitato R, Schonlau F, Virgili F. The antiinflammatory

pharmacology of Pycnogenol in humans

involves COX-2 and 5-LOX mRNA expression in leukocytes.

Int Immunopharmacol. 2009;9(10):1145-9.

19. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova

A, Durackova Z, et al. Inhibition of NF-kappaB activation

and MMP-9 secretion by plasma of human volunteers

after ingestion of maritime pine bark extract (Pycnogenol). J

Inflamm (Lond). 2006;3:1.

20. Schäfer A, Chovanova Z, Muchova J, Sumegova K, Liptakova

A, Durackova Z, et al. Inhibition of COX-1 and COX-2

activity by plasma of human volunteers after ingestion of

French maritime pine bark extract (Pycnogenol). Biomed

Pharmacother. 2005;60(1):5-9.

21. Figueiredo RR, de Azevedo AA, Penido Nde O. Tinnitus and

arterial hypertension: a systematic review. Eur Arch Otorhinolaryngol.


22. Neri S, Signorelli S, Pulvirenti D, Mauceri B, Cilio D,

Bordonaro F, et al. Oxidative stress, nitric oxide, endothelial

dysfunction and tinnitus. Free Radic Res. 2006;40(6):615-8.

23. Shulman A, Wang W, Luo H, Bao S, Searchfield G, Zhang

J. Neuroinflammation and Tinnitus. Curr Top Behav Neurosci.


For more information, please contact

Dr. Franziska Weichmann,

Manager of Scientific Communications

and Product Development

at Horphag Research

Tapping into a calm state of

mind amidst a hectic life

A natural ingredient for stress relief,

providing mental & physical well-being.

Extramel ®


No. 3 November/Dezember 2022


Fi & Hi Europe 2022

Let’s meet in Paris!

Leading ingredients trade show Fi & Hi Europe all set to welcome more than 20,000 visitors

from around the world

Fi & Hi Europe returns to France this year. From December 6 to 8,

the leading ingredients fair will be held for the first time at the Paris

Expo Porte de Versailles exhibition centre. More than 1,200 exhibitors

– from leading ingredients manufacturers to highly specialized

startups – will present themselves in four halls. The face-to-face exhibition

will be complemented by a comprehensive online offering. A

broad conference programme, as well as the renowned Innovation

Awards and Startup Innovation Challenge, will complete the trade

show experience.

In the heart of Paris, Fi & Hi Europe is set to attract exhibitors and

attendees from more than 135 countries around the world. The new

Paris Expo Porte de Versailles location is within walking distance

of many hotels, restaurants and bars, making logistics easier and

the event more visitor-friendly than ever before. Many leading ingredient

manufacturers have already confirmed their participation in

Paris, including ADM, Beneo, Brenntag, Cargill, DSM and Ingredion.

In addition to well- established companies, many new players

have also announced their intention to present their solutions to the

industry. In addition, there will be more country pavilions this year

than ever before.

Digitally enabled event concept

This year, Informa Markets is focusing on

a technologically enhanced hybrid show

concept. The combination of online and faceto-face

events offers participants the best of

both worlds, including a wide variety of live

and on-demand content as well as data-driven

networking options. All exhibiting companies

have their own online profile, allowing

them to find relevant contacts, network and

set up virtual or face-to-face meetings before

the event. A smartphone app also facilitates

on-site lead generation. “We look forward to

welcoming visitors and exhibitors from around

the world to an event that no one in the ingredients

industry should miss,” says Julien

Bonvallet, Group Brand Director at Informa

Markets. “After months of restriction and

uncertainty, many people have a great need

for face-to-face meetings. But even those who

48 No. 3 November/Dezember 2022

Fi & Hi Europe 2022

prefer to participate online can do so easily

thanks to our technical solutions.”

Multifaceted conference programme

The online event will begin on 28 November,

the week before doors open at Paris Expo

Porte de Versailles. It offers an extensive

conference programme covering the hottest

topics in the industry, with a focus on plantbased

nutrition, health & wellness, and reformulation.

In addition, interested participants

will find a wealth of information on application

areas that are currently trending – such

as baked goods, snacks, dairy products and

dairy alternatives. Overall, the conference

programme includes more than 55 expert

sessions on-site and online, giving global

audiences access to invaluable knowledge.

The platform Fi Global insights provides a lot of additional information

as well as exclusive reports covering the following topics:

– Protein

– Dairy and Dairy Alternatives

– Snacks, Bakery and Confectionery

– Plant-based

– Sustainability

– Beverages

Market products in the spotlight

On-site, the New Product Zone in cooperation with Innova Market

Insights offers an extensive selection of the most innovative products,

showcased alongside insightful information. It features product

innovations from leading industry players and provides the perfect

opportunity to give new ingredients the introduction to the market

that they deserve. A popular area for visitors and the press, this

feature has become a trendsetting spot for the nutrition industry.






2 active ingredients with profound

health advantages:

Astaxanthin & Phophatidylcholine

Product benefits:

Fast absorption

Easy to combine with vitamins

Clean labelling & vegan

BDI-BioLife Science | info@bdi-biolifescience.com

+43 3332 32042 10 | bdi-biolifescience.com

No. 3 November/Dezember 2022


Fi & Hi Europe 2022

Fi Europe Innovation Awards

The renowned Fi Europe Innovation Awards will once again be

adding extra value to the trade show. With one exception, the awards

will only be presented among Fi Europe exhibitors: The new “Food

Training & Education” category is also open to non-exhibitors. This

award is intended to recognise a company, institution or organisation

that contributes to better consumer health, for example, through

an educational initiative or a pioneering approach. The “Sustainability

Innovation Award” recognises environmentally, economi cally

or socially sustainable approaches and practices in the food and

beverage industry. Companies that create equal opportunities in

the work environment receive the “Diversity & Inclusion Innovation

Award”. The “Plant-based Innovation Award” acknowledges alternatives

to animal products and is given for the best ingredient or

application. In the “Sensory Innovation” category, the award is for

an ingredient or process that improves the overall sensory properties

of foods or beverages. The “Health Innovation Award” honours an

ingredient or process that provides a health benefit. The “Food Tech

Innovation Award” goes to companies that have developed innovative

processes, packaging or waste reduction solutions.

The decision as to who receives awards is made by industry experts

from the fields of consulting, management, product development

and trade media. Prof. Colin Dennis, Chairman of the Board of Trustees

of the IFIS organization and member of the Board of Trustees

of the British Nutrition Foundation, will again chair the jury this year.

The winners of all categories will be announced during Fi & Hi Europe

at a ceremony on December 6.

For more information, please visit


Award for innovative startups

The Fi Global Startup Innovation Challenge also enables young

companies to present their innovative concepts, products and ideas

to an international audience of experts, major companies and sponsors.

All companies founded no more than five years ago are eligible

to participate.

They can apply in one or more of the following categories:

Most innovative ingredient for food or beverage

Most innovative plant-based or alternative ingredient

Most innovative processing technology

Most innovative service, technology or digital solution for the food and

beverage industry

Finalists and winners will have access to the Startup Lounge, where

they can present their products and solutions on the Innovation Hub

stage, and network with industry representatives. Both the pitches

and the award ceremony will also be streamed via the Fi Europe

online platform and remain permanently available. Winners will have

a choice of several attractive prizes: A fully equipped booth at Fi

Europe next year, a comprehensive online marketing package or an

individual mentoring programme.

The latter can be coaching, for example, or the implementation of a

pilot project, or it can include access to corporate collaborations and

business accelerator programmes.

In addition to the Innovation Hub, visitors will find the new Sustainability

Hub at the exhibition, which focuses on sustainable food solutions

along the entire value chain. Here visitors will find information

on food waste, circular economy, regenerative agriculture and many

other topics. Finally, the Women’s Networking Breakfast, sponsored

by DSM, Lunch & Learn and other events are perfect for building a

professional network.


ISSN 2364-8104

Wellness Foods & Supplements | No. 3 /2022

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50 No. 3 November/Dezember 2022

Technology & Marketing

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