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2011 (pdf, 4 MB) - Universitätsklinikum Hamburg-Eppendorf

2011 (pdf, 4 MB) - Universitätsklinikum Hamburg-Eppendorf

Arbeits- und

Arbeits- und Forschungsbericht 2011 und Planung 2012 DGAUM and g-EQUAS (covered parameters included: heavy metals, solvents and pesticides). Reference laboratory for a range of biomarkers • Routine analytical facility for more than 60 different toxicological biomonitoring parameters, belonging to a variety of different chemical classes (by using GC-MS, Head-Space analytics, HPLC, AAS, etc), for 40 ambient monitoring parameters (TD-GC-MS) and for numerous (65 at the moment) immunological parameters (Immuno-CAP and other methods) as required • Ambient and biomonitoring analyses for a variety of companies, occupational medics and employee institutions • Consultancy services for preventative medicine personnel, occupational medics and employee institutions in respect of exposure assessment • Lecturing in the UKE Medical School: two complete seminar series that include the coverage of health risks from toxic chemicals and cancer as an occupational disease, as well as participating in the curriculum for occupational and environmental medicine Projects 2011-2012 Major Activities and Results Health Risks Posed by Goods Transport with AG Clinical Occupational Medicine Externally: Institute of Tumor Biology (UKE); Frauenhofer Institute IASIS, WHO Collaborating Centres. Externally funded project 1. Fumigants analysis: development and implementation of ambient monitoring a) Air analysis for the assessment of occupational health risks (Externally funded: BMBF Project Optima) Status 2011 • This study discovered and highlighted the presence of a substantial increase in contamination by fumigants and industrial chemicals not allowed in the EU. • Some of the results were communicated at the workshop: “How to handle import containers safely” • The planned compilation of recommendations for ambient monitoring at other European ports and the suggestions for control monitoring could not be implemented because of staff restrictions and is postponed. A joint application for external funding with the Universities of Århus and of Southern Denmark in Esbjerg (cooperation project) has been submitted. Plan 2012 • An extensive field study is planned for 2012 as part of the BMBF Project Optima. It is planned to extend the spectrum of measured parameters and to perform trend analyses in cooperation with others. (Fahrenholtz S, Hühnerfuss H, Baur X, Budnik LT. The measurement of hydrogen phosphide in the presence of volatile organic substances using gas chromatography. Zbl Arbeitsmed; in press) • In order to raise the awareness of and educate uninformed temporary workers about health risks and prevention measures, the WHO conference in Cancun, Mexico 3/ 2012 determined that a toolkit about the relevant chemicals should be prepared as a WHO collaboration • An information platform (in cooperation with the European Transport Trade Unions) is being prepared (an EU grant aplication is under preparation) b) Measurement technology developments (Externally funded: BMBF Project Optima) Status 2011 • The AG is supported by a BMBF research project of the Fraunhofer Institute for Intelligent Systems, St Augustin, and the commercial company Airsence, Schwerin, in the evaluation of the sniffer apparatus Electronic Nose GDA2 and to improve its accuracy during on-site measurements of import containers • Further toxic substances have been identified in the atmospheres of import containers (with a semiquantitative assessment) and the current analytical systems will be expanded to incorporate their measurement (Baur X, Budnik LT, Poschadel B. Practical issues – new developments in measurements and analyses of fumigants – Comparison of measurements by high throughput MS and GC-MS (ZfAM). Zbl Arbeitsmed 2011;61:412; Poschadel B, Fahrenholtz S, Budnik LT, Baur X, Fumigant and solvent contamination of container atmospheres – a comparison of two analysis systems, submitted). Plan 2012 53

Working and Research Activities 2011 and Plans 2012 Health Risks Posed by Goods Transport with AG Clinical Occupational Medicine Externally: Institute of Tumor Biology (UKE); Frauenhofer Institute IASIS, WHO Collaborating Centers. Externally funded project New Strategies of Exposure Detection and Risk Assessment with AG Clinical Occupational Medicine, AG Psychomental Strain and the Central Executive Partner: WHO Collaborating Centers • The methods will be extended to include the measurement of formaldehyde in the atmosphere of import containers. The HPLC-based extraction method is currently being validated. c) The fumigation of transported goods (health risks from toxic industrial chemicals) (External funding application submitted) Status 2011 • Quantification of fumigants by on-site measurements of containers with various cargoes Plan 2012 • The study will continue: an external funding application has been submitted in collaboration with the German Consumer Minister and the Federal Institute for Risk Evaluation. Budnik LT, Fahrenholtz S, Kloth S, Baur X. Fumigation of imported goods. Zbl Arbeitsmed 2011; 61:418-419; Preisser AM, Budnik LT, Hampel E, Baur X. Perilous surprises: toxic health hazards for employees unloading fumigated shipping containers. Sci Total Environ 2011;409:3106-3113] 2. Biomonitoring of Fumigants Biomonitoring of intoxication from halogen alkanes/ early detection of cancerogenic fumigant exposure (External funding continuation: Hamburg Foundaton for Fighting Cancer, Erich and Gertrud Roggenbuck Foundation) Status 2011 • A method for measuring the adduct formation of fumigants with haemoglobin was validated for routine use and applied to the long-term investigation of individual potentially exposed to fumigants (Employees of fumigating companies and in logistics) (Kloth S, Baur X, Budnik LT. Is biomonitoring in cases of fumigant intoxication and exposure of any use? Zbl Arbeitsmed; in press). • Establishment and testing for evidence of toxic substances in exhaled breath: the project was terminated for lack of personnel; as was the development of an analysis plan for cases of accidental intoxication. Plan 2012 • The early detection of the carcinogenic risk primarily depends upon the assessment of the cytotoxic and genotoxic potential of the fumigant revealed by the degree of fumigant-induced DNA methylation in the cells of an individual. The collaboration with the Institute of Tumor Biology, UKE, concentrates on mitochondrial DNA. • A multicentre application for external funding has been submitted to the DFG (includes the Institute of Tumor Biology, UKE, and Institute of Occupational Medicine at the University of Göttingen). (Budnik LT, Kloth S, Velasco-Garrido M, Baur X. Prostate cancer and toxicity from critical use exemptions of methyl bromide: Environmental protection helps protect against human health risks, meta-analysis of carcinogenic risk, Environmental Health, 2012; Preisser AM, Budnik LT, Baur X. Clinical diagnostics in cases of suspected fumigant intoxication. Zbl Arbeitsmed; in press) New Project Plan 2012 • Quantification of long-term exposure from mathematical analysis (Budnik LT, Baur X. 2011, Biomonitoring of Toxic Substances in the Work Environment: A Complex Diagnostic Scheme with Many Players, Praeger Handbook of Environmental Health, USA, Editor Robert H. Friis; Budnik LT, Brunswig-Spickenheier B, Müller D. The gonads and their magic bullet, 2012: lysophosphatidic acid: Physiological and toxicological functions of LPA in female and male reproductive systems in. Lysophospholipid Receptors: Signaling and Biochemistry. Editors Timothy Hla, Sarah Spiegel, Wouter Moolenaar and Jerold Chun, by John Wiley & Sons, Inc., Hoboken, New Jersey, U.S.A.) • Development of novel metabolic research models for the determination of fumigant exposure at periods in the distant past. Planned attendance at the International Congress on the Science of Exposure Assessment, Edinburgh, UK 2012 with three contributions: (Koth S, X Baur X, LT Budnik LT Biomonitoring after ac- 54

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