vor 5 Jahren

2011 (pdf, 4 MB) - Universitätsklinikum Hamburg-Eppendorf

2011 (pdf, 4 MB) - Universitätsklinikum Hamburg-Eppendorf

WHO-Projekte List of

WHO-Projekte List of major outcomes already achieved by this project List of additional major outcomes expected from this project by 2012 Describe the impact or influence of this project Health Departments and Labour ministries about H&S issues dealing with container fumigation. Several meetings were held (in Rotterdam, Berlin, Hamburg, and Rome were the plenary lecture was given at the OSHA meeting 2010) on developing possible mitigation strategies. International Meeting “How to handle import containers safely” is organized in Hamburg each year. Hazard monitoring strategies have been presented to the respective European commissions (during a special EU workshop in Brussels) Pilot H&S strategy has been developed with the labour inspectorate for the state of Hamburg has been published in German (is available nationwide as a tool kit). Boels D et al., Zbl Arbeitsmed 2010;60: 130-136. Methods allowing to detect fumigants usually found in container atmosphere have been published : Budnik LT et al., J Environ Monit, 2010,12(4):936-942; Fahrenholtz S et al., J Chromatogr A, 2010 1217 (52)8298-8307;Baur X; et al., Occup Environ Med 2010, 67(3): 207-212 Additionally, case control studies have been published: Baur X et al, Dtsch Med Wochenschr 2010, 135(11): 516-521, Preisser et al. Sci Total Environ, [Epub 2011]. Based on the pilot H&S tool kit (s.a.) partners are planning to implement the same strategies to other European harbours-in Denmark, Norway (the strategy will be published in Englisch, 2012). Currently, an implementation plan for the 2012/2013 for the North European harbours is discussed. - In cooperation with several external partners on side ambient monitoring methods will be tested. - Further contacts to labour unions and health inspectorates will be undertaken (or are already planned). - Biomonitoring tool kit will be developed 2012/2013, due to delay in founding. Project contributed to increased awareness about the possible health risks to logistic workers i.e. container unloaders and controlling bodies due to undeclared container fumigation and possible offgasing from fumigated goods. The need to protect workers in the transport and logistics sector has been recognized (a special H&S problem exists with subcontracting, migrating workers in the logistic sector) Pilot implementation of the developed tool kit is currently being adopted for the health inspectorates and the customs within the state area. Development of analytical diagnostic tools for occupational isocyanate asthma/ Prevention of occupational asthma (Objective 2) Project leader Ass. Prof. Dr. Lygia T. Budnik, Prof. Dr. Xaver Baur Network partners WHO Regions involved Country ministries involved External partners Institute and outpatient clinic for occupational and environmental medicine, Ludwig Maximilians University Munich, Germany; Global Ministries of occupational and environmental affairs in Europe Prof. Dr. Rainer Bischoff, University of Groningen, Analysical Biochemistra and Mass spectrometry center, Groningen 85

WHO-Projekte Summary of the project Target group and/or beneficiaries Events-opportunities for furthering the project Expected results of this project by 2012 (outcomes) Indicators of achievement (impact) Major Milestones Public health impact Dr. C. Lemière, Hôpital de Sacré Coeur, Montreal, Quebec, Canada Prof. Dr. D. Bernstein, Chincinnati Childrens Hospital Medical Center, University of Cincinatti, OH USA Most frequent type of occupational asthma is the isocyanate asthma. Clinical diagnosis and differentiation of isocyanates as the cause of occupational asthma is difficult. The gold-standard test, specific inhalation challenge, is successfully used in our outpatient clinic. However with the increasing use of isocyanates worldwide a need for an efficient routine laboratory test has emerged. Due to the unsatisfactory serological IgE tests based on poorly characterized isocyanate-albumin epitopes, the available tests recognize only small proportion of affected workers. In order to characterize biomarker of exposure in a larger population of occupationally exposed workers we will characterize the reaction products of isocyanates and albumin with a help of mass spectrometry analyses. Employer, worker representatives, OHS experts Presentations of intermediate and final results at European and international scientific meetings. Initial meetings of CCs, national & international meetings on occupational and environmental health/ follow up conferences on the topic as final events (EU) Implement the immunological assay for the diagnosis of patient samples. Recommendations for the prevention of occupational asthma based on biomonitoring screening Toolkit 1: characterise the kinetic conditions for the simulation of workplace exposure under laboratory conditions and implementation of the results for the patient analysis Toolkit 2: characterise the isocyanate-serum-albumin epitopes from patient samples with mass spectrometry Toolkit 3: develop a sensitive laboratory diagnostic method for the isocyanate asthma 1. biomonitoring methods (2009-2010) 2. implementation of the antibody assay (2010-2011) 3. recommendations for the prevention of occupational asthma (2012) Development of new diagnostic tools for occupational isocyanate asthma. Effective interventions to manage and prevent the risks. Funding source(s) German Research Council, DFG Dissemination Progress on Project The results in international journals. Papers to conferences, workshops, new electronic media, fact sheets and recommendations, use channels of the EASHW, websites of CCs, WHO, ILO Analytical research has been successfully done. Studies with isocyanate-albumin conjugates exhibited that those produced in vapour are superior to those produced in solution. New biomonitoring strategies have been developed. Data was presented at European Respiratory Society Meeting in Vienna, Austria 2009 and in Barcelona, Spain, 2010. Publications: Budnik LT, Nowak D., Merget R, Lemiere C, Baur X. Elimination kinetics of diisocyanates after specific inhalative challenges 86

2012 (pdf, 7 MB) - Universitätsklinikum Hamburg-Eppendorf
2006 (pdf, 24 MB) - Universitätsklinikum Hamburg-Eppendorf
April 2011 [pdf, 3,06 MB] - Universitätsklinikum Hamburg-Eppendorf
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