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Leukemia Lecture Part 2 - Pathology

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Chronic Lymphocytic <strong>Leukemia</strong><br />

■ Neoplastic proliferation of small matureappearing<br />

lymphocytes<br />

■ >99% are B-cell derived<br />

■ Older patients (> 40)<br />

■ Disease may be discovered incidentally<br />

■ Fatigue, weakness, weight loss, anorexia,<br />

and/or recurrent infections may occur<br />

■ Variable splenomegaly and nontender<br />

lymphadenopathy<br />

■ Leukemic counterpart of small lymphocytic<br />

lymphoma

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