Production of Bioactives by Intestinal bacteria:

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Gut bacteria produce an almost limitless set of metabolites Understanding these may provide the key to unlocking many heath-promoting functions of gut bacteria/probiotics Fergus Shanahan
1. Bacteriocin production Production of Salivaricin by Lactobacillus salivarius Discovery of Thuricin: a bacteriocin which specifically kills Clostridium dificile Microbial Production of Bioactives Probiotics versus our resident flora HOW PROBIOTICS WORK? Bifidobacterium breve 2. Fatty acid production Production of Conjugated linoleic acid (CLA), Production of DHA and EPA
Page 1: Production of Bioactives by Intesti
Page 5 and 6: 1. Bacteriocin production Productio
Page 7 and 8: Class 2 Mode of Action Lipid II Cla
Page 9 and 10: Corr S. C. et.al. PNAS 2007;104:761
Page 11 and 12: 11.6kg Control 11.7kg Probiotic 1 (
Page 13 and 14: Mean Live5 count in ileum = 1.3 x 1
Page 15 and 16: Salivaricin P, 13 kb Natural Varian
Page 17 and 18: Abp118 is encoded on megaplasmid pM
Page 19 and 20: Salivaricin T genes 4433.90 Da 5655
Page 21 and 22: Microbial Production of Bioactives
Page 23: Mary Rea Bacillus thuringiensis Rea
Page 26 and 27: Thuricin contains unusual post-tran
Page 28 and 29: ! # s s s "# s s s Rea et al. PNAS
Page 30 and 31: C. diff log 8 7 6 5 4 3 Faecal ferm
Page 32 and 33: Microbial Production of Bioactives
Page 34 and 35: • Gut microbiota proposed to exer
Page 36 and 37: % Conversion to CLA 90 80 70 60 50
Page 38 and 39: *** LA + B. breve LA BALB/c mice SC
Page 40 and 41: Compositional change is not limited
Page 42 and 43: Increased DHA content of brain foll
Page 44 and 45: Conclusions • Gut flora/probiotic
Page 47 and 48: Trn-! Trn-! T 0h T 5h Trn-! and ! t

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