Glial cells (stromal cells) Oligodendrocytes ... - CSU PVM 2014

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Another astrocytic response is development of visible cytoplasm. These plump active astrocytes are termed gemistocytic astrocytes. The photograph to the left is from a dog infected with CD virus Alzheimer type II cells They appear as paired swollen clear astrocytic nuclei. They manifest in metabolic disturbances when the liver or kidney is damaged (hepatoencephalopathy or uremic encephlaopathy). Alzheimer II cells have no relation to the disease When astrocytes react, they hypertrophy and become more visible: look like plump cells with abundant eosinophilic cytoplasm and eccentric nuclei Called gemistocytic astrocytes Will see these in canine distemper In uremia or liver damage, see Alzheimer II cells 4
Brain macrophages/microglial cells…glial nodules/neuronphagia/gitter cells Microgliosis refers to the proliferation of resident macrophages of the CNS (microglia). The proliferation may be diffuse or focal. Glial nodules – are hall mark of viral encephalitis Neurons are degenerating and surrounded by a proliferation of oligodendrocytes (satellitosis) and macrophages (are eating dead neurons, neuronphagia). Microglia are normally present in a resting stage until something invades the brain and activates them When activated, they proliferate and form glial nodules Surround affected neuron and eat it: neuronophagia If there is lipid turnover, glial cells will transform into Gitter cells Will remove debris Now we have three types of reaction to insult: satellitosis, astrocytosis, glial nodules 5
Page 1 and 2: Glial cells (stromal cells) Oligode
Page 6 and 7: Macrophages in the CNS are either a
Page 9 and 10: Status spongiosis Is a nonspecific
Page 11 and 12: Astrocytes come to fill this space
Page 13: Choroid plexus forms CSF They proje
Page 16 and 17: Vasogenic: integrity of vessel is a
Page 18 and 19: How to differentiate between edema
Page 20 and 21: 1. e.g. space occupying lesion aa o
Page 22 and 23: An unfortunate series of events: So
Page 26: eversible irreversible 26
Page 29 and 30: Hypoxia-ischemia is one of the most
Page 31 and 32: This cat has been poisoned with the
Page 33 and 34: gyri flattened due to increased pre
Page 36 and 37: potential for emboli = more deleter
Page 38 and 39: Vasogenic edema and dead neurons Po
Page 40: The right cerebral hemisphere is at
Page 44 and 45: Grey matter 44
Page 47 and 48: = thiamine deficiency 47
Page 50 and 51: hematoma = circumscribed collection
Page 52 and 53: Repeated trauma results in brain sw
Page 55 and 56:
will see large hemorrhage 55
Page 58 and 59:
Brain ricochets off opposite side o
Page 60 and 61:
spinal segments subjected to sudden
Page 63:
Common in older animals Health of I
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Glial cells (stromal cells) Oligodendrocytes ... - CSU PVM 2014

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