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What is BLAST<br />
Basic Local Alignment Search Tool<br />
Bad news: it is only a heuristics<br />
– Heuristics: A rule of thumb that often helps in solving<br />
a certain class of problems, but makes no guarantees.<br />
Perkins, DN (1981) The Mind's Best Work<br />
Basic idea:<br />
– High scoring segments have well<br />
conserved (almost identical) part<br />
– As well conserved part are identified,<br />
extend it to the real alignment<br />
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