VACCINES
VACCINES
VACCINES
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Different Types<br />
of Vaccines<br />
Imagine that a new infectious disease emerges somewhere<br />
in the world and begins to spread around the globe. The<br />
infectious agent jumps easily from person to person<br />
through the air, and it attacks the lungs, causing terrible<br />
coughing, fever, pneumonia, and sometimes paralysis of<br />
the respiratory system. Scientists quickly determine that<br />
disease X is caused by a new species of toxic bacterium.<br />
They call it “bacterium X.” Unfortunately, bacterium X<br />
is difficult to fight because it resists most antibiotics, the<br />
kind of drug used to treat bacterial infections.<br />
Everyone agrees a vaccine against bacterium X is needed,<br />
but how would scientists go about creating one? First,<br />
researchers would carefully study bacterium X. They<br />
would figure out what nutrients it requires. They would<br />
examine how it damages lung tissue. Geneticists would<br />
analyze bacterium X’s genes. Immunologists would<br />
explore how the immune system responds to bacterium<br />
X and why the body sometimes fails to fight off this<br />
microbe. They would identify antigens from X that best<br />
stimulate the immune system. Other scientists would<br />
discover and study the toxin secreted by bacterium X.<br />
Once scientists had some basic information about<br />
bacterium X, they could begin designing vaccines that<br />
might work against it. Following are some of the options<br />
that researchers might pursue. They will give you an<br />
idea of the main types of vaccine strategies. (This imaginary<br />
new disease is caused by a bacterium, but scientists<br />
would use approaches similar to those outlined below<br />
to develop a vaccine against a new virus.)<br />
UNDERSTANDING <strong>VACCINES</strong> 21