Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
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Class of<br />
<strong>Drug</strong><br />
ANxIOLyTICS /<br />
SEDATIVES/<br />
HyPNOTICS<br />
12<br />
Substrate<br />
class<br />
<strong>Drug</strong> Brand name (non<br />
exhaustive list,<br />
generics not listed).<br />
For a complete list,<br />
please consult<br />
www.bcfi.be or<br />
www.cbip.be<br />
Liverpool University (*) /<br />
Extra-information<br />
Recommendations SmPC/<br />
Scientific Literature<br />
CYP pathway(s)<br />
(www.cbip/bcfi.be)<br />
(www.mims.com.au)<br />
CYP3A4<br />
Substrate/<br />
Inhibitor/<br />
Inducer<br />
Triazolam oral Halcion ® Contraindicated † Contraindicated † Do not co-administer † CYP3A4 Substrate<br />
Trazodone Nestrolan ® , Trazolan ® Potential<br />
Interaction<br />
Zolpidem Stilnoct ® , Zolpitop ® Potential<br />
Interaction<br />
May<br />
[trazodone]*<br />
Use <strong>with</strong> caution and<br />
consider a lower dose of<br />
trazodone*<br />
Kiser et al., hepatology<br />
2012: With the HIV protease<br />
inhibitor, ritonavir, trazodone<br />
exposures are increased <strong>with</strong><br />
nausea, dizziness, hypotension,<br />
and syncope<br />
May [zolpidem]^ CYP1A2 / CYP3A4 Substrate
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