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34 Songül Budak DİLER and Mehmet TOPAKTAŞ Topaktaş M and Speit G. Sister Chromatid Exchange (SCE) Test Make Use of Detemine in the Mutagen and Carcinogen. C.U. Sağlık Bil Der 5: 73-84, 1990. Ueo HR, Takaki HY, K. Sugimachi. Mammary carcinoma induced by oral administration of ethyl methanesulphonate. Determination of some of the parameters affecting tumor induction. Carcinogenesis 2(12): 1223-8, 1981.
Journal of Cell and Molecular Biology 7(2) & 8(1): 35-43, 2010 Research Article Haliç University, Printed in Turkey. http://jcmb.halic.edu.tr Protective effect of pomegranate peel ethanol extract against ferric nitrilotriacetate induced renal oxidative damage in rats Mahgoub Mohammed AHMED *, 1 and Safaa Eid ALI 2 1 Molecular Drug Evaluation Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt 2 Food Technology Research Inst., Agricultural Research Center (ARC), Giza, Egypt (* author for correspondence; dr_mahgoub1@yahoo.com ) Received: 18 December 2009; Accepted: 02 April 2010 Abstract Pomegranate is an important source of bioactive compounds. The nephroprotective effect of pomegranate peel ethanol extract against ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative stress was studied. The results showed that Fe-NTA enhances renal lipid peroxidation with reduction in renal glutathione content, antioxidant enzymes, viz., glutathione peroxidase, catalase, glutathione reductase and phase-II metabolizing enzyme, glutathione-S-transferase. It also enhances serum urea and creatinine. Treatment of rats orally with pomegranate peel extract (100 and 200 mg/kg/day, for seven days) resulted in significant decrease in lipid peroxidation and serum urea and creatinine levels. Renal glutathione content, glutathione-S-transferase and antioxidant enzymes were also recovered to a significant level (P
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