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Read the endMS Impact Report - Multiple Sclerosis Society of Canada

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e n d M S C a M p a i g n i M p a C t R e p o R t


Vancouver<br />

Calgary<br />

Edmonton<br />

Red Deer<br />

Lethbridge<br />

Saskatoon<br />

Regina<br />

<strong>endMS</strong> Regional Research and Training Centres: Five major hubs across <strong>Canada</strong><br />

<strong>endMS</strong> Network academic and health institutions: 65 institutions across <strong>Canada</strong><br />

MS <strong>Society</strong> funded research: Major MS <strong>Society</strong> funded research hubs<br />

<strong>endMS</strong> Summer Schools: Five occurring across <strong>Canada</strong> since <strong>endMS</strong> campaign began<br />

Winnipeg<br />

<strong>endMS</strong> Transitional Career Development Award recipients: Three working in <strong>Canada</strong>, two in <strong>the</strong> United States<br />

Thunder Bay Quebec<br />

St. John<br />

Thank you for accelerating MS research in <strong>Canada</strong>.<br />

London<br />

Ottawa<br />

Toronto<br />

Guelph<br />

Laval<br />

Montreal<br />

Kingston<br />

Sherbrooke<br />

Halifax<br />

St. John’s


M i s s i o n s t a t e M e n t<br />

To be a leader in finding a cure for multiple sclerosis and enabling people<br />

affected by MS to enhance <strong>the</strong>ir quality <strong>of</strong> life.<br />

t a b l e o f c o n t e n t s<br />

Leadership message. ...........................................2<br />

<strong>endMS</strong> campaign: How and why ..................................3<br />

<strong>endMS</strong> Regional Research and Training Centres ......................4<br />

<strong>endMS</strong> Summer School .........................................6<br />

<strong>endMS</strong> Transitional Career Development Award .......................8<br />

<strong>endMS</strong> Scholar Program for Researchers in Training ..................10<br />

<strong>endMS</strong> Conference ............................................11<br />

MS <strong>Society</strong> research program. ...................................12<br />

<strong>endMS</strong> campaign donors .......................................15<br />

<strong>endMS</strong> national campaign cabinet ................................17


Yves Savoie<br />

President & chief executive<br />

<strong>of</strong>ficer, MS <strong>Society</strong> <strong>of</strong> <strong>Canada</strong><br />

With your help, we raised $60 million to secure <strong>the</strong> next generation <strong>of</strong> MS researchers. Thank you.<br />

Message from <strong>the</strong> honorary national campaign chair,<br />

national campaign chair, president & CEO<br />

On behalf <strong>of</strong> <strong>the</strong> <strong>Multiple</strong> <strong>Sclerosis</strong> <strong>Society</strong><br />

<strong>of</strong> <strong>Canada</strong>, <strong>the</strong> <strong>Multiple</strong> <strong>Sclerosis</strong> Scientific<br />

Research Foundation and <strong>the</strong> <strong>endMS</strong> national<br />

campaign cabinet, we would like to express our<br />

deepest gratitude to all <strong>of</strong> <strong>the</strong> generous donors<br />

and committed volunteers who have helped make<br />

<strong>the</strong> <strong>endMS</strong> campaign a tremendous success.<br />

Your support has enabled us to raise more<br />

than $60 million for <strong>the</strong> <strong>endMS</strong> Research and<br />

Training Network and <strong>the</strong> ongoing research,<br />

training and collaboration activities <strong>of</strong> researchers<br />

and trainees focused on ending MS.<br />

Thanks to your investment, <strong>the</strong> <strong>endMS</strong> Network<br />

has brought toge<strong>the</strong>r more than 1,000 experienced<br />

researchers and trainees from more than 65<br />

Canadian academic and health institutions to<br />

collaborate through five <strong>endMS</strong> Regional Research<br />

and Training Centres. The <strong>endMS</strong> Network has<br />

attracted, trained and retained talented medical<br />

Sandy Aird<br />

National<br />

campaign chair<br />

Rick Waugh<br />

Honorary national<br />

campaign chair<br />

and research pr<strong>of</strong>essionals at varying stages <strong>of</strong><br />

<strong>the</strong>ir careers, in order to secure <strong>the</strong> future <strong>of</strong> MS<br />

research in <strong>Canada</strong>.<br />

Because <strong>of</strong> <strong>the</strong> <strong>endMS</strong> campaign, more<br />

researchers are involved in MS research in<br />

<strong>Canada</strong> than ever before.<br />

The <strong>endMS</strong> campaign has achieved its<br />

fundraising goal, but our work must continue.<br />

While great progress has been made to help<br />

people with relapsing-remitting MS, <strong>the</strong>re are<br />

still no effective treatments for those living<br />

with primary-progressive MS. More research<br />

is urgently needed to understand progressive<br />

forms <strong>of</strong> MS, and people living with this disease<br />

deserve answers about <strong>the</strong>ir future quality <strong>of</strong> life.<br />

We remain committed to raising funds beyond<br />

<strong>the</strong> <strong>endMS</strong> campaign so that MS researchers<br />

will have <strong>the</strong> resources <strong>the</strong>y need to identify<br />

<strong>the</strong> cause <strong>of</strong> <strong>the</strong> disease, improve symptom<br />

management and ultimately find a cure for all<br />

forms <strong>of</strong> MS.<br />

On behalf <strong>of</strong> those living with MS and<br />

MS <strong>Society</strong> volunteers and staff across <strong>the</strong><br />

country, please accept our sincere appreciation<br />

for your generous support in helping to make<br />

our <strong>endMS</strong> campaign a success. Thank you for<br />

helping us in our fight against MS.


<strong>endMS</strong> campaign and <strong>endMS</strong> Research and Training<br />

Network: How and why<br />

I’m Dr. Jack Antel, and I want to<br />

congratulate you for making <strong>the</strong> <strong>endMS</strong><br />

campaign a success. I became involved<br />

with <strong>the</strong> <strong>endMS</strong> Research and Training<br />

Network because I wanted to secure a<br />

brighter future for MS research – and this<br />

meant attracting, training and retaining<br />

new researchers to <strong>the</strong> field <strong>of</strong> MS in<br />

<strong>Canada</strong>. Thanks to you, our valued<br />

donors and volunteers, our network <strong>of</strong><br />

researchers is stronger than ever.<br />

Over <strong>the</strong> last several decades,<br />

Canadian clinicians and scientists have<br />

contributed to <strong>the</strong> significant progress<br />

that has been made in understanding<br />

MS, and in <strong>the</strong> development <strong>of</strong><br />

treatments for <strong>the</strong> disease. This is<br />

thanks in part to <strong>the</strong> MS <strong>Society</strong>’s long<br />

history <strong>of</strong> fostering exceptional MS<br />

researchers and research.<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

You helped ensure that people living with MS will get answers about <strong>the</strong>ir disease.<br />

Despite this investment in people and<br />

research, important questions remain<br />

with respect to <strong>the</strong> cause, prevention<br />

and cure for MS. In this context, <strong>the</strong><br />

<strong>endMS</strong> Research and Training Network<br />

was created with <strong>the</strong> aim to fur<strong>the</strong>r<br />

increase <strong>Canada</strong>’s contribution to<br />

<strong>the</strong> global effort to end MS in <strong>the</strong><br />

shortest possible timeframe.<br />

While <strong>the</strong>re remain many questions<br />

to answer, <strong>the</strong> <strong>endMS</strong> campaign<br />

has contributed to accelerating<br />

progress in <strong>the</strong> field <strong>of</strong> MS research<br />

in <strong>Canada</strong> in an unprecedented way.<br />

I believe in a future free <strong>of</strong> MS, and<br />

through <strong>the</strong> <strong>endMS</strong> campaign we are<br />

closer than ever before.<br />

Dr. Jack Antel, scientific director, <strong>endMS</strong> Research<br />

and Training Network, pr<strong>of</strong>essor and neurologist,<br />

Montreal Neurological Institute, McGill University<br />

The <strong>endMS</strong> Research and Training Network complemented and<br />

streng<strong>the</strong>ned <strong>the</strong> MS <strong>Society</strong>’s research program. To read more<br />

about how your donations helped fund research through <strong>the</strong><br />

MS <strong>Society</strong> and <strong>the</strong> MS Scientific Research Foundation, turn to page 12.<br />

e n d M S . c a 2 | 3


Attract<br />

You helped attract researchers to <strong>the</strong> field <strong>of</strong> MS.<br />

<strong>endMS</strong> Regional Research and Training Centres<br />

Dr. Dessa Sadovnick on <strong>the</strong> impact <strong>of</strong> <strong>the</strong> <strong>endMS</strong> Regional Research and<br />

Training Centres (RRTC)<br />

My connection to MS began before<br />

I was born. I grew up with Evelyn<br />

Opal, MS <strong>Society</strong> founder, and<br />

her family in Montreal. Back <strong>the</strong>n,<br />

<strong>the</strong>re were little to no resources<br />

and knowledge about MS, so my<br />

community worked toge<strong>the</strong>r to<br />

care for Evelyn and her family. After<br />

graduating from McGill University<br />

with a master’s degree in genetics,<br />

Evelyn encouraged me to study<br />

MS. I’m not sure I would have<br />

chosen <strong>the</strong> field without my early<br />

exposure to <strong>the</strong> disease.<br />

Students need mentors to guide<br />

<strong>the</strong>m early in <strong>the</strong>ir careers. When I<br />

was a young researcher, genetics<br />

were thought to be a futile avenue<br />

for MS research – now, because I<br />

was encouraged by mentors,<br />

I pursued my chosen field.<br />

Dr. Dessa Sadovnick, director,<br />

Western-Pacific <strong>endMS</strong> RRTC<br />

Today, <strong>the</strong> importance <strong>of</strong> gene/<br />

environment interactions in MS<br />

susceptibility, pathogenesis and<br />

prognosis is a major focal point<br />

for MS research.<br />

As director <strong>of</strong> <strong>the</strong> Western-Pacific<br />

<strong>endMS</strong> RRTC, I know it’s crucial<br />

for RRTCs to educate students<br />

about MS research as a possible<br />

avenue. RRTCs fulfill <strong>the</strong> important<br />

role <strong>of</strong> broadening <strong>the</strong> scope <strong>of</strong><br />

MS research, engaging students<br />

and researchers in peripheral<br />

fields that have relevance to MS<br />

research, such as occupational<br />

<strong>the</strong>rapy, psychology and nutrition,<br />

in addition to <strong>the</strong> many facets <strong>of</strong> MS<br />

research itself. The overall goal <strong>of</strong><br />

<strong>the</strong> RRTCs is to attract and shape<br />

well-rounded researchers who will<br />

understand both <strong>the</strong> science <strong>of</strong> MS<br />

and <strong>the</strong> real impact <strong>of</strong> <strong>the</strong> disease<br />

on a person’s life.


NeTwoRk gRowTh:<br />

Number <strong>of</strong> researchers and<br />

trainees in <strong>the</strong> <strong>endMS</strong> Network<br />

n Researchers<br />

n Trainees<br />

n O<strong>the</strong>r MS-related pr<strong>of</strong>essionals<br />

<strong>endMS</strong> Regional Research and Training Centres<br />

Five collaborative <strong>endMS</strong> Regional Research and Training Centres<br />

(RRTCs) across <strong>Canada</strong> form an integrated nationwide network <strong>of</strong><br />

engaged trainees, clinicians and researchers. Facilitating collaboration<br />

and encouraging <strong>the</strong> sharing <strong>of</strong> ideas, <strong>the</strong> RRTCs design and deliver<br />

workshops, research conferences, journal clubs, inter-institution<br />

research transfers, traineeships and mentorship programs to students<br />

at all levels, from undergraduates to post-doctoral fellows.<br />

RRTCs host national programs such as <strong>the</strong> <strong>endMS</strong> Summer School,<br />

SPRINT and <strong>the</strong> <strong>endMS</strong> Conference. Their role is to provide <strong>the</strong> tools<br />

and resources for trainees to maximize <strong>the</strong>ir MS research careers, or<br />

learn more about MS research if <strong>the</strong>y are considering <strong>the</strong> field.<br />

RRTCs across <strong>the</strong> country are generously funded by:<br />

Alberta Ministry <strong>of</strong> Enterprise and Advanced Education<br />

Scotiabank<br />

Fondation J. Armand Bombardier<br />

Reimer Express Foundation<br />

Novartis Pharmaceuticals <strong>Canada</strong> Inc.<br />

For more information on <strong>the</strong> RRTCs, visit mssociety.ca/<br />

RegionalCentres<br />

500<br />

400<br />

300<br />

200<br />

100<br />

0<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

2009 2010 2011 2012<br />

“<br />

I know <strong>the</strong> stress <strong>of</strong> having a<br />

young child with MS and <strong>the</strong><br />

daily struggles <strong>the</strong> disease<br />

brings to <strong>the</strong>se children, who<br />

<strong>the</strong>mselves don’t understand<br />

what’s going on with <strong>the</strong>ir<br />

bodies. My son Tyrell has been<br />

part <strong>of</strong> many studies at Sick<br />

Kids, and we believe that a<br />

cure will be found thanks to<br />

researchers who are part <strong>of</strong><br />

<strong>the</strong> <strong>endMS</strong> Network.<br />

”<br />

— Stephanie, mo<strong>the</strong>r <strong>of</strong><br />

Tyrell, who was diagnosed<br />

with MS at <strong>the</strong> age <strong>of</strong> six<br />

e n d M S . c a 4 | 5


Train<br />

You helped train <strong>the</strong> next generation <strong>of</strong> researchers to<br />

discover new ways to look at MS.<br />

<strong>endMS</strong> Summer School<br />

Joshua Lee on <strong>the</strong> impact <strong>of</strong> <strong>the</strong> <strong>endMS</strong> Summer School<br />

I was introduced to MS research<br />

near <strong>the</strong> end <strong>of</strong> my bachelor’s<br />

degree in microbiology and<br />

immunology at <strong>the</strong> University <strong>of</strong><br />

British Columbia. After graduation,<br />

I started my master’s degree<br />

and began work in Dr. Dessa<br />

Sadovnick’s lab, where I began<br />

studying MS in Asian populations.<br />

I have continued this work as a<br />

PhD student, and I have chosen<br />

to dedicate my career to<br />

MS research. I want to<br />

discover more about<br />

<strong>the</strong> genetic and<br />

environmental factors<br />

in MS susceptibility<br />

and severity, and<br />

how those<br />

elements<br />

interact.<br />

I have attended three consecutive<br />

<strong>endMS</strong> Summer School programs.<br />

While I have a strong foundation in<br />

MS research, <strong>the</strong> <strong>endMS</strong> Summer<br />

Schools exposed me to areas <strong>of</strong><br />

research I o<strong>the</strong>rwise would not<br />

be familiar with. The first summer<br />

school I attended focused on <strong>the</strong><br />

neuropsychological effects <strong>of</strong> MS,<br />

and it gave me ideas on how to<br />

integrate this aspect <strong>of</strong> MS in my<br />

own research.<br />

The <strong>endMS</strong> Summer School<br />

program engenders a collaborative,<br />

collegial environment for <strong>the</strong> next<br />

generation <strong>of</strong> MS researchers.<br />

I enjoyed being able to connect<br />

with o<strong>the</strong>r young trainees in <strong>the</strong><br />

same boat as me, in <strong>the</strong> spirit <strong>of</strong><br />

collaboration now and collaboration<br />

in <strong>the</strong> future. I am proud to be part<br />

<strong>of</strong> this group and hope to one day<br />

also be proud <strong>of</strong> <strong>the</strong> role I will play<br />

in ending MS.<br />

Joshua Lee, MS research<br />

trainee and three-time <strong>endMS</strong><br />

Summer School attendee


<strong>endMS</strong> Summer School<br />

<strong>endMS</strong> Summer School is an annual interactive education program<br />

that aims to enhance knowledge and skill in MS research among<br />

students at <strong>the</strong> master, doctoral and postdoctoral/clinical fellowship<br />

levels. It provides young MS trainees with a unique collaborative training<br />

opportunity designed to foster <strong>the</strong>ir interest in MS research and support<br />

<strong>the</strong>ir pursuit <strong>of</strong> knowledge in this field.<br />

Each year, <strong>the</strong> <strong>endMS</strong> Summer School brings toge<strong>the</strong>r students from<br />

a variety <strong>of</strong> disciplines to learn about MS research topics. The program<br />

features lecture-based plenary sessions and facilitated workshops that<br />

place emphasis on creating an interdisciplinary agenda, which provides<br />

participants a comprehensive understanding <strong>of</strong> ei<strong>the</strong>r basic science or<br />

clinical and population health research.<br />

For more information on <strong>the</strong> <strong>endMS</strong> Summer School, visit<br />

mssociety.ca/SummerSchool<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

each year, <strong>the</strong> <strong>endMS</strong> Summer School opens its doors to over 40 MS research trainees in <strong>Canada</strong>. In total,<br />

over 150 attendee spots have been filled for <strong>the</strong> <strong>endMS</strong> Summer School since it began. over 80 per cent<br />

<strong>of</strong> <strong>endMS</strong> Summer School attendees rated <strong>the</strong> program as “very effective” or “effective”.<br />

The 2010 and 2011 <strong>endMS</strong> Summer Schools<br />

were generously funded by Deloitte.<br />

“<br />

As a mom and <strong>the</strong> second<br />

person in my family diagnosed<br />

with MS, I will always wonder<br />

if I have passed along a<br />

genetic weakness that would<br />

increase my daughters’<br />

chances <strong>of</strong> having MS. I hope<br />

that, as <strong>the</strong>y collaborate and<br />

share ideas, researchers will<br />

solve <strong>the</strong> genetic piece <strong>of</strong> <strong>the</strong><br />

MS puzzle and help end MS.<br />

— Marilyn, diagnosed in 2000<br />

”<br />

e n d M S . c a 6 | 7


Retain<br />

You helped retain researchers in <strong>the</strong> field <strong>of</strong> MS.<br />

<strong>endMS</strong> Transitional Career Development Award<br />

Dr. Steven Kerfoot on <strong>the</strong> impact <strong>of</strong> <strong>the</strong> Garrett Herman <strong>endMS</strong> Transitional<br />

Career Development Award (TCDA)<br />

Before receiving <strong>the</strong> Garrett<br />

Herman <strong>endMS</strong> Transitional Career<br />

Development Award, I was doing<br />

B cell immunology work in <strong>the</strong><br />

United States. Through previous<br />

research collaboration, I was<br />

encouraged to apply for <strong>the</strong> award<br />

because my work was relevant to<br />

<strong>the</strong> field <strong>of</strong> MS. Being selected as<br />

<strong>the</strong> recipient <strong>of</strong> <strong>the</strong> award attracted<br />

me to <strong>the</strong> MS research community<br />

in <strong>Canada</strong>, where I now hold an<br />

assistant pr<strong>of</strong>essor position at<br />

Western University.<br />

My research looks at how B<br />

cells activate T cells in chronic<br />

autoimmune disease in <strong>the</strong> central<br />

nervous system. I’m working to<br />

identify subsets <strong>of</strong> B cells that<br />

have a pathogenic role, which<br />

could open doors to improve MS<br />

<strong>the</strong>rapies. I am also working to<br />

obtain a clearer picture <strong>of</strong> <strong>the</strong><br />

immune system and how it drives<br />

chronic inflammation in MS.<br />

Equipment and laboratory staff are<br />

expensive, and funding agencies<br />

have significantly cut back on<br />

what <strong>the</strong>y’re able to fund. Without<br />

this award, I would have been set<br />

back months or years trying to get<br />

funding. This award has allowed me<br />

to invest in <strong>the</strong> research tools that<br />

are necessary for me to carry out<br />

my work and achieve my goals. It<br />

has empowered me to accelerate<br />

<strong>the</strong> pace <strong>of</strong> discovery in MS<br />

research in <strong>Canada</strong>.<br />

Dr. Steven Kerfoot, recipient <strong>of</strong> <strong>the</strong><br />

Garrett Herman <strong>endMS</strong> Transitional<br />

Career Development Award


TCDA recipients<br />

Garrett Herman <strong>endMS</strong><br />

Transitional Career<br />

Development Award<br />

Dr. steven Kerfoot<br />

Western University<br />

Research focus: Role <strong>of</strong> B cells<br />

in multiple sclerosis<br />

Women against Ms (WaMs)<br />

<strong>endMS</strong> Transitional Career<br />

Development Award<br />

Dr. cornelia laule<br />

University <strong>of</strong> British Columbia<br />

Research focus: Developing<br />

magnetic resonance (MR)<br />

techniques to study <strong>the</strong><br />

pathology <strong>of</strong> MS<br />

<strong>endMS</strong> Transitional Career Development Award<br />

eMD serono <strong>endMS</strong><br />

Transitional Career<br />

Development Award<br />

Dr. Manu Rangachari<br />

Brigham and Women’s Hospital<br />

at Harvard Medical School<br />

Research focus: Pathogenic<br />

role <strong>of</strong> T cells in a mouse<br />

model <strong>of</strong> MS<br />

The <strong>endMS</strong> Transitional Career Development Award program supports<br />

outstanding postdoctoral and clinical fellows who are currently<br />

conducting research in an area related to MS.<br />

The award provides Canadian researchers with <strong>the</strong> means to establish<br />

a strong foundation for <strong>the</strong>ir MS-focused independent research career.<br />

This $500,000 award funds <strong>the</strong> last two years <strong>of</strong> <strong>the</strong> award recipient’s<br />

postdoctoral study and <strong>the</strong> first three years <strong>of</strong> <strong>the</strong>ir independent MSrelated<br />

faculty position in a Canadian institution. This award would not be<br />

possible without <strong>the</strong> generous support <strong>of</strong> those donors who funded <strong>the</strong><br />

award in its entirety each year.<br />

For more information on <strong>the</strong> TCDA, visit mssociety.ca/TCDA<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

David l. torrey <strong>endMS</strong><br />

Transitional Career<br />

Development Award<br />

Dr. Jorge alvarez<br />

University <strong>of</strong> Montréal Hospital<br />

Research Centre<br />

Research focus: Central<br />

nervous system barriers and<br />

how <strong>the</strong>y may be involved in<br />

MS-related inflammation<br />

“<br />

Decker family <strong>endMS</strong><br />

Transitional Career<br />

Development Award<br />

Dr. Jiwon oh<br />

Johns Hopkins University<br />

Research focus: Using<br />

advanced MRI techniques to<br />

determine how spinal cord<br />

lesions cause sensorimotor<br />

deficits<br />

Researchers like Dr. Kerfoot<br />

are working hard to answer<br />

questions about a disease<br />

that affects me every day.<br />

The TCDA decreases some<br />

<strong>of</strong> <strong>the</strong> funding challenges<br />

he faces as a researcher<br />

and ensures his commitment<br />

to MS research to develop<br />

treatments that help<br />

”<br />

me manage my disease.<br />

— Marie, diagnosed in 1996<br />

e n d M S . c a 8 | 9


Collaborate<br />

You helped increase opportunities for collaborative MS research.<br />

<strong>endMS</strong> Scholar Program for Researchers in<br />

Training (SPRINT)<br />

Dr. C.J. MacMillan on <strong>the</strong> impact <strong>of</strong> <strong>the</strong> <strong>endMS</strong> SPRINT program<br />

Growing up in Atlantic <strong>Canada</strong>,<br />

multiple sclerosis was part <strong>of</strong> my<br />

life and those <strong>of</strong> my family and<br />

friends. I began studying MS as a<br />

PhD candidate in neuropathology<br />

because <strong>of</strong> <strong>the</strong> high prevalence <strong>of</strong><br />

<strong>the</strong> disease in my region. During<br />

discussions with family and friends,<br />

it was clear to me that more<br />

research is desperately needed.<br />

In 2009, I was encouraged to<br />

enrol in <strong>the</strong> SPRINT program<br />

through my local <strong>endMS</strong><br />

Regional Research and Training<br />

Centre. SPRINT’s focus on <strong>the</strong><br />

importance <strong>of</strong> interdisciplinary<br />

and collaborative research<br />

piqued my interest. Like<br />

me, several <strong>of</strong> <strong>the</strong> program<br />

participants focus <strong>the</strong>ir research<br />

on neuropathology, while o<strong>the</strong>rs<br />

Dr. C.J. MacMillan,<br />

SPRINT participant<br />

focus on immunology and o<strong>the</strong>r<br />

fields related to MS. My research<br />

looks at angiogenesis – <strong>the</strong><br />

formation <strong>of</strong> new capillary<br />

blood vessels in <strong>the</strong> body – and<br />

<strong>the</strong> role it plays in MS.<br />

SPRINT provided me with <strong>the</strong><br />

opportunity to make valuable<br />

connections in <strong>the</strong> field <strong>of</strong> MS<br />

research. During <strong>the</strong> <strong>endMS</strong><br />

Summer School, I was able to<br />

collaborate with two trainees and<br />

a mentor on a project. I now have<br />

<strong>the</strong> skills necessary to effectively<br />

participate in collaborative<br />

research and translate my basic<br />

science research findings into<br />

everyday practice. SPRINT has<br />

been critical in my development<br />

as a trainee and inspired me to<br />

continue my pursuit for answers.


<strong>endMS</strong> SPRINT program<br />

SPRINT supports graduate students and postdoctoral and clinical fellows<br />

who are interested in conducting MS research. The program aims to enhance<br />

trainees’ knowledge and skill in MS research by increasing opportunities<br />

for collaborative MS research and creating a peer network. Trainees<br />

participate in two consecutive <strong>endMS</strong> Summer School sessions and a career<br />

development session before <strong>the</strong>y are paired with a mentor.<br />

For more information on SPRINT, visit mssociety.ca/SPRINT<br />

<strong>endMS</strong> Conference<br />

The <strong>endMS</strong> Conference is a national research conference aimed at fostering<br />

knowledge exchange on MS-related research, networking opportunities<br />

and collaboration amongst researchers and trainees. The three-day event<br />

features lectures, workshops, poster sessions and networking opportunities.<br />

It enables participants to learn about o<strong>the</strong>r research taking place in <strong>Canada</strong><br />

and to present and receive feedback on <strong>the</strong>ir work.<br />

<strong>endMS</strong> Conference attendance<br />

2013: Forthcoming in Saint-<br />

Sauveur, QC<br />

2010: 207 attendees, Whistler, BC<br />

2007: 225 attendees, Banff, AB<br />

For more information on <strong>the</strong><br />

<strong>endMS</strong> Conference, visit<br />

mssociety.ca/conference<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

“<br />

As I manage my multiple<br />

sclerosis, I look to research<br />

for possible answers about my<br />

future health. The SPRINT<br />

program gives me hope, as it<br />

lets me know <strong>the</strong> best and<br />

brightest minds are learning<br />

and collaborating with each<br />

o<strong>the</strong>r to find those answers.<br />

— Carol, diagnosed in 2003<br />

”<br />

e n d M S . c a 10 | 11


Research<br />

You helped fund invaluable MS research in <strong>Canada</strong>. Thank you.<br />

MS <strong>Society</strong> research program<br />

The <strong>endMS</strong> campaign contributed $60 million to <strong>the</strong> MS <strong>Society</strong> research<br />

program, which funds work in several research areas across <strong>the</strong> country in addition<br />

to <strong>the</strong> campaign’s flagship investment <strong>of</strong> <strong>the</strong> <strong>endMS</strong> Research and Training<br />

Network, designed to boost <strong>the</strong> research program. Because <strong>of</strong> you, <strong>the</strong> MS <strong>Society</strong><br />

and <strong>the</strong> <strong>Multiple</strong> <strong>Sclerosis</strong> Scientific Research Foundation are able to annually<br />

spend $8 to $10 million on research to find <strong>the</strong> cause <strong>of</strong> MS, treat symptoms and<br />

improve quality <strong>of</strong> life, and ultimately discover a cure for <strong>the</strong> disease.<br />

The MS <strong>Society</strong> funds as many promising avenues <strong>of</strong> research as possible, such<br />

as remyelination, cell signalling, CCSVI and stem cell research, so that researchers<br />

may answer <strong>the</strong> many questions that remain about MS. The following chart<br />

illustrates <strong>the</strong> many areas <strong>of</strong> research we fund so that people living with MS may<br />

have <strong>the</strong> answers <strong>the</strong>y seek.<br />

MS <strong>Society</strong> research program: What we fund<br />

n Neuroimmunology: 23%<br />

n MRI studies: 12%<br />

n Remyelination: 12%<br />

n Cell signalling: 12%<br />

n Preclinical models: 10%<br />

n Therapeutics: 7%<br />

n Quality <strong>of</strong> life: 6%<br />

n Population health: 5%<br />

n Neuropathology: 4%<br />

n Cognitive impairment: 3%<br />

n Genetics: 3%<br />

n Etiology: 2%<br />

n Stem cells: 1%


Research we fund: Looking for answers<br />

eTIology: What causes multiple sclerosis?<br />

Finding answers: Dr. Christina Wolfson, McGill University<br />

A population study <strong>of</strong> risk factors for multiple<br />

sclerosis: The Canadian contribution to an<br />

international study<br />

The cause <strong>of</strong> MS remains unknown despite more than 100<br />

years <strong>of</strong> research. Researchers have, however, determined<br />

a few possible individual risk factors, including infectious<br />

agents, smoking and vitamin D deficiency. A team <strong>of</strong> MS<br />

researchers from Europe and <strong>Canada</strong> are conducting<br />

a study including participants from five countries with<br />

differing MS risk that is large enough to examine how <strong>the</strong><br />

factors work toge<strong>the</strong>r. Once completed, this case control<br />

will be <strong>the</strong> largest MS risk factor study ever conducted.<br />

QuAlITy oF lIFe AND CogNITIve IMPAIRMeNT:<br />

How do I cope with <strong>the</strong> invisible cognitive<br />

symptoms <strong>of</strong> MS?<br />

Finding answers: Dr. Neil Rector, Sunnybrook Research<br />

Institute<br />

A randomized controlled trial testing <strong>the</strong> additive<br />

benefits <strong>of</strong> CBT and exercise for depression and<br />

cognitive dysfunction in MS<br />

<strong>Multiple</strong> sclerosis is a disease that can cause depression<br />

and cognitive deficits, which affect at least half <strong>of</strong> people<br />

living with MS. Dr. Rector investigates <strong>the</strong> effects <strong>of</strong><br />

cognitive behavioural <strong>the</strong>rapy, exercise and a combination<br />

<strong>of</strong> both on depression and neuropsychological functioning<br />

in MS to enable people living with MS to improve <strong>the</strong>ir<br />

quality <strong>of</strong> life.<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

ReMyelINATIoN: Can <strong>the</strong> myelin damage caused by<br />

MS be reversed?<br />

Finding answers: Dr. Jack Antel, McGill University<br />

Cellular immune injury <strong>of</strong> human oligodendrocytes<br />

The neurologic deficits in MS are a consequence <strong>of</strong><br />

injury and loss <strong>of</strong> myelin and <strong>the</strong> oligodendrocyte (OL) in<br />

<strong>the</strong> central nervous system. Dr. Antel’s work examines<br />

MS lesions to study how OLs may be injured by several<br />

mechanisms, and why <strong>the</strong>y are unable to trigger<br />

remyelination after damage done due to MS. The results<br />

from this study may lead to remyelination treatments that<br />

would repair <strong>the</strong> central nervous system.<br />

NeuRoIMMuNology: Why does <strong>the</strong> immune system<br />

malfunction in MS to attack <strong>the</strong> central nervous system?<br />

Finding answers: Dr. Robin Yates, University <strong>of</strong> Calgary<br />

Exploring <strong>the</strong> mechanisms <strong>of</strong> myelin antigen<br />

processing within <strong>the</strong> endosomal systems <strong>of</strong><br />

macrophages and dendritic cells<br />

MS is a disease wherein immune cells (T-cells) mistakenly<br />

react to <strong>the</strong>ir own proteins in myelin, resulting in<br />

neurologic impairment. While autoimmune T-cells trigger<br />

<strong>the</strong> inflammation seen in <strong>the</strong> disease, it is <strong>the</strong> antigen<br />

presenting cells (APCs) that engulf myelin debris that are<br />

responsible for activating <strong>the</strong> T-cells in <strong>the</strong> first place. Dr.<br />

Yates investigates how modifying <strong>the</strong> way APCs digest<br />

protein may eventually render it possible to control MS<br />

while maintaining beneficial immune responses.<br />

e n d M S . c a 12 | 13


Research<br />

<strong>Multiple</strong> <strong>Sclerosis</strong> Scientific Research Foundation<br />

The MS <strong>Society</strong> also funds <strong>the</strong> <strong>Multiple</strong> <strong>Sclerosis</strong> Scientific Research Foundation to<br />

stimulate innovative and collaborative research that will lead to major advances in MS.<br />

These funds support large, multi-centre, collaborative studies that are beyond <strong>the</strong><br />

scope <strong>of</strong> <strong>the</strong> regular research program.<br />

Prospective study <strong>of</strong> <strong>the</strong> clinical<br />

epidemiology, pathobiology and<br />

neuroimaging features <strong>of</strong> Canadian<br />

children with acquired demyelinating<br />

syndromes<br />

$4,300,000<br />

This study is designed to better<br />

understand <strong>the</strong> symptoms <strong>of</strong><br />

demyelination in children. By comparing<br />

<strong>the</strong> features <strong>of</strong> children diagnosed<br />

with MS to <strong>the</strong> features <strong>of</strong> children<br />

who experience a full recovery from<br />

an isolated attack <strong>of</strong> demyelination,<br />

researchers hope to learn important<br />

information about <strong>the</strong> causes <strong>of</strong> MS.<br />

Dr. Brenda Banwell, Children’s<br />

Hospital <strong>of</strong> Philadelphia (study taking<br />

place at Hospital for Sick Children,<br />

Toronto)<br />

Pathobiology <strong>of</strong> MS:<br />

Complex interplay between<br />

degeneration and inflammation<br />

$3,800,000<br />

While <strong>the</strong> cause <strong>of</strong> brain inflammation<br />

and degeneration in MS is unknown,<br />

it is apparent that this vicious cycle<br />

drives tissue damage and patient<br />

disability. This team project will study<br />

<strong>the</strong> molecular mechanisms <strong>of</strong> how nerve<br />

fibres are permanently injured in <strong>the</strong><br />

brain and spinal cord <strong>of</strong> MS patients to<br />

better understand what happens in <strong>the</strong><br />

earliest phases <strong>of</strong> this disease, which<br />

may have significance for people living<br />

with progressive forms <strong>of</strong> MS.<br />

Dr. Peter Stys, University <strong>of</strong> Calgary<br />

For complete information on<br />

MS <strong>Society</strong> funded research, visit<br />

mssociety.ca/researchsummaries


<strong>endMS</strong> campaign: Our valued donors<br />

<strong>endMS</strong> Circle ($1,000,000+)<br />

Alberta Ministry <strong>of</strong> Enterprise &<br />

Advanced Education<br />

Astral Media<br />

Canwest Global<br />

The Waugh Family Foundation<br />

Breakthrough Circle<br />

($500,000-$999,999)<br />

BMO Financial Group<br />

CIBC<br />

Bob & Pat Decker<br />

EMD Serono<br />

Garrett Herman<br />

Louis J. Maroun<br />

Scotiabank<br />

David L. Torrey<br />

Women Against MS (WAMS)<br />

Anonymous<br />

Discovery Circle<br />

($250,000-$499,999)<br />

Don Barkwell<br />

The Rudolph P. Bratty Family<br />

Foundation<br />

The Goodman Family and <strong>the</strong><br />

Dundee Group <strong>of</strong> Companies<br />

Manulife Financial<br />

Polygon Homes Limited<br />

Power Corporation <strong>of</strong> <strong>Canada</strong><br />

Rogers Communications<br />

Shaw Communications Inc.<br />

Anonymous<br />

knowledge Circle<br />

($100,000-$249,999)<br />

Sandy & Margot Aird<br />

Biogen Idec <strong>Canada</strong> Inc.<br />

Fondation J. Armand Bombardier<br />

The John & Judy Bragg Family<br />

Foundation<br />

La Capsule sportive, MSA financial<br />

and Houston Golf Tournament<br />

Albert Diamond Cohen<br />

Purdy & Bea Crawford<br />

Ian & Kiki Delaney<br />

Deloitte & Touche Foundation<br />

<strong>Canada</strong><br />

Ernst & Young LLP<br />

FRQS (Fonds de recherche du<br />

Québec - Santé)<br />

Jayman MasterBUILT<br />

KPMG Foundation<br />

Jon & Nancy Love<br />

Debbie & Fred Moore<br />

Susan A. Murray<br />

National Bank Financial Group<br />

Robert H. Pitfield<br />

Larry Plotnick, with family & friends<br />

PricewaterhouseCoopers LLP<br />

Reimer Express Foundation<br />

Research In Motion Limited<br />

Bruce & Sylvia Richmond<br />

Sherritt International Corporation<br />

Joanne Stansfield & Bill Gallacher<br />

Kevin & Sandra Sullivan<br />

Larry & Judy Tanenbaum<br />

TELUS<br />

Richard & Hea<strong>the</strong>r Thomson<br />

Anonymous<br />

Patron<br />

($50,000-$99,999)<br />

Altus Energy Services Partnership<br />

Bob & Joy Antenbring<br />

Gayelene Bonenfant<br />

Brandt Group <strong>of</strong> Companies<br />

Dr. F.J. Brooks-Hill<br />

Richard Charlton<br />

Co-operators<br />

Costco Wholesale <strong>Canada</strong> Ltd.<br />

John Feld & Phyllis Yaffe<br />

Alistair M. Fraser<br />

GMP Securities<br />

IBM <strong>Canada</strong><br />

Milan & Maureen Ilich Foundation<br />

Industrielle Alliance<br />

Jazz Air LP<br />

Peter & Allison Jelley<br />

Daniel Larouche<br />

Kenneth Macgowan<br />

e n d M S C a M p a i g n i M p a C t R e p o R t<br />

We are grateful to <strong>the</strong> following donors who have contributed to <strong>the</strong> <strong>endMS</strong> campaign.<br />

Novartis Pharmaceuticals <strong>Canada</strong><br />

Inc.<br />

Onex Corporation<br />

Riddell Family Charitable Foundation<br />

SNC-Lavalin<br />

Teva <strong>Canada</strong> Innovation<br />

Mark & Sarah Wellings<br />

Herbert Wyman<br />

Anonymous (3)<br />

Benefactor<br />

($25,000-$49,999)<br />

Ainsworth Charitable Trust<br />

Avtar Bains & Monika Deol<br />

Bay Tank & Vessel Ltd.<br />

Stewart Busbridge<br />

The Charlton Group<br />

CN<br />

John F. Clifford<br />

Donald & Valerie Copeland<br />

Cuddy Farms Corporation,<br />

in memory <strong>of</strong> A.M. Cuddy<br />

The Cullen Family<br />

Rueben & Rhonda Devlin<br />

George Fine<br />

David & Beverly Garton<br />

Gibson Energy<br />

Goodman Investment Counsel<br />

Barry Gordon Family<br />

Haywood Securities Inc.<br />

Highland Farms Inc.<br />

Helen Kearns<br />

David L. Knight<br />

Laval Chapter, MS <strong>Society</strong> <strong>of</strong> <strong>Canada</strong><br />

Harold & Yvonne Lenfesty<br />

John & Gail MacNaughton<br />

Terry McGibbon<br />

David McGraw<br />

McMillan LLP<br />

Kathleen Murphy & Harry Joosten<br />

J.E. Panneton Family Foundation<br />

Paradigm Capital<br />

Peak Energy Services Trust<br />

Honourable Madam Justice Sarah<br />

Pepall<br />

Phillips, Hager & North Investment<br />

Management Ltd.<br />

Pollard Family Foundation<br />

Marjorie Anne Sauder<br />

Yves Savoie<br />

Sun Life Financial<br />

William D. Swisher<br />

Trudell Medical International, in<br />

memory <strong>of</strong> A.M. Cuddy<br />

Gabriel Tsampalieros<br />

Anonymous<br />

leader<br />

($10,000-$24,999)<br />

Paul Atkinson<br />

Rob Barbara<br />

The Bellini Foundation<br />

Michael Bernstein & Nandini<br />

DasGupta<br />

Gil Blutrich<br />

Bosa Properties Foundation<br />

Canadian Western Bank<br />

Frances Carmichael & Jack Cashman<br />

Barry & Laurie Cavanaugh<br />

Neil & Andrea Chrystal<br />

Norm Cressey<br />

Rossano DeCottis<br />

Dinner and Jazz for MS<br />

Elan Pharmaceuticals<br />

Emerson Real Estate Group<br />

Lindsay & Elizabeth Gordon<br />

Glen Gowland<br />

Sam & Sally Grippo<br />

Stanley H. Hartt<br />

In honour <strong>of</strong> Susan Huycke & Sylvia<br />

Bosworth<br />

The Dick & Lois Haskayne Fund at<br />

The Calgary Foundation<br />

Chris Haslam<br />

Ramsay Holmes<br />

HUB International<br />

I.M.P. Group International Inc.<br />

ING Direct<br />

Richard Ilich & Lauren Melville<br />

e n d M S . c a 14 | 15


Our valued donors (continued)<br />

leader<br />

($10,000-$24,999)<br />

(continued)<br />

Ralph Jordan<br />

Andy Kent<br />

The Henry White Kinnear Foundation<br />

Jack Kowarsky & Maya Coco<br />

Peter & Kay Legge<br />

Brian D. Lerner<br />

Loewen Ondaatje McCutcheon Ltd.<br />

Lohn Foundation<br />

Samuel & Vivien Ludwin<br />

William S. & Jana Maclagan<br />

Macquarie Group Foundation<br />

Hugh & Sherri Magee<br />

George Marlatte<br />

Andrew Mahon Foundation<br />

Ken & Suzanne Mayhew<br />

Nixon Charitable Foundation<br />

Leslie Noble<br />

Daniel Nowlan<br />

Onni Group<br />

Herb & Aster Osen<br />

Maria Pinelli & Paul Fletcher<br />

David & Mary Beth Poole<br />

Jack & Darlene Poole<br />

Procura Real Estate Services Limited<br />

Joe Randell<br />

Larry & Gre<strong>the</strong> Rank<br />

Jim & Marcia Ratsoy<br />

RBC Capital Markets<br />

Jeffrey C. Rice<br />

The Rix Family Foundation<br />

Rollagain Holdings<br />

Sassafraz<br />

William L. Sauder<br />

Scotia Capital<br />

The Joseph Segal Family Foundation<br />

Michael Shuh & Michelle Fiebig<br />

Sidoo Family Foundation<br />

South Edmonton Lions Club<br />

Thane & Darci Stenner<br />

Torys LLP<br />

Variety - The Children’s Charity <strong>of</strong><br />

British Columbia<br />

Warrior Resources Corporation<br />

Wesik Construction Limited<br />

The James & Kathleen Winton<br />

Foundation<br />

Anonymous (5)<br />

Investor<br />

($5,000-$9,999)<br />

AllianceBernstein <strong>Canada</strong>, Inc.<br />

Aurion Capital<br />

David Bardal<br />

Bell Aliant<br />

Bio-Extraction Inc.<br />

BioMS Medical Corp.<br />

Bonavista Energy Corporation<br />

Yolanda Bronstein<br />

Sushil & Diana Chari<br />

Mr. Peter Cashin <strong>of</strong> Quest Rare<br />

Minerals<br />

CI Investments Inc.<br />

Colliers International<br />

Mike den Haan & Family<br />

David Doritty<br />

Charles J. Ford<br />

Richard Grafton<br />

Halifax International Airport Authority<br />

Dominique Hansen<br />

Kelly Heed<br />

Sibylla Hesse Foundation<br />

Sean Hodgins<br />

The Hon. Henry N.R. Jackman<br />

Jolera<br />

Brian Jones<br />

Greg & Lisa Kerfoot<br />

Morley & Myrna K<strong>of</strong>fman<br />

Douglas C. & Ann Mackay<br />

Joan MacKinnon<br />

Robert & Debra MacLeod<br />

Keith MacPhail<br />

Martinrea International Inc.<br />

Senator Paul J. Massicotte & Sylvie<br />

Dragon<br />

Medcan Clinic<br />

Mike McClintock<br />

Seth & Theresa Mersky<br />

Oberon Capital<br />

Lisa & Roger Park<br />

Gestion Picory Inc.<br />

Raymond James<br />

The Larry & Cookie Rossy Family<br />

Foundation<br />

Rohit Sehgal<br />

The Shaw Group<br />

Shelter Canadian Properties Inc.<br />

Dena Simon<br />

Peter Smiechowski<br />

Sterling Senior Living<br />

Stoneham Drilling Inc.<br />

TNG Corporation<br />

Waterbury Newton<br />

Jack Way<br />

Brendan Wood International<br />

Woods LLP<br />

Anonymous<br />

Supporter<br />

($1,000-$4,999)<br />

Michelle Amerie & Raymond Cohen<br />

Apex Distribution Inc.<br />

Joshua Arbuckle<br />

Larry Arsenault<br />

The Azrieli Foundation<br />

Brent S. Belzberg<br />

Herbert Black<br />

Chris Breen<br />

Elizabeth Breen<br />

Department <strong>of</strong> Microbiology &<br />

Immunology, University <strong>of</strong> British<br />

Columbia<br />

Dennis and Darla Brown<br />

Burgundy Asset Management Ltd.<br />

Dr. Greg A. Burk<br />

CAE Inc.<br />

Fiona A. Campbell<br />

Jennifer Carter<br />

David Christie<br />

Jacqui Cohen/Army & Navy Stores<br />

Concord Pacific Group Inc.<br />

Patricia Davidson<br />

Douglas Deruchie<br />

Discovery Solutions International Inc.<br />

Leslie & Irene Dube<br />

Rick Durst<br />

Ge<strong>of</strong>frey J. Dyer<br />

Jonathan Ehrlich<br />

Brad Forden & Carole Fujimoto<br />

Ian Fraser<br />

GARAGA Inc.<br />

Natasha Hughes Germain<br />

Judy Goldring<br />

Jeff & Sandra Goldstein<br />

Bill Gray<br />

Greater Toronto Airport Authority<br />

Rohit & Aimee Gupta<br />

Richard Hodgson<br />

Valerie Hussey Family Fund via Tides<br />

<strong>Canada</strong> Foundation<br />

Greg Kalil<br />

Dr. Stephen Kerfoot<br />

Sass & Sharmeen Khazzam<br />

Gene & Cathy Kosmyna<br />

Kevin Li & Lori Sugarman<br />

Larry R. Lunn<br />

Craig Macadam<br />

Larry Maloney<br />

Tammy Masoumi<br />

The Jeffrey & Marilyn McCaig Family<br />

Foundation<br />

James C. McKnight<br />

Mitchell McConnell Insurance Ltd.<br />

Dr. Jock & Janet Murray<br />

Norton Rose<br />

Fred & Gail Pamenter<br />

Paul Pathak<br />

David G. Patterson<br />

Piston Ring Service<br />

Alexandre Prat<br />

Quebecor World Inc.<br />

Jeremy Rakusin<br />

Jonathan Robbins<br />

Mahon Rowland Foundation<br />

Irene Russell<br />

Dr. Dessa Sadovnick<br />

David Sapunjis – Sapunjis Family<br />

Trust<br />

Alan M. Schwartz<br />

Selective Asset Management Inc.<br />

Robert Sellars<br />

Shaw Pipe Limited<br />

La maison Simons<br />

Allen Stern<br />

Stock Network Media<br />

Lyane Van Schank-Munk<br />

Victoria Foundation<br />

C.J. Viner Family Foundation<br />

John Webb<br />

Waterloo Chapter, MS <strong>Society</strong> <strong>of</strong><br />

<strong>Canada</strong> -- Fall Fashion Fantasy Show<br />

Stephen Waugh<br />

Mark Whitmore<br />

Anonymous (5)<br />

We apologize for any errors or omissions.


e n d M S n a t i o n a l C a M p a i g n C a b i n e t *<br />

Honorary national<br />

campaign chair<br />

Mr. Richard E. Waugh<br />

National campaign chair<br />

Mr. Alexander R. Aird<br />

National campaign<br />

vice-chairs<br />

Mr. Purdy Crawford<br />

Ms. Helen M. Kearns<br />

Quebec campaign chair<br />

Mr. Claude Gagnon<br />

Ontario campaign chair<br />

Mr. David A. Garton<br />

BC-Yukon<br />

campaign chair<br />

Mr. David M. Poole<br />

Atlantic campaign chair<br />

Mr. Joseph D. Randell<br />

Cabinet members<br />

Mr. Alistair M. Fraser<br />

Mr. Stanley H. Hartt<br />

Mr. Garrett Herman<br />

Mr. Daniel Larouche<br />

Mr. Louis J. Maroun<br />

Mr. Fred Moore<br />

Mr. Bryan Rakusin<br />

Mr. Bruce R. Richmond<br />

Mr. Yves Savoie<br />

Mr. Richard M. Thomson<br />

Mr. David L. Torrey<br />

*List from December 2012


1-800-268-7582 info@mssociety.ca mssociety.ca<br />

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