PHA 5451 Clinical Biochemistry
4 Semester Credit Hours
The course will provide a biochemical foundation for the understanding of drug action, drug
absorption and drug metabolism. Examples of biochemical basis for different disease states will
provide a framework in understanding cause of disease.
Course Faculty and Office Hours
Email: firstname.lastname@example.org Office: P4-27, Health Science Center
Anthony Palmieri III
Communication with Instructor can be done through the course discussion board, email or make
an appointment (please allow at least 24 hours to response).
See Appendix A for contact information of Teaching Assistants.
Place and Time of Class Sessions
Room: C1-11; Time: 10:40-11:30 AM, Monday, Tuesday, Wednesday and Friday, except 8:30-
9:20 AM on Sep 18, Oct 16 and Nov 20 (see appendix B)
How This Course Relates to the Learning Outcomes You Will Achieve in the
This course prepares the Pharm.D. student to accomplish the following abilities and the related Student
Learning Outcomes (SLOs) upon graduation:
1. Provide Patient-centered Care - Specifically: Design, implement, monitor, evaluate, and adjust
pharmacy care plans that are patient-specific; address health literacy, cultural diversity, and
behavioral psychosocial issues; are evidence-based and accomplished in collaboration with
other health professionals. (Foundational)
2. Use pharmacy knowledge in the care of patients and resolution of practice problems.
Upon completion of this course, the student will be able to:
1) Describe the structure, function and metabolic pathways for carbohydrates, amino acids and
2) Explain the alterations in lipid and carbohydrate metabolism that occur as a result of diabetes.
3) Explain the metabolism of lipoproteins, medical problems associated with abnormal lipoprotein
levels and therapeutic agents used to treat lipid disorders.
4) Describe how enzyme activity is regulated through second messengers and hormones.
5) Describe the biochemistry of membranes including chemical composition and structure of
biological membranes, as well as drug transporters.
6) Describe intercellular and intracellular signal transductions and explain the molecular
mechanism of drug actions.
7) Describe the processes involved in replication, transcription and translation of genetic
8) Describe DNA recombination and discuss the impact it has on production of proteins as drugs.
9) Apply biochemistry concepts to solve clinical scenarios.
10) Clarify the information of biochemistry in eukaryotic cells, with an emphasis on those of human
11) To translate the biochemical event at cellular levels to physiological processes in human body.
Pre-Requisite Knowledge and Skills
Organic Chemistry (CHM 2210 and 2211, CHM 2215 and 2216, or their equivalents at other
universities) or consent of instructor.
Course Structure & Outline
a) Learning activities are video lectures and students are required to come to campus for exams,
b) Multiple self-directed learning activities are required (e.g., videos, readings and web-based
learning); students must come to class for exams.
Course Outline/Activities. See Appendix B.
Textbook of Biochemistry with Clinical Correlations
T.M. Devlin Editor, Wiley-Liss, John Wiley & Sons, Inc. 7th Edition 2010
Recycled 5th or 6th editions of the same textbook can also be used.
Active Learning Requirements
The lectures will follow the syllabus. There will be overlap between topics covered in Clinical
Biochemistry and in Medicinal Chemistry. These should not be viewed as redundant but rather
reinforcing the understanding of fundamental chemical principles regarding both Biochemistry
and Drug Action. Students are encouraged to review those clinical correlations in the textbook
for better understanding biochemical concepts related to disease or drug action.
Student Evaluation & Grading
The average grade of 4 exams will be the final grade of the course for each student. If necessary,
grades may be scaled at the end of the course based on the performance of the class.
Based on UF grading system
• >90 A (4.0)
• >87, 83, 80, 77, 73, 70, 67, 63, 60, 57,
1. University Grading Policies
2. Academic Integrity Policy
3. How to request learning accommodations
4. Faculty and course evaluations
5. Student expectations in class
6. Discussion board policy
7. Email communications
8. Religious holidays
9. Counseling & student health
10. How to access services for student success
Please see the following URL for this information:
Should you have any complaints with your experience in this course please visit:
http://www.distancelearning.ufl.edu/student-complaints to submit a complaint.
Appendix A: Directions for Contacting Faculty & Course Faculty List
Directions for Contacting Course Faculty
Communication with instructors can be done through the course discussion board, email or
make an appointment. Approximately 70 to 80 students are assigned to each Teaching
Assistant. Check the “Groups” key on the course web site to find out which TA you have been
assigned to. The Teaching Assistants will hold office hours electronically for one hour per week
using the group discussion board. The Teaching Assistant will select a time that accommodates
the majority of their students and the Teaching Assistant’s schedule. ]
Sihong Song, Associate Professor, email@example.com
Anthony Palmieri III, Assistant Clinical Professor, firstname.lastname@example.org
Graduate Student Teaching Assistants
Anandharajan Rathinasabapathy Group 1 Anandharajanr@ufl.edu
Karin Haug Group 2 email@example.com
Li Li Group 3 firstname.lastname@example.org
Xuyang Song Group 4 email@example.com
Appendix B. Schedule of Course Activities/Topics
(Room: C1-11; Time: 10:40-11:30 AM, Monday, Tuesday, Wednesday and Friday except 8:30-
9:20 AM on Sep 18, Oct 16 and Nov 20)
1 8/22 w 1 Palmieri Introduction of the course. Water, pH, buffers
2 8/24 F 1 Palmieri Eukaryotic cellular structure and function
3 8/27 M 3 Palmieri Amino Acids-Chemical Properties
4 8/28 T 3 Palmieri Transition from amino acids to proteins
5 8/29 W 3 Palmieri Protein Structure
6 8/31 F 9 Palmieri Immunoglobulin
9/3 M Labor Day Holiday-NO CLASS!!!
7 9/4 T 9 Palmieri Serine Proteases, Protease Inhibitors
8 9/5 W 9 Palmieri Hemoglobin: Structure and Function
9 9/7 F 9 Palmieri Basal lamina protein complex
10 9/10 M 10 Palmieri Enzyme Classification and Reaction Kinetics
11 9/11 T 10 Palmieri Enzyme Kinetics and Enzyme Inhibition
12 9/12 W 10 Palmieri Regulation of Enzyme Activity
9/14 F Palmieri Review for Exam I (covers Ch. 1, 3, 9 &10)
13 9/17 M 11 Palmieri Cytochromes P450
14 9/18 T 11 Palmieri Nitric Oxide Synthases (8:30 AM)
15 9/19 W 12 Palmieri Biological Membranes I-composition
16 9/21 F 12 Palmieri Biological Membranes II-structure
9/24 M Palmieri Exam I (covers Ch. 1, 3, 9 &10; at 4:30-6:30PM)
17 9/25 T 12 Palmieri Biological Membranes II-Function
18 9/26 W 14 Palmieri Biochemical Thermodynamics
19 9/28 F 14 Palmieri Tricarboxylic Acid Cycle
20 10/1 M 14 Palmieri Electron Transport Chain
21 10/2 T 14 Palmieri Mitochondrial Diseases
22 10/3 W 15 Palmieri Glycolysis
23 10/5 F 15 Palmieri Regulation of Glycolysis
24 10/8 M 15 Palmieri Glycogen Synthesis and Degradation
10/9 T Palmieri Review for Exam II (covers Ch. 11,12,14 &15)
25 10/10 W 16 Palmieri Pentose Phosphate Pathway
10/12 F Palmieri Exam II (covers Ch. 11,12, 14 &15; at 4:30-6:30 PM)
26 10/15 M 16 Palmieri Sugar Interconversions
27 10/16 T 17 Palmieri Lipid Metabolism I (8:30AM)
28 10/17 W 17 Palmieri Lipid Metabolism I
29 10/19 F 18 Palmieri Lipid Metabolism II
30 10/22 M 18 Palmieri Lipid Metabolism II
31 10/23 T 19 Palmieri Amino Acid Metabolism:
32 10/24 W 19 Palmieri Amino Acid Metabolism:
33 10/26 F 19 Palmieri Amino Acid Metabolism:
34 10/29 M 20 Palmieri Purine and Pyrimidine Nucleotide Metabolism
35 10/30 T 20 Palmieri Purine and Pyrimidine Nucleotide Metabolism
10/31 W Palmieri Review for Exam III (covers Ch. 16,17,18,19 & 20)
36 11/2 F 2 Song DNA & RNA: Composition and Structure
11/5 M Palmieri Exam III (Ch. 16, 17, 18, 19 & 20; 4:30-6:30 PM)
37 11/6 T 2 Song DNA & RNA: Composition and Structure
38 11/7 W 4 Song DNA Replication
11/9 F Home Coming-NO CLASS!!!
11/12 M Veterans Day-No Class!!!
39 11/13 T 4 Song DNA Recombination and Repair
40 11/14 W 5 Song RNA: Transcription and RNA processing
41 11/16 F 5 Song RNA: Transcription and RNA processing
42 11/19 M 6 Song Protein synthesis-translation
43 11/20 T 6 Song Posttranslational modifications (8:30AM)
44 11/21 W 13 Song Signal transduction-I
11/23 F Thanksgiving Holidays-NO CLASS!!!
45 11/26 M 13 Song Signal transduction-I
46 11/27 T 8 Song Regulation of gene expression in Bacteria
47 11/28 W 8 Song Regulation of gene expression in eukaryotes
48 11/30 F 7 Song Recombinant DNA and Biotechnology
49 12/3 M 7 Song Application of Biotechnology
12/4 T Song Exam IV Review (Ch.. 2, 4, 5, 6, 13, 8 & 7)
12/5 W No lecture
12/7 F No lecture
12/13 Th Song Exam IV (Ch. 2, 4, 5, 6, 13, 8 & 7; at 10 AM-12 noon
12/14 F The End