PHA 5451 Clinical Biochemistry - College of Pharmacy

cop.ufl.edu

PHA 5451 Clinical Biochemistry - College of Pharmacy

PHA 5451 Clinical Biochemistry

4 Semester Credit Hours

Course Purpose:

The course will provide a biochemical foundation for the understanding of drug action, drug

absorption and drug metabolism. Examples of biochemical basis for different disease states will

provide a framework in understanding cause of disease.

Course Faculty and Office Hours

Course Coordinator:

Sihong Song

Email: shsong@ufl.edu Office: P4-27, Health Science Center

Phone: 352-273-7867

Co-Coordinator:

Anthony Palmieri III

Email: palmieri@cop.ufl.edu

Office Hours

Communication with Instructor can be done through the course discussion board, email or make

an appointment (please allow at least 24 hours to response).

See Appendix A for contact information of Teaching Assistants.

Place and Time of Class Sessions

Room: C1-11; Time: 10:40-11:30 AM, Monday, Tuesday, Wednesday and Friday, except 8:30-

9:20 AM on Sep 18, Oct 16 and Nov 20 (see appendix B)

How This Course Relates to the Learning Outcomes You Will Achieve in the

Pharm.D. Program:

This course prepares the Pharm.D. student to accomplish the following abilities and the related Student

Learning Outcomes (SLOs) upon graduation:

1. Provide Patient-centered Care - Specifically: Design, implement, monitor, evaluate, and adjust

pharmacy care plans that are patient-specific; address health literacy, cultural diversity, and

behavioral psychosocial issues; are evidence-based and accomplished in collaboration with

other health professionals. (Foundational)

2. Use pharmacy knowledge in the care of patients and resolution of practice problems.

Course Objectives

Upon completion of this course, the student will be able to:

1) Describe the structure, function and metabolic pathways for carbohydrates, amino acids and

lipids.

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2) Explain the alterations in lipid and carbohydrate metabolism that occur as a result of diabetes.

3) Explain the metabolism of lipoproteins, medical problems associated with abnormal lipoprotein

levels and therapeutic agents used to treat lipid disorders.

4) Describe how enzyme activity is regulated through second messengers and hormones.

5) Describe the biochemistry of membranes including chemical composition and structure of

biological membranes, as well as drug transporters.

6) Describe intercellular and intracellular signal transductions and explain the molecular

mechanism of drug actions.

7) Describe the processes involved in replication, transcription and translation of genetic

information.

8) Describe DNA recombination and discuss the impact it has on production of proteins as drugs.

9) Apply biochemistry concepts to solve clinical scenarios.

10) Clarify the information of biochemistry in eukaryotic cells, with an emphasis on those of human

tissues.

11) To translate the biochemical event at cellular levels to physiological processes in human body.

Pre-Requisite Knowledge and Skills

Organic Chemistry (CHM 2210 and 2211, CHM 2215 and 2216, or their equivalents at other

universities) or consent of instructor.

Course Structure & Outline

Course Structure.

a) Learning activities are video lectures and students are required to come to campus for exams,

b) Multiple self-directed learning activities are required (e.g., videos, readings and web-based

learning); students must come to class for exams.

Course Outline/Activities. See Appendix B.

Textbooks

Textbook of Biochemistry with Clinical Correlations

T.M. Devlin Editor, Wiley-Liss, John Wiley & Sons, Inc. 7th Edition 2010

http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470601523.html

Recycled 5th or 6th editions of the same textbook can also be used.

Active Learning Requirements

The lectures will follow the syllabus. There will be overlap between topics covered in Clinical

Biochemistry and in Medicinal Chemistry. These should not be viewed as redundant but rather

reinforcing the understanding of fundamental chemical principles regarding both Biochemistry

and Drug Action. Students are encouraged to review those clinical correlations in the textbook

for better understanding biochemical concepts related to disease or drug action.

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Student Evaluation & Grading

Evaluation Methods

The average grade of 4 exams will be the final grade of the course for each student. If necessary,

grades may be scaled at the end of the course based on the performance of the class.

Grading Scale

Based on UF grading system

(http://www.registrar.ufl.edu/catalog/policies/regulationgrades.html)

• >90 A (4.0)

• >87, 83, 80, 77, 73, 70, 67, 63, 60, 57,


1. University Grading Policies

2. Academic Integrity Policy

3. How to request learning accommodations

4. Faculty and course evaluations

5. Student expectations in class

6. Discussion board policy

7. Email communications

8. Religious holidays

9. Counseling & student health

10. How to access services for student success

Please see the following URL for this information:

http://www.cop.ufl.edu/wpcontent/uploads/dept/studaff/policies/General%20COP%20Course%20Policies.pdf

Complaints

Should you have any complaints with your experience in this course please visit:

http://www.distancelearning.ufl.edu/student-complaints to submit a complaint.

Appendix A: Directions for Contacting Faculty & Course Faculty List

Directions for Contacting Course Faculty

Communication with instructors can be done through the course discussion board, email or

make an appointment. Approximately 70 to 80 students are assigned to each Teaching

Assistant. Check the “Groups” key on the course web site to find out which TA you have been

assigned to. The Teaching Assistants will hold office hours electronically for one hour per week

using the group discussion board. The Teaching Assistant will select a time that accommodates

the majority of their students and the Teaching Assistant’s schedule. ]

Course Coordinator

Sihong Song, Associate Professor, shsong@ufl.edu

Instructor

Anthony Palmieri III, Assistant Clinical Professor, palmieri@cop.ufl.edu

Graduate Student Teaching Assistants

Anandharajan Rathinasabapathy Group 1 Anandharajanr@ufl.edu

Karin Haug Group 2 karinhaug@ufl.edu

Li Li Group 3 lili1982@ufl.edu

Xuyang Song Group 4 songxuyang@ufl.edu

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Appendix B. Schedule of Course Activities/Topics

(Room: C1-11; Time: 10:40-11:30 AM, Monday, Tuesday, Wednesday and Friday except 8:30-

9:20 AM on Sep 18, Oct 16 and Nov 20)

Weeks

Week 1

Week 2

Week 3

Week 4

Week 5

Week 6

Week 7

Week 8

Lecture

Date Day

Book

Chapter

Lecturer

Specific Topics

1 8/22 w 1 Palmieri Introduction of the course. Water, pH, buffers

2 8/24 F 1 Palmieri Eukaryotic cellular structure and function

3 8/27 M 3 Palmieri Amino Acids-Chemical Properties

4 8/28 T 3 Palmieri Transition from amino acids to proteins

5 8/29 W 3 Palmieri Protein Structure

6 8/31 F 9 Palmieri Immunoglobulin

9/3 M Labor Day Holiday-NO CLASS!!!

7 9/4 T 9 Palmieri Serine Proteases, Protease Inhibitors

8 9/5 W 9 Palmieri Hemoglobin: Structure and Function

9 9/7 F 9 Palmieri Basal lamina protein complex

10 9/10 M 10 Palmieri Enzyme Classification and Reaction Kinetics

11 9/11 T 10 Palmieri Enzyme Kinetics and Enzyme Inhibition

12 9/12 W 10 Palmieri Regulation of Enzyme Activity

9/14 F Palmieri Review for Exam I (covers Ch. 1, 3, 9 &10)

13 9/17 M 11 Palmieri Cytochromes P450

14 9/18 T 11 Palmieri Nitric Oxide Synthases (8:30 AM)

15 9/19 W 12 Palmieri Biological Membranes I-composition

16 9/21 F 12 Palmieri Biological Membranes II-structure

9/24 M Palmieri Exam I (covers Ch. 1, 3, 9 &10; at 4:30-6:30PM)

17 9/25 T 12 Palmieri Biological Membranes II-Function

18 9/26 W 14 Palmieri Biochemical Thermodynamics

19 9/28 F 14 Palmieri Tricarboxylic Acid Cycle

20 10/1 M 14 Palmieri Electron Transport Chain

21 10/2 T 14 Palmieri Mitochondrial Diseases

22 10/3 W 15 Palmieri Glycolysis

23 10/5 F 15 Palmieri Regulation of Glycolysis

24 10/8 M 15 Palmieri Glycogen Synthesis and Degradation

10/9 T Palmieri Review for Exam II (covers Ch. 11,12,14 &15)

25 10/10 W 16 Palmieri Pentose Phosphate Pathway

10/12 F Palmieri Exam II (covers Ch. 11,12, 14 &15; at 4:30-6:30 PM)

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Weeks

Week 9

Week

10

Week

11

Week

12

Week

13

Week

14

Week

15

Week

16

Lecture

Date Day

Book

Chapter

Lecturer

Specific Topics

26 10/15 M 16 Palmieri Sugar Interconversions

27 10/16 T 17 Palmieri Lipid Metabolism I (8:30AM)

28 10/17 W 17 Palmieri Lipid Metabolism I

29 10/19 F 18 Palmieri Lipid Metabolism II

30 10/22 M 18 Palmieri Lipid Metabolism II

31 10/23 T 19 Palmieri Amino Acid Metabolism:

32 10/24 W 19 Palmieri Amino Acid Metabolism:

33 10/26 F 19 Palmieri Amino Acid Metabolism:

34 10/29 M 20 Palmieri Purine and Pyrimidine Nucleotide Metabolism

35 10/30 T 20 Palmieri Purine and Pyrimidine Nucleotide Metabolism

10/31 W Palmieri Review for Exam III (covers Ch. 16,17,18,19 & 20)

36 11/2 F 2 Song DNA & RNA: Composition and Structure

11/5 M Palmieri Exam III (Ch. 16, 17, 18, 19 & 20; 4:30-6:30 PM)

37 11/6 T 2 Song DNA & RNA: Composition and Structure

38 11/7 W 4 Song DNA Replication

11/9 F Home Coming-NO CLASS!!!

11/12 M Veterans Day-No Class!!!

39 11/13 T 4 Song DNA Recombination and Repair

40 11/14 W 5 Song RNA: Transcription and RNA processing

41 11/16 F 5 Song RNA: Transcription and RNA processing

42 11/19 M 6 Song Protein synthesis-translation

43 11/20 T 6 Song Posttranslational modifications (8:30AM)

44 11/21 W 13 Song Signal transduction-I

11/23 F Thanksgiving Holidays-NO CLASS!!!

45 11/26 M 13 Song Signal transduction-I

46 11/27 T 8 Song Regulation of gene expression in Bacteria

47 11/28 W 8 Song Regulation of gene expression in eukaryotes

48 11/30 F 7 Song Recombinant DNA and Biotechnology

49 12/3 M 7 Song Application of Biotechnology

12/4 T Song Exam IV Review (Ch.. 2, 4, 5, 6, 13, 8 & 7)

12/5 W No lecture

12/7 F No lecture

12/10 M

12/11 T

12/12 W

12/13 Th Song Exam IV (Ch. 2, 4, 5, 6, 13, 8 & 7; at 10 AM-12 noon

12/14 F The End

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