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(Photos: C.R. Lee, CCR) f e a t u r e Squamous cell carcinoma (top) is a relatively aggressive skin cancer, and it shares many of the features of lethal solid tumors of the internal organs. The Yuspa laboratory’s efforts to model the biology of skin have given great insight into the genesis and treatment of this and other major skin malignancies, such as basal cell carcinoma (middle), and malignant melanoma (bottom). 26 ccr connections | v OLUME 2, NO . 1 | 2008 No Longer Skimming the Surface of Skin Cancer When Stuart H. Yuspa, M.D., began studying the skin in the late 1960s, scientists understood some of the basic biology of skin cancer. They knew what was required to produce and diagnose benign and malignant tumors—but not much more. “We’ve made remarkable leaps since then,” says the Co-Chief of CCR’s Laboratory of Cancer Biology and Genetics (LCBG). Stuart H. Yuspa, M.D. (Photo: E. Branson)

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