Plasma levels of microRNA-124 as an early diagnostic marker of ...

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Plasma levels of microRNA-124 as an early diagnostic marker of ...

Plasma Levels of MicroRNA-124 as an

Early Diagnostic Marker of Neuronal

Death in Acute Stroke

J. ALFREDO CACERES, M.D.

J. Philip Kistler Stroke Research Center

Massachusetts General Hospital

INTERNATIONAL STROKE CONFERENCE 2012. NEW ORLEANS, LA


Plasma Levels of MicroRNA-124 as an Early Diagnostic Marker of Neuronal

Death in Acute Stroke

• Aims:

-To evaluate if levels of miRNA-124 are elevated in patients with AIS

compared to controls.

-Correlate levels with variables

-Potential use as a diagnostic aid

• Significance:

There is currently no single biomarker or combined panel sufficiently

sensitive and specific to be useful as a diagnostic test of acute ischemic

stroke.


Plasma Levels of MicroRNA-124 as an Early Diagnostic Marker of Neuronal

Death in Acute Stroke

• miRNA-124: - induces neuronal differentiation

- expressed in neurons and microglia (not Astrocytes)

- are abundant in the brain

- are stable in the serum

www.micrornaworld.com


Plasma Levels of MicroRNA-124 as an Early Diagnostic Marker of Neuronal

Death in Acute Stroke

• Approach:

Blood samples at three-time points: BL (


Plasma Levels of MicroRNA-124 as an Early Diagnostic Marker of Neuronal

Death in Acute Stroke

• Innovation:

miRNAs were first described less than 20 years ago

Never measured in a prospective cohort of AIS

patients

Add the long-awaited specificity


Plasma Levels of MicroRNA-124 as an Early Diagnostic Marker of Neuronal

Death in Acute Stroke

• Potential implications in other research fields:

Differentiate AIS vs. TIA

Differentiate AIS vs. ICH

Neuronal death in COMA patients

Combination with ischemia-specific markers

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