Research projects (880 - 900 of 7502)

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Research projects (880 - 900 of 7502)

N-ribohydrolases as activators of prodrugs

Vrije Universiteit Brussel

Abstract: Both research teams will join forces to design inactive non-toxic prodrugs that can be hydrolysed specifically into ribose and a toxic

(parasiticidal) product by particular bacterial or parasitic N-ribohydrolases. The choice for bacterial and parasitic N-ribohdrolases, a family of

enzymes that has no representatives within mammals, as generic prodrug activating enzymes opens the way to two different prodrug strategies,

leading to different therapeutic applications.

The first prodrug strategy consists of killing particular bacteria or parasites by systemic cytotoxic compounds that are selectively activated by the

parasite's N-ribohydrolase. By including the hyrolases of the genera Campylobacter, Escherichia, Staphylococcus, Trypanosoma, Plasmodium,

Leishmania, Pseudomonas, Mycobacterium, and Toxoplasma, we aim to discover a number of new lead compounds that can be developed and

validated for the treatment food poisoning and opportunistic infections and against (neglected) infectious diseases including malaria, tuberculosis,

sleeping sickness, Chagas disease, and Leishmaniasis.

Our second prodrug strategy is based on delivery techniques and includes the activation of non toxic compounds by exogenous ribohydrolases that

are targeted to a particular cell type. In this part of the program, we would like to validate gated Self-Assembling NanoStructures (SONS) filled with

ribohydrolases as nanoreactors to activate particular prodrugs 'in situ'. To deliver these SONS to particular cells, specific single domain antibodies

will be fused to theses nanoparticles by chemical or biochemical means.

Organisations:

• Applied Biological Sciences

Researchers:

• JAN STEYAERT

Comparison of multivariate calibration methods

Vrije Universiteit Brussel

Abstract: In this project the updating of PLS models is studied.

It is also planned to compare the multivariate PLS and Delaunay triangulation methods.

Organisations:

• Analytical Chemistry and Pharmaceutical Technology

Researchers:

• Yvan VANDER HEYDEN

Pre-feasibility study for an Underground Container Transport System for the Deurganckdock in the port of Antwerp.

University of Antwerp

Abstract: The Deurganckdock container dock is expected to induce significant container traffic between the left bank and the right bank of the river

Scheldt in the port of Antwerp. The current hinterland transportation modes might not be able to accommodate this increase in container traffic. This

research project is a pre-feasibility study to explore the potential of an underground container transport system for moving containers between both

river banks.

Organisations:

• ITMMA

Researchers:

• Willy Winkelmans

• Theo Notteboom

• Wout Dullaert

The evolutional importance of the XTH-multigene family is studied in the root elongationzone of the primitive vascular

plant Selaginella.

University of Antwerp

Abstract: During this project the presence of xyloglucan endotransglucosylase (XTH), a cell wall modifying enzyme and the complexity of the XTHgene

family in the genome of the primitive vascular plant Selaginella family is studied. Root elongation-specific XTHs will be expressed

heterologously and the resulting enzymes will be functionally analyzed. The main goal of this research will be a better understanding of the

importance of these enzymes during the evolution of cell elongation.

Organisations:

• Plant morphology

Researchers:

• Yves Guisez

• Jean-Pierre Verbelen

Synthesis and biological evaluation of nucleoside hydrolase inhibitors as potential anti-parasitic agents.

University of Antwerp

Abstract: Protozoa such as Plasmodia, Leishmania and Trypanosomes are the causative agents of several life-threatening or debilitating human

tropical diseases, such as malaria, sleeping sickness, Chagas disease and several forms of leishmaniasis. New drugs for these diseases are

urgently needed. This project contains computer-aided design, synthesis and enzymatic evaluation of inhibitors of nucleoside hydrolase, a new

antiparasitic target.

Organisations:

• Medicinal Chemistry (UAMC)

Researchers:

• Achiel Haemers

• Koen Augustyns

• Annelies Goeminne

Quantitaive analysis of rolling emulsions by means of infrared spectrometry and partial least squares regression.

University of Antwerp

Abstract: The composition of rolling emulsions varies throughout the production process. Since the exact composition at a certain time is unknown,

it is nearly impossible to provide standard solutions in the laboratory. Hence, in this work, emulsions emerging from the process stream are

quantified by dint of the generalized standard additions method (GSAM). These solutions are then used as standards for calibration, which is being

done by means of partial least squares regression (PLS). Albeit this technique has become a standard routine in many a laboratory, its theoretical

aspects remain mostly unknown. In this work, these theoretical aspects are investigated and elucidated, which leads to the construction of more

realistic sample specific prediction intervals, as well as to a more robust method.

Organisations:

• Chemometrics (Mitac 3)

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