Hyperbare Zuurstoftherapie: Rapid Assessment - KCE

KCE Reports 74 Hyperbaric Oxygenation Therapy 17
Glioblastoma Multiforme
Slowing the Degenerative Process, Long
Lasting Effect of Hyperbaric Oxygen Therapy
in Retinitis Pigmentosa
Effect of Body Mass Index on the Dose of
Intrathecal Hyperbaric Bupivacaine for
Elective Cesarean Section
Effect of Repeated Exposures to Compressed
Air on Patients With AIDS
Can Erythopoietin Protect the Cerebral
Blood Flow and Oxygenation During
Simulated Dive?
Effects of Mild Hypobaric Hypoxia on Sleep
and Post-Sleep Performance
The Evaluation of OrCel for the Treatment of
Venous Ulcers
The Use of Pentoxifylline and Vitamin E in the
Treatment of Late Radiation Related Injuries
not stated Azienda Policlinico Umberto I Completed
dec/07
not stated
Samuel Lunenfeld Research
Institute, Mount Sinai Hospital
Designed Altobaric Non-
Atmospheric Environmental
Technology
Recruiting
Suspended
jan/07 Rigshospitalet, Denmark Recruiting
aug/07
Oklahoma State University
Center for Health Sciences; The
Boeing Company
not stated Ortec International
not stated
University Health Network,
Toronto; Princess Margaret
Hospital, Canada
Active, not
recruiting
Active, not
recruiting
Recruiting
A Study of the Safety and Efficacy of a New
Treatment for Diabetic Macular Edema
jun/14 Allergan
National Center for
Complementary and Alternative
Recruiting
Trial to Assess Chelation Therapy (TACT) jul/09 Medicine (NCCAM); National
Heart, Lung, and Blood Institute
(NHLBI)
Recruiting
Source: NIH Clinical Trials database (www.clinicaltrials.gov)
For the evaluation of the effectiveness of HBOT for different indications we have
chosen to use the most recent systematic reviews and HTAs available. Where available,
we also include results from the more recent RCTs not yet included in those systematic
reviews.
3.4 EVIDENCE FOR SPECIFIC INDICATIONS
The specific data sources used are listed in more detail and by indication in the
appendix.
3.4.1 Carbon Monoxide (CO) intoxication
3.4.1.1 Short description of the condition
Carbon monoxide (CO) is a gas generated during incomplete combustion of carbonbased
(fossil) fuels such as coal. It is a colourless and odourless gas and CO intoxication
is an important source of accidental or intentional intoxication worldwide and has a high
mortality rate. The affinity of CO to bind to haemoglobin (but also to intra- and extracellular
haeme-containing proteins), is much greater than that of oxygen, forming
carboxy-haemoglobin (COHb) thereby decreasing the ability of the oxygen-carrying
capacity of blood in addition to other important pathophysiological mechanisms. Injuries
caused by CO have been viewed as mainly due to hypoxic stress mediated through an
elevated carboxy-haemoglobin level, but recent investigations have established that
systemic oxidative stress can arise from exposure to CO and cause perivascular and
neuronal reperfusion injury. 8 The two most vulnerable organs are the brain and the
heart.