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Urticaria - Dermatology

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<strong>Urticaria</strong>: Basic Facts<br />

Pathophysiology<br />

(non-immunologic<br />

(non immunologic urticaria): urticaria):<br />

it is not<br />

dependent on the binding of IgE<br />

receptors.<br />

For example, aspirin may induce histamine release<br />

through a pharmacologic mechanism where its effect on<br />

arachidonic<br />

acid metabolism causes a release of<br />

histamine from mast cells.<br />

Physical stimuli may induce histamine release through<br />

direct mast cell degranulation<br />

Histamine then acts as described previously

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