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Dermatologic Differential Diagnosis.pdf. - Famona Site

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INFLAMMATORY DISORDERS<br />

Erythema multiforme with epidermal necrosis<br />

Pyoderma gangrenosum, bullous BJD 102:235–237, 1980;<br />

Trans St John’s Hosp Dermatol Soc 60:142–151, 1974;<br />

association with polycythemia vera Clin Exp Dermatol<br />

12:375–377, 1987; leukemia JAAD 9:751–758, 1983; CML Proc<br />

R Soc Med 67:1239–1240, 1974; hairy cell leukemia JAAD<br />

11:300–302, 1985<br />

METABOLIC<br />

Acrodermatitis enteropathica<br />

Cryoglobulinemia – mixed cryoglobulinemia secondary to<br />

hepatitis C infection Cutis 72:290,295, 2003<br />

Diabetic bulla – intraepidermal or subepidermal separation<br />

without acantholysis JAAD 7:427–455, 1982<br />

Disseminated intravascular coagulation – obstetric<br />

complications, extensive tissue damage, gram-negative<br />

septicemias, immune reactions, malignancy, snake bites,<br />

angiomas, protein S or protein C deficiency Br Med J<br />

312:683–687, 1996; BJD 88:221–229, 1973<br />

Hyperhomocysteinemia and antiphospholipid antibodies JAAD<br />

49:S161–163, 2003<br />

Neonatal purpura fulminans – ecchymoses of limbs at sites of<br />

pressure in first day of life; enlarge rapidly, hemorrhagic bullae<br />

with central necrosis; homozygous protein C or protein S<br />

deficiency Semin Thromb Hemost 16:299–309, 1990<br />

Paroxysmal nocturnal hemoglobinuria – petechiae, ecchymoses,<br />

red plaques which become hemorrhagic bullae with necrosis;<br />

lesions occur on legs, abdomen, chest, nose, and ears;<br />

deficiency of enzymes – decay-accelerating factor (DAF) and<br />

membrane inhibitor of reactive lysis (MIRL); acquired<br />

intravascular hemolytic anemia; due to a drop in pH of serum<br />

during sleep; Ham test (acid hemolysis); sucrose lysis test, low<br />

leukocyte alkaline phosphatase; anemia, hemoglobinuria (dark<br />

urine), increased serum hemoglobin, hemosiderinuria; abdominal<br />

pain, recurrent infections, headache, venous thrombosis,<br />

progressive bone marrow failure, and ultimately lymphoreticular<br />

malignancy (especially, leukemia) AD 138:831–836, 2002;<br />

AD 122:1325–1330, 1986; AD 114:560–563, 1978<br />

Pellagra Cutis 69:96–98, 2002; Semin Dermatol 10:282,1991<br />

Porphyria cutanea tarda (PCT)<br />

Pseudo-PCT<br />

Renal failure with or without furosemide<br />

Scurvy JAAD 41:895–906, 1999<br />

Wilson’s disease JAAD 21:1030, 1989<br />

NEOPLASTIC DISEASES<br />

Congenital self-healing reticulohistiocytosis JAAD 48:S75–77,<br />

2003<br />

Lymphoma – cutaneous T-cell lymphoma Bull Soc Fr Derm<br />

Syph 73:373–376, 1966<br />

PARANEOPLASTIC DISEASES<br />

Paraneoplastic pemphigus BJD 144:1255–1261, 2001<br />

PHOTOSENSITIVITY DISORDERS<br />

Hydroa vacciniforme – red macules progress to tender papules,<br />

hemorrhagic vesicles or bullae, umbilication and crusting;<br />

pock-like scars Ped Derm 18:71–73, 2001; JAAD 42:208–213,<br />

BULLAE, HEMORRHAGIC 101<br />

2000; Dermatology 189:428–429, 1994; JAAD 25:892–895,<br />

1991; JAAD 25:401–403, 1991; BJD 118:101–108, 1988;<br />

AD 118:588–591, 1982; familial BJD 140:124–126, 1999;<br />

AD 114:1193–1196, 1978; AD 103:223–224, 1971; late onset<br />

BJD 144:874–877, 2001<br />

Polymorphic light eruption<br />

Sunbed use BMJ 296:1708, 1988<br />

PRIMARY CUTANEOUS DISEASE<br />

Angina bullosa hemorrhagica AD 135:593–598, 1999<br />

Balanitis xerotica obliterans JAAD 37:1–24, 1997<br />

Benign hemorrhagic bullous stomatitis Ann DV 126:525–526,<br />

1999<br />

Darier’s disease of the hands and feet AD 89:523–527, 1964<br />

Epidermolysis bullosa, many types; EBS herpetiformis –<br />

Dowling–Meara – begins in infancy with hemorrhagic blisters<br />

of fingers and toes JAAD 28:859–861, 1993; EBS, Ogna<br />

variant – autosomal dominant; plectin abnormality;<br />

seasonal blistering of hands and feet, bruising,<br />

hemorrhagic bullae, onychogryphotic first toenails<br />

Hum Hered 23:189–196, 1973; epidermolysis<br />

simplex with mottled pigmentation – acral blistering,<br />

hemorrhagic bullae, focal punctate keratoderma,<br />

dystrophic thick nails BJD 144:40–45, 2001<br />

Epidermolysis bullosa atrophicans generalisata mitis JAAD<br />

12:836–844, 1985<br />

Erythema elevatum diutinum AD 132:1360–1364, 1996<br />

Lichen nitidus AD 105:430–431, 1972<br />

Lichen planus, bullous<br />

Lichen sclerosus et atrophicus, bullous JAAD 39:500–501,<br />

1998; JAAD 10:346–350, 1984<br />

Toxic erythema of the newborn<br />

Transient acantholytic dermatosis (Grover’s disease)<br />

PSYCHOCUTANEOUS DISORDERS<br />

Factitial dermatitis<br />

SYNDROMES<br />

Antiphospholipid antibody syndrome<br />

Behçet’s disease JAAD 36:689–696, 1997<br />

Ichthyosiform dermatosis with superficial blister formation and<br />

peeling JAAD 34:379–385, 1996<br />

Kindler’s syndrome<br />

Reflex sympathetic dystrophy (bullae on dorsal foot) JAAD<br />

28:29–32,1993<br />

Sweet’s syndrome – predominance of women; upper<br />

extremities, neck and upper trunk; arthralgias, conjunctivitis,<br />

episcleritis, aphthosis, proteinuria, and high ESR; 10–15%<br />

associated with malignancy, most commonly acute<br />

myelogenous leukemia. In malignancy-associated Sweet’s,<br />

male to female ratio is 1:1 and patients more likely to have<br />

bullous or ulcerative lesions AD 126:527–532, 1990<br />

Wells’ syndrome<br />

TRAUMATIC<br />

Altitude injury – petechiae and hemorrhagic bullae of external<br />

auditory canal in pilots descending from high altitudes<br />

Laryngoscope 56:225–236, 1946

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