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Dermatologic Differential Diagnosis.pdf. - Famona Site

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120 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1<br />

Goltz’s syndrome<br />

Lipoid proteinosis JAAD 39:149–171, 1998<br />

Melkersson–Rosenthal syndrome<br />

Multicentric reticulohistiocytosis – digital papule; knuckle pads<br />

yellow papules and plaques Rook p.2325–2326, 1998, Sixth<br />

Edition; AD 126:251–252, 1990; Oral Surg Oral Med Oral Pathol<br />

65:721–725, 1988; Pathology 17:601–608, 1985; JAAD<br />

11:713–723, 1984; AD 97:543–547, 1968<br />

Multiple endocrine neoplasia syndrome (MEN I) – gingival<br />

cobblestoning AD 133:853–857, 1997<br />

Multiple mucosal neuroma syndrome – MEN Type II (palate)<br />

Neurofibromatosis – papillomatosis of the palate<br />

Nevus sebaceous syndrome<br />

(Schimmelpenning–Feuerstein–Mims syndrome) –<br />

cobblestoning of hard palate JAAD 52:S62–64, 2005;<br />

Am J Dis Child 104:675–679, 1962; Fortschr Roentgenstr<br />

87:716–720, 1957<br />

Pachyonychia congenita<br />

Pseudoxanthoma elasticum JAAD 42:324–328, 2000;<br />

Dermatology 199:3–7, 1999; AD 124:1559, 1988<br />

Reiter’s syndrome<br />

Sjögren’s syndrome<br />

Sweet’s syndrome<br />

Tuberous sclerosis – gingival fibromas<br />

Xerostomia – tongue cobblestoning<br />

TOXINS<br />

Nicotine stomatitis<br />

Tobacco chewing – diffuse epithelial hyperplasia<br />

TRAUMA<br />

Morsicatio buccarum (cheek biting) – oral papillomatosis due to<br />

chronic buccal trauma Cutis 43:254–257, 1989; cobblestoning<br />

with biting papillomas Bolognia p.1085, 2003; Dentate tongue –<br />

scalloping<br />

Papillary hyperplasia of the palate<br />

VASCULAR<br />

Lymphangioma circumscriptum Rook p.2292,3066, 1998,<br />

Sixth Edition; Otolaryngol Head Neck Surg 90:283, 1982<br />

Lymphatic malformation BJD 148:1279–1282, 2003<br />

Pyogenic granuloma – verrucous or vegetative lesion<br />

Wegener’s granulomatosis (gingival hyperplasia)<br />

AD 130:861–867, 1994; JAMA 246:2610, 1981<br />

COBBLESTONE APPEARANCE<br />

OF SKIN<br />

AUTOIMMUNE DISEASES, AND DISEASES<br />

OF IMMUNE DYSFUNCTION<br />

Dermatomyositis – cutaneous mucinosis JAAD 14:1–18, 1986<br />

Lupus erythematosus – discoid lupus erythematosus; papular<br />

and nodular mucinosis with SLE BJD 115:631–636, 1986<br />

Scleroderma – cobblestoning of dorsum of hand Rook p.2529,<br />

1998, Sixth Edition<br />

CONGENITAL LESIONS<br />

Smooth muscle hamartoma<br />

DRUG-INDUCED<br />

Cyclosporine-induced folliculodystrophy – cobblestoned follicular<br />

facial and earlobe papules (viral-associated trichodysplasia?)<br />

JAAD 50:318–322, 2004) JAAD 50:310–315, 2004<br />

EXOGENOUS AGENTS<br />

Aquagenic syringeal acrokeratoderma (aquagenic palmoplantar<br />

keratoderma, aquagenic keratoderma BJD 152:394–395, 2005;<br />

Dermatology 204:8, 2002; JAAD 45:124, 2001<br />

Cold urticaria – positive ice cube test<br />

Exogenous ochronosis (grainy appearance) – topical<br />

application of hydroquinone JAAD 22:529–531, 1990<br />

INFECTIONS AND/OR INFESTATIONS<br />

Blastomycosis-like pyoderma<br />

Botryomycosis JAAD 9:428–434, 1983<br />

Condyloma acuminatum Rook p.3216, 1998, Sixth Edition<br />

Generalized deep dermatophytosis (trichophytic granuloma) –<br />

Trichophyton rubrum AD 140:624–625, 2004<br />

Leishmaniasis – post-kala-azar dermal leishmaniasis; rippled<br />

skin BJD 143:136–143, 2000<br />

Leprosy, lepromatous<br />

Lobomycosis<br />

Molluscum contagiosum in AIDS Ped Derm 20:436–439, 2003;<br />

Rook p.2752, 1998, Sixth Edition<br />

Pitted keratolysis<br />

Protothecosis BJD 146:713–715, 2002<br />

Schistomiasis – vulvar cobblestoned nodule Am J Surg Pathol<br />

8:787–790, 1984<br />

Small pox scarring<br />

Verrucae vulgaris, including flat warts in AIDS – HPV 5, 6 or 11<br />

Cutis 63:91–94, 1999; JAAD 23:978–981, 1990; warts in<br />

Netherton’s syndrome BJD 144:1044–1049, 2001<br />

INFILTRATIVE<br />

Amyloidosis – lichen amyloidosis Rook p.2628–2630, 1998,<br />

Sixth Edition; macular amyloid tumefactive (nodular) amyloidosis –<br />

uncommon variant of cutaneous localized amyloid; female<br />

predominance; deposits of amyloid in papillary and reticular<br />

dermis and subcutaneous fat; 15% of these patients actually<br />

have primary systemic amyloidosis AD 124:769–774, 1988;<br />

AD 102:8–19, 1970; BJD 82:129–136, 1970<br />

Benign non-X histiocytosis – including xanthoma disseminatum,<br />

generalized eruptive histiocytoma, or indeterminate cell disorder<br />

JAAD 18:1282–1289, 1988<br />

Colloid milium<br />

Focal cutaneous mucinosis<br />

Langerhans cell histiocytosis Clin Exp Dermatol<br />

27:135–137, 2002<br />

Lichen myxedematosis BJD 144:594–596, 2001;<br />

scleromyxedema – associated with paraproteinemia<br />

(IgG lambda light chains) (110 Kd 7S IgG); may be missing a<br />

portion of the Fc fragment; not usually associated with myeloma<br />

(those are IgG kappa light chains) Cutis 39:219–223, 1987

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