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Dermatologic Differential Diagnosis.pdf. - Famona Site

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HYPERPIGMENTATION, DIFFUSE<br />

AUTOIMMUNE DISEASES, AND DISEASES<br />

OF IMMUNE DYSFUNCTION<br />

Dermatomyositis Rook p.1782, 1998, Sixth Edition<br />

Graft vs. host reaction, chronic AD 134:602–612, 1998<br />

Lupus erythematosus, systemic Rook p.1782, 1998,<br />

Sixth Edition<br />

Morphea – generalized morphea – diffuse hyperpigmentation<br />

Rook p.2511, 1998, Sixth Edition<br />

Pemphigus foliaceus<br />

Rheumatoid arthritis Rook p.1782, 1998, Sixth Edition<br />

Scleroderma (progressive systemic sclerosis) – diffuse<br />

cutaneous form; CREST syndrome, morphea Rook p.1782,<br />

2527, 1998, Sixth Edition<br />

Still’s disease Rook p.1782, 1998, Sixth Edition<br />

CONGENITAL GENERALIZED<br />

HYPERPIGMENTATION<br />

Carbon baby syndrome – universal acquired melanosis – entire<br />

skin deep black Textbook of Neonatal Dermatology, p.381,<br />

2001; AD 114:775–778, 1978<br />

Congenital adrenal hyperplasia – congenital generalized<br />

hyperpigmentation JAAD 33:323–326, 1995<br />

Congenital diffuse pigmentation (Wende–Bauckus)<br />

Epidermal melanocytosis AD 86:412–418, 1962<br />

Familial pigmentation with nail dystrophy AD 71:591–598, 1955<br />

Familial progressive hyperpigmentation AD 103:581–8, 1971<br />

Green baby – due to intrauterine exposure to Evan’s blue dye<br />

Am J Perinatol 5:234–235, 1988<br />

DRUG-INDUCED<br />

Cutis 59:77, 1977<br />

ACTH administration Rook p.1780, 1998, Sixth Edition<br />

Adriamycin<br />

Amiodarone Bolognia p.980, 2003<br />

Argyria – slate-gray pigmentation of sun-exposed areas<br />

(forehead, nose, hands); entire skin may be hyperpigmented<br />

NEJM 351:2349–2350, 2004; Am J Kidney Dis 37:1048–1051,<br />

2001; BJD 104:19–26, 1981; AD 114:373–377, 1978<br />

Arsenic – brown diffuse macular hyperpigmentation Ghatan<br />

p.231, 2002, Second Edition<br />

Atabrine (mepacrine) – greenish–yellow pigmentation of face,<br />

hands, feet; then diffuse Am J Med Sci 192:645–650, 1936<br />

Bismuth – generalized hyperpigmentation resembling argyria<br />

and/or blue–black line at the gingival margin JAAD 39:524–525,<br />

1998; JAAD 37:489–490, 1997<br />

Bleomycin AD 107:553–555, 1973<br />

Busulfan – diffuse JAAD 9:645–663, 1983; Addisonian Arch Int<br />

Med 124:66–71, 1969<br />

Chemotherapy JAAD 40:367–398, 1999<br />

Chloramphenicol overdose in infants – gray baby syndrome<br />

Clin Pediatr 21:571–572, 1982<br />

Chloroquine Ghatan p.6, 2002, Second Edition<br />

Chlorpromazine<br />

Chrysiasis<br />

Clofazimine – orange–red hyperpigmentation JAAD<br />

23:236–241, 1990<br />

Cyclophosphamide Bolognia p.978, 2003<br />

Dactinomycin Bolognia p.978, 2003<br />

Daunorubicin JAAD 46:S1–3, 2002; JAAD 26:255–256, 1992<br />

5-fluorouracil<br />

Hydantoin<br />

Hydroxychloroquine<br />

Hydroxyurea JAAD 49:339–341, 2003; AD 135:818–820, 1999;<br />

JAAD 36:178–182, 1997; AD 111:183–187, 1975<br />

Immunosuppressive therapy in transplant recipients – diffuse<br />

hyperpigmented xerotic dermatitis JAAD 44:932–939, 2001<br />

Lichenoid drug eruption<br />

Methotrexate<br />

Minocycline – diffuse hyperpigmentation Arthr Rheum<br />

50:3698–3701, 2004; JAAD 3:244–247, 1980<br />

MSH administration Ghatan p.6, 2002, Second Edition<br />

Nitrogen mustard, topical AD 113:1387–1389, 1977<br />

Oral contraceptives<br />

Phenolphthalein – diffuse brown pigmentation (fixed drug) Arch<br />

Dermatol Syphilol 32:915–921, 1935<br />

Phenothazines, including chlorpromazine AD 90:471–476, 1964<br />

Phototoxic and photodynamic drug reactions Rook p.1787,<br />

1998, Sixth Edition; AD 106–148, 1972<br />

Psoralens (PUVA)<br />

Quinidine AD 122:1062–1064, 1986<br />

Quinine AD 88:419–426, 1963<br />

Rifabutin<br />

Silver sulfadiazine cream JAAD 12:1112–1114, 1985<br />

Tetracosactrin BJD 82:389–396, 1970<br />

Zidovudine JAAD 46:284–293, 2002<br />

EXOGENOUS AGENTS<br />

Heavy metals<br />

Arsenic<br />

Gold<br />

Lead<br />

Mercury<br />

Bismuth<br />

INFECTIONS AND INFESTATIONS<br />

AIDS Tyring p.371, 2002; lichenoid hyperpigmentation of AIDS<br />

Chronic infection – malaria, kala-azar (black sickness,<br />

leishmaniasis) J Inf Dis 173:758, 1996, schistosomiasis,<br />

tuberculosis Rook p.1781, 1998, Sixth Edition<br />

Chronic mucocutaneous candidiasis J Clin Endocrinol 16:1374,<br />

1956<br />

Erythrasma<br />

Pediculosis Rook p.1784, 1998, Sixth Edition<br />

INFILTRATIVE DISEASES<br />

HYPERPIGMENTATION, DIFFUSE 255<br />

Amyloidosis – macular amyloid<br />

Langerhans cell histiocytosis – bronze hyperpigmentation<br />

Curr Prob Derm VI:1–24, 1994

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