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Dermatologic Differential Diagnosis.pdf. - Famona Site

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Penicillamine Rook p.3395, 1998, Sixth Edition<br />

Phenytoin JAAD 48:161–179, 2003; Rook p.3395, 1998, Sixth<br />

Edition<br />

Phenothiazine Ghatan p.68, 2002, Second Edition<br />

Psoralens – PUVA therapy Cutis 41:199–202, 1988;<br />

Arch Dermatol Res 278:82–83, 1985; BJD 109:657–660, 1983<br />

Streptomycin JAAD 48:161–179, 2003; Rook p.3395, 1998,<br />

Sixth Edition<br />

Tamoxifen Ghatan p.68, 2002, Second Edition<br />

Testosterone proprionate Ghatan p.68, 2002, Second Edition<br />

Thiouracil<br />

Verapamil Lancet 338 (8776) 1215–1216, 1991<br />

Zidovudine JAAD 46:284–293, 2002; AIDS 5:1395–1396, 1991<br />

INFECTIONS<br />

Post-encephalitis Ped Derm 18:57–59, 2001; Rook p.2893,<br />

1998, Sixth Edition<br />

Post-mumps Rook p.2890–2891, 1998, Sixth Edition<br />

INFLAMMATORY DISEASES<br />

Cerebral abnormalities JAAD 48:161–179, 2003<br />

Multiple sclerosis Ped Derm 18:57–59, 2001<br />

METABOLIC DISEASES<br />

Acromegaly Ghatan p.69,165, 2002, Second Edition<br />

Cushing’s syndrome<br />

Hypothyroidism – back and extensor extremities Arch Dis<br />

Child 60:763–766, 1985; JAMA 157:651–652, 1955<br />

Malnutrition or starvation – hypertrichosis; trichomegaly Ped<br />

Derm 18:57–59, 2001; Acta Paediatr Scand 40:59–69, 1951<br />

Porphyria – porphyria cutanea tarda Rook p.2590, 1998,<br />

Sixth Edition; congenital erythropoietic porphyria Ped Derm<br />

20:498–501, 2003; harderoporphyria, hepatoerythropoietic<br />

porphyria – blisters and prominent hypertrichosis –<br />

uroporphyrinogen decarboxylase deficiency (8–18% of<br />

normal values); differential diagnosis includes infantile PCT<br />

(clinically indistinguishable), erythropoietic protoporphyria<br />

(no hypertrichosis or bullae), and Gunther’s disease (severe<br />

mutilation, erythrodontia, splenomegaly and hemolytic anemia)<br />

Ped Derm 4:229–233, 1987; variegate porphyria JAAD 2:36–43,<br />

1980; hereditary coproporphyria BJD 96:549–554, 1977;<br />

Q J Med 46:229–241, 1977; BJD 84:301–310, 1971<br />

Starvation Ghatan p.68, 2002, Second Edition<br />

Stein–Leventhal syndrome – polycystic ovarian disease<br />

NEOPLASTIC DISORDERS<br />

Epidermal nevus – secreting LHRH – hirsutism<br />

Melanocytic nevus – giant congenital melanocytic nevus Ped<br />

Derm 18:369–377, 2001<br />

Giant nevoid hypertrichosis Ped Derm 19:64–66, 2002<br />

PARANEOPLASTIC DISORDERS<br />

Hypertrichosis lanuginosa acquisita (malignant down) – 41<br />

cases; lung, colon carcinomas most common; also breast, gall<br />

bladder, uterus, urinary bladder if accompanied by acanthosis<br />

nigricans; the malignancy is always an adenocarcinoma J Surg<br />

Oncol 68:199–203, 1998; AD 122:805–808, 1986<br />

PRIMARY CUTANEOUS DISEASES<br />

Epidermolysis bullosa, dystrophic Bolognia p.1053, 2003<br />

Prepubertal hypertrichosis Textbook of Neonatal Dermatology,<br />

p.495–496, 2001<br />

Primary generalized hypertrichosis (hypertrichosis lanuginosa<br />

congenital, congenital generalized hypertrichosis, universal<br />

hypertrichosis) AD 137:877–884, 2001; Clin Genet 10:303–306,<br />

1976<br />

PSYCHOCUTANEOUS DISORDERS<br />

Eating disorders – anorexia nervosa, bulemia nervosa –<br />

increased lanugo body hair Ped Derm 18:57–59, 2001;<br />

Int J Derm 39:348–353, 2000; Ped Derm 16:90–94, 1999<br />

Schizophrenia Ghatan, Second Edition, 2002, p.69<br />

SYNDROMES<br />

HYPERTRICHOSIS, GENERALIZED 269<br />

Acromegaloid facial appearance and generalized hypertrichosis<br />

J Med Genet 33:972–974, 1996<br />

Acro-osteolysis (Hajdu–Cheney syndrome) Birth Defects<br />

10:106–123, 1974<br />

Ambras syndrome – unique hypertrichosis universalis congenita<br />

Clin Genet 44:121–128, 1993<br />

Barber–Say syndrome – macrostomia, hypertelorism, atrophic<br />

skin, hypertrichosis, ectropion Am J Med Genet 73:366–367,<br />

1997; Am J Med Genet 47:20–23, 1993<br />

Berardinelli’s (Berardinelli–Seip) syndrome – lipodystrophy with<br />

muscular hypertrophy; coarse hypertrichotic skin J Clin<br />

Endocrinol Metab 14:193–204, 1954<br />

Cantu syndrome – congenital hypertrichosis, cardiomegaly,<br />

osteochondrodysplasia, coarse facial features, deep plantar<br />

creases Am J Med 92:191–194, 2000; Am J Med Genet<br />

94:421–427, 2000; Am J Med Genet 69:138–151, 1997<br />

Cataract, hypertrichosis, and mental retardation – autosomal<br />

recessive Am J Med Genet 41:432–433, 1991<br />

Cerebral malformation, seizures, hypertrichosis, distinct face,<br />

claw hands, and overlapping fingers Am J Med Genet<br />

47:698–701, 1993<br />

Coffin–Siris syndrome – hypertrichosis of the face and body,<br />

bushy eyebrows, lumbosacral hirsutism; coarse facial features,<br />

low birthweight, retarded growth, mental retardation, hypoplastic<br />

or absent fifth fingernails and toenails J Med Genet<br />

27:333–336, 1990; Am J Dis Child 132:1044, 1978<br />

Cone–rod congenital amaurosis associated with congenital<br />

hypertrichosis J Med Genet 26:504–510, 1989<br />

Congenital cataracts, sensorineural deafness, hypogonadism,<br />

hypertrichosis, short stature Clin Dysmorphol 4:283–288,<br />

1995<br />

Cornelia de Lange (Brachmann–de Lange) syndrome –<br />

generalized hypertrichosis, confluent eyebrows, low hairline,<br />

hairy forehead and ears, hair whorls of trunk, cutis marmorata,<br />

single palmar crease, physical and mental retardation<br />

Am J Med Genet 47:959–964, 1993<br />

Costello syndrome – generalized hypertrichosis; warty papules<br />

around nose and mouth, legs, perianal skin; loose skin of neck,<br />

hands, and feet; acanthosis nigricans; low set protuberant ears,<br />

thick palmoplantar surfaces with single palmar crease, gingival<br />

hyperplasia, hypoplastic nails, moderately short stature,

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