Dermatologic Differential Diagnosis.pdf. - Famona Site

644 A CLINICIAN’S GUIDE TO DERMATOLOGIC DIFFERENTIAL DIAGNOSIS, VOLUME 1
Darier’s disease
Fissured tongue
Hypertrophy of circumvallate, foliate, or fungiform papillae
TRAUMA
Tension, scalloped tongue JAAD 15:1289, 1986
SYNDROMES
Blue rubber bleb nevus syndrome
Cowden’s syndrome – scrotal tongue JAAD 11:1127–1141, 1984
Down’s syndrome – scrotal tongue Rook p.3123, 1998,
Sixth Edition
Epidermal nevus syndrome
Focal epithelial hyperplasia (Heck’s disease) BJD 96:375–380,
1977
Gardner’s syndrome – multiple fibrous tumors
Goltz’s syndrome
LAMB syndrome – myxoma JAAD 10:72–82, 1984
Maffucci’s syndrome – multiple hemangiomas BJD 99
(Suppl 16):31–33, 1978; J Bone Jt Surg 55A:1465–1479, 1973
Melkersson–Rosenthal syndrome – scrotal tongue; orofacial
edema; edema of cheeks, forehead, eyelids, scalp Oral Surg
Oral Med Oral Pathol 75:220–224, 1993; Oral Surg Oral Med
Oral Pathol 74:610–619, 1992; JAAD 21:1263–1270, 1989
Multicentric reticulohistiocytosis JAAD 20:530–532,535–536,
1989; Oral Surg Oral Med Oral Pathol 65:721–725, 1988
Multiple mucosal neuroma syndrome (MEN IIB) (Gorlin’s
syndrome) – skin-colored papules and nodules of lips, tongue,
oral mucosa AD 139:1647–1652, 2003; JAAD 36:296–300,
1997; Oral Surg 51:516–523, 1981; J Pediatr 86:77–83, 1975;
Am J Med 31:163–166, 1961
Neurofibromatosis Syndromes of the Head and Neck, p.395, 1990
Nevus sebaceous syndrome (Schimmelpenning–Feuerstein–
Mims syndrome) – papillomas of tongue, gingival hyperplasia,
thickened mucosa, anodontia, dysodontia JAAD 52:S62–64,
2005; Ped Derm 13:22–24, 1996; Int J Oral Maxillofac Surg
12:437–443, 1983
Oral–facial–digital syndrome type I (Papillon–Leage syndrome) –
X-linked dominant; short upper lip, hypoplastic alanasi, hooked
pug nose, hypertrophied labial frenulae, bifid or multilobed
tongue with small tumors within clefts, clefting of hard and soft
palate, teeth widely spaced, trident hand or brachydactyly,
syndactyly, or polydactyly; hair dry and brittle, alopecic,
numerous milia of face, ears, backs of hands, mental retardation
Ped Derm 9:52–56, 1992
Oral–facial–digital syndrome type II – autosomal recessive;
lobulated, bifid tongue; poly-, syn- and brachydactyly, cleft
palate, broad bifid nasal tip Clin Genet 2:261–266, 1971
Oral–facial–digital syndrome type III – lobulated hamartomatous
tongue, mental retardation, eye abnormalities, dental
abnormalities, bifid uvula, skeletal anomalies Clin Genet
2:248–254, 1971
Pachyonychia congenita – scrotal tongue
Sjögren’s syndrome – scrotal tongue
Werdnig–Hoffmann spinal muscular atrophy
VASCULAR DISORDERS
Lymphangioma
TONGUE, RED
AUTOIMMUNE DISEASES, AND DISEASES
OF IMMUNE DYSFUNCTION
Dermatomyositis
Graft vs. host reaction
Scleroderma
DRUG-INDUCED
Antibiotics
Anticholinergics
Chemotherapy
Drug rash
Interleukin-2 JAMA 258:1624–1629, 1987
EXOGENOUS AGENTS
Mouthwash
Reverse smoking
INFECTIONS AND INFESTATIONS
Candidiasis – acute atrophic oral candidiasis Am J Med
30:28–33, 1984
Herpes simplex – herpetic geometric glossitis
HIV infection – acute retroviral syndrome – glossitis
Scarlet fever – white or red strawberry tongue JAAD
39:383–398, 1998
Syphilis – secondary, tertiary (syphilitic glossitis) – red, smooth
tongue with loss of papillae Rook p.1252, 1998, Sixth Edition
Toxic shock syndrome, either staphylococcal or streptococcal
JAAD 39:383–398, 1998
INFILTRATIVE DISEASES
Amyloidosis, primary systemic – red nodule AD 126:235–240,
1990
INFLAMMATORY DISEASES
Acrodermatitis continua
Crohn’s disease – glossitis Rook p.3120, 1998, Sixth Edition
Eruptive lingual papillitis – tongue papules composed of fungiform
papillae of tip and side of tongue BJD 150:299–303, 2004
Erythema multiforme major (Stevens–Johnson syndrome)
Foliate papillitis Rook p.3110, 1998, Sixth Edition
Impetigo herpetiformis
Median rhomboid glossitis – possibly related to candidiasis
BJD 93:399–405, 1975
METABOLIC DISEASES
Acrodermatitis enteropathica
Celiac disease Rook p.3120, 1998, Sixth Edition
Deficiency states
Folic acid deficiency – glossitis JAAD 12:914–917, 1985
Iron deficiency anemia QJM 34:145, 1965
Kwashiorkor Cutis 51:445–446, 1993