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NRL Proficiency Study Report

NRL Proficiency Study Report

1. Introduction

1. Introduction Sulfonamides are widely used as antibacterials in veterinary medicine for the treatment and prevention of respiratory and gastro-intestinal tract infections. However, large applications of these drugs raise the risk of the persistence of residues in food products, mostly the result of improper observance of withdrawal times. Therefore, the European Union (EU) has defined maximum residue limits (MRLs) of 100 µg kg -1 for all sulfonamides in edible tissues of all food-producing animals. Macrolide antibiotics are extensively used in veterinary medicine against Gram-positive bacteria and mycoplasma. Macrolides are used therapeutically for the treatment of e.g. dysentery and pneumonia in pigs. To protect the consumer’s health, the EU has fixed MRLs for different tissues and animal species (see Table 1). Active substance Erythromycin Tilmicosin Tulathromycin Table 1. Overview of the different MRLs for macrolide antibiotics Animal species All food producing animals except: 4 MRL (µg kg -1 ) Chicken 300 Target Tissue 200 Muscle, Fat, Liver, 400 Porcine (as spiramycin 1) 250 All food producing animals 2000 1000 50 1000 Poultry 75 Bovine 1000 250 100 3000 Porcine 100 Tylosin All food producing animals 3000 Kidney Skin and Fat Liver Muscle Liver Kidney Muscle, Fat Liver, Kidney Muscle, Skin and Fat Liver Kidney Fat Liver and Kidney Skin and Fat Liver and Kidney 100 Muscle, Skin and Fat, Liver, Kidney

As National Reference Laboratory, the Scientific Institute of Public Health (IPH) organized, in collaboration with the Federal Agency for the Safety of the Food Chain, in April 2010 a proficiency test for the analysis (screening and/or confirmation) of sulfonamide and macrolide antibiotics in porcine muscle tissue. The participants were free to use any reliable method of their choice. Each participating laboratory received two batches of five porcine muscle tissue samples. One batch should be analysed for macrolide antibiotics, the other for sulfonamides. Samples contain one of the sulfonamides or macrolides listed in Table 2. Table 2. Overview of the sulfonamide and macrolide antibiotics possibly present in the samples Sulfonamides 5 Macrolides Sulfadiazine Spiramycin Sulfathiazole Erythromycin Sulfamerazine Josamycin Sulfapyridine Tilmicosin Sulfamethizole Tylosin Sulfadimidine Sulfamethoxypyridazine Sulfamonomethoxine Sulfachlorpyridazine Sulfadoxine Sulfadimethoxine Sulafquinoxaline Sulfamoxole Sulfanilamide Sulfaguanidine 2. Planning of the study • January 2010: Animal experiment • January – April: Stability and homogeneity study by IPH • 8 March 2010: Sending Invitation to laboratories • 29-31 April 2010: Dispatching of the frozen samples to the participants by IPH courier • 22 April 2010: Deadline for the reporting of the results to IPH • May-June 2010: Sending of the final report to the participating laboratories and copy to the Federal Agency for Food Safety together with identification of the participants

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