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the potential risks arising from nanoscience and ... - Favv

the potential risks arising from nanoscience and ... - Favv

Exposure scenarios •

Exposure scenarios • Outline anticipated exposure scenarios as this will influence the extent of the hazard characterisation. – Direct or indirect addition to food/feed – Certain applications may give rise to a very limited exposure – Where nano-form exposure is not detected by appropriate methods, conventional risk assessment should be performed 14

Toxicity testing strategies • In vitro tests not yet validated. Provide screening and initial understanding of biological effects. – Genotoxicity and mutagenicity tests • In vivo test – ADME – 90-day rodent repeat oral toxicity, considering extended endpoints (e.g. endocrine activity and immuno- and reproductive toxicity) • Additional tests triggered by initial results 15

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NANOTECHNOLOGY IN THE FOOD CHAIN - Favv
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