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the potential risks arising from nanoscience and ... - Favv

the potential risks arising from nanoscience and ... - Favv

Benchmark with

Benchmark with the Risk Assessment Paradigm HAZARD IDENTIFICATION Identification of adverse health effects Animal-based toxicological studies In vitro toxicology data Structure-activity consideration Human data HAZARD ASSESSMENT Quantification of adverse health effects Dose-response for critical effect Selection of critical data Mode/mechanism of action Kinetic variability Dynamic variability RISK CHARACTERISATION “Risk = hazard x exposure” EXPOSURE ASSESSMENT Active principle Dose of toxicant Dose in individuals Dose in special population groups Max/min, chronically/occasionally 18

Main uncertainties and challenges • Analytical limitations in the measurement of nanomaterials in various matrices make assessment of toxicity and exposure data difficult. • More testing experience with nanomaterials is needed to establish optimal approaches. • Long term oral exposure information is missing and extrapolation from shorter exposure is not yet reliable. • Bioaccumulating and persistent nanomaterials are likely to end up in the food/feed chain as contaminants. 19

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