References 52 78. Grayson,W.L., Zhao,F., Izadpanah,R., Bunnell,B. & Ma,T. Effects of hypoxia on human mesenchymal stem cell expansion and plasticity in 3D constructs. J. Cell Physiol 207, 331-339 (2006). 79. Ren,H. et al. Proliferation and differentiation of bone marrow stromal cells under hypoxic conditions. Biochem. Biophys. Res. Commun. 347, 12-21 (2006). 80. Pasarica,M. et al. Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58, 718-725 (2009). 81. Barzilay,R., Sadan,O., Melamed,E. & Offen,D. Comparative characterization of bone marrow-derived mesenchymal stromal cells from four different rat strains. Cytotherapy. 11, 435-442 (2009). 82. Koay,E.J. & Athanasiou,K.A. Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality. Osteoarthritis. Cartilage. 16, 1450-1456 (2008). 83. Nekanti,U., Dastidar,S., Venugopal,P., Totey,S. & Ta,M. Increased proliferation and analysis of differential gene expression in human Wharton's jellyderived mesenchymal stromal cells under hypoxia. Int. J. Biol. Sci. 6, 499-512 (2010). 84. Giese,A.K. et al. Erythropoietin and the effect of oxygen during proliferation and differentiation of human neural progenitor cells. BMC. Cell Biol. 11, 94 (2010). 85. Ingraham,C.A., Park,G.C., Makarenkova,H.P. & Crossin,K.L. Matrix metalloproteinase (MMP)-9 induced by Wnt signaling increases the proliferation and migration of embryonic neural stem cells at low O2 levels. J. Biol. Chem. (2011). 86. Koning,M., Werker,P.M., van Luyn,M.J. & Harmsen,M.C. Hypoxia Promotes Proliferation of Human Myogenic Satellite Cells: A Potential Benefactor in Tissue Engineering of Skeletal Muscle. Tissue Eng Part A (2011). 87. Fernandes,T.G., Diogo,M.M., Fernandes-Platzgummer,A., da Silva,C.L. & Cabral,J.M. Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia. Stem Cell Res. 5, 76-89 (2010). 88. Iida,K. et al. Hypoxia enhances colony formation and proliferation but inhibits differentiation of human dental pulp cells. Arch. Oral Biol. 55, 648-654 (2010). 89. Santilli,G. et al. Mild hypoxia enhances proliferation and multipotency of human neural stem cells. PLoS. One. 5, e8575 (2010). 90. Zachar,V. et al. The effect of human embryonic stem cells (hESCs) long-term normoxic and hypoxic cultures on the maintenance of pluripotency. In Vitro Cell Dev. Biol. Anim 46, 276-283 (2010).
References 53 91. Launay,T. et al. Blunting effect of hypoxia on the proliferation and differentiation of human primary and rat L6 myoblasts is not counteracted by Epo. Cell Prolif. 43, 1-8 (2010). 92. Coussens,M. et al. RNAi screen for telomerase reverse transcriptase transcriptional regulators identifies HIF1alpha as critical for telomerase function in murine embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A 107, 13842-13847 (2010). 93. Davy,P. & Allsopp,R. Hypoxia: are stem cells in it for the long run? Cell Cycle 10, 206-211 (2011). 94. Boker,W. et al. Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J. Cell Mol. Med. 12, 1347-1359 (2008). 95. Mets,T. & Verdonk,G. In vitro aging of human bone marrow derived stromal cells. Mech. Ageing Dev. 16, 81-89 (1981). 96. Colter,D.C., Sekiya,I. & Prockop,D.J. Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells. Proc. Natl. Acad. Sci. U. S. A 98, 7841-7845 (2001). 97. Docheva,D. et al. Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy. J. Cell Mol. Med. 12, 537-552 (2008). 98. Sekiya,I. et al. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 20, 530-541 (2002). 99. Domke,J. et al. Substrate dependent differences in morphology and elasticity of living osteoblasts investigated by atomic force microscopy. Colloids Surf. B Biointerfaces. 19, 367-379 (2000). 100. DiGirolamo,C.M. et al. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br. J. Haematol. 107, 275- 281 (1999). 101. Smith,J.R., Pochampally,R., Perry,A., Hsu,S.C. & Prockop,D.J. Isolation of a highly clonogenic and multipotential subfraction of adult stem cells from bone marrow stroma. Stem Cells 22, 823-831 (2004). 102. Settleman,J. Tension precedes commitment-even for a stem cell. Mol. Cell 14, 148-150 (2004). 103. Korchev,Y.E. et al. Cell volume measurement using scanning ion conductance microscopy. Biophys. J. 78, 451-457 (2000). 104. Liu,T. et al. Regulation of vimentin intermediate filaments in endothelial cells by hypoxia. Am. J. Physiol Cell Physiol 299, C363-C373 (2010).