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References 54 105.

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References 55 119. Shih,Y.R., Tseng,K.F., Lai,H.Y., Lin,C.H. & Lee,O.K. Matrix stiffness regulation of integrin-mediated mechanotransduction during osteogenic differentiation of human mesenchymal stem cells. J. Bone Miner. Res. 26, 730-738 (2011). 120. Hamidouche,Z. et al. Priming integrin alpha5 promotes human mesenchymal stromal cell osteoblast differentiation and osteogenesis. Proc. Natl. Acad. Sci. U. S. A 106, 18587-18591 (2009). 121. Hamidouche,Z., Fromigue,O., Ringe,J., Haupl,T. & Marie,P.J. Crosstalks between integrin alpha 5 and IGF2/IGFBP2 signalling trigger human bone marrow-derived mesenchymal stromal osteogenic differentiation. BMC. Cell Biol. 11, 44 (2010). 122. Kundu,A.K., Khatiwala,C.B. & Putnam,A.J. Extracellular matrix remodeling, integrin expression, and downstream signaling pathways influence the osteogenic differentiation of mesenchymal stem cells on poly(lactide-co-glycolide) substrates. Tissue Eng Part A 15, 273-283 (2009). 123. Song,H. et al. Reactive oxygen species inhibit adhesion of mesenchymal stem cells implanted into ischemic myocardium via interference of focal adhesion complex. Stem Cells 28, 555-563 (2010). 124. Liu,L., Wise,D.R., Diehl,J.A. & Simon,M.C. Hypoxic reactive oxygen species regulate the integrated stress response and cell survival. J. Biol. Chem. 283, 31153-31162 (2008). 125. Keely,S. et al. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J. 23, 1338-1346 (2009). 126. Kong,T., Eltzschig,H.K., Karhausen,J., Colgan,S.P. & Shelley,C.S. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc. Natl. Acad. Sci. U. S. A 101, 10440-10445 (2004). 127. Cowden Dahl,K.D., Robertson,S.E., Weaver,V.M. & Simon,M.C. Hypoxiainducible factor regulates alphavbeta3 integrin cell surface expression. Mol. Biol. Cell 16, 1901-1912 (2005).

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