The EPI-RET-3 wireless retina implant system is suitable to ... - FBMI

fbmi.cvut.cz

The EPI-RET-3 wireless retina implant system is suitable to ... - FBMI

EPI-RET-3

A Wireless Retina Implant in Human Trial

Dipl.-Ing. Christian Koch


Retinitis Pigmentosa

Symptoms of Retinitis Pigmentosa

Night blindness

Narrowing of the field of sight

Totally blindness (in most cases)

Congenital retinal disease

3,000,000 patients (worldwide)

untreatable

EPI-RET-3 – A Wireless Retina Implant in Human Trial

2


Pigments

Degeneration of Light

Sensitive Cells due to

Retinitis Pigmentosa

Photoreceptors

(Rods and Cones)

Cross Section Through the Retina

Bipolar Cells

Ganglion Cells

Nerve Fibers to the Brain

EPI-RET-3 – A Wireless Retina Implant in Human Trial

Electrode Array

3


Technical Concept

EPI-RET-3 – A Wireless Retina Implant in Human Trial

4


CMOS-

Camera

Retina-Encoder Telemetry Unit

Image sensor

380 x 300 Pixel

Extraocular Components

DSP

PDA

FPGA Transmitter

During the first clinic trials the retina-encoder and the camera

were replaced by a PC and a software for pattern generation!

EPI-RET-3 – A Wireless Retina Implant in Human Trial

Implant

5


Receiver coil

Energy und data

transmission via

inductive coupling.

Telemetry signal

Implant – Functional Diagram

Receiver for power

and data

D + T D

Clock and data

separation

U

T

D

Programmable

current source

EPI-RET-3 – A Wireless Retina Implant in Human Trial

x,y

Shift register

for current and

electrode selection

Receiver IC Stimulator IC

I

Electrode selection

I

1

...

n

Ganglion cell Retina

Biphasic current pulses

6


Fully assembled retinal implant

Implant – Fabrication

Encapsulated implant with folded microcoil

EPI-RET-3 – A Wireless Retina Implant in Human Trial

7


Retina Implant in Animal Trial

24 implants successfully implanted and stimulated

One implant is working for more than one year in a mini-pig

EPI-RET-3 – A Wireless Retina Implant in Human Trial

8


Retina Implant in Human Trial

transmitter unit

tactile I/O unit

Complete stimulation setup

PC with software for

pattern generation

EPI-RET-3 – A Wireless Retina Implant in Human Trial

recording unit

recording electrodes

9


Retina Implant in Human Trial

Recorded stimulation artifact as proof

of implant functionality

EPI-RET-3 – A Wireless Retina Implant in Human Trial

Successful commissioning

In all 6 patients

Up to a transmission distance

of 25 mm

Without failure due to head or

eye movements

For more than one hour

10


Conclusion

The EPI-RET-3 wireless retina implant system is suitable to elicit

visual sensations in legally blind RP patients.

Using micro fabrication and micro assembly techniques a small

and low weight but robust implant was designed and fabricated.

The implantation surgery is feasible and the implant is well

tolerated.

The EPI-RET-3 wireless retina implant system is the first

wireless retinal prosthesis implanted completely within the eye

without any cable connection crossing the eye’s wall.

EPI-RET-3 – A Wireless Retina Implant in Human Trial

11


Thanks to:

Prof. Wilfried Mokwa (IWE1)

Acknowledgement

Prof. Peter Walter, Dr. Gernot Rössler, Dr. Bernd Sellhaus (UK-Aachen)

Michael Görtz, Dr. Ingo Krisch (FHG-IMS)

Dr. Thomas Laube, Dr. Claudia Brockmann (UK-Essen)

Dr. Arthur Messner, Harald Röthgen (DS-IOL)

Uwe Thomas, Dirk Höhl, Stefan Rein (TREC)

EPI-RET-3 – A Wireless Retina Implant in Human Trial

12

More magazines by this user
Similar magazines