Understanding Hair Transplants and Hair Loss - Pacific Hair

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Understanding Hair Transplants and Hair Loss - Pacific Hair

(VEGF) and follicular growth factor-7 (FGF-7), while taurine and ornithine stimulate

outer root sheath growth . At one month, vessel diameter and hair shaft diameter

were both larger than placebo . Revascularization was quicker by nearly threefold,

and the follicle growth was improved .

Since the outer root sheath is more accessible to topical therapy than the dermal

papilla, it may be that topical 1-3 Atodine solution might be effective .

19) According to Dr . Carlos O . Uebel OF Brazil, the way to obtain platelet-derived

growth factors is as follows:

“The flasks are centrifuged at 1000 rpm for 10 minutes. The slow speed is important

so that the platelets remain moved and redistributed into 4 other flasks for a

second centrifugation of 5000 rpm for 10 minutes . The plasma supernatant is then

removed, leaving only 2 cc of the concentrate, which is the platelet-rich plasma

(PRP) . The PRPR contains four to six times more platelets than normal plasma

and includes a high concentration of growth factors . This concentrate is then

added to the FUs prior to their implantation . The PRP is kept in contact with the

hair follicles for 15 minutes to allow the growth factors to attach to the stem cells

located in the bulge area . Next, we add ten drops of 10% calcium chloride with the

intent of transforming fibrinogen into fibrin in order to produce a plasmatic gel that

will seal the micrografts with the growth factors around them .”

20) According to Drs . Kim and Kim of Korea, frontal scalp and beard dermal papilla

cells, respond differently to DHT . Beard dermal papilla cells respond positively

through the Wnt pathway and produce hair growth stimulating signals such as

EDA2R . Frontal scalp dermal papilla cells respond with the production of Wnt inhibiting

signals such as dickhoff (DKK)-1, which inhibit hair growth .

Circulating androgens enter the dermal papilla through its capillaries and, after

binding to androgen receptors, activate or repress target genes . These target

genes produce paracrine regulatory factors . Dermal papilla cells in the balding

frontal scalp secrete transforming growth factor (TGF)-β, which inhibits the epithelial

cell growth in response to androgens . These frontal DP cells also contain more

AR and type II 5-alpha reductase than non-balding occipital DP cells. They are

known to secrete inhibitory autocrine factors that affect the growth of DP cells . The

data suggests that androgen-driven alteration of the autocrine and paracrine factors

may be the key to the pathogenesis of androgenetic alopecia .

U n d e r s t a n d i n g H a i r T r a n s p l a n t s a n d H a i r L o s s

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