Prof. Dr. Roland Eils Institute of Pharmacy and Molecular ... - HBIGS
Prof. Dr. Roland Eils Institute of Pharmacy and Molecular ... - HBIGS
Prof. Dr. Roland Eils Institute of Pharmacy and Molecular ... - HBIGS
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<strong>Pr<strong>of</strong></strong>. <strong>Dr</strong>. <strong>Rol<strong>and</strong></strong> <strong>Eils</strong><br />
<strong>Institute</strong> <strong>of</strong> <strong>Pharmacy</strong> <strong>and</strong> <strong>Molecular</strong> Biotechnology (IPMB)<br />
University <strong>of</strong> Heidelberg<br />
69120 Heidelberg, Germany<br />
Phone: +49-(0)6221-42 3600<br />
Fax: +49-(0)6221-42 3610<br />
E-mail: r.eils@urz.uni-heidelberg.de<br />
26/05/1965, Krefeld<br />
CURRICULUM VITAE<br />
2002 – present appointed director <strong>of</strong> department “Bioinformatics <strong>and</strong> Functional<br />
Genomics” <strong>and</strong> full pr<strong>of</strong>essor (C4) at University <strong>of</strong> Heidelberg<br />
2002 – present head <strong>of</strong> division „Theoretical Bioinformatics“ at the German Cancer<br />
Research Center (dkfz), Heidelberg, presently with 25 researchers<br />
2000 head <strong>of</strong> the bioinformatics group „Intelligent bioinformatics systems“ at<br />
the German Cancer Research Center (dkfz)<br />
1996 – 1999 Head <strong>of</strong> the biocomputing group „Structure <strong>and</strong> function in cell biology“,<br />
IWR, University <strong>of</strong> Heidelberg, Germany<br />
1996 – 1996 Guest researcher at the Institut Albert Bonniot, Université Grenoble<br />
1995 – 1996 Postdoctoral student at the IWR.<br />
1992 − 1995 Ph.D. study at University <strong>of</strong> Heidelberg (Ruprecht-Karl-Universität<br />
Heidelberg);<br />
COORDINATING FUNCTIONS<br />
2004 – present Member Rektoratskommission “BIOQUANT”<br />
2002 – present coordinator National Platform (SMP Bioinformatics, National Genome<br />
Research Network (NGFN)<br />
HONORS<br />
2005 Award for new innovative research by Helmholtz Society: “Systems<br />
Biology <strong>of</strong> Complex Diseases”<br />
2005 Micros<strong>of</strong>t Research award “Computational tools for advancing science”<br />
2002/2003 Nominated for full pr<strong>of</strong>essor positions (C4) at University <strong>of</strong> Gießen,<br />
University <strong>of</strong> Bonn <strong>and</strong> University <strong>of</strong> Heidelberg<br />
1999 BioFuture prize from the German Ministry for Education <strong>and</strong> Research<br />
(approx. 1.2 Million €)<br />
FIELDS OF INTEREST<br />
Analysis <strong>and</strong> mathematical modelling <strong>of</strong> complex processes in molecular <strong>and</strong> cell biology
CURRENTLY FUNDED PROJECTS (SINCE 2000)<br />
More than 8 million € project funds granted by the DFG (German Research Council), the<br />
BMBF (Federal Ministry <strong>of</strong> Education <strong>and</strong> Research), the Ministry <strong>of</strong> the State Baden-<br />
Württemberg for Science, Research <strong>and</strong> Arts, the Human Frontier Science Programme, the<br />
Helmholtz society, Deutsche Krebshilfe, <strong>and</strong> the EU<br />
PUBLICATIONS (10 most important publications ):<br />
Bacher CP, Guggiari M, Brors B, Augui S, Clerc P, Avner P, <strong>Eils</strong> R*, Heard E* (2006)<br />
Transient colocalization <strong>of</strong> X-inactivation centres accompanies the initiation <strong>of</strong> X inactivation.<br />
Nat. Cell Biol. 2006 Jan 24; [Epub ahead <strong>of</strong> print] *corresp. author <strong>and</strong> equal contribution.<br />
Bulashevska S, <strong>Eils</strong> R (2005) Inferring regulatory logic from gene expression data.<br />
Bioinformatics 21: 2706-2713.<br />
Lenart P., CP Bacher , N Daigle , A H<strong>and</strong> , R <strong>Eils</strong> , M Terasaki, J Ellenberg (2005) A<br />
contractile nuclear actin network drives chromosome congression in oocytes. Nature 436:<br />
812-8.<br />
R. König <strong>and</strong> R. <strong>Eils</strong> (2004) Gene expression analysis on biochemical networks using the<br />
potts spin model. Bioinformatics 20: 1500-1505.<br />
S. Bulashevska, O. Szakacs, B. Brors, R. <strong>Eils</strong>* <strong>and</strong> G. Kovacs (2004) Pathways <strong>of</strong> urothelial<br />
cancer progression suggested by Bayesian network analysis <strong>of</strong> allelotyping data. Int. J.<br />
Cancer 110: 850 –856. *corresponding author<br />
Bentele M, Lavrik I, Ulrich M, Stosser S, Heermann DW, Kalth<strong>of</strong>f H, Krammer PH, <strong>Eils</strong> R.<br />
(2004) Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J.<br />
Cell Biol. 166: 839-51.<br />
J. Wiemer, F. Schubert, M..Granzow, T. Ragg, J. Fieres, J. Mattes, R. <strong>Eils</strong> (2003) Informatics<br />
United: exemplary studies combining medical informatics, neuroinformatics <strong>and</strong><br />
bioinformatics. Methods Inf. Med. 42:126-33.<br />
Gerlich, D., Kalbfuss, B., Beaudouin, J., Daigle, N., <strong>Eils</strong>, R.*, Ellenberg, J. (2003) Inheritance<br />
<strong>of</strong> chromosome topology throughout mitosis. Cell 112: 751-764. *corresponding author<br />
D. Gerlich, J. Beaudouin, M. Gebhard, J. Ellenberg, R. <strong>Eils</strong> (2001) 4-D Imaging <strong>and</strong><br />
Quantitative Reconstruction to Analyse Complex Spatiotemporal Processes in Live Cells.<br />
Nat. Cell Biol. 3: 852-855.<br />
W. Tvaruskó, M. Bentele, T. Misteli, R. Rudolf, C. Kaether, D.L. Spector, H.H. Gerdes,<br />
R. <strong>Eils</strong> (1999) Time-resolved analysis <strong>and</strong> visualization <strong>of</strong> dynamic processes in living cells.<br />
Proc. Natl. Acad. Sci USA 96: 7950-7955.
EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES<br />
Member <strong>of</strong> DFG funded Graduate College<br />
Co-initiator <strong>of</strong> major in Systems Biology within Master programme at the University <strong>of</strong><br />
Heidelberg<br />
Member <strong>of</strong> numerous thesis <strong>and</strong> thesis advisory committees<br />
International reviewer <strong>of</strong> doctoral theses<br />
Supervised 11 doctoral theses<br />
SUPERVISED DISSERTATIONS (last 5 years)<br />
Patrick Warnat, PhD (2006) Studienübergreifende Analyse von Tumor-Genex-<br />
Pressionspr<strong>of</strong>ilen unter besonderer Berücksichtigung des Neuroblastoms<br />
Current occupation: Heidelberg Instruments<br />
Stefan Wörz (2006) 3D Parametric Intensity Models for Localization <strong>of</strong> 3D Anatomical Point<br />
L<strong>and</strong>marks <strong>and</strong> 3D Segmentation <strong>of</strong> Human Vessels<br />
Current occupation: Postdoc at dkfz Heidelberg<br />
Christian Bacher, PhD (2005) Computational imaging <strong>of</strong> dynamic nuclear processes in living<br />
somatic <strong>and</strong> germ line cells – summa cum laude<br />
Current occupation: Consultant<br />
Alla Bulashevska, PhD (2005) Model-based classification for subcellular localization<br />
prediction <strong>of</strong> proteins – summa cum laude<br />
Current occupation: Postdoc at dkfz Heidelberg<br />
Juntao Gao, PhD (2005) Quantitative Analysis <strong>of</strong> Chromosome / Gene Spatial Distribution –<br />
magna cum laude<br />
Current occupation: Postdoc at Stowers <strong>Institute</strong>, USA<br />
Martin Bentele, PhD (2004) Stochastic Simulation <strong>and</strong> System Identification <strong>of</strong> large Signal<br />
Transduction Networks in Cells – summa cum laude<br />
Current occupation: Senior Consultant for Accenture<br />
Svitlana Bulashevska, PhD (2004) IBayesian Network models for inferring cancer<br />
pathogenectic <strong>and</strong> gene regulatory pathways – summa cum laude<br />
Current occupation: Postdoc at dkfz Heidelberg<br />
Christian Conrad, PhD (2004) High content screening on human cell arrays by automated<br />
microscopy <strong>and</strong> pattern recognition – magna cum laude<br />
Current occupation: Postdoc at EMBL Heidelberg<br />
Matthias Gebhard, PhD (2004) Multidimensionale Segmentierung in Bildfolgen und<br />
Quantifizierung dynamischer Prozesse<br />
Current occupation: Daimler Benz, Stuttgar<br />
Chaitanya Athale, PhD (2003) Modelling Nuclear Body Dynamics in Living Cells by 4-D<br />
Microscopy, Image Analysis <strong>and</strong> Simulation – magna cum laude<br />
Current occupation: Postdoc at EMBL Heidelberg<br />
Daniel Gerlich, PhD (2002) Dynamics <strong>of</strong> nuclear architecture investigated by live cell<br />
microscopy - summa cum laude<br />
Current occupation: Group leader at ETH Zurich
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