alzheimer: 100 years and beyond - Hertie-Institut für klinische ...

ALZHEIMER: 100 YEARS AND BEYOND
www.alz100.de
SPEAKERS INCLUDE:
K. Ashe, USA
K. Beyreuther, Germany
H. Braak, Germany
M. Breteler, Netherlands
J.-P. Brion, Belgium
M. Citron, USA
P. Davies, USA
M. De Leon, USA
B. De Strooper, Belgium
N. Fox, UK
B. Frangione, USA
A. Goate, USA
M. Goedert, UK
T. Golde, USA
C. Haass, Germany
J. Hardy, USA
M. Hutton, USA
B. Hyman, USA
Y. Ihara, Japan
K. Iqbal, USA
T. Iwatsubo, Japan
Z. Khachaturian, USA
W. Klunk, USA
V. Lee, USA
E. Mandelkow, Germany
C. Masters, Australia
J. Morris, USA
R. Nitsch, Switzerland
S. Paul, USA
D. Price, USA
A. Roses, USA
T. Saido, Japan
G. Schellenberg,USA
D. Schenk, USA
D. Selkoe, USA
S. Sisodia, USA
P. St. George-Hyslop, Canada
R. Tanzi, USA
R. Terry, USA
L. Thal, USA
J. Trojanowski, USA
C. Van Broeckhoven, Belgium
B. Winblad, Sweden
M. Wolfe, USA
C. Wong, USA
B. Yankner, USA
S. Younkin, USA
centenary meeting
november 2 – 5, 2006
tübingen, germany
organized by M. Jucker, K. Beyreuther, G. Buchkremer,
Y. Christen, C. Haass, K. Maurer,
J. Mervaillie, R. Nitsch

Alzheimer: 100 Years and Beyond
centenary meeting
november 2 - 5, 2006
tübingen, germany
On November 3, 1906 Alois Alzheimer travelled to the university city of Tübingen,
Germany to present an unusual case of dementia. Auguste D. would become
known as the first documented case of Alzheimer’s disease (AD) – a disorder of the
brain's nerve cells that impairs memory, cognition and behavior. AD is widely known
today as the most common form of dementia, which currently affects about 20
million people worldwide. Alois Alzheimer described the pathological
characteristics of the disease in the auditorium of the Clinic for Psychiatry at the
University of Tübingen, the same location where we will mark this milestone’s 100-
year anniversary on November 2-5, 2006.
This historic event will begin in the evening of November 2 with an opening session
for the public. November 3 will be a retrospective day featuring «pioneers» who
contributed to AD research over the last 100 years. On November 4, leading
scientists will present in the morning «current concepts in AD research» and will
discuss in the afternoon the most important «challenges for the new century of AD
research». Attendees of the meeting will have the possibility to look at the original
histological sections through the microscope of Alois Alzheimer, and the way they
were projected. On November 5, there will be the possibility to visit Marktbreit, the
charming birthplace of Alois Alzheimer where his life and tremendous scientific work
can be appreciated. Because of space limitations in these historic buildings, the
meeting must be limited to 200 people.
To mark this historic event, a well documented book about the achievements in AD
research from 1906-2006 with an outlook into the new century will be published at
the time of the symposium.
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

We expect significant media attention from Germany and abroad in response to
this symposium. The meeting has also been selected as one of the «365 Places in
the Land of Ideas», a project organised by the German government on the
occasion of the 2006 Football World Championship in Germany. The AD centenary
meeting will serve as a powerful retrospective as well as a forward-reaching
gathering of experts, and will also provide an opportunity to promote awareness
and funding of AD research and related neurodegenerative disease into the next
century. In Germany and most other industrialized societies the number of people
over 65 years of age is projected to increase 25-30% by 2030 with a dramatic
increase in the incidence of age-related neurodegenerative diseases – making
research and political awareness for the expected social and economical burden
more essential than ever before.
Such a meeting requires substantial logistic and financial support. We already have
the support of the Ipsen Foundation in Paris who are also instrumental in organizing
the event. Morever, we receive support from the Breuer Foundation and Hertie
Foundation in Frankfurt, the German Research Foundation, and various other
donators, whose contributions are greatly appreciated. We are, however, looking
for additional help to support this special event.
The local organization commmittee
Mathias Jucker, Jacqueline Mervaillie, Yves Christen, Konrad Beyreuther, Christian
Haass, Konrad Maurer, Roger Nitsch, Gerhard Buchkremer
The scientific advisory board
Karen Ashe, Konrad Beyreuther, Heiko Braak, Jean-Pierre Brion, Yves Christen, Martin
Citron, Carl Cotman, Mony De Leon, Bart De Strooper, Monica Di Luca, Karen Duff,
Falk Fahrenholz, Blas Frangione, Dora Games, Sam Gandy, Michel Goedert, Paul
Greengard, John Growdon, Christian Haass, John Hardy, Jean-Jacques Hauw, David
Holtzman, Michael Hutton, Bradley Hyman, Yasuo Ihara, Khalid Iqbal, Takeshi
Iwatsubo, Mathias Jucker, Zaven Khachaturian, June Kinoshita, Eddie Koo, Frank
LaFerla, Peter Lansbury, Lars Lannfelt, Virginia Lee, Eva Mandelkow, Eckard
Mandelkow, Eliezer Masliah, Colin Masters, Mark Mattson, Konrad Maurer, Patrick
McGeer, Roger Nitsch, Margaret Pericak-Vance, George Perry, Don Price, Allen
Roses, Gerard Schellenberg, Dale Schenk, Dennis Selkoe, Sam Sisodia, Peter St.
George-Hyslop, Gabrielle Strobel, Rudy Tanzi, Robert Terry, Leon Thal, John
Trojanowski, Christine Van Broeckhoven, Bengt Winblad, Michael Wolfe, Bruce
Yankner, Steve Younkin.
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

Timetable
Thursday, November 2, 2006
18.00 Public Session in German:
100 Jahre Alzheimer Krankheit
Welcome and moderation: Mathias Jucker
Hertie Institute for Clinical Brain Research, Tübingen
Program
- Aging and Alzheimer - a politician’s view:
Erwin Teufel (former Prime Minister of Baden-Württemberg)
- Alois Alzheimer - a historical view: Konrad Maurer (University of Frankfurt)
- Aging and Alzheimer - a scientist's view: Konrad Beyreuther (State Secretary)
- Aging and Alzheimer - an author's view: Martin Suter (author of Small World)
- Aging and Alzheimer - a theologian's view: Hans Küng (Weltethos)
21.00 Theater play about the life and work of Alois Alzheimer
For further information please see
www.oeffentliche_veranstaltung.html
Friday, November 3, 2006
9.00 – 17.00 Scientific Meeting
Session 1: The Pioneers & The Beginning
20.00 Theater (reserved for the symposium participants)
Saturday, November 4, 2006
9.00 – 16.00 Scientific Meeting
Session 2: Current concepts
Session 3: Challenges for the Future
20.00 Conference Dinner
Sunday, November 5, 2006
Optional visit to Marktbreit, the birth place of Alois Alzheimer
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

Speakers
The following speakers were selected by voting of the Scientific Advisory Board and
have confirmed their participation.
The Pioneers:
Session 1
The Pioneers & The Beginning
R. Terry, USA (will also present the contributions of
G. Blessed, A. Brun, J. A. N. Corsellis, P. Divry, D. A. Drachman, N.K. Gonates, M. Kidd,
G. Margolis, M. Roth, H. Sjogren, B. E. Tomlinson, H. M. Wisniewski)
The Beginning:
K. Ashe, USA Y. Ihara, Japan
K. Beyreuther, Germany K. Iqbal, USA
H. Braak, Germany C. Masters, Australia
J.-P. Brion, Belgium
A. Roses, USA
M. Citron, USA G. Schellenberg, USA
P. Davies, USA D. Schenk, USA
M. De Leon, USA S. Sisodia, USA
B. Frangione, USA P. St George-Hyslop, Canada
A. Goate, USA R. Tanzi, USA
M. Goedert, UK C. Wong, USA
C. Haass, Germany B. Yankner, USA
M. Hutton, USA S. Younkin, USA
B. De Strooper, Belgium
B. Hyman, USA
W. Klunk, USA
V. Lee, USA
E. Mandelkow, Germany
J. Morris, USA
R. Nitsch, Switzerland
T. Saido, Japan
C. Van Broeckhoven, Belgium
M. Wolfe, USA
Session 2
Current Concepts
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

Session 3
Challenges for the Future
M. Breteler, Netherlands
N. Fox, UK
T. Golde, USA
J. Hardy, USA
T. Iwatsubo, Japan
Z. Khachaturian, USA
S. Paul, USA
D. Price, USA
D. Selkoe, USA
L. Thal, USA
J. Trojanowski, USA
B. Winblad, Sweden
For the Detailed Scientific Program please see www.alz100/scientific_meeting.html
Neckar Tübingen
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

Details & Additional Program
CLINIC FOR PSYCHIATRY, UNIVERSITY OF TÜBINGEN
The symposium will take place at this historic building, the Klinik für Gemüts- und
Nervenheilkunde, where the “37. Versammmlung Südwestdeutscher Irrenärzte“
gathered in 1906. At this meeting, on
Nov 4, Alois Alzheimer presented his
seminal Alzheimer case to his
colleagues; among them were Franz
Nissl, Robert Gaupp, Oswald Bumke,
Hans Curschmann, Otto Binswanger
and C.G. Jung, all of whom now have
important places in the history of
medicine. Prof. Gerhard Buchkremer
has been the clinic’s director since
1990.
THEATER
A new production of the theater play
about the life and work of Alois Alzheimer
written by Konrad and Ulrike Maurer, which
has been sucessfully staged in Zürich and
Frankfurt, is being created by the new
theater director of Tübingen (Simone Sterr).
It will be put on stage in German but can
equally be understood by English speakers
as the translation will be provided via
earphones. Attendees will be able to enjoy
the play in a historic lecture hall at the
Institute of Anatomy.
EXHIBITION
In collaboration with Carl Zeiss Mikrosokopie we are planning to put up a small
exhibition on the History of Microscopy in Alzheimer Research at the venue of the
symposium. The exhibition will be open to the public on Thursday afternoon, to
symposium attendees from Thursday afternoon until Saturday afternoon.
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

CONFERENCE DINNER
The conference dinner will be held at the
Museum Restaurant, the same location
where the participants of the gathering
had dinner 100 years ago.
ALZHEIMER’S BIRTHPLACE
On Sunday, Nov 5, participants will have the opportunity to visit Alois Alzheimer’s
birthplace. The 19th century house has been carefully restored and exhibits little
treasures such as a microscope Alzheimer worked with and the original medical
record and brain sections of Auguste D. This
historical site gives you the rare opportunity to
gain valuable insight into Alzheimer’s life and
research work. It is located in Marktbreit, a
charming old town approx. 150 km southeast of
Frankfurt and thus lies nearly en route to Frankfurt
from Tübingen. On Sunday there will be a bus
transfer (of 2 ½ hours) from Tübingen to Marktbreit
leaving around 9 am. From there you can either
take the bus back to Tübingen or take the train to
Frankfurt airport (1 1 ½ - 2 hours).
Alzheimer’s biographers, Konrad und Ulrike
Maurer, will be your guides for the entire day, give
you a tour through the town and birthplace, and
will do their best to answer all your questions
regarding Alois Alzheimer’s life and work.
CITY TOURS
On Thursday afternoon city tours through the
beautiful old city of Tübingen will be offered in both
English and German. Emphasis will be on the history
of science (e. g. on the work of Friedrich Miescher,
who discovered the DNA in his laboratory at the
local castle and following Alois Alzheimer’s tracks)
and famous German poets and thinkers. For further
information on the city of Tübingen please see also
the city’s homepage: www.tuebingen.de/en
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

General Information
LOCATION
Symposium:
University Clinic for Psychiatry
Osianderstraße 25
D - 72076 Tübingen
Germany
Public Session:
Neue Aula, University of Tübingen
Wilhelmstraße 7
D - 72076 Tübingen
Germany
LANGUAGE
English is the official language of the symposium. The public session and the theater
performance on Thursday, Nov 2, will be held in German.
CLIMATE
The average November temperature in
Tübingen is between 3 – 14 °C. We hope we will
enjoy some beautiful fall days but advisably you
should also be prepared for some rain.
AIRPORT INFORMATION
Most airplanes from overseas arrive in Frankfurt,
which is located approximatly 250 km north of
Tübingen. The trainride from Frankfurt to Tübingen
via Stuttgart takes 2 – 3 hours, during the day
trains run every 30-60 minutes.
Stuttgart airport is located approx. 50 km north of
Tübingen, which you can then reach by taxi, bus
or train. Depending on means of transport the
journey will take 30-80 minutes.
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany

REGISTRATION
There will be no registration fee, but due to space limitations participation will
unfortunately have to be limited to 181 people. For further information please see
www.alz100.de/registration/html.
Please note that we are planning to broadcast the entire conference as a live video
stream via Internet and to produce a DVD which will be available after the meeting.
For further information please see www.alz100.de/live_video.html
HOTEL ACCOMMODATION
The booking of hotel rooms for speakers will be organized by the administrative
secretariat. Other participants should please make their bookings through our
homepage www.alz100.de, where a Accommoation Form can be downloaded.
LIST OF CURRENT SPONSORS
Abbott GmbH
Boehringer Ingelheim
Eisai GmbH
Elan Pharmaceuticals
Hoffmann-La Roche
Novartis GmbH
LOCAL ORGANIZATION
Hertie Institute for Clinical Brain Research
Department of Cellular Neurology
Prof. Dr. Mathias Jucker
Otfried-Müller-Str. 27
D - 72076 Tübingen, Germany
Administrative Secretariat
Simone Eberle
Phone: +49-7071-29 81947
Fax: +49-7071-21 4521
e-mail: info@alz100.de
www.hih-tuebingen.de/en/
www.alz100.de
The latest version of the program can be downloaded here:
http://www.hih-tuebingen.de/en/zellbiologie/congresses-organization/
www.alz100.de
Please address suggestions, comments, questions, and potential sponsoring to the organizers
at info@alz100.de.
ALZHEIMER: 100 YEARS AND BEYOND
centenary meeting • november 2 – 5, 2006, tübingen, germany