Research projects (13000 - 13500 of 26984)

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Organisations: • Division of Gene Technology Researchers: • Bruno Goddeeris • Rob Lavigne Aging and executive control mechanisms: neural structure-function relationships for inhibitory control of bimanual actions. K.U.Leuven Abstract: Aging is often associated with a progressive decline of cognitive and motor functions. However, recent evidence points to neuroplastic changes , which remain manifest across the lifespan. This view has convincingly been supported by studies demonstrating the recruitment of extra neural resources in older vs younger adults, i.e., age-related compensatory neural "overactivation". In the present project, we will go beyond these base descriptions of compensatory networks by unraveling its deeper mechanisms during tasks requiring 'executive control'. In phase 1, we will determine cortical overactivations in tasks requiring inhibition of planned responses and/or switching to different responses with the hypothesis that basal ganglia (BG) degeneration/dysfunction may account for cortical overactivation. In phase 2, we will study inhibitory processes during complex bimanual responses and will explore relations between overactivation and structural integrity of the cormus callosum. Detailed reg Organisations: • Movement Control & Neuroplasticity Resea Researchers: • Stefan Sunaert • Stephan Swinnen • Nicole Wenderoth • Raf Meesen • Daniel Goble • James Coxon Identification of biomarkers and new therapeutic targets in HTLV-1-associated pathologies. K.U.Leuven Abstract: Human T Lymphotropic Virus-1 (HTLV-1) was discovered 20 years ago as the first retrovirus associated to human cancer. In 3 to 5% of infected individuals, the virus causes adult T cell leukaemia/lymphoma (ATL), an aggressive form of leukaemia, characterised by resistance to chemotherapy and very poor prognosis (median survival time for the acute form: 6 months). Another 3 to 5% may develop HTLV I associated myelopathy (HAM), also known as tropical spastic paraparesis (TSP), a progressive neurodegenerative disease, leading to gradual paralysis and, eventually, death. In two decades, very little progress has been made in prevention of infection, clinical management or understanding of HTLV-1- associated pathogenesis. Our goal is to obtain new insight into HTLV-1-associated pathogenesis, in a stepwise manner. First, we will collect and manage epidemiologicic, clinical, virological and immunological HTLV-1 patient data (obtained through our collaboration with Brazil) in a database system and Organisations: • Laboratory of Clinical and Epidemiologic Researchers: • Anne-Mieke Vandamme • Christophe Pannecouque Investigation of hydrogels and cryogels with single molecule spectroscopy: from new synthetic strategies to in-situ characterisation on molecular level. K.U.Leuven Abstract: No English Abstract Organisations: • Molecular Imaging and Photonics Researchers: • Johan Hofkens A profound study of the anti-inflammatory condition of the mouse strain SPRET/Ei, with emphasis on the glucocorticoidreceptor and the X chromosome Ghent University Abstract: The LPS-resistance of SPRET/Ei is genetically linked to chromosomes 2 and X, and dependent on higher glucocortiod receptor expression levels. We want to search for the basis of this higher expression, and the relation with the loci on chromosomes 2 and X. We also want to study the X-locus in more detail, to possibly identify a protecting gene. Organisations: • Department of Biomedical molecular biology Researchers: • Claude Libert Biocompatibility and cariogenicity of composite dental restorative materials. K.U.Leuven Abstract: Information regarding biocompatibility and cariogenicity of composite restorative materials (tooth-colored fillings) is so far scarce. As thepolymerization of composites is never complete (the degree of polymerization is usually around 50-60%), it has been shown that several uncured components may be released. Even though clinical observations are reassuring, several disturbing studies have been published, warning for possible biotoxic effects (allergenicity, cytotoxicity, mutagenicity, reproductive toxicity). In addition, there are some indications that monomers leached out of composites may promote cariogenic bacteria, hence inducing secondary caries. The main aim of this translational research project isto clear out the discrepancy between the alarming literature and the reassuring clinical observations. The biocompatibility will be investigated multidisciplinarily by in-vivo (toxicokinetic research) and in-vitro research (cell cultures). Not only conventional resin-based dental m Organisations: • Conservative Dentistry Researchers: • Marc Quirynen • Filip Meersman • Peter Hoet • Bartholomeus Van Meerbeek • Eric Nies • Jan Tytgat • Wim Teughels
• Kirsten Van Landuyt Words at vue - A psycholinguïstische study of noticing in the acquisition of vocabulary in a foreign language. Vrije Universiteit Brussel Abstract: Words at vue - A psycholinguïstische study of noticing in the acquisition of vocabulary in a foreign language. Organisations: • Language and literature Researchers: • MICHEL PIERRARD • Alexis HOUSEN Early event in the interaction of antigens/microorganisms with intestinal epithelial cells and intestinal dendritic cells: development of new oral delivery system Ghent University Abstract: This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach with the pig microarray of Affymetrix will be used to study the early responses and dual photon-microscopy to study the passage of antigens/microorganisms through the epithelial barrier and their uptake by DCs. Organisations: • Departement of Pathology Researchers: • Claude Cuvelier Genetic basis of phenotypic tolerance in Pseudomonas aeruginosa. Vrije Universiteit Brussel Abstract: Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium and also an important nosocomial pathogen and the major pathogen chronically colonizing the lungs of cystic fibrosis patients. It is known for its high resistance to many antibiotics and for its capacity of adaptation to stress conditions. The aim of the FWO project was to get a better insight into the mechanisms of persistence of P. aeruginosa after antibiotic treatment as well as into the mechanisms involved in resistance to different stresses. The FWO project G.0299.07 project is a collaborative project coordinated by prof. Jan Michiels (CMPG/KULeuven) and our group. The KULeuven group studies the physiology and the genes involved in the persister phenotype. SCVs are slow growing phentypic variants that typically are more resistant to antibiotics and can revert to wild-type phenotype. We are investigating such a gentamycin-resistant SCV from P. aeruginosa (PhD of Q. Wei). In both cases profound phenotypic changes were observed including defective iron uptake and plating efficiency for the oxyR mutant as well as other phenotypic changes suggesting a disruption of quorum sensing (Vinckx et al., 2008), and absence of the production of the PQS quorum sensing molecule in the SCV mutant this research combines physiological characterization, transcriptomic, a,d proteomic analysis and is ongoing. We expect to submit two other publications based on these results in a near future. Organisations: • Applied Biological Sciences Researchers: • PIERRE CORNELIS Platform for advanced 3D-stacked image sensors University College Ghent Abstract: Abstract not yet available Organisations: • Faculty of Applied Engineering Sciences • Department of Electronics Researchers: • Peter Veelaert The Borrowed Gaze. Research of the use of displacement in time and space of the photographical image of the past in the paintings of Karin Hanssen. University of Antwerp Abstract: The purpose of the research is to see how the flashback operates in figurative contemporary painting and to define its meaning, form and use from a practical and a theoretical point of view. This research of the flashback will take the work of Karin Hanssen (new and existing) as a point of departure. This will undergo a comparative study with the work of other contemporary artists. The kind of image that is used as source material and selected for this research is the public conventional photographic image from the recent past (ca. 1950-ca.1980). Organisations: • Research Centre for Visual Poetics Researchers: • Kurt Vanhoutte Fatty acids in dairy cattle in relation to human and animal health. University of Antwerp Abstract: This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel. Organisations: • Veterinary physiology and biochemistry Researchers: • Peter Bols • Jo Leroy Unravelling the diversity in family firm performance: Effects of entrepreneurial orientation and family orientation on firm performance across generations Universiteit Hasselt Abstract: During the last decade, there has been considerable debate whether family firms perform better than non-family firms. Contrary to existing research, we want to unravel the diversity of family firm performance by considering it as a multidimensional construct encompassing both
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University of Antwerp Abstract: Thi
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Research projects (13000 - 13500 of 26984)

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