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NOVEL RESVERATROL ANALOGUES - Leicester Research ...

NOVEL RESVERATROL ANALOGUES - Leicester Research ...

NOVEL RESVERATROL ANALOGUES - Leicester Research

NOVEL RESVERATROL ANALOGUES: SYNTHESIS, METABOLISM AND CELL PROLIFERATION Thesis submitted for the degree of Doctor of Philosophy at the University of Leicester by Charles Simon (MSc, Ingénieur Chimiste ESCOM – France) Department of Chemistry University of Leicester November 2010

  • Page 2 and 3: Table of Content ACKNOWLEDGMENTS VI
  • Page 4 and 5: 12.1. SULFATION 98 12.1.1. SULFATIO
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  • Page 8 and 9: AcO Acetate ABBREVIATIONS AhR Aryl
  • Page 10 and 11: LDL Low density lipoprotein Lit. Li
  • Page 12 and 13: TNF Tumour Necrosis Factor TPA 12-O
  • Page 14 and 15: Chapter 1: Introduction 1. Cancer C
  • Page 16 and 17: Chapter 1: Introduction direction o
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    Chapter 1 - Introduction a) CHCl3,

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    Chapter 1 - Introduction a) Pd(PPh3

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    Chapter 1 - Introduction Zykova et

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    Chapter 1 - Introduction analogues

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    Chapter 1 - Introduction analogues

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    Chapter 1 - Introduction The methox

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    Chapter 1 - Introduction 5. Aims of

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 2 - Synthesis of resveratro

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    AU Enzymatic sulfation 0.020 0.015

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    Enzymatic glucuronidation Enzymatic

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Chapter 3 - Pharmacological Studies

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    Cell number relative to the control

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    Chapter 3 - Pharmacological Studies

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    % cells in each phase 100 80 60 40

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    Chapter 3 - Pharmacological Studies

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    15.3. Discussion HCA-7 c29 cells we

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    GENERAL CONCLUSION AND FUTURE WORK

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    with the synthesised analogues woul

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    Chapter 4 - Experimental Part 16. P

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    Chapter 4 - Experimental Part stirr

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    Chapter 4 - Experimental Part IR ν

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    Chapter 4 - Experimental Part Synth

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    Chapter 4 - Experimental Part Synth

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    Chapter 4 - Experimental Part Synth

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    Chapter 4 - Experimental Part Synth

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    Chapter 4 - Experimental Part succe

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    Chapter 4 - Experimental Part 18. W

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    Chapter 4 - Experimental Part (CH2)

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    Chapter 4 - Experimental Part CHO),

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    Chapter 4 - Experimental Part 6.96

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    Chapter 4 - Experimental Part 4.59

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    Chapter 4 - Experimental Part New c

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    Chapter 4 - Experimental Part Synth

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    Chapter 4 - Experimental Part MeOH

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    Chapter 4 - Experimental Part that

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    Chapter 4 - Experimental Part 5% CO

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    Chapter 4 - Experimental Part 20.9.

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    (37) Millar, A. W.; Brown, P. D.; M

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    (92) Patel, K. R.; Brown, V. A.; Jo

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    (140) Wadsworth, W. R. J.; Emmons,

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    (199) Grothusen, A.; Hardt, J.; Bra

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    Additional training done during the

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