DRUG-INDUCED LEUKOPENIA

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DRUG-INDUCED LEUKOPENIA

LITERATURE REVIEW

STUDIES

Faguer et al.

Gorchynski et

al.

Matsumoto et

al.

YEARS STUDIES DESIGN OUTCOME

2007

2008

Case Report

Case report of Linezolid-induced

pancytopenia in patient infected with

MRSA

2010 PK study Renal dysfunction increases linezolid

trough level and AUC. Higher drugexposure

induces thrombocytopenia

Rao et al. 2004 Prospective,

Observational

study

Soriano et al. 2007 Comparative

study

Recent treatment with vancomycin

increased the risk (thrombocytopenia)

whose therapy was switched to linezolid

compare linezolid alone.

Haematological toxicity is directly related

to the degree of linezolid exposure

17) Faguer S, Kamar N, Fillola G, Guitard J, Rostaing L. Linezolid-related pancytopenia in organ-transplant patients: Report of two cases. Infection. 2007;35:275–7

18) Gorchynski J, Rose J. Complications of MRSA treatment: Linezolid-induced myelosuppression Presenting with Pancytopenia. West J Emerg Med. 2008 August;9(3):177–8

19) Matsumoto K, Takeshita A, Ikawa K, Shigemi A, Yaji K, Shimodozono Y, et al. Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction. International Journal of Antimicrobial

Agents. 2010;36(2):179-81.

20) Rao N, Ziran BH, Wagener MM, Santa ER, Yu VL. Similar Hematologic Effects of Long-Term Linezolid and Vancomycin Therapy in a Prospective Observational Study of Patients with Orthopedic Infections. Clinical

Infectious Diseases. 2004 April 15, 2004;38(8):1058-64.

21) Soriano A, Ortega M, García S, Peñarroja G, Bové A, Marcos M, et al. Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid. Antimicrob

Agents Chemother. 2007;51(7 ):2559-63

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