DRUG-INDUCED LEUKOPENIA

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DRUG-INDUCED LEUKOPENIA

INTRODUCTION

Adverse Drug Reaction (ADR)

Definition (WHO):

• Any response to a drug which is noxious and unintended,

and which occurs at doses normally used in man for

prophylaxis, diagnosis, or therapy of disease, or for the

modification of physiological function . 1

Major cause of Morbidity and Mortality worldwide 2

• Most common cause of iatrogenic illness. 3

• Accounts for approximately 10% of the hospital admission

in some countries. 4

1) Requirements for adverse reaction reporting. Geneva, Switzerland: World Health Organization; 1975

2) Rield MA, Casillas AM. Adverse drug reactions: types and treatment options. Am Fam Physician. 2003 Nov 1;68(9):1781-90.

3) Ditto AM. Drug allergy. In: Grammer LC, Greenberger PA, eds. Patterson's Allergic diseases. 6th ed. Philadelphia: Lippincott Williams & Wilkins, 2002:295.

4) WHO. Safety of Medicines. WHO/EDM/QSM/2002.2 [Online]; Available from: URL:http://whqlibdoc.who.int/hq/2002/WHO_EDM_QSM_2002.2.pdf

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