Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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References 10. Stabuc B, Vrhovec L, Stabuc-Silih M, et al. Improved Prediction of Decreased Creatinine Clearance by Serum Cystatin C: Use in Cancer Patients Before and During Chemotherapy. Clinical Chemistry, 2000; 46(2): 193-7. 11. Lavezo LA, Davis RL. Vancomycin pharmacokinetics in spinal cod injured patients: a comparison with age-matched, able-bodied controls. J Spinal Cord Med 1995; 16: 233-235) 12. Chikkalingaiah KBM, Grant ND, Mangold TM et al. Performance of Simplified Modification of Diet in Renal Disease and Cockcroft-Gault Equations in Patients With Chronic Spinal Cord Injury and Chronic Kidney Disease. Am J Med Sci 2010; 339(2): 108-16. 13. Bookstaver PB, Johnson JW, McCoy TP et al. Modification of Diet in Renal Disease and modified Cockcroft-Gault formulas in predicting aminoglycoside elimination. Ann Pharmacother 2008, 42(12): 1758-1765. 14. Ryzner KL. Evaluation of Aminoglycoside Clearance Using the Modification of Diet in Renal Disease Equation Versus the Cockcroft-Gault Equation as a Marker of Glomerular Filtration Rate. Ann Pharmacother 2010; 44: 1030-1037. 15. Pai MP, Nafziger AN, Bertino JS. Simplified Estimation of Aminoglycoside Pharmacokinetics in Underweight and Obese Adult Patients. Antimicrob Agents Chemother. 2011 September; 55(9): 4006–4011. 16. Winters M Basic Clinical Pharmacokinetics. Fourth Edition. 2004 Lippincott Williams and Wilkins 17. Rushing TA, Ambrose PJ. Clinical application and evaluation of vancomycin dosing in adults. J Pharm Technol 2001; 17: 33–38.
Post-Test Assessment Questions • T / F: Higher peak and trough concentrations increase risk of aminoglycoside-induced ototoxicity and nephrotoxicity. • T / F: Creatinine production declines with age, immobility, and reduced muscle mass. • T / F: Individuals with spinal cord injury (SCI) have better drug clearance rates than the general population.
Page 1 and 2: Evaluation of Methods to Estimate R
Page 3 and 4: Disclosures • Jennifer Lee, Pharm
Page 5 and 6: VA Long Beach Healthcare System •
Page 7 and 8: Creatinine • A muscle breakdown p
Page 9 and 10: Vancomycin & Aminoglycosides • Do
Page 11 and 12: Cockcroft-Gault (CG) 7 CL CG (mL/mi
Page 13 and 14: MDRD equation 8 4-Variable MDRD: eG
Page 15 and 16: CKD-EPI equation 9 eGFR = 141 x min
Page 17 and 18: 24-Hour Endogenous Creatinine Clear
Page 19 and 20: Inclusion Criteria • Patients at
Page 21 and 22: Methodology • VA electronic medic
Page 23 and 24: Methodology • Actual drug clearan
Page 25 and 26: Results
Page 27 and 28: Evaluation of different methods to
Page 29 and 30: Number of Patients Difference betwe
Page 31 and 32: Actual Drug Clearance (mL/min) 120
Page 33 and 34: CL DRUG vs. CL SCI • T-Test showe
Page 35 and 36: DISCUSSION
Page 37 and 38: Discussion • CL SCI = 2.3286 * x
Page 39 and 40: Conclusion • Current methods used
Page 41: References 1. Macdiarmid S, Mcintyr

Jennifer P. Lee, PharmD, BCPS - Paralyzed Veterans of America

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