View presentation from Professor John Fisher
View presentation from Professor John Fisher
View presentation from Professor John Fisher
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Force/Width (N/m)<br />
iMBE<br />
MULTI SCALE TISSUE SPECIFIC BIOMECHANICAL BIOCOMPATIBILITY<br />
Micro-scale scaffold structure & architecture determines cell strain and function-<br />
Macro<br />
forces and<br />
biomechanics<br />
Scaffold architecture and structure<br />
determines<br />
Micro scale -local cell - strain field<br />
Drives<br />
scaffold - cell<br />
strain / interactions<br />
Model<br />
anisotropic<br />
scaffold<br />
160<br />
120<br />
80<br />
40<br />
Fixed Aortic<br />
Fixed Pulmonary<br />
Fresh Aortic<br />
0<br />
0 5 10 15 20 25 30 35 40<br />
Strain (%)<br />
Each tissue has its<br />
own unique<br />
scaffold<br />
architecture<br />
Micro-scale strain<br />
drives cell<br />
differentiation