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Force/Width (N/m)<br />

iMBE<br />

MULTI SCALE TISSUE SPECIFIC BIOMECHANICAL BIOCOMPATIBILITY<br />

Micro-scale scaffold structure & architecture determines cell strain and function-<br />

Macro<br />

forces and<br />

biomechanics<br />

Scaffold architecture and structure<br />

determines<br />

Micro scale -local cell - strain field<br />

Drives<br />

scaffold - cell<br />

strain / interactions<br />

Model<br />

anisotropic<br />

scaffold<br />

160<br />

120<br />

80<br />

40<br />

Fixed Aortic<br />

Fixed Pulmonary<br />

Fresh Aortic<br />

0<br />

0 5 10 15 20 25 30 35 40<br />

Strain (%)<br />

Each tissue has its<br />

own unique<br />

scaffold<br />

architecture<br />

Micro-scale strain<br />

drives cell<br />

differentiation

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