Pharmacologic Management of Urinary Incontinence

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Pharmacologic Management of Urinary Incontinence

Normal Bladder

Muscular anatomy

Wall - detrusor & smooth muscle

Neck - involuntary internal urethral sphincter (IUS)

Neuroanatomy

Parasympathetic - S2,3,4 via pelvic splanchnic nerves & pelvic vesical

plexi

Acetylcholine (ACh) = detrusor muscle contraction via M3 muscarinic

receptors

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