Pharmacologic Management of Urinary Incontinence

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Pharmacologic Management of Urinary Incontinence

Bladder Filling & Emptying

As bladder fills, spinal sympathetic reflexes cause

Stimulation of α1 adrenergic receptors in bladder outlet causing

increased resistance

Sympathetic activation of β3 receptors in detrusor inhibiting contraction

Direct inhibition of detrusor motor neurons in sacral spinal cord

Gradual increase in urethral pressure as bladder fills due to pudendal nerve

activation of striated sphincter (EUS) - guarding reflex

Urethral mucosal seal forms secondary to submucosal portion of urethra

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