3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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Kinetics <strong>of</strong> RNA replication C.K. Biebricher, M. Eigen, W.C. Gardiner, Jr. Biochemistry 22:2544-2559, 1983
A point mutation is caused by an incorrect incorporation <strong>of</strong> a nucleobase into the growing chain during replication: plus strand minus strand U C A G Replication and mutation are parallel chemical reactions.
Page 2 and 3: Evolutionary Dynamics A physicists
Page 4 and 5: 1. Charles Darwins pathbreaking tho
Page 6 and 7: Populations adapt to their environm
Page 8 and 9: time Charles Darwin, The Origin of
Page 10 and 11: The molecular clock of evolution Mo
Page 12 and 13: RNA sample 0 1 2 3 4 5 6 69 70 Time
Page 14 and 15: „Replication fork“ in DNA repli
Page 18 and 19: Stock solution: activated monomers,
Page 20 and 21: An example of ‘artificial selecti
Page 22 and 23: tobramycin RNA aptamer, n = 27 Form
Page 24 and 25: A ribozyme switch E.A.Schultes, D.B
Page 26 and 27: The sequence at the intersection: A
Page 28 and 29: Application of molecular evolution
Page 30 and 31: Results from evolution experiments:
Page 32 and 33: 1971 1977 1988 Chemical kinetics of
Page 34 and 35: Formation of a quasispecies in sequ
Page 36 and 37: Formation of a quasispecies in sequ
Page 38 and 39: Uniform distribution in sequence sp
Page 40 and 41: Error threshold: Individual sequenc
Page 42 and 43: Molecular evolution of viruses
Page 46 and 47: O 5' - end CH 2 O N 1 5'-end GCGGAU
Page 48 and 49: many genotypes one phenotype
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Page 53 and 54: d H = 1 lim p→0 x1 ( p) = x2( p)
Page 55 and 56: Consensus sequence of a quasispecie
Page 57 and 58: Consensus sequence of a quasispecie
Page 61 and 62: Structure of randomly chosen initia
Page 63 and 64: In silico optimization in the flow
Page 65: Evolutionary trajectory Spreading o
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Charles Darwin. The Origin of Speci
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Acknowledgement of support Fonds zu
Page 74:
Web-Page for further information: h
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3. Chemical kinetics of molecular evolution - TBI - UniversitÃ¤t Wien

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