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Evolution<br />

and 3d<br />

structure<br />

Isocitrate<br />

dehydrogenase:<br />

The distance from<br />

the active site<br />

(yellow) determines<br />

the rate of evolution<br />

Dean, A. M. and G. B. Golding. 2000,<br />

Enzyme evolution explained (sort of),<br />

Pacific Symposium on Bioinformatics<br />

2000

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