Luis C. Afonso, MD, FACC Associate Professor of - Division of ...

med.wayne.edu

Luis C. Afonso, MD, FACC Associate Professor of - Division of ...

Luis C. Afonso, M.D., FACC

Associate Professor of Internal Medicine

Division of Cardiology

Wayne State University, Detroit, MI

01/11/2010

__________________________

Signature

Office Address:

Harper University Hospital

8 Brush, Division of Cardiology

3990 John R

Detroit, MI 48201

Office:745 2620

Fax: 745 8643

lafonso@med.wayne.edu

EDUCATION

1980-1984 MBBS Degree, Goa Medical College, Panjim, Goa affiliated to the University of

Bombay, India

POSTGRADUATE TRAINING

1984-1986 Rotating Internship, Goa Medical College Affiliated Hospitals, Goa India

1986-1989 Junior Residency Internal Medicine, Goa Medical College Affiliated Hospitals,

Goa, India

1989-1993 Senior Residency Internal Medicine, Goa Medical College Affiliated Hospitals,

Goa, India

1993-1996 Residency Internal Medicine, Wayne State University Affiliated Hospitals,

Detroit, MI

1996-1997 Fellowship in Geriatrics, Wayne State University Affiliated Hospitals, Detroit, MI

1997-2000 Fellowship in Cardiology, Wayne State University Affiliated Hospitals, Detroit,

MI


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FACULTY APPOINTMENTS

2001-2009 Assistant Professor, Internal Medicine Cardiology, Wayne State University,

Detroit, MI

2002-present Program Director, Cardiology Fellowship Training Program, Wayne State

University, Detroit, MI

2009-present Associate Professor, Internal Medicine Cardiology, Wayne State University,

Detroit, MI

HOSPITAL OR OTHER PROFESSIONAL APPOINTMENTS

2001-2004 Director, Echocardiography Laboratory, John D Dingell VA Medical Center,

Detroit, MI.

2002-present Consultant Cardiologist, Renal and Pancreatic Transplant Service, Detroit

Medical Center, Detroit, MI

2004-present Director, Echocardiography Laboratory, Harper University Hospital,

Detroit, MI

MAJOR PROFESSIONAL SOCIETIES

Member of the American Heart Association

Fellow, American College of Cardiology, FACC

Member, American Society of Echocardiography

Member Steering Committee Michigan Society of Echocardiography

Associate, American College of Physicians

Member, American Medical Association

MEDICAL LICENSURE

DEA License 2002 (Active)

State of Michigan:

Permanent Physician License #4301062290 (Active)

Controlled Substance License #4301062290 (Active)


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BOARD CERTIFICATION

1984 MBBS Degree, University of Bombay, India

1989 Postgraduate MD Degree, Internal Medicine, University of Bombay, India

1992 FMGEMS II (Clinical Sciences)

1993 Federal Licensing Examination (FLEX Components I & II)

1993 Foreign Medical Graduate Exams in the Medical Science FMGEMS (Basic Science)

1996 Certified American Board of Internal Medicine 1996-2006

1998 Certified American Board of Internal Medicine, Special Qualification Geriatric Medicine

1998-2008

2000 Certified American Board of Internal Medicine, Cardiovascular Disease 2000-10

2002 Radiation Physics Course (200 hrs) required by Nuclear Regulatory Commission for

NRC licensure

2003 Testamur, Board Certification, American Society of Echocardiography

2007 Level II Cardiac Computerized Tomographic Angiography (CCTA)

HONORS/AWARDS

1984 Ranked First in MBBS Class of 1984 and Second in Internal Medicine, University of

Bombay

1989 Ranked First in Class of 1989, M.D. Degree Exam. Goa Medical College University of

Bombay

1997-98”Outstanding Fellow of the Year” award, Division of Cardiology, Wayne State

University, Detroit Medical Center, Detroit, MI

1998 Award Winner, American College of Cardiology, Michigan Chapter, Clinical Vignette,

Competition, Fall 1998

1998-99 “Best Teaching Fellow Award” selected by Residents in the Internal Medicine

Residency Program, Wayne State University, Affiliated Hospitals, Detroit, MI

199-00 Chief Fellow, Division of Cardiology, Wayne State University, Detroit, MI


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2000 “Abstract selected for the “Young Investigator Award” Competition of the American

Society of Nuclear Medicine Annual Meeting June 2000

2005 “Academic Teacher of the Year” award 2004-05. Division of Cardiology, Wayne State

University, Detroit, MI

2006 “School of Medicine Teaching Award” Wayne State University, School of Medicine,

Detroit, MI

SERVICE

2002-09Assistant Professor of Medicine Department of Internal Medicine Cardiology, Wayne

State University School of Medicine. UPG 4 C Clinic, Geriatrics Clinic 5B

Consulting 2002-present Consultant Cardiologist, Renal and Pancreatic Transplant Service,

Detroit Medical Center, Detroit, MI

2009-present Associate Professor of Medicine Department of Internal Medicine Cardiology,

Wayne State University School of Medicine. UPG 4 C, Geriatrics Clinic 5 B

Roles:

1. Patient Care:

Clinical Rounder in the Coronary Care Unit and Consult Service 3 months of the

year. Super clinical rounder 12 weekends a year

University Health Center Cardiology Outpatient Clinic: Supervisor of 6 trainees

half day/week

Geriatric Cardiology Clinic Consultant 5 B UHC: Supervising 2-3 Fellows ½ day

alt weeks.

2. Echocardiography

Annually responsible for interpretation of roughly:

6500 surface echoes

650-700 Transesophageal echoes

600 Exercise or Doubatine echoes

144 specialized imaging studies such as dsynchrony analysis, strain imaging,

tissue Doppler and 3-D imaging

3. Electrocardiography Reading for the DMC

Average of four-2 hr slots a month, approximately 12000 ECG’s annually

4. Digital Transition of Harper Echo Lab

Responsible for conceiving and implementing analog (video tape) to Digital transition of

the Echo Lab, upgrading imaging equipment and implementing electronic reporting. The

University Lab offers “state of the art” services such as 3-D imaging. Tissue Doppler,


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Tissue synchronization, strain and speckle tracking imaging. Electronic reporting was

also phased in allowing for efficient, timely and cost-effective transmission of echo

reports to the hospital database.

5. Medical Director, Harper University Hospital

Quality Analysis and Improvement Meetings and Measures

Maintaining and implementing Echo Procedures/Protocols of the DMC

Compilation of requirements for Lab accreditations.

Undertake and conduct monthly CME for songraphers and nursing staff

Recent effort leading on to accreditation of Harper and DRH Echo labs by

the prestigious Intersocietal Commission for Accreditation of

Echocardiography Laboratories (ICAEL), certificate valid to 2011.

6. Cardiology Fellowship Training, Program Director

Overwhelming contribution to Core Curriculum document compilation

Development of Division Trainee In-Service exam

Regular formal and bedside didactics

Faculty Mentoring

Clinical research mentoring, weekly session.

7. Applicant Interviews:

This very time consuming responsibility and comprises a labor-intensive adjudication and

interviewing of >100 candidates for 4 Fellowship positions. Short listing done after

careful review of 540 applicant folders including letters of recommendations, USME

scores and research accomplishments.

8. DMC Renal-Pancreatic Transplant Team Cardiology Consultant

Responsible for risk stratification and preop assessment of transplant candidates, weekly

clinical appraisal sessions.

9. Internal Site Reviewer: Participated as one of 2 expert reviewers in the mid cycle

Internal review of the Cardiothoracic Residency Training Program

10. Annual Meeting Abstract Reviewer. Michigan Chapter, American College of

Physicians, Scientific Meetings.

11. Member Pharmacy and Therapeutics Committee, Harper University Hospital 2007

to present.

Community:

Women and Heart Disease, Feb 2009. Lay person lecture to parishioners, St. Thomas

Aquinas Parish, Dearborn Heights, MI


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DMC Annual Health Fair, Fox Theatre, Detroit, MI (2007-present) . Annual Screening

echoes 1 full day for employees of Fox Theatre. Entails limited screening of roughly 50

Employees.

DMC Annual Health Fair Compuware Employees (2007-present). Annual Screening

echoes, 1 full day for employees of Compuware. Entails limited screening of roughly 45-50

Employees.

Consulting:

2002-present Consultant Cardiologist, Renal and Pancreatic Transplant Service,

Detroit Medical Center

** Other: Annual NBA Mandate Preseason Screening and Physicals for the Detroit Pistons

(2006 – present)

Responsible for coordinating Physicals and Stress echo testing as part of the annual

preseason screening mandated by the NGA for professional basketball players. This is a

major undertaking, held annually at the Palace of Auburn Hills, entails transportation of

echo machines, treadmills, etc to the Palace, an all day affair starting with physicals,

culminating with exercise stress testing for all players, subs and coaches. This is a high

profile, prestigious, gratuitous service that the DMC provides and is coordinated by me

that incidentally received wide press coverage this year (Detroit Free Press).

Scholarly Service

Service for Peer-Reviewed Journals

Manuscript Reviewer

2005-present: Chest (2 Manuscripts)

2006-present: Clinical Cardiology (15 Manuscripts)

2007: American Journal Cardiology (8 Manuscripts)

2007: Circulation (1 Manuscript)

Regional Service Contributions

2008-09

Michigan Society of Echocardiography, Member Steering Committee.

This is a prestigious position and regional recognition of expertise in the field of

Echocardiography. Role entails attending (Quarterly Meetings) actively participate in

discussion, planning etc.


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TEACHING

Years at Wayne State University 2001-present, 8 years at Wayne State (of these 3 years spent at

the VA as full time faculty)

Course taught at Wayne State in the last 5 years:

2 nd Year Wayne State University Medical Students:




Annual Pathophysiology Lectures series

Annual Physical Diagnosis Instruction

Annual Clinical Cardiovascular Exam lecture

3 rd Year Wayne State University Medical Students on Clinical Rotation

3 rd Year Wayne State University Medical Students Physical Diagnosis Instruction

4 th Year Wayne State University Medical Students on Elective Rotation (one-on-one

teaching)

WSU First Year Cardiology Fellow Clinical Consult Rotation (one-on-one) Teaching:

WSU First Year Cardiology Fellow Cardiac Intensive Care Rotation (one-on-one)

Teaching

WSU Year I, II, and III Cardiology Fellow Echocardiography (one-on-one) Teaching

WSU Cardiology Fellow Mentor (6Fellows)

WSU Cardiology Fellow Didactic Teaching:

Core Curriculum Lecture throughout the year with a focus on:

Echocardiography

Mentoring of Clinical Research and Scholarly activities

Faculty Mentoring

Bedside Teaching: Consistently impart clinical skills at the bedside to trainees ranging from

medical students to rotating residents and fellows ranging from bedside clinical exam skill to

ECG’s nuclear perfusion and diagnostic angiography interpretation.

Ambulatory Clinic Supervision: Responsible for close supervision of fellows and rotating

residents with a considerable attention to bedside skills, treatment guideline adherence, cost

effective care instruction, preventive cardiology, risk factor modification and care plan

assessment at 2 Clinic sites: 1. University Health Center Cardiology Clinic 4C and 2. Geriatric

Cardiology 5 B University Health Center, Geriatric Center of Excellence


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Echo Lab Interaction: Shoulder to shoulder performance and interpretive instruction to

Cardiology Fellowship trainees throughout the year. Extensive time commitment to this activity,

involves technology updates, digital processing, special techniques and instrument handling etc.

Resident Teaching: Regular formal Cardiology Series lectures and Board Review 4-6 sessions

during the academic year. Particular focus on Arrhythmia Management, ECG interpretation

and clinical exam skills. Training of interested residents in echo interpretation during monthly

noninvasive rotation. Research Mentor for residents conducting cardiology related research.

Interdisciplinary Lectures: Cardiothoracic Resident teaching, cross-disciplinary lectures and

instruction during joint weekly conferences.

Physical Diagnostic Course Participant: Regular contributor to this annual effort since 1999.

(6 sessions x medical students, annually)

Physician Shadowing: Hosted countless premed and accelerated track WSU (MEDSTART)

medical students as part of shadowing experience to expose trainees to the daily routine of an

attending physician over the course of the year.

MENTORING: (includes clinical research projects and scholarly activity)

** The overwhelming majority of abstracts and articles have been collaborative efforts with

trainees at all levels from residency to fellows. A sampling is listed below. Due to the large

volume, have opted not to list all mentees, please refer to the abstract / publication section where

trainees are identified by asterisks*

2006-present. (All projects listed below culminated in Published Article/Abstracts)

Veeranna V PGYIII and Fakhry H PGYIII

Severity of Coronary Artery Disease in Obese Patients Undergoing Coronary Angiography

and Intervention (Data Published Clin Cardiol. 2007)

Correlation of Lipid Profile Undergoing coronary angiography. American Heart

Association Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke

Conference, April 2009, Washington DC.

Niraj Ashutosh PGYII

Severity of coronary artery disease in obese patients undergoing coronary angiography

“obesity paradox” revisited. Published article Clin Cardiol. 2007

Ethnic and Gender Differences in Disease Burden in Patients Undergoing Coronary

Angiography: The Confounding Influence of Obesity. Accepted for publication Ethnicity and

Disease.


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Tamam Mohammad PGYII

Cocaine-Related Chest Pain _ Utility of TIMI Risk Stratification and Effects of Beta

Blockers on Outcome. Published Supplement Journal American Coll Card. JACC 47(4);

288A Feb 2006

Crack Whips the Heart: A comprehensive Review of the Cardiovascular Toxicity of

Cocaine. Am J Cardiol. 2007 Sept 15;100(6):1040-3

Role of Cardiac MRI in Peripartum Cardiomyopathy: Ongoing study of newly diagnosed

patients with PPC exploring the etiologic role of inflammatory myocarditis and

hyperprolactenemia

Full length article Cocaine-Induced Chest Pain and Beta-Blockade: An Inner City

Experience Am J Ther. 2008 Nov-Dec;15(6):531-5

Ivan Hanson PGYI and Rayan Hourani PGYII

Comparison of Two-Dimensional versus Three-Dimensional Echocardiography Techniques

to Measure Left Atrial Volume: Correlation with Left Ventricular Filling Pressure

(Abstract published 18 th Annual Scientific Session of the American Society of Echocardiography

(ASE)

Do Mitral Annular and Inflow Velocities Correlate with Indices of Left Atrial Mechanical

Function Derived Volumetrically by 3-Dimensional Echo? Presented at the 18 th Annual

Scientific Sessions of the American Society of Echocardiography (ASE)

Danialdo Rodrigues PGYII

Submassive Pulmonary Embolism: To Lyse or not to Lyse? Presented 30 th Annual Society

for General Internal Medicine Scientific Session, April 2007

Terefe Yared PGYII

Myocardial Infarction with Angiographically Normal Coronary Arteries Abstract. Full

length article published in J Coron Artery Dis 2007

Khaled Awad PGYIII

Midventricular Ballooning Cardiomyopathy: Epicardial spasm vs. Microvascular

Dysfunction: Can Echo Identify the Culprit? Second Annual Cases Competition at the 18 th

Annual Scientific Sessions of the American Society of Echocardiography (ASE) Seattle, WA

June 16-20, 2007


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Bandaru Himabindu PGYII

Predictors of Cardiac Troponin – I Release in Patients with Hypertensive Emergency.

XIVth Scientific Sessions of the Inter-American Society for Hypertension (IASH) and the

Consortium for Southeastern Hypertension Control May 2007

Mengistu Simegn, PGYII

Loss of Base to Apex Strain Gradient and Low Global Longitudinal Strain Identifies

Hypertrophic Cardiomyopathy From Outer Forms of Left Ventricular Hypertrophy.

Abstract accepted American Society of Echocardiography Annual Scientific Session, Orlando,

FL 2009

Strain Dispersion Index and Global Longitudinal Strain in Differentiating Hypertrophic

Cardiomyopathy From Other Forms of Left Ventricular Hypertrophy. Abstract Accepted

for the American College of Cardiology 58 th Annual Scientific Session, Orlando, FL 2009

Anil Mathew PGYII

Tei Index and Spectrum of Diastolic Abnormalities in Takotsubo Cardiomyopathy 14 th

World Congress on Heart Disease. The International Congress on Heart Disease Annual

Scientific Sessions, Toronto, Canada July 2008

Anupama Kottam, PGYII

Improving Diagnostic Yield of Transesophageal Echocardiography for Patent Foramen

Ovale: Can Fluid Bolusing Release the Door-Jam? Oral Abstract to be presented American

Society of Echocardiography Annual Scientific Session Orlando, Fl 2009

Jyotiranjan Pradhan PGYI

Determinants of Amount of Contrast Utilized in Patients Undergoing Percutaneous

Coronary Procedures. Coron artery Dis. 2007

Anil Mathew PGYII

Does the Tei Index Characterize Cardiac Performance in Takotsubl Cardiomyopathy?

Congress on Heart Disease. The International Congress on Heart Disease Annual Scientific

Session, Toronto Canada July 2008

Shalini Modi Fellow YRIII


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Unusual Pulmonary Venous Flow Profile in a Patient with mitral Valve Perforation

secondary to Bacterial Endocarditis. Published article Echocardiography. 2006

Feb;23(2):137-9

Gender, Carotid Stenosis And Risk Factor Treatment in African American Patients with

CAD. Second International Conference in Women, Heart Disease and Stroke, American Heart

Association 2005

Juan Bernal Fellow YRII

The Echocardiographic assessment of Hypertrophic Cardiomyopathy: Emphasis on Novel

Imaging Modalities. (Under review for J Amer College of Cardiology Imaging 2008)

Acute Pulmonary Edema Following Pericardiocentesis for Cardiac Tamponade. Published

Can J Cardiol. 2007

M. Reddy Fellows YRII

Apical Hypertrophic Cardiomyopathy: Potential Utility of Strain imaging in Diagnosis.

Published Article EUR J Echo 2007

Sridevi Pitta Fellow YRII

Metastatic Extracavitary Cardiac melanoma: The Role of Contemporary Imaging

Techniques in Diagnosis and Surgical planning. Published Circulation 2007

Incremental Utility of Real-time Three Dimensional Echocardiography in the Diagnosis

and Pre-operative Assessment of Cleft mitral Valve in Adults. Published European Journal

Echocardiography

Thromboembloic Complications of Left Ventricular Noncompaction-Case Report and

Brief Review of the Literature J Clin Ultrasound. 2007 May 7;35(8):465-468

Quadricuspid Aortic Valve associated with Unruptured Sinus of Valsalva Aneurysm

Accepted for publication European Journal Echocardiography Ref: Ms. No. EJE. 07.387.1574R1

Hui Jin YRIII

Recurrent Heart Failure with preserved Ejection fraction but Markedly elevated BNP in a

51 year-old Female on Hemodialysis with oversized AV Fistula. Published Int J Cardiol 2006

Khaled Bachour Fellow YRII

Takotsubo Cardiomyopathy: Pathogenetic Insights and Myocardial Perfusion Kinetics

Using Myocardial Contrast Echocardiography. Accepted for publication European J of

Echocardiography 2008 Ms. No. EJE. 08.103.1692RI


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Significance of Valvular Perforation in Left-Sided Infective Endocarditis. (Novel dataon the

significance of Valvular Perforation in Endocarditis)

FACULTY MENTORING: both have several abstracts in national meetings and peerreviewed

publications



Ashok Knodur

Mahahan Nitin

Sampling of Ongoing Activity with Interns/Residents and manuscripts near completion

Kottam A, Afonso L. Improving Diagnostic Yield of Transeophageal Echocardiography for

Patent Foramen Ovale: Can Fluid Bolusing Release the Door-Jam?

Vikas Veeranna, Ashutsoh Niraj, Hesham Fakhry, Jyotiranjan Pradhan, Luis Afonso.

Correlation of Lipid Profile and Angiographic Coronary Artery Disease Burden Among

Elderly patients Undergoing Coronary Angiography.

Apurva Badheka, Ankit Rathod, Mohamad A. Kizilbash, Xongshan Lai, Neh Garg, Samrat Bhat,

Luis Afonso, Sony Jacob. Implantable Cardiac Defibrillator Shocks Do Not Predict Death

in a Secondary Prevention.

Bhadheka, Neha Garg, Mohammad A. Kizilbash, Samrat Bhat, Ankit Rathod, Sony Jacob, Luis

Afonso. Incident Diabetes Mellitus in Patients with Stable Coronary Artery Disease

Mengistu Alemayeh Simegn, Ashok Kondur, Preeti Ramappa, Tamam Mohammad, Luis

Afonso. Strain Dispersion Index and Global longitudinal Strain in Differentiating

Hypertrophic Cardiomyopathy From Other Forms of Left Ventricular Hypertrophy.

Mengistu Alemayehu Simegn, Firas Zahwe, Khaled Bachour, Tamam Mohamad, Kidmealem

Zekarias, Preeti Ramappa, Luis Afonso, Deepak Thatai. Cardiac Troponin-I, In-Hospital

Mortality and the Need for Emergency Valve Replacement Surgery in Infective

Endocarditis.

COURSE/ CURRICULUM DEVELOPMENT

Cardiology Core Curriculum Document

Spearheaded effort to develop an extensive and comprehensive Core Curriculum for the

Cardiology Fellowship. This extensive document was compiled and serves as the official

guideline document and course syllabus for the Fellowship training program.

Fellowship Policy Manual

Compiled a complete set of documents that outline the Fellow operations, responsibilities and

code of conduct in accordance with ACGME guidelines. This document details rules and


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regulations relating to duty hours, order writing, moonlighting, relationship to private faculty,

and due process.

Booklet for the Applicant

Compiled a booklet that is handed out to the applicant that comes for an interview with the

department. It outlines the responsibilities of the fellow once they enter into the program.

Outlines the clinical rotation, echo, nuclear, EP, and cath rotation.

Monthly Conference Schedule

Relates to assembling and planning relevant conference topics, lectures and speakers for

monthly didactics including Cardiology Grand Rounds

In-service Training Exam 2006-present

Instrumental in developing an annual Medical Knowledge assessment instrument to help

longitudinally evaluate/monitor Fellow training and process

Monthly Structured Testing 2007-present

Responsible for and executing and developing this knowledge assessment metric used to monitor

trainee process in the field of Cardiology based on preassigned syllabus based on a core

curriculum. (Entails setting ~50 multiple choice questions on a peaessigned topic).

Performance tracking and remediation of areas of weakness now possible with this tool.

Spectacular results with 100% passage rates in General Cardiology. Echocardiography and

Nuclear Cardiology Boards, activity highly regarded by trainees.

MCQ Tests designed and completed include:

Valvular HD and Endocarditis

Congestive Heart Failure

Electrophysiology

Pericardial Diseases

Pulmonary Hypertension

Each of these tests entails a set of 50 MCQ’s on the assigned topic from Braunwalds Textbook of

Cardiology, are exclusively for our program and is a very time consuming exercise. Over 90%

of the questions sets in aggregate were developed by me. We use the results to monitor Fellow

training and these become part of the performance record in their files.

Cardiology Fellowship Accreditation: In 2008 the WSU/DMC Adult Cardiovascular

Fellowship trading Program underwent a site visit for continuing accreditation. As

Program Director, I was directly responsible for safeguarding our accreditation status.

Preparation for this visit was exhaustive and thorough. We were awarded continuing

ACGME accreditation for an additional 5 years without a single citation: a remarkable

achievement for the program, unprecedented in my tenure as Program Director. The

Program can boast of 100% passage rate in the Annual ABIM Cardiology Board Exams,

National Board of Echocardiography Exams, the American Nuclear Cardiology Society

and the Society for Cardiac CT (SCCT)Exams. Two of our graduating Fellows landed

prestigious Interventional Fellowship positions at the Massachusetts General Hospital and


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Mayo Clinic Interventional Programs, testifying to the caliber of trainees graduating from

our Program.

GRANTS, CONTRACTS, AND OTHER FUNDING

2009 In review NIH-NIA T35 eight week Summer Research Program Enhancing Geriatric

Assessment Research skills and knowledge (EGAR). Co-PIs Jennifer Mendez, PhD, WSU

SOM and Luis Afonso, MD, FACC

Role of Cardiac magnetic Resonance Imaging in the Diagnosis of Peripartum

Cardiomyopathy submitted for WSU intramural grant support: not funded 2008

CLINICAL TRIALS ACTIVITIES

1999 Co-investigator and Collaborating investigator in successful grant proposal for intramural

funding for research titled “Effects of Adenosine on Microvascular Function in Patients with

Acute myocardial Infarction” JR Spears, Luis Afonso, Eric Racine, James Janisse, Marcelo Di

Carli.

2001 Co-investigator STICH Trial The Surgical Treatment for Ischemic Heart Failure

assessing the benefits of aneurysmectomy in improving LV geimetry and systolic function.

Active National/International Grants and Contracts

2002 Co-investigator Irbesartan in Heart Failure with preserved Systolic function (I-

PRESERVE) Sponsored by Bristol-Myers Squibb. (VA Medical Center) Effects of Angiotensin

receptor blocker Irbesartan on left ventricular systolic and diastolic function.

2002-03 Sub PI for A-HEFT (African-American heart failure Trial) VA Medical Center The

assessment of Hydrallazine-Nitrates combination on the morbidity and mortality of Congestive

Heart Failure in African-Americans

2007 Cardiology PI A multicenter, Randomized, Double-Blind, Placebo-Controlled Study to

Evaluate the Safety and Efficacy of SCH530348 in Addition to Standard of Care in Subjects

With a History of Atherosclerotic Disease: Thrombin Receptor Antagonist in Secondary

Prevention of Atherothrambotic Ischemic Events (TRA 2’P-TIMI-50)

2009 Co-investigator with Dr. Jeffrey Zondee (PI), Karmanos Institute. Study of Multiple

Myeloma and Cardiac Amyloidosis: will serve as Core Echo Lab for Multicenter National Trial.


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PUBLICATIONS: I am the senior or lead author in nearly all below listed publications

Original Peer-Reviewed Publications

1. Afonso L, Sowers JR. Effects of Advancing Age on Cardiovascular Baroreflex Function

Proceedings of the 3 rd International Congress of Hypertension in the Elderly, Feb.

1995;95-107

2. Afonso L, Dihenkar G, Alangaden J. Leptospirosis: Unusual cause of Fever, Jaundice

and Renal Failure. Infectious Diseases in Clinical Practice 1997;6(3):203-205

3. Sowers JR, Raman BB, Afonso LC, Bedford-Rice K, Standley PR. Effect of

Antihypertensive Therapy on Platelet Cytosolic Calcium Responses to Low Density

Lipoprotein Cholesterol. Journal of Human Hypertension 1996;10:177-180

4. Afonso LC, Edelson GW, Sowers JR. Metabolic abnormalities in Hypertension.

Current Opinion in Nephrology and Hypertension. 1997;6:219-223

5. Di Carli M. Afonso L, Campisi R, Ramappa P, Bianco-Battles D, Grunberger G,

Schelbert H. Coronary vascular dysfunction in premenopausal women with diabetes

mellitus. American Heart Journs 2002;144:711-718

6. *Reddy M, Thatai D, *Bernal J, Afonso L. Aptical Hypertrophic Cardiomyopathy:

Potential Utility of Train Imaging in Diagnosis. Eur J Echocardiogr. 2007May 27,

7. *Pradhan J, Niraj A, Afonso L. Determinants of Amount of Contrast Utilized in Patients

Undergoing Percutaneous Coronary Procedures. Coron Artery Dis. 2007:

June;18(4):275-82

8. *Niraja A, *Pradhan J, *Veeranna V, *Fakhury H, Afonso L. Severity of Coronary

Artery Disease in Obese Patients Undergoing Coronary Angiography:”Obesity Paradox”

revisited. Clin Cardiol. 2007 Aug;30(8):391-6

9. *Teref YG, *Niraj A, *Pradhan J, *Kondur A, Afonso L. Myocardial infarction with

Angiographically Normal Coronary Arteries in the Contemporary Era. Coron Artery

Dis. 2007 Dec;18(8):621-6

10. Afonso L, *Niraj A, *Pradhan J, Veeranna V, Fakhry H. Ethnic and Gender Differences

in Disease Burden in Patients Undergoing Coronary Angiography: The Confounding

Influence of Obesity. Ethn Dis. 2008 Winter;18(1):53-8

11. Kondur A, *Pitta SR, Afonso L. Incremental Utility of Real-time Three Dimensional

Echocardiography in the Diagnosis and Preoperative Assessment of Cleft Mitral Valve in

Adults. Accepted for publication. Eur J Echocardiogr. 2008;9(4):586-8. Epub 2008

Mar 5.


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12. Kondur A, Tao L, Vaitkevicius P, Afonso L. Quantification of Myocardial Iron

Overload by T2* Cardiovascular Magnetic Resonance Imaging. Accepted Clinical

Cardiology Manuscript ID CLC-07-0502. 2008 April, Epub Ahead of Print

13. *Pradhan J, Venkalaya H, *Niraj A, Kumaravelu P, *Trivedi M, Afonso L, Thatai D.

QT Dispersion at Rest and During Adenosine Stress Myocardial Perfusion Imaging

Correlation with Myocardial Jeopardy Score. Clinical Cardiology, 2008

May;31(5):205-10

14. *Pradhan J, *Schreiber T, *Niraj A, Veeranna V, Ramesh K, Saigh L, Afonso L.

Comparison of Five Year Outcome in African Americans versus Caucasians Following

Percutaneous Coronary Intervention. Catheter Cardiovasc Interv 2008:Jul1;72(1):36-

44

15. Afonso L, *Khaled B, Khaled A. Takotsubo Cardiomyopathy: Pathogenetic insights and

Myocardial Perfusion Kinetic Using Myocardial Contrast Echocardiography. Eur J

Echocardiogr. 20008 Nov;9(6):849-54

16. *Mohamad T, *Kondur A, Vaitkevicius P, *Bachour K, Thatai D, Afonso L. Cocaine-

Induced Chest Pain and Beta-Blockade: An Inner City Experience. AM J Ther. 2008

Nov-Dec;15(6):531-5

17. Mahajan N, Ganguly J, Simegn M, Bhattacharya P, Shankar L, Madhavan R, Chaturvedi

S, Ramappa P, Afonso L. Predictors of Stroke in Patients with Severe Systolic

Dysfunction in Sinus Rhythm: Role of Echocardiography. Int J Cardiol. 2009 Ju 9

(Epub ahead of Print) PMID: 19520443

18. Afonso L, Pradhan J, Veeranna V, Niraj A, Jacob S. Global and Regional left

Ventricular Contractile Impairment in Patients with Wolff-Parkinson-White Syndrome

Indian Pacing and Electrophysiology J 2009 Jul. 1;9(4):195-206

19. Khetarpal V, Mahajan N, Madhavan R, Batra S, Mopala P, Sagar A, Rapolu P, Nangia S,

Afonso L, Calcification Aortic Valve and Spontaneous Embolic Stroke: A Review of

Literature J Neurol Sci. Aug 2009 A 25

20. *Mohamad T, *Niraja A, Obideen, *Farah J, *Badheka A, Kondur A, Thatai D, Afonso

L. Spectrum of Electrocardiographic and Angiographic Coronary Artery Disease

Findings in Patients with Cocaine-Associated Myocardial infarction. Accepted to

Journal of Coronary Artery Disease Coron artery Dis. 2009 Aug;20(5):332-6

21. *Veeranna V, *Pradhan J, *Niraj A, *Fakhry H, Afonso L. traditional Cardiovascular

Risk Factors and Severity of Angiographic Coronary Artery Disease in the Elderly

Accepted for Publication J of Preventive Cardiology, 2009


17

22. Afonso L, *Kottam A, *Khetarpal V. “Myocardial Cleft, Crypt, Diverticulum or

Aneurysm? Does it Really Matter?” Clinical Cardiology, 2009 Aug32(8):E48-51

23*Bachour K, *Zmily H, *Kizilbash M, *Awad K, *Hourani R, Hammad H, Sobel JD,

Ghali JK, Levine D, Afonso L. Significance of Valvular Perforation in Left-Sided

Infective Edocarditis. MS#CLC-08-0246.RI Clin Cardiol 2009 Dec;32(12):E55-62

24. Mahajan N, Povalaram L, Venkalaya H, Ference B, Want Y, Ager J, Kovach J, Afonso

L. Diagnostic Accuracy of Single Photon Emission Computed Tomography Myocardial

Perfusion Imaging and Stress Echocardiography for the Diagnosis of Left Main and

Triple Vessel Coronary Artery Disease: A Comparative Meta-Analysis. Accepted

ID#:Heart JNL/2009/182295

25. Manickam P, Rathod A, Badheka A, Aravindhakshan R, Afonso L, Jacob S. Effect of

Statins on Ventricular Tachyarrhythmias in Patients with implantable Cardioverter

Defibrillator-A Meta-Analysis CIRCULATIONAHA/2009/919571 MS

26. *Veeranna V, *Pardhan J, *Niraj A, *Fakhry H, Afonso L. Traditional Cardiovascular

Risk Factors and Severity of Angiographic Coronary Artery Disease in the Elderly.

Accepted for Publication J of Preventive Cardiology 2009

27. Afonso L, Mahana N. Single Photon Emission Computed Tomography (SPECT)

Myocardial Perfusion Imaging (MPI) in the Diagnosis of Left Main Disease. Accepted

for Publication Clin Cardiol. 2009 Dec;32(12):E11-5-PMID:20014205 (PubMed –

in process)

Case Reports (Peer reviewed and published/accepted)

1. *Modi S, Koul D, Afonso L. Unusual Pulmonary Venous Flow Profile in a Patient with

Mitral Valve Perforation secondary to Bacterial Endocarditis. Echocardiography, 2006

Feb.23 (2): 137-9

2. *Pitta SR, Kondur A, Afonso L. Metastatic Extracavitary Cardiac Melanoma: The Role

of Contemporary Imaging Techniques in Diagnosis and Surgical Planning.

Circulation 2007 Apr 14;115 (16) :e415-7

3 *Pitta S, Thatai D, Afonso L. Thromboembolic Complications of Left Ventricular

Noncompaction Case Report and Brief Review of the Literature. J Clin Ultrasound.

2007 May 7;35(8):465-468

4. *Jin H, Afonso L, Singh A, Midgal S, Spears JR. Recurrent heart failure with preserved

ejection fraction but markedly elevated BNP in a 51 year old female on hemodialysis

with oversized AV fistula. Int J Cardiol. 2006 June 28:110(3):429-30


18

5. Lakireddy Dr, Li T, Afonso L, Kondur AK. Is Acute Back Pain a Warning Sign for

Penetrating Atherosclerotic Ulcer? (in press) American Journal Medicine, 2007

6. *Penugonda N, Afonso L. Complex Endocarditis in an Immunocompromised Host: The

Role of 3-Dimensional Echocardiography. J Am Soc Echocardiogr. 2007

Nov;20(11):134 e 9-11

7.*Bernal J, Pradhan J, Tchokonte R, Li T, Afonso L. Acute Pulmonary Edema Following

Pericardiocentesis For Cardiac Tamponade. Can J Cardiol. 2007 Dec;23(14);1155-6

8.*Pitta SR, Kondur A, Afonso L. Quadricuspid Aortic Valve associated with Unruptured

Sinus of Valsalva Aneurysm. Accepted for publication European Journal

Echocardiography. Ref: MS No EJE.07.387.1574R1

9. Kondur A, Afonso L, Berenbom LD, Lakkireddy Dr. Implantable cardioverter

defibrillators save lives from lightning-related electrocution too! Pacing Clin

Electrophysiol. 2008 Feb;31(2):256-7

10. Mahajan N, Afonso L. Right Ventricular Extension of Inferior Wall Myocardial

Infarction: Role of Right Sided Electrocardiogram. South Med J. 2008 Dec;

101(12):1276-7

11. Hari P, Afonso L. An unusual case of Undifferentiated Connective Tissue Disease

presenting as Cardiac Tamponade. Rheumatology International Ref.: Ms.No. RHEID-

09-00708 (Clinical and Experimental investigations)

12.*Matthew A, Afonso L, Jacob S. An unusual case of diaphragmatic stimulation after

cardiac resynchronization therapy. Europasce Apri;11(4):411, Epub 2009 Mar 5

13.Jacob S, Kondur A, Khetarpal V, Afonso L. reversal of right ventricular apex pacinginduced

left ventricular apical dyskinesis: utility of intraoperative 3-D echocardiography

in resynchronization therapy. Circ Arrhythm Electrophysiol. 2009 Aug;2(4):e21-3

14.Mahahan N, Khetarpal V, Afonso L. Stroke secondary to calcific bicuspid aortic valve:

Case report and literature review. Cardiolo. 2009 Aug;54(1):158-61

15.Veeranna V, Pradhan J, Ference B, Afonso L. “Complex Intervention of an In-Stent

Restenosis of Ostial Right Coronary Artery stent protruding into Aortic Sinus of Valsalva

– A Case Report and Review of Literature J Invasive Cardiol. 2009 Nov;21(11):E226-

8

16. Afonso L, Hari P, Mohamad T, Kondur A, Pidlaoan V, Li T, Khetarpal V, Jacob S.

Acute Myocarditis: Can novel echocardiographic techniques assist with diagnosis?

Accepted European J Echocardiography 2009, Nov 24 EJE 09 227 2242


19

17.Hari PMD, Mohamad T, Kondur A, Jahania S, Afonso L. Incremental value of contrast

echocardiography in the diagnosis of atrial papillary myxoma. Accepted

Echocardiography 2009 ID ECHO-2009-0361

Case Reports (peer-reviewed): Posters at national Conferences and Electronic

Publications

18. *Povalaram SR, Guglin M, Afonso L. Hiatal hernia Presenting as Recurrent Syncope.

Oral Presentation. Society of General Internal Medicine, 2005 Midwest Regional

Meeting 2005 Chicago, IL

19. *Pitta S, Elder M, Afonso L. Quadricuspid Aortic Valve associated with Unruptured

Sinus of Valsalva Aneurysm. Valves in the Heart of the Big Apples IV: Evaluation

and Management of Valvular Heart Disease 2005

20. *Pitta SR, Afonso L. Noncompaction with the Left Ventricular Myocardium with Mitral

Valve prolapse and AV Block. ACC Michigan Chapter, Feb. 2005

21. *Penugonda N, Afonso L. Complex Endocarditis in an Immunocompromised Host

Second Annual American Medical Association Resident, Fellow and Student (AMA-

RFS) Research Poster Symposium Dallas, TX, Nov. 25

22. Pitta S, Kumaravelu P, Afonso L. 44-Year Old Male with Heart Failure and Continuous

Murmur. Online Case Studies. Cardiosource issue 11/22/2006

23. *Pitta SR, Vaitkevicius P, Afonso L. Extensive Circumferential Aortic Intramural

hematoma Treated with Endovascular Stenting Case of the week, Nov. 20, 2006

TCTMD-The comprehensive Cardiology and Interventional Resource, 2006

24. Afonso L, Pitta S, Vaitkevicius P. Extensive Circumferential Aortic Intramura

Hematoma Treated with Endovascular Stenting, www.tctmd.com Nov. 2006

25. *Pitta SR, Kumaravelu P, Afonso L. Unusual Physical Examination and Unusual

Diagnosis : Rare case of Aortic arch and Left Brachiocephalic Vein Fistula. Case Study

Published in Cardiosource, American College of Cardiology, Nov. 22, 2006

26. *Rudraiah L, Dhabuwala J, Awad K, Afonso L. Dobutamine Induced Coronary Artery

Spasm Presenting AS ST Evaluation During Stress Echo with Normal Coronaries on

Angiogram. MD. Annual Scientific Sessions Michigan ACC Chapter 2006

27. *Pitta SR, Penugonda N, Afonso L, Thatai D. A combination of pulmonary valve and

pulmonary artery stenosis in an adult with corrected Tetralogy of Fallot. Valves in the

Heart of the Big Apple V, April 12-14, NYC, 2007

28. Kondur A, Pitta SR, Afonso L. Cleft Mitral valve in Adults: The role of 3-D Echo in

diagnosis and surgical planning. Valves in the Big Apple V, April 12-14, NYC, 2007


20

29. Kondur A, Afonso L. “Implantable Cardioverter Defibrillators Save Lives from

Lightening Related Electrocution too..! PACE MS #PACE-07-0190

30. *Bachour K, Awad K, Afonso L. Midventricular Ballooning Cardiomyopathy:

Epicardial spasm vs. Microvascular Dysfunction: Can Echo Identify the Culprit? Second

Annual Case Competition at the 18 th Annual Scientific Sessions of the American

Society of Echocardiography (ASE) Seattle, WA June 16-20, 2007

Review Articles (Peer-Reviewed)

1. Afonso L, *Mohamad T, Thatai D. Crack Whips the Heart: A Comprehensive Review of

the Cardiovascular Toxicity of Cocaine . Am J Cardiol. 2007 Sept. 15;100(6):1040-3

2. Mahajan N, Khetarpal V, Afonso L. Stroke Secondary to Calcific Bicuspid Aortic

Valve: Case Report and Literature Review. Accepted to Jap Journal of Cardiology.

JJCC-D-08-0094R1. Nov. 2008

3. Afonso L, *Bernal J, Bax J, Abraham TP. The Echocardiographic Assessment of

hypertrophic Cardiomyopathy: Emphasis on Novel Imaging Modalities. J Am Coll

Cardiol Img. 2008;1:787-800

4. *Nelson K, Li T, Afonso L. Diagnostic Approach and Role of MRI in the Assessment of

Myocarditis. Cardiolo Rev. 2009 Jan-Feb 17(1):24-30

5. Khetarpal V, Mahajan N, Madhavan R, Batra S, Mopala P, Sagar A, Rapolu P, Nangia S,

Afonso L. Calcific Aortic Valve and Spontaneous Embolic Stroke: A Review of

Literature. J Neurol Sci. 2009 Dec 15;28(1-2);32-5. Epub 2009 Aug 26.

PMID:19712938

****************************E-REVIEWS*******************************

1. *Mohamad T, Ramappa , Afonso L. Primary and Secondary Prevention of Coronary

Artery Disease. A Review. E-medicine 2006. www.emedicine.com

2. *A Kondur, Daram D, Afonso L. Arrhythmic and Mechanical Complications of Acute

Myocardial Infarction. A review. E-medicine 2006 www.emedicine.com

3. *Hanson I, Afonso L. Mitra; Regurgitation. L Review Article. E-medicine 2008.

www.emedicine.com (update active 2009)

Editorials/Commentaries/Letters to the Editor

1. Dandapantula HK, Spears JK, Chandu L, Katkuri H Afonso L. Cigarette smoking and

myocardial infarction in young men and women – “Let us not forget coronary

vasospasm” Int J Cardiolo. 2007 Jun 25 PMID: 19594910


21

2. Dandapantula HK, Afonso L, Katkuri H, Chandu L, Spears JR. Unexplained pulmonary

hypertension in elderly patients: role of heart Failure with normal ejection fraction.

Bernheim effect and reverse Bernheim effect. Chest 2007 Jun;131(6):1987-8

(intellectual content)

3. Jacob S, Agarwal K, Afonso L. QRS Fragmentation in Patients with Repaired Tetralogy

of Fallot. American J of Cardiology 2009 Sep. 1;104(5):740-1

4. Afonso L, Kondur A, Hari P, Schreiber T. Findings at left heart cardiac catheterization

in nonagenarians. Clin Cardiol. 2009 Nov;32(11):659

Books Authorships, Editorships, and Chapters

1. Kleerekoper K, Hisham Alrefai, Afonso L, Ramam BB “Metabolic bone disease’ in

Challenging Cases in Endocrinology Humana Press 2002

2. Afonso L, Di Carli MF. Coronary Flow Regulation in Diabetes. Lanzer P and Topol E.

J. Theory and Practice of Vascular Medicine; 1 st ed Springe Verlag 2002

3. Afonso L, Mohamad T*, Badhaeka A*. Carditoxicity associated with drugs of abuse in

Cardiovascular Toxicology, 2 nd Edition. Volume 6 of the Comprehensive Toxicology

Series. Elsevier. 2008 (A massive and exhaustive compilation of cardiovascular toxicity

of drugs of abuse, time and labor intensive review, will be a Chapter in one of 8 Volumes

I press

4. Afonso L, Bachour K*. Chapter “Assessment of LV Size and Mass” ringer, handbook

of Echocardiography. *The Experts Pocket Guide to Echocardiography: The Experts

Handbook of Echocardiology** A case base approach to bedside echocardiography* The

Echo Pocket Guide 2009 (in press)

5. Afonso L, Mengistu S*. Prosthetic Heart Valves Springer. Handbook of

Echocardiography. The Expert Pocket Guide to Echocardiography: The Experts

handbook of Echocardiography A case based approach to bedside echocardiography.

The Echo Pocket Guide. 2009 (in press)

6. Afonso L, Mathew A*. The Assessment of Diastolic Dysfunction. Springer, Handbook

of Echocardiography. The Experts Pocket Guide to Echocardiography: The

echocardiography* The Echo Pocket Guide 2009 (in press)

Abstracts (last five years)

1. *Pitta SR, Afonso L. Left-ventricular Noncompaction. Oral presentation ACC

Michigan Chapter, MI 2004


22

2. *Pitta SR, Kalra N, Meri A, Afonso L. Misdiagnosis of Critical Mitral Stenosis-Poster

Presentation ACP-ASIM Michigan Scientific Chapter, MI 2003

3. *Modi S, Kronenberg M, Afonso L, Chaturvedi. Gender, Carotid Stenosis and Risk

Factor Treatment in African American Patients with CAD. Second International

Conference on Women, Heart Disease and Stroke. American Heart Association,

2005

4. *Mohamad T, Vaitkevicius P, *Bachour K, Ibrahim M, Higassy H, Agha SD, Afonso L.

Cocaine-Related Chest Pain – Utility of TIMI Risk Stratification and Effects of Beta

Blockers on Outcome. Abstract published Supplement Journal American Coll Card,

JACC 47 (4):288A. Feb 2006

5. *Pradhan J, *Niraj A, Afonso L. Determinants of Amount of Contrast Utilized in

Patients Undergoing Percutaneous Coronary Procedure. Abstract published Catheter

Cardiovasc Inter 2006;67(5):812-813

6. *Pradhan J, *Hui Jin, Afonso L. Global and Regional Contractile Abnormalities in

patients with Wolff-Parkinson-White Syndrome Using Speckle Tracking Imaging. ACC

Michigan Chapter Annual Scientific Sessions Oct. 2006

7. *Bachour K, Awad K, Afonso L. Predictors of Valve Perforation and Mortality in

Infective Endocarditis. Poster presented at the Valvular Heart Disease: New

Strategies, Mayo Clinic Conference. Las Vegas, NV 2006

8. Kondur AK, Afonso L, Vaka S, Stauffer N, Parker D, Kreighbaum K, Berenboom LD,

Pimentel R, Emert E, Lakkireddy Dr. Implantable Cardioverter Defibrillators Save Lives

from Lightening Related Electrocution too ….! 28 th Annual Scientific Sessions of the

Heart Rhythm Society, May 2007, Denver, CO

9. Cardozo L, Afonso L, Steinberg J, Vaitkevicius P, Brown G, Checcobelli. The Value of

Case Managed Tele Homecare (CMTH) in Recently Discharged Elderly Patients.

Journal of the American Geriatrics Society, Volume 55, Issue s1, Page S1-S218, D-

129, April 2007. Short listed for the Presidential Poster Session (top 25% abstracts)

10. *Bhandaru H, Mohammad K, Jareer F, Afonso L. Clinical Predictors of Myonecrosis in

Patients Presenting with Hypertensive Emergencies. Selected by the Abstract Review

Board for presentation as a poster finalist for the ACP Research Poster

Competition, Internal Medicine 2007 Scientific Sessions in San Diego, CA April 19,

2007

11. *Severity of Coronary Artery Disease in Obese Patients Undergoing Coronary

Angiography and Intervention: “Obesity Paradox” Revisited Abstract J Am Coll

Cardiol. 2007 March 6 Supplement 1;49(():A212-13


23

12. *Rodrigues D, *Pitta SR, Afonso L. Submassive Pulmonary Embolism: To Lyse or not

to Lyse? Shortlisted for Oral Presentation 30 th Annual Society for General Internal

Medicine Scientific Sessions, April 2007, Toronto, Canada

13. *Pradhan J, Veeranna V, Niraj A, Ramesh K, Afonso L, Schreiber TL. Racial

Differences in Outcome After Percutaneous Intervention: A Five-Year Follow Up.

Poster Presentation at the Society for Cardiovascular Angiography and

Interventions (SCAI), 13 th Annual Scientific Sessions, Orlando, FL May 2007,

Catheter Cardiovasc Interv. 2007 May 1;69(6):S75-76.

14. *Terefe Y, *Pradhan J, Afonso L. Myocardial Infarction with Angiographically Normal

Coronary Arteries. Poster Presentation at the Society for Cardiovascular

Angiography and Interventions (SCAI), 13 th Annual Scientific Sessions, Orlando

FL, May 2007 (abstract #C-37). Catheter Cardiovasc Interv Vol 2007 May

I;69(6):S69

15. *Hourani R, *Hanson ID, Afonso L. Do Mitral Annular and Inflow Velocities Correlate

with indices of Left Atrial Mechanical Function Derived Volumetrically by 3-

Dimensional Echo? Journal American Society Echocardiography Vol 20(5);611,

May 2007

16. *Hanson ID, *Venkalaya H, Mohamad T, Afonso L. Comparison of Two-Dimensional

Versus Three-Dimensional Echocardiography Techniques to Measure Left Atrial

Volume: Correlation with Left Ventricular Filling Pressure. Journal American Society

Echocardiography Vol 205(5);567, May 2007

17. *Bandaru H, Mohammed K, *Jareer F, Afonso L. Predictors of Cardiac Troponin-I

Release in Patients with Hypertensive Emergency. XIVth Scientific Sessions of the

Inter-American Society for Hypertension (IASH) and the Consortium for

Southeastern Hypertension Control, May 2007

18. * Niraj A, Pradhan J, Veeranna V, Afonso L. Racial Disparities in Coronary

Angiography and Noninvasive Testing: Myth or Reality. 14 th World Congress on

Heart Disease. The International Congress on Heart Disease Annual Scientific

Sessions, 2008

19. *Veeranna V, *Niraj A, Pradhan J, Afonso L. Do traditional Cardiovascular Risk

Factors Predict Extent of Angiographic Stenosis in Elderly Patients. 14 th World

Congress on Heart Disease. The International Congress on Heart Disease Annual

Scientific Sessions, Toronto, Canada July 2008.

20. Kondur AK, Niraj A, Afonso L. Systolic Intraventicular Dyssynchrony in Hypertrophic

Cardiomyopathy: Differentiation from Athlete. Heart 14 th World Congress on Heart

Diseases. The International Congress on Heart Disease Annual Scientific Session,

Toronto, Canada July 2008


24

21. *Mathew A, *Bhandare D, Kizilbash M, Afonso L. Tei Index and Spectrum of Diastolic

Abnormalities in Takotsubo Cardiomyopathy. 14 th World Congress on Heart

Disease. The International Congress on Heart Disease Annual Scientific Session,

Toronto, Canada July 2008

22. Afonso L, Mahajan N, Prigent F. Spectrum of Gated SPECT Myocardial Perfusion

Imaging (MPI) Abnormalities in Patients with Left Main Coronary Artery Disease: A

Tertiary Medical Center Experience “Journal of Nuclear Cardiology; Volume 15,

Number 4;S25-31 July / August 2008. Annual American Society of Nuclear

Cardiology Scientific Session ASNC Sept. 2008

23. Kondur A, Jacob S, Niraj A, Pradhan J, Sandidge G, Afonso L. Pattern and Extent of

Systolic Intraventricular Dyssynchrony in Patients with Hypertrophic Cardiomyopathy:

Comparison with Hypertensive and Athlete Hearts Using Tissue Doppler Imaging. **

Selected Oral e-presentation American Heart Association . Scientific Sessions.

Abst#1061. Nov 2008. New Orleans, LA. Circulation. 2008;118:s-641-642

24. Mahjan N, Mahavan R, Chaturvedi S, Afonso L. Predictors of Stroke in Patients with

Low Ejection Fraction and Sinus Rhythm: Left Ventricular Non Compaction is a Risk

Factor. American Heart Association’s International Stroke Conference 2009 Feb 18-

20 San Diego, CA

25. Veeranna V, Niraj A,*Fakhry H, Pradhan J, Afonso L. Correlation of Lipid Profile with

Angiographic Coronary Artery Disease Burden Among Elderly Patients Undergoing

Coronary Angiography. American Heart Association Quality of Care and Outcomes

Research in Cardiovascular Disease and Stroke Conference April 2009, Washington

DC.

26. *Fakhry H, Veeranna V, Zalawadiya SK< Panaich S, Niraj A, Pradhan J, Afonso L.

Coronary Artery Bypass Grafting vs. Percutaneous Coronary Intervention in

Octogenarians: Impact on Clinical Outcomes. To be presented at the American Heart

Association Quality of Care and Outcomes Research in Cardiovascular Disease and

Stroke Conference, April 2009, Washington DC.

27. *Fakhry H, Veeranna V, Zalawadiya SK, Panaich S, Niraj A, Pradhan J, Afonso L.

Detectable Troponin in Non-Acute Coronary Syndrome Patients in the Intensive Care

Unit Setting. Long Term Prognosis. Society for Cardiovascular Angiography and

Interventions (SCAI) 2009 Annual Scientific Sessions, May 2009, Las Vegas, NV

28. *Fakhry H, Veeranna V, *Zalawadiya S, *Niraj A, Pradhan J, Afonso L. Long Term

(>3yrs) Survival Benefit for Coronary Artery Bypass Grafting vs. Percutaneous

Intervention in Octogenarians: Is there Any? Accepted, Society for Cardiovascular

Angiography and Interventions (SCAI) 2009 Annual Scientific Sessions, May 2009,

Las Vegas, NV

29. *Badhela A, Rathod A, Kizilbash MA, Lai Z, Garg N, Bhat S, Afonso L, Jacob S.

Implantable Cardiac Defibrillator Shocks Do Not Predict Death in a Secondary


25

Prevention Population. Poster Presentation at the American College of Cardiology 58 th

Annual Scientific Session Orlando, FL 2009. J Am Coll Cardiol. 2009;53(1) Supp

1:A131

30. Badheka A, Rathod A, Kizilbash MA, Lai Z, Garg N, Bhat S, Afonso L. Effect of Renal

Disease on Recurrent Arrhythmia and Death in Survivors of Life Threatening Ventricular

Tachyarrhythmias. Poster Presentation at the American College of Cardiology 58 th

Annual Scientific Session in Orlando, FL, 2009. J Am Coll Cardiol

2009;53(10)Supp 1:A132

31. *Badheka A, Garg N, Kizilbash MA, Bhat S, Rathod A, Jacob S, Afonso L. Incident

Diabetes Mellitus in Patients with Stable Coronary Artery Disease. Incident Diabetes

Mellitus in Patients with Stable Coronary Artery Disease. Poster Presentation at the

American College of Cardiology 58 th Annual Scientific Session in Orlando, FL,

2009. J Am Coll Cardiol 2009;53(10) Supp 1:A346

32. *Badheka A, Bhat S, Kizilbash MA, Garg N, Rathod A, Jacob S, Afonso L. Predicting

Critical Peripheral Arterial Disease in Patients with Stable Coronary Artery Disease: A

Simple Risk Prediction Score. Poster Presentation at the American College of

Cardiology 58 th Annual Scientific Session in Orlando, FL, 2009. J Am Coll Cardiolg

2009;53(1) Supp 1:A450

33. Mahajan N, *Polarvaram I, *Venkalaya H, Wang Y, Agar J, Ference B, Afonso L.

Diagnostic Accuracy of Single-Photon Emission Computed Tomography Myocardial

Perfusion Imaging and Stress Echocardiography for the Diagnosis of Left Main and

Triple Vessel Disease: A Comparative Meta-Analysis. Accepted for the American

College of Cardiology 58 th Annual Scientific Session, Orlando, FL 2009

34. *Mengistu Alemayehu Simegn, Ashok Kondur, Preeti Ramappa, Tamam Mohammed,

Afonso L. Strain Dispersion Index and Global Longitudinal Strain in Differentiating

Hypertrophic Cardiomyopathy From Other Forms of Left Ventricular Hypertrophy.

Accepted for the American College of Cardiology 58 th Annual Scientific Sessions in

Orlando, FL 2009

35. Mahajan N, Kondur A, Niraj A, Veeranna V, Sudhakkar R, Afonso L. Drug Eluting

Stents (DES) versus Bare Metal Stents (BMS) in Octogenarians: A Comparative

Outcome Analysis. Accepted for the American College of Cardiology 58 th Annual

Scientific Sessions in Orlando, FL. 2009

36. Mahajan N, Bhattacharya P, Madhavan R, Dunn JK, Sacks FM, Afonso L. Predictors of

Cerebrovascular Disease Following Myocardial Infarction: Role of Non-HDL

Cholesterol in Risk Stratification. Accepted for the American College of Cardiology

58 th Annual Scientific Sessions in Orlando, FL 2009

37. Mahajan N, Kondur A, Bhat S, Kumar S, Afonso L. Impact of Renal Insufficiency on

Percutaneous Coronary Interventions Outcome in Elderly: A single Tertiary Center


26

Experience. Accepted American College of Cardiology 58 th Annual Scientific

Sessions, Orlando, FL, 2009

38. *Apurva Badheka, Ankit Rathod, *Mohammad A Kizilbash, Tamam Mohamad,

Zongshan Lai, Neha Garg, Samrat Bhat, Anil Mathew, Afonso L, Sony Jacob. Epileptic

Survivors of Sudden Death Cardiac Death are at Significantly Greater Risk of Recurrent

Arrhythmias and Death. 30 th Annual Scientific Session of the Heart Rhythm Society

2009, Boston, MA

39. *Apurva Badheka, *Ankit Rathod, *Mohammad A. Kizilbash, *Neha Garg, Tamam

Mohamad, Zongshan Lai, Samrat Bhat, Joya Ganguly, Luis Afonso, Sony Jacob. ECG

Predictors of Recurrence of Life Threatening Ventricular Tachyarrythmias. 30 th Annual

Scientific Session of the Heart Rhythm Society, 2009, Boston, MA

40. *Apurva Badheka, *Ankit Rathod, Mohammad A. Kizilbash, Neha Garg, Tamam

Mohamad, Joya Ganguly, Anil Mathew, Afonso L, Sony Jacob. Early and Consistent

Lipid Lowering Therapy is Associated with Decreased mortality in Atrial Fibrillation.

30 th Annual Scientific Session of the Heart Rhythm Society, 2009, Boston, MA

41. Badheka A, Rathod A, Kizilbash MA, Garg N, Mohamad T, Mathew A, Afonso L, Jacob

S. An Obesity paradox in Outcomes of Atrial Fibrillation. 30 th Annual Scientific

Session of the Heart Rhythm Society, 2009, Boston, MA

42. *Rathod A, Badheka A, Kizilbash MA, Garg N, Mohamad T, Ganguly J, Afonso L,

Jacob S. Mortality and Ischemic Stroke in Patients with Atrial Fibrillation and Heart

Failure with Preserved Ejection Fraction. 30 th Annual Scientific Session of the Heart

Rhythm Society, 2009 Boston, MA

43. Mahajan N, *Ganguly J, *Simegn M, Bhattacharya P, Shankar L, Madhavan R, Preeti

Ramappa, Afonso L. Predictors of Thromboembolic Events in Adults with Isolated Left

Ventricular Non Compaction. Society for Cardiovascular Angiography and Interventions

SCAI’s 32 nd Annual Scientific Sessions in Las Vegas, NV, May 6-9, 2009

44. Kondur A, Mahajan N, *Sudhakar R, *Niraj A, Veeranna V, Bhat S, Afonso L.

Mortality Trends of Percutaneous Coronary Interventions in Octogenarians: Bare Metal

Stents vs. Drug Eluting Stents. Society for Cardiovascular Angiography and

Interventions SCAI’s 32 nd Annual Scientific Sessions in Las Vegas, NV, May 6-9,

2009

45. *Badheka A, *Bhat S, * Rathod A, Kizilbash M, Garg N, Mohamad T, Lai Z, Afonso L,

Jacob S. Stroke Risk and CHADS2 Score For Risk Stratification In Patients with Atrial

Fibrillation And Heart Failure With Preserved Ejection Fraction. Atherosclerosis,

Vascular Thrombosis and Biology Scientific Sessions, AHA 2009 09-A-731-AHA-

ATVB


27

46. Mahjan N, Kondur A, *Sudhakar R, *Bhat S, Afonso L. Predictors of Cardiovascular

Events Following Percutaneous Coronary Intervention: Role of non HDL, Cholesterol in

Risk Stratification in Octogenarians. SCAI’s 32 nd Annual Scientific Sessions in Las

Vegas, NV, May 6-9, 2009

47. Mahajan N, *Ganguly J, *Simegn M, Bhattacharya P, Shankar L, Madhavan R, Ramappa

P, Afonso L. Echocardiographic Predictors of Thromboembolic Events in Patients with

left Ventricular Non Compaction: Pulmonary Hypertension is a Risk Factor. American

Society of echocardiography 20 th Annual Scientific Sessions, 2009, Washington, DC.

48. *Bhadheka A, *Rathod A, *Kizilbash MA, *Garg N, Mohamad T, Jacob S, Afonso L.

Left Atrial Diameter is a Predictor of Mortality in Patients with Atrial Fibrillation and

Preserved Ejection Fraction. American Society of Echocardiography 20 th Annual

Scientific Session 2009, Washington, DC

49. *Kottam A, Afonso L. Improving Diagnostic Yield of Transeophaegeal

Echocardiography for Patent Foramen Ovale: Can Fluid Bolusing Release the Door-

Jam? American Society of Echocardiography 20 th Annual Scientific Session, 2009,

Washington, DC.

50. A Badheka, S Bhat, A Rathod, M Kizilbash, N Garg, T Mohamad, Z Lai, L Afonso, S

Jacob. Stroke Risk and CHADS2 For Risk Stratification in Patients with Atrial

Fibrillation and Heart Failure with Preserved Ejection Fraction. Atherosclerosis

Thrombosis and Vascular Biology, AHA, Scientific Sessions, Washington, DC. 2009

51. *Mengistu Simegn, Vikas Veeranna, Kondur A, Ramappa P, Pradhan JP, Tamam

Mohammad, Afonso Luis. Loss of Base to Apex Strain Gradient and Low Global

Longitudinal Strain Identifies Hypertrophic Cardiomyopathy From Other Forms of Left

Ventricular Hypertrophy. American Society of Echocardiography 20 th Annual

Scientific Sessions, 2009, Washington,DC

52. *Bhandare D, Afonso L., Jacob S. Rate of Ejection Fraction “Decay” (Delta EF) Prior to

Implantation Predicts Cardiac Resynchronization Therapy American Society of

Echocardiography 20 th Annual Scientific Sessions, 2009, Washington, DC.

53. *Badehka A, *Rathod A, *Kizilbash MA, *Garg N, *Mohamad T, Jacob S, Afonso L.

Does modality of Measurement of Ejection Fraction Matter in Survivors of Myocardial

infarction with Preserved or Slightly Depressed Ejection Fraction in the Modern Era?

American Society of Echocardiography 20 th Annual Scientific Sessions, 2009,

Washington, DC.

54. Veeranna V, Niraj A, Fakhry H, Pradhan J, Afonso L. Correlation of Lipid Profile and

Angiographic Coronary Artery Disease Burden Among Elderly patients Undergoing

Coronary. Angiography Society for Cardiovascular Angiography & Interventions

(SCAI) 32 nd Annual Scientific Sessions, Las Vegas, NV, May 6-9, 2009


28

55. Rathod A, Badheka A, Kizilbash MA, Garg N, Veeranna V, Mohamad T, Jacob S,

Afonso L. Abstract 3148: Development of Heart Failure is a Risk Factor for Incident

new Onset Diabetes in the Community. Oral Presentation, Circulation, Nov.

2009;120:S749.

56. Veeranna V, Niraj A, Zalawadiya S, Pradhan J, Afonso L. Alcohol Consumption and

Cardiovascular Risk Among United State Adults: An Analysis From the US National

Health and Nutrition Examinations Survey (1999-2006), Circulation, Nov.

2009;120:S487

57. Mahajan N, Sarsam S, Mopala P, Polavaram L, Venkalaya H, Wang Y, Agar J, Ference

B, Afonso L. Exercise Single Photon Emission Computed Tomography (SPECT)

Imaging or Exercise Echocardiography? A Meta-Analysis of Exercise Testing for

Diagnosis of High-Risk Coronary Artery Disease. Circulation, Nov. 2009, ;120:S369.

58. Bernard D, Pinheiro A, Bhandare D, Dimaano VL, Nazarian S, Afonso L, George R,

Thompson R, Brenner J, and Abraham TP. Electrocardiography versus

Echocardiography in High-Volume, Community-Based Screening for Potentially Life-

Threatening Cardiac Pathologies in Athletes: Implications for Optimal Screening

Strategies, Circulation, Nov. 2009;120:S410-S411.

59. Rathod A, Badheka A, Kizilbash M, Garg N, Veeranna V, Mohamad T, Jacob S, Afonso

L. Development of Heart Failure is a Risk Factor for Incident New Onset Diabetes in the

Community. Oral Presentation. American Heart Association, Scientific Session. Nov.

2009, Orlando, FL

60. Rathod A, Veeranna V, Manickam P, Badheka A, Niraj A, Pradhan J, Jacob S, Afonso L.

Effect of Lipid Subclasses on The Risk of Cardiovascular Outcomes in An Ethnically

Diverse Asymptomatic Population. American College of Cardiology 59 th Scientific

Session, March 14-16, 2010 in Atlanta, GA

61. Rathod A, Badheka A, Manickam P, Veeranna V, Sudhakar R, Mohamad T, Jacob S,

Afonso L. Progression of Atherosclerosis in an Asymptomatic Population-Effect of

Lipid Subclass. American College of Cardiology 59 th Annual Scientific Session,

March 14-16, 2010 in Atlanta, GA

62. Zalawadiya SK, Pradhan J, Niraj A, Veeranna V, Manickam P, Hari PK, Sony J, Afonso

L. Waist Hip Ratio, Not Body Mass Index Predicted Cardiovascular Risk in a Multi

Ethnic Cohort of Healthy Adults. American College of Cardiology 59 th Annual

Scientific Session, March 14-16, 2010, in Atlanta, GA

63. Zalawadiya SK, Niraj A, Veeranna V, Pradhan J, Panaich S, Sony J, Afonso L. Is There

a Gender Disparity in Risk Association of Inflammatory Biomarkers with New Onset

Diabetes in Healthy Adult Population? American College of Cardiology 59 th Annual

Scientific Session, March 14-16, 2010 , in Atlanta, GA


29

64. Manickam P, Rathod A, Badheka A, Hari PK, Veeranna V, Pradhan J, Jacob S, Afonso

L. Prognostic implications of Atherogenic/Anti-Atherogenic Lipid Rations in an

Ethnically Diverse Population. American College of Cardiology 59 th Annual

Scientific Session, March 14-16, 2010, in Atlanta, GA.

65. Manickam P, Rathod A, Badheka A, Hari PK, Veeranna V, Pradhan J, Jacob S, Afonso

L. Disparities in Association of Various Lipid Ratios on the Location and Severity of

Atherosclerosis in Different Vascular Beds. American College of Cardiology 59 th

Annual Scientific Sessions, March 14-16, 2010, in Atlanta, GA

66. Manickam P, Veeranna V, Rathod A, Hari PK, Zalawadiya S, Badheka A, Jacob S,

Afonso L. Novel Biomarkers Associated with Left Ventricular Hypertrophy. American

College of Cardiology 59 th Annual Scientific Session, March 14-16, 2010, in Atlanta,

GA

67. Hari PK, Veeranna V, Manickam P, Zalawadiya S, Mengistu S, Pradhan J, Jacob S,

Afonso L. Microalbuminuria in Non-Diabetic Patient with Metabolic Syndromes is a

Strong Predictor of Carotid Artery Distensibility and Thickness. American College of

Cardiology 59 th Annual Scientific Session, March 14-16, 2010, in Atlanta, GA

68. Hari PK, Veeranna V, Sudhakar R, Manickam P, Niraj A, Kaur R, Jacob S, Afonso L.

Gender and Ethnic Differences in Cardiovascular Events and Mortality in Patients with

Depressive Symptoms. American College of Cardiology 59 th Annual Scientific

Session, March 14-16, 2010, in Atlanta, GA

69. Hari PK, Veeranna V, Manickam P, Sudhakar R, Simegn M, Zalawadiya S, Jacob S,

Afonso L. Microalbuminuria in Non-Diabetic Patients with metabolic Syndrome is

Strongly Associated with Systemic Inflammation. American College of Cardiology

59 th Annual Scientific Session, March 14-16, 2010, in Atlanta, GA

70. Hari PK, Veeranna V, Sudhakar R, Manickam P, Pradhan J, Jacob S, Afonso L.

Microalbuminuria in Non-Diabetic Patients with Metabolic Syndrome is a Strong

Predictor of Subclinical Atherosclerosis: A Multi-Ethnic Perspective. American College

of Cardiology 59 th Annual Scientific Session, March 14-16, 2010, in Atlanta, GA

71. Hari PK, Veeranna V, Sudhakar R, Manickam P, Kaur R, Pradhan J, Jacob S, Afonso L.

Does the Presence of Microalbuminuria Portend a Worse Outcome in Non-Diabetic

Patients with Metabolic Syndrome? American College of Cardiology 59 th Annual

Scientific Session, March14-16, 2010, in Atlanta, GA

72. Veeranna V, Niraj A, Zalawadiya S, Pradhan J, Jacob S, Afonso L. Gender Difference in

Novel Biomarkers for Predicting Future Cardiovascular and Coronary Events. American

College of Cardiology 59 th Annual Scientific Session, March 14-16, 2010, in Atlanta,

GA.


30

73. Mahajan N, Sagar A, Khetarpal V, Kondur A, Sarsam S, Polavaram L, Venkalaya H,

Wang Y, Agar J, Afonso L. Pharmacologic Single Photon Emission Computed

Tomography (SPECT) Imaging or Pharmacologic Echocardiography? A Meta Analysis

of Pharmacologic Testing for Diagnosis of High Risk Coronary Artery Disease.

American College of Cardiology 59 th Annual Scientific Session, March 14-16, 2010,

in Atlanta, GA

INVITED LECTURES/PRESENTATIONS

1. Invite Expert: Michigan Society of Echo, Stump the Stars. Regional Chapter Meeting,

Aug 2005

2. Diastolic Heart Failure: Feeling or Filling out of Sorts. Michigan Chapter. American

College of Cardiology Scientific Meeting, Oct. 2005 Traverse City, MI

3. Update on ECG Interpretation, (Clinical Skills Development Session). Michigan

Chapter, American College of Physicians, Scientific Meeting, Sept. 2005. Also served as

judge for Poster Competition, Michigan Chapter and American College of Physicians,

Scientific Meeting Sept. 2005

4. Cardiac Resynchronization Therapy. Pathophusiologic insights and identification of

responders. Congestive Heart Failure. New Frontiers in Cardiology 2 nd Annual

Conference organized by Providence Hospital, Westin Hotel, Southfield, MI Sept. 21,

2006

5. Current Status of 3 D Echocardiography: Overview with Illustrative Examples

Michigan Society of Echocardiography, Annual Conference, Crystal Mountain, MI Feb

8 th 2009

6. Strain Imaging: Principles to Practice. Michigan Society of Echocardiography, Annual

Conference. Crystal Mountain, MI Feb 8 th 2009

7. The Echocardiographic Assessment of Prosthetic Heart Valves Michigan Society of

Echocardiography, Spring Meeting May 2009. Kresge Auditorium Harper Hospital,

Detroit MI

Invited Seminars and Grand Rounds

1. “Tissue Doppler Imaging: Contemporary Applications, 2006. Invited lecture to

Cardiology Section of the Perinatology Research Branch NIH, Wayne State University,

Detroit, MI

2. Recent Advances in Echocardiography, Medical School Grand Rounds, Nov. 15, 2006.

Scott Hall Wayne State University Medical School, Detroit, MI


3. Peripartum Cardiomyopathy: Focus on Etipathogenesis and Diagnosis. Perinatology

Research Branch, National Institute of Health, Harper University Hospital, Detroit, MI,

Aug. 2008

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