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Plaque Ruptur

Plaque Ruptur

Advanced, Complicated

Advanced, Complicated Lesion Early progression of the atherosclerotic lesion Ross, R 1999; N. Engl. J. Med. 340:115-126 VJ. Dzau et al. Nat. Med. 2002; 8:1249-1256 Vascular smooth muscle cells mediate proliferation, inflammation, matrix alterations and contraction Formation of the advanced and stable lesion VJ. Dzau et al. Nat. Med. 2002; 8:1249-1256 VJ. Dzau et al. Nat. Med. 2002; 8:1249-1256 Unstable Fibrous Plaques in Atherosclerosis Ruptured Atherosclerotic Plaque lipid core fissure thin cap Ross, R 1999; N. Engl. J. Med. 340:115-126

Vulnerable plaque formation and plaque rupture Plaque Ruptur Thrombus Fibröse Kappe VJ. Dzau et al. Nat. Med. 2002; 8:1249-1256 Lipid Kern M.L. Higuchi Activated platelets Ruggeri ZM, Nat Med 2002; 8:1227-1234 Platelet adhesion, activation, and aggregation Ruggeri ZM, Nat Med 2002; 8:1227-1234 Thrombogenicity of atherosclerotic plaque at different stages of progression. Life history of an atheroma Libby; Nature 2002; 420:868-674 Khrenov AV; Trends Cardiovasc Med 2002;12: 317-24

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