MONOGRAPH PREVNAR 13® - PfizerPro

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MONOGRAPH PREVNAR 13® - PfizerPro

THE BURDEN OF PNEUMOCOCCAL DISEASE IN ADULTS 50 YEARS OF AGE AND OLDER

THE IMPACT OF ANTIBIOTIC-RESISTANT S PNEUMONIAE

CAP AND S PNEUMONIAE

CAP affects an estimated 4 million Americans annually, with S pneumoniae being the causative pathogen up to 36% of the

time. 2,3,14,18,19 CAP due to S pneumoniae is associated with significant morbidity and costs. 3 These costs are particularly high

in adults aged 50+. Based on an estimate of US health care utilization costs for 2004, Huang et al estimated that adults aged

50+ accounted for over half of the productivity and work losses. 10

According to current census figures, adults 50 years of age and older constitute almost one-third of the total US population,

and a growing population of adults 50 years of age and older may mean that more patients will be at risk. 20 Despite efforts

to both prevent and manage this disease in adults, the overall burden of PD among adults 50 years of age and older

continues to be substantial. 13,21

THE IMPACT OF ANTIBIOTIC-RESISTANT S PNEUMONIAE

The emergence of antimicrobial resistance has become a major challenge for health care professionals in their efforts to

control a variety of infectious diseases. In fact, the Infectious Diseases Society of America (IDSA) has stated, “Until recently,

research and development (R&D) efforts have provided new drugs in time to treat bacteria that became resistant to older

antibiotics. That is no longer the case.” 22

Management of S pneumoniae may be significantly complicated by this emergence of antimicrobial resistance,

particularly multidrug resistance, defined as resistance to 3 or more different antimicrobial classes. 23,24 S pneumoniae

has been cited by the IDSA as one of the “bad bugs,” which are characterized by an ability to rapidly develop

multidrug-resistant strains. 22 S pneumoniae is a pathogen that can be vaccinated against to help prevent disease.

Taking steps to reduce PD should be an important public health priority.

THE IMPACT OF ANTIBIOTIC-

RESISTANT S PNEUMONIAE

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