CONTACT: Daina Cardillo FOR IMMEDIATE ... - Upsher-Smith

upsher.smith.com

CONTACT: Daina Cardillo FOR IMMEDIATE ... - Upsher-Smith

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neuronal gap junction modulator. Based on results of preclinical models of seizures,

Upsher-Smith will focus on development of tonabersat for the treatment of epilepsy. In July

2008, Upsher-Smith entered into a worldwide licensing agreement with Proximagen

Neuroscience Plc for the development and commercialization of the PRX1 program for the

symptomatic treatment of Parkinson’s disease.

About Epilepsy and Parkinson’s Disease

Epilepsy is a neurological condition that produces seizures affecting a variety of mental

and physical functions. Almost three million people in the U.S. have some form of active

epilepsy with about 200,000 new cases of epilepsy diagnosed each year. 1

Parkinson’s disease is a chronic, progressive neurodegenerative disease that causes

impairment in motor function, as well as many non-motor complications throughout the various

stages of the disease. As many as 1 million people in the U.S. suffer from Parkinson’s disease,

with 1 in 100 people over the age of 60 affected. 2

About Upsher-Smith

Upsher-Smith Laboratories, Inc., founded in 1919, is a rapidly growing, privately held

pharmaceutical company that develops, manufactures, and markets prescription and over-thecounter

products. Upsher-Smith’s product portfolio focuses in the areas of women’s health,

dermatology, cardiology, and central nervous system diseases. The company’s growing CNS

pipeline concentrates on diseases with significant unmet need, including epilepsy and

Parkinson’s disease. To expand its CNS pipeline, Upsher-Smith seeks alliances and codevelopment

programs, pursues licensing and acquisitions, and leverages the development of

its core competency in formulation development. For more information, visit www.upshersmith.com.

# # #

1. Epilepsy Foundation. Available at: http://www.epilepsyfoundation.org/. Accessed on May 19, 2010.

2. The Michael J. Fox Foundation for Parkinson’s Research. Available at: http://www.michaeljfox.org/. Accessed on May 19, 2010.

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