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Appendix B: Bioassay Quality Assurance [5.6 Mb - pdf] - ustur

Appendix B: Bioassay Quality Assurance [5.6 Mb - pdf] - ustur

Appendix B: Bioassay Quality Assurance [5.6 Mb - pdf] -

IMBA Expert OCAS/ORAU-Edition (Vers. 4.0) User Manual Appendix B: Bioassay Quality Assurance August, 2005 Prepared by ACJ & Associates, Inc. 129 Patton Street Richland, WA 99354-1618 Tel: (509) 375-7718 FAX: (509) 375-5190 E-mail: imba@acj-associates.com Web Site: www.imbaexpertsupport.com © 2001-2005 ACJ & Associates, Inc. Anthony C. James, Ph.D. ‡ James W. Marsh, Ph.D. § Alan W. Phipps, Ph.D. § Alan Birchall, Ph.D. § Naomi S. Jarvis, Ph.D. † David King § Tracy Smith § Katie Davis § Noelle Easterday ‡ Antonia H. James £ This Appendix provides quality assurance of the accuracy of bioassay calculations performed by IMBA Expert OCAS/ORAU-Edition, by comparing the calculated results with “benchmark” values obtained by running the Health Protection Agency – Radiation Protection Division’s (HPA- RPD’s) PLEIADES code. PLEIADES was one of the codes used by the International Commission on Radiological Protection (ICRP) to calculate the intake retention functions (IRFs) for bioassay analysis and dose coefficients currently recommended by ICRP. ‡ ACJ & Associates, Inc., Richland, WA 99354, USA. § Health Protection Agency, Centre for Radiation, Chemical, and Environmental Hazards, Radiation Protection Division, Didcot, OXON OX11 0RQ, UK. † Consultant, Allison Park, PA 15101, USA. £ Guy’s, King’s & St. Thomas’ School of Medicine, London, SE1 1UL, UK.

  • Page 2 and 3: Contents B.1. QUALITY ASSURANCE PLA
  • Page 4 and 5: B.7.22.2. Fecal Excretion Rate ....
  • Page 6 and 7: B.7.48.3. Whole Body Retention ....
  • Page 8 and 9: B.7.74.4. Lung Retention...........
  • Page 10 and 11: B.7.101.3. Whole Body Retention ...
  • Page 12 and 13: B.7.127.4. Lung Retention..........
  • Page 14 and 15: B.7.153.3. Whole Body Retention ...
  • Page 16 and 17: B.7.179.3. Whole Body Retention ...
  • Page 18 and 19: B.7.206. STRONTIUM - INHALATION OF
  • Page 20 and 21: B.7.234. THALIUM - INJECTION OF 202
  • Page 22 and 23: B.7.259. URANIUM - INGESTION OF 232
  • Page 24 and 25: B.7.283.2. Fecal Excretion Rate ...
  • Page 26 and 27: This page intentionally blank XXVI
  • Page 28 and 29: B.1.2. Use of Benchmark Comparisons
  • Page 30 and 31: Table B.2.1. (Contd). Maximum Diffe
  • Page 32 and 33: B.2.2. Summary of “Benchmark” R
  • Page 34 and 35: Table B.2.2. (Contd). Maximum Diffe
  • Page 36 and 37: Table B.2.3. (Contd). No. Element/I
  • Page 38 and 39: Table B.2.3. (Contd). Maximum Diffe
  • Page 40 and 41: Table B.3.2. Comparison of urinary
  • Page 42 and 43: Table B.4.2. Comparison of fitted v
  • Page 44 and 45: B.5. Fitting Multiple Bioassay Quan
  • Page 46 and 47: B.6. Validation of IMBA-FIT’s Use
  • Page 48 and 49: Table B.6.1 gives the results of th
  • Page 50 and 51: B.7.2.1. Urinary Excretion Rate TIM
  • Page 52 and 53:

    B.7.5. Antimony - Inhalation of 125

  • Page 54 and 55:

    B.7.8. Antimony - Injection of 125

  • Page 56 and 57:

    B.7.11.2. Fecal Excretion Rate TIME

  • Page 58 and 59:

    B.7.14.3. Whole Body Retention 100

  • Page 60 and 61:

    B.7.17.2. Fecal Excretion Rate TIME

  • Page 62 and 63:

    500 1.80E-06 1.80E-06 0 1,000 1.19E

  • Page 64 and 65:

    B.7.23.1. Urinary Excretion Rate TI

  • Page 66 and 67:

    B.7.26.2. Fecal Excretion Rate TIME

  • Page 68 and 69:

    B.7.29.2. Fecal Excretion Rate TIME

  • Page 70 and 71:

    B.7.33. Cerium - Ingestion of 143 C

  • Page 72 and 73:

    B.7.36.1. Urinary Excretion Rate TI

  • Page 74 and 75:

    B.7.39.1. Urinary Excretion Rate TI

  • Page 76 and 77:

    1,000 3.764E-06 3.766E-06 -0.04 2,0

  • Page 78 and 79:

    B.7.45.3. Whole Body Retention TIME

  • Page 80 and 81:

    B.7.49.1. Urinary Excretion Rate TI

  • Page 82 and 83:

    B.7.52. Cobalt - Ingestion of 60 Co

  • Page 84 and 85:

    B.7.55.1. Urinary Excretion Rate TI

  • Page 86 and 87:

    B.7.58.1. Urinary Excretion Rate TI

  • Page 88 and 89:

    B.7.61.1. Urinary Excretion Rate TI

  • Page 90 and 91:

    B.7.65.1. Urinary Excretion Rate TI

  • Page 92 and 93:

    B.7.68.1. Urinary Excretion Rate TI

  • Page 94 and 95:

    B.7.71. Iodine - Injection of 131 I

  • Page 96 and 97:

    B.7.74. Iridium - Inhalation of 192

  • Page 98 and 99:

    B.7.77.1. Urinary Excretion Rate TI

  • Page 100 and 101:

    B.7.80.1. Urinary Excretion Rate TI

  • Page 102 and 103:

    2 3.377E-01 3.376E-01 0.00 5 2.568E

  • Page 104 and 105:

    B.7.87. Lead - Ingestion of 210 Pb

  • Page 106 and 107:

    50 8.86E-07 8.86E-07 -0.01 100 7.26

  • Page 108 and 109:

    2,000 6.484E-20 N/A N/A 5,000 2.803

  • Page 110 and 111:

    B.7.97. Molybdenum - Inhalation of

  • Page 112 and 113:

    100 4.952E-02 4.955E-02 -0.05 200 4

  • Page 114 and 115:

    2 3.105E-02 3.105E-02 -0.02 5 1.225

  • Page 116 and 117:

    1 5.650E-02 5.651E-02 -0.01 2 5.377

  • Page 118 and 119:

    B.7.111. Phosphorus - Inhalation of

  • Page 120 and 121:

    2 6.379E-03 6.379E-03 0.01 5 3.442E

  • Page 122 and 123:

    500 2.391E-08 2.394E-08 -0.12 1,000

  • Page 124 and 125:

    B.7.120.3. Whole Body Retention TIM

  • Page 126 and 127:

    100 4.739E-08 4.736E-08 0.08 200 3.

  • Page 128 and 129:

    B.7.126.3. Whole Body Retention TIM

  • Page 130 and 131:

    500 2.416E-08 2.419E-08 -0.12 1,000

  • Page 132 and 133:

    B.7.132.3. Whole Body Retention TIM

  • Page 134 and 135:

    100 4.739E-08 4.735E-08 0.08 200 3.

  • Page 136 and 137:

    5,000 6.288E-06 6.275E-06 0.22 10,0

  • Page 138 and 139:

    500 7.20E-05 7.20E-05 0 1,000 5.07E

  • Page 140 and 141:

    B.7.145. Polonium - Ingestion of 20

  • Page 142 and 143:

    B.7.148.2. Fecal Excretion Rate TIM

  • Page 144 and 145:

    20 6.37E-02 6.37E-02 0 50 1.31E-02

  • Page 146 and 147:

    B.7.155. Praseodymium - Inhalation

  • Page 148 and 149:

    B.7.160.2. Fecal Excretion Rate TIM

  • Page 150 and 151:

    2,000 9.20E-32 N/A N/A Maximum: -0.

  • Page 152 and 153:

    B.7.168. Protactinium - Injection o

  • Page 154 and 155:

    B.7.172. Radium - Inhalation of 226

  • Page 156 and 157:

    B.7.175. Radium - Inhalation of 228

  • Page 158 and 159:

    B.7.178. Ruthenium - Inhalation of

  • Page 160 and 161:

    10 5.681E-02 5.681E-02 -0.01 20 5.1

  • Page 162 and 163:

    B.7.184. Samarium - Ingestion of 15

  • Page 164 and 165:

    B.7.187.1. Urinary Excretion Rate T

  • Page 166 and 167:

    B.7.190.3. Whole Body Retention TIM

  • Page 168 and 169:

    B.7.194. Strontium - Ingestion of 8

  • Page 170 and 171:

    B.7.197.2. Fecal Excretion Rate TIM

  • Page 172 and 173:

    100 4.583E-02 4.580E-02 0.05 200 9.

  • Page 174 and 175:

    B.7.204. Strontium - Ingestion of 9

  • Page 176 and 177:

    Maximum: -0.27 B.7.207.4. Lung Rete

  • Page 178 and 179:

    5 9.404E-01 9.404E-01 0.00 10 8.818

  • Page 180 and 181:

    B.7.214.3. Whole Body Retention TIM

  • Page 182 and 183:

    B.7.218. Technetium - Ingestion of

  • Page 184 and 185:

    B.7.222.2. Fecal Excretion Rate B.7

  • Page 186 and 187:

    B.7.227.1. Urinary Excretion Rate T

  • Page 188 and 189:

    B.7.232.3. Whole Body Retention TIM

  • Page 190 and 191:

    20 9.86E-03 9.86E-03 0 50 1.21E-03

  • Page 192 and 193:

    B.7.239.3. Whole Body Retention TIM

  • Page 194 and 195:

    5,000 1.900E-08 1.896E-08 0.20 10,0

  • Page 196 and 197:

    1,000 1.177E-08 1.177E-08 0.05 2,00

  • Page 198 and 199:

    B.7.248.3. Whole Body Retention TIM

  • Page 200 and 201:

    50 2.15E-01 2.15E-01 -0.06 100 5.09

  • Page 202 and 203:

    B.7.255. Tin - Injection of 113 Sn

  • Page 204 and 205:

    B.7.257.4. Kidney Retention TIME IM

  • Page 206 and 207:

    2,000 5.91E-06 5.92E-06 -0.09 5,000

  • Page 208 and 209:

    10 5.953E-02 5.955E-02 -0.03 20 5.1

  • Page 210 and 211:

    5,000 2.740E-11 2.740E-11 -0.03 10,

  • Page 212 and 213:

    B.7.268.4. Lung Retention TIME IMBA

  • Page 214 and 215:

    5,000 2.740E-11 2.740E-11 -0.03 10,

  • Page 216 and 217:

    10,000 8.085E-04 8.083E-04 0.02 20,

  • Page 218 and 219:

    20,000 4.483E-12 4.484E-12 -0.02 Ma

  • Page 220 and 221:

    B.7.281.3. Whole Body Retention TIM

  • Page 222 and 223:

    10 5.23E-04 5.23E-04 -0.02 20 2.86E

  • Page 224 and 225:

    B.7.288.4. Lung Retention TIME IMBA

  • Page 226 and 227:

    B.7.292.1. Urinary Excretion Rate T

  • Page 228 and 229:

    B.7.295.3. Whole Body Retention TIM

  • Page 230 and 231:

    1,000 3.772E-11 3.786E-11 -0.37 2,0

  • Page 232:

    B.8. References Birchall A, Jarvis

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